Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Clinical and Experimental Treatment of Primary Humoral Immunodeficiencies
Clin Exp Immunol. 2024 Feb 2:uxae008. doi: 10.1093/cei/uxae008. Online ahead of print.ABSTRACTSelective IgA deficiency (sIgAD) and Common Variable Immunodeficiency (CVID) and Transient Hypogammaglobulinemia of Infancy (THI) are the most frequent forms of primary antibody deficiencies. Difficulties in initial diagnosis, especially in the early childhood, the familiar occurrence of these diseases, as well as the possibility of progression to each other suggest common cellular and molecular patomechanism and a similar genetic background. In this review, we discuss both similarities and differences of these three humoral immun...
Source: Clinical and Developmental Immunology - February 2, 2024 Category: Allergy & Immunology Authors: Anna Szaflarska Marzena Lenart Magdalena Rutkowska-Zapa ła Maciej Siedlar Source Type: research

The alteration of mucosal bile acid profile is associated with nerve growth factor expression in mast cells and bowel symptoms in diarrhea-predominant irritable bowel syndrome
In conclusion, IBS-D patients showed an altered BA profile in the colonic mucosa. Approximately 20% of them exhibit elevated mucosal BA content, which may be associated with MMC-derived NGF signaling and bowel symptoms.PMID:38290436 | DOI:10.1093/cei/uxae006 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - January 30, 2024 Category: Allergy & Immunology Authors: Bi-Yu Wu Ping Xu Li Cheng Qian-Qian Wang Hong-Yi Qiu Xiu-Juan Yan Sheng-Liang Chen Source Type: research

Revolutionising immune research with organoid-based co-culture and chip systems
Clin Exp Immunol. 2024 Jan 27:uxae004. doi: 10.1093/cei/uxae004. Online ahead of print.ABSTRACTThe intertwined interactions various immune cells have with epithelial cells in our body require sophisticated experimental approaches to be studied. Due to the limitations of immortalised cell lines and animal models, there is an increasing demand for human in vitro model systems to investigate the microenvironment of immune cells in normal and in pathological conditions. Organoids, which are self-renewing, 3D cellular structures that are derived from stem cells, have started to provide gap-filling tissue modelling solutions. In...
Source: Clinical and Developmental Immunology - January 27, 2024 Category: Allergy & Immunology Authors: D Papp T Korcsmaros I Hautefort Source Type: research

Catalase inhibition can modulate the ability of peripheral blood T cells to undergo apoptosis in Crohn's disease
In conclusion, apoptosis inhibition of CD T cells is a feature of these cells before they can migrate to the intestinal mucosa. Noteworthy, the impaired apoptosis of T cells can be directly influenced by catalase inhibition.PMID:38247555 | DOI:10.1093/cei/uxad134 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - January 22, 2024 Category: Allergy & Immunology Authors: In és Moret-Tatay Pilar Nos Marisa Iborra Francisco Rausell Bel én Beltrán Source Type: research

Organoids as a tool to study the impact of heterogeneity in gastrointestinal epithelium on host-pathogen interactions
Clin Exp Immunol. 2024 Jan 20:uxae002. doi: 10.1093/cei/uxae002. Online ahead of print.ABSTRACTThe epithelium of the gastrointestinal tract has been extensively characterized using advanced histological and RNA sequencing techniques, which has revealed great cellular diversity. Pathogens, such as viruses and bacteria, are highly adapted to their host and often exhibit not only species-specificity, but also a preference or tropism for specific gastrointestinal segments or even cell types - some of these preferences are so specific, that these pathogens still cannot be cultured in the lab. Organoid technology now provides a ...
Source: Clinical and Developmental Immunology - January 21, 2024 Category: Allergy & Immunology Authors: Mindaugas Pau žuolis Pilar Samperio Ventayol Mastura Neyazi Sina Bartfeld Source Type: research

PNAd-expressing vessels characterize the dermis of CD3+ T cell-mediated cutaneous diseases
Clin Exp Immunol. 2024 Jan 16:uxae003. doi: 10.1093/cei/uxae003. Online ahead of print.ABSTRACTT-cell recruitment to skin tissues is essential for inflammation in different cutaneous diseases; however, the mechanisms by which these T cells access the skin remain unclear. High endothelial venules expressing peripheral node address in (PNAd), an L-selectin ligand, are located in secondary lymphoid organs and are responsible for increasing T-cell influx into the lymphoid tissues. They are also found in non-lymphoid tissues during inflammation. However, their presence in different common inflammatory cutaneous diseases and the...
Source: Clinical and Developmental Immunology - January 16, 2024 Category: Allergy & Immunology Authors: Fatimah Mohammad Budair Takashi Nomura Hirata Masahiro Kenji Kabashima Source Type: research

Effect of the ketone beta-hydroxybutyrate on markers of inflammation and immune function in adults with type 2 diabetes
Clin Exp Immunol. 2024 Jan 9:uxad138. doi: 10.1093/cei/uxad138. Online ahead of print.ABSTRACTPre-clinical and cell culture evidence supports the role of the ketone beta-hydroxybutyrate (BHB) as an immunomodulatory molecule that may inhibit inflammatory signalling involved in several chronic diseases such as type 2 diabetes (T2D), but studies in humans are lacking. Therefore, we investigated the anti-inflammatory effect of BHB in humans across three clinical trials. To investigate if BHB suppressed pro-inflammatory cytokine secretion, we treated LPS-stimulated leukocytes from overnight-fasted adults at risk for T2D with BH...
Source: Clinical and Developmental Immunology - January 9, 2024 Category: Allergy & Immunology Authors: Helena Neudorf Hashim Islam Kaja Falkenhain Barbara Oliveira Garett S Jackson Alfonso Moreno-Caba ñas Kenneth Madden Joel Singer Jeremy J Walsh Jonathan P Little Source Type: research

Role of inter-alpha-trypsin inhibitor heavy chain 4 and its citrullinated form in experimental arthritis murine models
Clin Exp Immunol. 2024 Jan 8:uxae001. doi: 10.1093/cei/uxae001. Online ahead of print.ABSTRACTInter α trypsin inhibitor heavy chain 4 (ITIH4) is a major protein in serum and reported to be up-regulated at the onset of rheumatoid arthritis (RA). Its citrullinated form, cit-ITIH4, is specifically found in serum and synovial fluid of patients with RA. However, the detailed function of ITIH4 in arthritis remains unknown. The aim of this study was to clarify the role of ITIH4 and its citrullinated form using experimental arthritis models. ITIH4 and cit-ITIH4 expression was examined in steady-state mice and two different arthri...
Source: Clinical and Developmental Immunology - January 8, 2024 Category: Allergy & Immunology Authors: Tamaki Iwai Ayako Ohyama Atsumu Osada Taihei Nishiyama Masaru Shimizu Haruka Miki Hiromitsu Asashima Yuya Kondo Hiroto Tsuboi Seiya Mizuno Satoru Takahashi Akihito Ishigami Isao Matsumoto Source Type: research

Enhanced efficacy of the novel recombinant clone VasSF in a mouse model of antineutrophil cytoplasmic antibody-associated vasculitis
Clin Exp Immunol. 2023 Dec 29:uxad140. doi: 10.1093/cei/uxad140. Online ahead of print.ABSTRACTBased on the efficacy of intravenous immunoglobulin (IVIg) for the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), we developed a recombinant single-chain-fragment variable clone, VasSF, therapeutic against AAV in a mouse model (SCG/Kj mice). VasSF is thought to bind to vasculitis-associated apolipoprotein A-II (APOA2) as a target molecule. VasSF is a promising new drug against AAV, but difficulties in the yield and purification of VasSF remain unresolved. We produced monomers of new VasSF mol...
Source: Clinical and Developmental Immunology - December 29, 2023 Category: Allergy & Immunology Authors: Minako Koura Yosuke Kameoka Fukuko Kishi Yoshio Yamakawa Fuyu Ito Ryuichi Sugamata Yuko Doi Kazuko Uno Toshinori Nakayama Takashi Miki Hiroshi Nakajima Kazuo Suzuki Osamu Suzuki Source Type: research

Neutrophil depletion attenuates antibody-mediated rejection in a renal transplantation mouse model
Clin Exp Immunol. 2023 Dec 27:uxad128. doi: 10.1093/cei/uxad128. Online ahead of print.ABSTRACTAntibody-mediated rejection (AMR) can cause graft failure following renal transplantation. Neutrophils play a key role in AMR progression, but the exact mechanism remains unclear. We investigated the effect of neutrophils on AMR in a mouse kidney transplantation model. The mice were divided into five groups: syngeneic transplantation (Syn), allograft transplantation (Allo), and three differently treated AMR groups. The AMR mouse model was established using skin grafts to pre-sensitize recipient mice. Based on the AMR model, Ly6G-...
Source: Clinical and Developmental Immunology - December 27, 2023 Category: Allergy & Immunology Authors: Xingku Li Yakun Zhao Wenying Sun Cong Zhang Yadi Yu Bo Du AiShun Jin Ye Liu Source Type: research