Clinical and Developmental Immunology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Itaconate as a key regulator of respiratory disease
Clin Exp Immunol. 2023 Nov 29:uxad127. doi: 10.1093/cei/uxad127. Online ahead of print.ABSTRACTMacrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to itaconate (by aconitate decarboxylase-1, ACOD1) in the mitochondrial matrix. Recent studies have highlighted the potential of targeting itaconate as a therapeutic strategy for lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and respiratory infections. This review a...
Source: Clinical and Developmental Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Christina Michalaki Gesa J Albers Adam J Byrne Source Type: research
Itaconate as a key regulator of respiratory disease
Clin Exp Immunol. 2023 Nov 29:uxad127. doi: 10.1093/cei/uxad127. Online ahead of print.ABSTRACTMacrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to itaconate (by aconitate decarboxylase-1, ACOD1) in the mitochondrial matrix. Recent studies have highlighted the potential of targeting itaconate as a therapeutic strategy for lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and respiratory infections. This review a...
Source: Clinical and Developmental Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Christina Michalaki Gesa J Albers Adam J Byrne Source Type: research
Itaconate as a key regulator of respiratory disease
Clin Exp Immunol. 2023 Nov 29:uxad127. doi: 10.1093/cei/uxad127. Online ahead of print.ABSTRACTMacrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to itaconate (by aconitate decarboxylase-1, ACOD1) in the mitochondrial matrix. Recent studies have highlighted the potential of targeting itaconate as a therapeutic strategy for lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and respiratory infections. This review a...
Source: Clinical and Developmental Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Christina Michalaki Gesa J Albers Adam J Byrne Source Type: research
Itaconate as a key regulator of respiratory disease
Clin Exp Immunol. 2023 Nov 29:uxad127. doi: 10.1093/cei/uxad127. Online ahead of print.ABSTRACTMacrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to itaconate (by aconitate decarboxylase-1, ACOD1) in the mitochondrial matrix. Recent studies have highlighted the potential of targeting itaconate as a therapeutic strategy for lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and respiratory infections. This review a...
Source: Clinical and Developmental Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Christina Michalaki Gesa J Albers Adam J Byrne Source Type: research
Itaconate as a key regulator of respiratory disease
Clin Exp Immunol. 2023 Nov 29:uxad127. doi: 10.1093/cei/uxad127. Online ahead of print.ABSTRACTMacrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to itaconate (by aconitate decarboxylase-1, ACOD1) in the mitochondrial matrix. Recent studies have highlighted the potential of targeting itaconate as a therapeutic strategy for lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and respiratory infections. This review a...
Source: Clinical and Developmental Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Christina Michalaki Gesa J Albers Adam J Byrne Source Type: research
Itaconate as a key regulator of respiratory disease
Clin Exp Immunol. 2023 Nov 29:uxad127. doi: 10.1093/cei/uxad127. Online ahead of print.ABSTRACTMacrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to itaconate (by aconitate decarboxylase-1, ACOD1) in the mitochondrial matrix. Recent studies have highlighted the potential of targeting itaconate as a therapeutic strategy for lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and respiratory infections. This review a...
Source: Clinical and Developmental Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Christina Michalaki Gesa J Albers Adam J Byrne Source Type: research
Itaconate as a key regulator of respiratory disease
Clin Exp Immunol. 2023 Nov 29:uxad127. doi: 10.1093/cei/uxad127. Online ahead of print.ABSTRACTMacrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to itaconate (by aconitate decarboxylase-1, ACOD1) in the mitochondrial matrix. Recent studies have highlighted the potential of targeting itaconate as a therapeutic strategy for lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and respiratory infections. This review a...
Source: Clinical and Developmental Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Christina Michalaki Gesa J Albers Adam J Byrne Source Type: research
Itaconate as a key regulator of respiratory disease
Clin Exp Immunol. 2023 Nov 29:uxad127. doi: 10.1093/cei/uxad127. Online ahead of print.ABSTRACTMacrophage activation results in the accumulation of endogenous metabolites capable of adopting immunomodulatory roles; one such bioactive metabolite is itaconate. After macrophage stimulation, the TCA-cycle intermediate cis-aconitate is converted to itaconate (by aconitate decarboxylase-1, ACOD1) in the mitochondrial matrix. Recent studies have highlighted the potential of targeting itaconate as a therapeutic strategy for lung diseases such as asthma, idiopathic pulmonary fibrosis (IPF), and respiratory infections. This review a...
Source: Clinical and Developmental Immunology - November 29, 2023 Category: Allergy & Immunology Authors: Christina Michalaki Gesa J Albers Adam J Byrne Source Type: research
Immunological dynamic characteristics in AML predict the long-term outcomes and GVHD occurrences post-transplantation
Clin Exp Immunol. 2023 Nov 16:uxad123. doi: 10.1093/cei/uxad123. Online ahead of print.ABSTRACTTo investigate the relationship between immune dynamic and GVHD risk, 111 initial diagnostic AML patients were reviewed. The flow cytometry data of 12 major lymphocyte subsets in BM from 60 transplant patients at 4 different time points were analyzed. Additionally, 90 immune subsets in PB of 11 post-transplantation on day 100 were reviewed. Our results demonstrated that transplant patients had longer OS compared to non-transplant patients (P<0.001). Among transplant patients, those who developed GVHD showed longer OS than thos...
Source: Clinical and Developmental Immunology - November 16, 2023 Category: Allergy & Immunology Authors: Weiwei Wang Haibo Li Yukun Guo Lihua Zhang Wenli Jiang Naisheng Zheng Se Peng Xiaolin Guan Guang Fan Lisong Shen Source Type: research
Immunological dynamic characteristics in AML predict the long-term outcomes and GVHD occurrences post-transplantation
Clin Exp Immunol. 2023 Nov 16:uxad123. doi: 10.1093/cei/uxad123. Online ahead of print.ABSTRACTTo investigate the relationship between immune dynamic and GVHD risk, 111 initial diagnostic AML patients were reviewed. The flow cytometry data of 12 major lymphocyte subsets in BM from 60 transplant patients at 4 different time points were analyzed. Additionally, 90 immune subsets in PB of 11 post-transplantation on day 100 were reviewed. Our results demonstrated that transplant patients had longer OS compared to non-transplant patients (P<0.001). Among transplant patients, those who developed GVHD showed longer OS than thos...
Source: Clinical and Developmental Immunology - November 16, 2023 Category: Allergy & Immunology Authors: Weiwei Wang Haibo Li Yukun Guo Lihua Zhang Wenli Jiang Naisheng Zheng Se Peng Xiaolin Guan Guang Fan Lisong Shen Source Type: research
Immunological dynamic characteristics in AML predict the long-term outcomes and GVHD occurrences post-transplantation
Clin Exp Immunol. 2023 Nov 16:uxad123. doi: 10.1093/cei/uxad123. Online ahead of print.ABSTRACTTo investigate the relationship between immune dynamic and GVHD risk, 111 initial diagnostic AML patients were reviewed. The flow cytometry data of 12 major lymphocyte subsets in BM from 60 transplant patients at 4 different time points were analyzed. Additionally, 90 immune subsets in PB of 11 post-transplantation on day 100 were reviewed. Our results demonstrated that transplant patients had longer OS compared to non-transplant patients (P<0.001). Among transplant patients, those who developed GVHD showed longer OS than thos...
Source: Clinical and Developmental Immunology - November 16, 2023 Category: Allergy & Immunology Authors: Weiwei Wang Haibo Li Yukun Guo Lihua Zhang Wenli Jiang Naisheng Zheng Se Peng Xiaolin Guan Guang Fan Lisong Shen Source Type: research
Immunological dynamic characteristics in AML predict the long-term outcomes and GVHD occurrences post-transplantation
Clin Exp Immunol. 2023 Nov 16:uxad123. doi: 10.1093/cei/uxad123. Online ahead of print.ABSTRACTTo investigate the relationship between immune dynamic and GVHD risk, 111 initial diagnostic AML patients were reviewed. The flow cytometry data of 12 major lymphocyte subsets in BM from 60 transplant patients at 4 different time points were analyzed. Additionally, 90 immune subsets in PB of 11 post-transplantation on day 100 were reviewed. Our results demonstrated that transplant patients had longer OS compared to non-transplant patients (P<0.001). Among transplant patients, those who developed GVHD showed longer OS than thos...
Source: Clinical and Developmental Immunology - November 16, 2023 Category: Allergy & Immunology Authors: Weiwei Wang Haibo Li Yukun Guo Lihua Zhang Wenli Jiang Naisheng Zheng Se Peng Xiaolin Guan Guang Fan Lisong Shen Source Type: research
Immunological dynamic characteristics in AML predict the long-term outcomes and GVHD occurrences post-transplantation
Clin Exp Immunol. 2023 Nov 16:uxad123. doi: 10.1093/cei/uxad123. Online ahead of print.ABSTRACTTo investigate the relationship between immune dynamic and GVHD risk, 111 initial diagnostic AML patients were reviewed. The flow cytometry data of 12 major lymphocyte subsets in BM from 60 transplant patients at 4 different time points were analyzed. Additionally, 90 immune subsets in PB of 11 post-transplantation on day 100 were reviewed. Our results demonstrated that transplant patients had longer OS compared to non-transplant patients (P<0.001). Among transplant patients, those who developed GVHD showed longer OS than thos...
Source: Clinical and Developmental Immunology - November 16, 2023 Category: Allergy & Immunology Authors: Weiwei Wang Haibo Li Yukun Guo Lihua Zhang Wenli Jiang Naisheng Zheng Se Peng Xiaolin Guan Guang Fan Lisong Shen Source Type: research
Immunological dynamic characteristics in AML predict the long-term outcomes and GVHD occurrences post-transplantation
Clin Exp Immunol. 2023 Nov 16:uxad123. doi: 10.1093/cei/uxad123. Online ahead of print.ABSTRACTTo investigate the relationship between immune dynamic and GVHD risk, 111 initial diagnostic AML patients were reviewed. The flow cytometry data of 12 major lymphocyte subsets in BM from 60 transplant patients at 4 different time points were analyzed. Additionally, 90 immune subsets in PB of 11 post-transplantation on day 100 were reviewed. Our results demonstrated that transplant patients had longer OS compared to non-transplant patients (P<0.001). Among transplant patients, those who developed GVHD showed longer OS than thos...
Source: Clinical and Developmental Immunology - November 16, 2023 Category: Allergy & Immunology Authors: Weiwei Wang Haibo Li Yukun Guo Lihua Zhang Wenli Jiang Naisheng Zheng Se Peng Xiaolin Guan Guang Fan Lisong Shen Source Type: research
Immunological dynamic characteristics in AML predict the long-term outcomes and GVHD occurrences post-transplantation
Clin Exp Immunol. 2023 Nov 16:uxad123. doi: 10.1093/cei/uxad123. Online ahead of print.ABSTRACTTo investigate the relationship between immune dynamic and GVHD risk, 111 initial diagnostic AML patients were reviewed. The flow cytometry data of 12 major lymphocyte subsets in BM from 60 transplant patients at 4 different time points were analyzed. Additionally, 90 immune subsets in PB of 11 post-transplantation on day 100 were reviewed. Our results demonstrated that transplant patients had longer OS compared to non-transplant patients (P<0.001). Among transplant patients, those who developed GVHD showed longer OS than thos...
Source: Clinical and Developmental Immunology - November 16, 2023 Category: Allergy & Immunology Authors: Weiwei Wang Haibo Li Yukun Guo Lihua Zhang Wenli Jiang Naisheng Zheng Se Peng Xiaolin Guan Guang Fan Lisong Shen Source Type: research
