Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Allergens induce upregulated IL-18 and IL-18R α expression in blood Th2 and Th17 cells of patients with allergic asthma
Clin Exp Immunol. 2024 Apr 8:uxae022. doi: 10.1093/cei/uxae022. Online ahead of print.ABSTRACTAllergic asthma (AA) is closely associated with the polarization of T helper (Th)2 and Th17 cells. Interleukin (IL)-18 acts as an inducer of Th2 and Th17 cell responses. However, expressions of IL-18 and IL-18 receptor alpha (IL-18Rα) in blood Th2 and Th17 cells of patients with AA remain unclear. We therefore investigated their expressions in Th2 and Th17 cells using flow cytometric analysis, qPCR and murine AA model. We observed increased proportions of Th2, Th17, IL-18+, IL-18+ Th2 and IL-18+ Th17 cells in blood CD4+ T cells o...
Source: Clinical and Developmental Immunology - April 8, 2024 Category: Allergy & Immunology Authors: Junling Wang Mengmeng Zhan Yaping Zhai Siqin Wang Fangqiu Gu Zhuo Zhao Zhaolong Zhang Yifei Li Xin Dong Yijie Zhang Bingyu Qin Source Type: research

Organoids as a tool to study homeostatic and pathological immune-epithelial interactions in the gut
Clin Exp Immunol. 2024 Mar 29:uxad118. doi: 10.1093/cei/uxad118. Online ahead of print.ABSTRACTThe intestine hosts the largest immune cell compartment in the body as a result of its continuous exposure to exogenous antigens. The intestinal barrier is formed by a single layer of epithelial cells which separate immune cells from the gut lumen. Bidirectional interactions between the epithelium and the immune compartment are critical for maintaining intestinal homeostasis by limiting infection, preventing excessive immune activation, and promoting tissue repair processes. However, our understanding of epithelial-immune interac...
Source: Clinical and Developmental Immunology - March 29, 2024 Category: Allergy & Immunology Authors: Emma H øjmose Kromann Ainize Pe ña Cearra Joana F Neves Source Type: research

Human Cytomegalovirus Seropositivity and Its Influence on Oral Rotavirus Vaccine Immunogenicity: A Specific Concern for HIV-Exposed-Uninfected Infants
This study highlights the complexity of immunological responses and the need for targeted interventions to ensure oral rotavirus vaccine efficacy, especially in vulnerable subpopulations.PMID:38546123 | DOI:10.1093/cei/uxae029 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 28, 2024 Category: Allergy & Immunology Authors: Natasha Laban Samuel Bosomprah Roma Chilengi Michelo Simuyandi Caroline Chisenga Harriet Ng'ombe Kalo Musukuma-Chifulo Martin Goodier Source Type: research

Leukocyte Dysfunction and reduced CTLA-4 Expression are Associated with Perianal Crohn's Disease
In conclusion, IL-6, TNF, and CTLA-4 exhibit a distinct expression pattern in CD patients with a history of PCD, regardless of disease activity. These findings clarify some mechanisms involved in the development of the perianal manifestations and may have a great impact in the disease management.PMID:38517030 | DOI:10.1093/cei/uxae027 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Murillo Duarte-Silva Rog ério Serafim Parra Marley Ribeiro Feitosa Viviani Nardini Sandra Regina Maruyama Jos é Joaquim Ribeiro da Rocha Omar Feres Cristina Ribeiro de Barros Cardoso Source Type: research

Neutrophil extracellular traps induce pyroptosis of pulmonary microvascular endothelial cells by activating the NLRP3 inflammasome
This study aimed to investigate the specific mechanism underlying NET-induced injury to human pulmonary microvascular endothelial cells (HPMECs). HPMECs were stimulated with NETs (200 ng/ml) in vitro. Cell death was detected by propidium iodide staining. The morphological changes of the cells were observed by transmission electron microscopy (TEM). Pyroptosis markers were detected by western blot, immunofluorescence and quantitative real-time PCR, and the related inflammatory factor IL-1β was verified by ELISA. Compared with the control group, HPMECs mortality increased after NET stimulation, and the number of pyroptosis ...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Peipei Zhao Jiarui Zhu Ling Bai Wenlan Ma Feifei Li Cen Zhang Liangtao Zhao Liuyang Wang Sigong Zhang Source Type: research

The role of extracellular vesicle immune checkpoints in cancer
Clin Exp Immunol. 2024 Mar 22:uxae026. doi: 10.1093/cei/uxae026. Online ahead of print.ABSTRACTImmune checkpoints (ICPs) play a crucial role in regulating the immune response. In the tumor, malignant cells can hijack the immunosuppressive effects of inhibitory ICPs to promote tumor progression. Extracellular vesicles (EVs) are produced by a variety of cells and contain bioactive molecules on their surface or within their lumen. The expression of ICPs has also been detected on EVs. In vitro and in vivo studies have shown that extracellular vesicle immune checkpoints (EV ICPs) have immunomodulatory effects and are involved i...
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Authors: Weiming Zhang Mingrong Ou Ping Yang Mingzhe Ning Source Type: research

Correction to: Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis
Clin Exp Immunol. 2024 Mar 22:uxae024. doi: 10.1093/cei/uxae024. Online ahead of print.NO ABSTRACTPMID:38518785 | DOI:10.1093/cei/uxae024 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Source Type: research