Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Regulatory T cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction
This study aimed to analyze, by flow cytometry, the circulating levels of CD69+ regulatory T cells and CD4+ CD25hi Foxp3+ cells, its IL-10+ production as well as their function in patients with acute myocardial infarction (AMI), and its possible relation with ventricular dysfunction. We found a significant difference in the percentage of CD4+ CD25hi Foxp3+ cells and IL-10+ MFI in patients with AMI at 72 hours compared with the healthy control group, and the levels of these cells were reduced six months post-AMI. Regarding the suppressive function of CD4+ CD25+ regulatory cells, they were dysfunctional at three- and six-mon...
Source: Clinical and Developmental Immunology - February 22, 2024 Category: Allergy & Immunology Authors: Elena Berenice Mart ínez-Shio Sherell Mar ín-Jáuregui Alma Celeste Rodr íguez Ortega Lesly Marsol Don íz Padilla Roberto Gonz ález-Amaro Carlos David Escobedo-Uribe Adriana Elizabeth Monsiv áis-Urenda Source Type: research

Altered CD226/TIGIT expressions were associated with activated NK phenotypes in primary anti-phospholipid syndrome and affected by IL-4/JAK pathway
Conclusion: Our data revealed significant imbalanced CD226/TIGIT expressions on NK cells in pAPS, which closely associated with activated NK subsets phenotypes and more complicated autoantibody status. CD226/TIGIT imbalanced may be affected by IL-4/JAK pathway activation.PMID:38386917 | DOI:10.1093/cei/uxae016 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 22, 2024 Category: Allergy & Immunology Authors: Yan Long Ke-Jia Lu Chang-Sheng Xia Jing-Hong Feng Wen-Yi Li Yin-Ting Ma Yuan-Yuan Sun Chun-Hong Fan Chun Li Source Type: research

Chronic malaria exposure is associated with inhibitory markers on T cells that correlate with atypical memory and marginal zone-like B cells
Clin Exp Immunol. 2024 Feb 22:uxae015. doi: 10.1093/cei/uxae015. Online ahead of print.ABSTRACTChronic immune activation from persistent malaria infections can induce immunophenotypic changes associated with T cell exhaustion. However, associations between T and B cells during chronic exposure remain undefined. We analyzed peripheral blood mononuclear cells from malaria-exposed pregnant women from Papua New Guinea and Spanish malaria-naïve individuals using flow cytometry to profile T cell exhaustion markers phenotypically. T cell lineage (CD3, CD4, CD8), inhibitory (PD1, TIM3, LAG3, CTLA4, 2B4) and senescence (CD28-) mar...
Source: Clinical and Developmental Immunology - February 22, 2024 Category: Allergy & Immunology Authors: Robert A Mitchell Itziar Ubillos Pilar Requena Joseph J Campo Maria Ome-Kaius Sarah Hanieh Alexandra Umbers Paula Samol Diana Barrios Alfons Jim énez Azucena Bardaj í Ivo Mueller Clara Men éndez Stephen Rogerson Carlota Doba ño Gemma Moncunill Source Type: research

Splenectomy at Early stage of Autoimmune Arthritis Delayed Inflammatory Response and Reduced Joint Deterioration in Mice
In conclusion, splenectomy in early stages of GIA delayed the inflammatory response, suggesting a protective effect against the development and progression of severe destructive arthritis.PMID:38363980 | DOI:10.1093/cei/uxae013 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Esam Khanfar Katalin Olasz Szonja G ál Erzs ébet Gajdócsi B éla Kajtár Tam ás Kiss P éter Balogh Timea Berki Ferenc Boldizs ár Source Type: research

Albumin influences leucocyte FcRn expression in the early days of kidney transplantation
Clin Exp Immunol. 2024 Feb 13:uxae011. doi: 10.1093/cei/uxae011. Online ahead of print.ABSTRACTFcRn, a receptor originally known for its involvement in IgG and albumin transcytosis and recycling, is also important in the establishment of the innate and adaptive immune response. Dysregulation of the immune response has been associated with variations in FcRn expression, as observed in cancer. Recently, a link between autophagy and FcRn expression has been demonstrated. Knowing that autophagy is strongly involved in the development of reperfusion injury in kidney transplantation and that albuminemia is transiently decreased ...
Source: Clinical and Developmental Immunology - February 14, 2024 Category: Allergy & Immunology Authors: Pierre Boulard Nicolas Azzopardi Romain Levard Jean-Marie Cornec Juliette Lamamy B érénice Prieur Marie-V éronique Demattei Herv é Watier Philippe Gatault Val érie Gouilleux-Gruart Source Type: research

Defining the cross-reactivity between peanut allergens Ara h 2 and Ara h 6 using monoclonal antibodies
Clin Exp Immunol. 2024 Feb 12:uxae005. doi: 10.1093/cei/uxae005. Online ahead of print.ABSTRACTIn peanut allergy, Arachis hypogaea 2 (Ara h 2) and Arachis hypogaea 6 (Ara h 6) are two clinically relevant peanut allergens with known structural and sequence homology and demonstrated cross-reactivity. We have previously utilized X-ray crystallography and epitope binning to define the epitopes on Ara h 2. We aimed to quantitatively characterize the cross-reactivity between Ara h 2 and Ara h 6 on a molecular level using human monoclonal antibodies (mAbs) and structural characterization of allergenic epitopes. We utilized mAbs c...
Source: Clinical and Developmental Immunology - February 12, 2024 Category: Allergy & Immunology Authors: Orlee Marini-Rapoport Monica L Fern ández-Quintero Tarun Keswani Guangning Zong Jane Shim Lars C Pedersen Geoffrey A Mueller Sarita U Patil Source Type: research

Exposure to Gestational Diabetes Mellitus increases subclinical inflammation mediated in part by obesity
In this study, there was significant evidence of subclinical inflammation, and significant alterations in clusters of NK cells, T-cells and tissue monocyte populations in GDM. While increased adiposity assimilates with increased inflammation in the non-pregnant state, this overt relationship may not be as evident during pregnancy and warrants further examination in future longitudinal studies.PMID:38334487 | DOI:10.1093/cei/uxae010 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 9, 2024 Category: Allergy & Immunology Authors: Andrea Musumeci Colm John McElwain Samprikta Manna Fergus McCarthy Cathal McCarthy Source Type: research

Letter to the Editor: Seronegative NMOSD patients display distinctive peripheral blood T cell subset frequencies
Clin Exp Immunol. 2024 Feb 9:uxae012. doi: 10.1093/cei/uxae012. Online ahead of print.NO ABSTRACTPMID:38334497 | DOI:10.1093/cei/uxae012 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 9, 2024 Category: Allergy & Immunology Authors: Elif Sanli Zerrin Karaaslan Vuslat Yilmaz Tuncay Gunduz Murat Kurtuncu Recai Turkoglu Cem İsmail Kucukali Erdem Tuzun Source Type: research

Allogeneic NK cells induce the in vitro activation of monocyte-derived and conventional type-2 dendritic cells and trigger an inflammatory response under cancer-associated conditions
In this study, we analyzed how an allogeneic off-the-shelf cord blood stem cell-derived NK cell product influenced the activation of dendritic cells (DC). Crosstalk between NK cells and healthy donor monocyte-derived DC (MoDC) resulted in the release of IFNγ and TNF, MoDC activation, and the release of the T-cell-recruiting chemokines CXCL9 and CXCL10. Moreover, in the presence of prostaglandin-E2, NK cell/MoDC crosstalk antagonized the detrimental effect of IL-10 on MoDC maturation leading to higher expression of multiple(co-)stimulatory markers. The NK cells also induced activation of conventional DC2 (cDC2) and CD8+ T ...
Source: Clinical and Developmental Immunology - February 8, 2024 Category: Allergy & Immunology Authors: E C Toffoli A A van Vliet C Forbes A J Arns H W M Verheul J Tuynman H J van der Vliet J Spanholtz T D de Gruijl Source Type: research

Increased expression of complement C3c, iC3b and cells containing CD11b or CD14 in experimentally induced psoriatic lesion
In this study, the tape-stripping technique was used to induce the development of Köbner reaction in 18 subjects with psoriasis. Eight subjects developed the positive reaction. To study the early cellular changes, skin biopsies were taken at the baseline and subsequent time points of 2 hours, 1 day, 3 days and 7 days for the immunostaining of complement C3c, iC3b, and cells expressing complement receptor 3 (CD11b/CD18; a receptor of iC3b) or CD14. The results show that the positive Köbner reaction associated with rapid (2h-1d) and sustained (3-7d) increase in the expression of epidermal C3c and iC3b and dermal C3c. In ad...
Source: Clinical and Developmental Immunology - February 4, 2024 Category: Allergy & Immunology Authors: Dina Rahkola Rauno J Harvima Ilkka T Harvima Source Type: research