Clinical and Developmental Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Correction to: Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis
Clin Exp Immunol. 2024 Mar 22:uxae024. doi: 10.1093/cei/uxae024. Online ahead of print.NO ABSTRACTPMID:38518785 | DOI:10.1093/cei/uxae024 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - March 22, 2024 Category: Allergy & Immunology Source Type: research

Specific deletion of Mettl3 in IECs triggers the development of spontaneous colitis and dysbiosis of T lymphocytes in mice
Clin Exp Immunol. 2024 Mar 20:uxae025. doi: 10.1093/cei/uxae025. Online ahead of print.ABSTRACTThe enzymatic core component of m6A writer complex, Mettl3, plays a crucial role in facilitating the development and progress in gastric and colorectal cancer (CRC). However, its underlying mechanism in regulating intestinal inflammation remains unclear and poorly investigated. Firstly, the characteristics of Mettl3 expression in IBD patients were examined. Afterwards we generated the mice line with IECs-specific deletion of Mettl3 verified by various experiments. We continuously recorded and compared the physiological status inc...
Source: Clinical and Developmental Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Miao Fang Jie Yao Haifeng Zhang Jiahui Sun Yiping Yin Hongzhou Shi Guangqing Jiang Xin Shi Source Type: research

Specific deletion of Mettl3 in IECs triggers the development of spontaneous colitis and dysbiosis of T lymphocytes in mice
Clin Exp Immunol. 2024 Mar 20:uxae025. doi: 10.1093/cei/uxae025. Online ahead of print.ABSTRACTThe enzymatic core component of m6A writer complex, Mettl3, plays a crucial role in facilitating the development and progress in gastric and colorectal cancer (CRC). However, its underlying mechanism in regulating intestinal inflammation remains unclear and poorly investigated. Firstly, the characteristics of Mettl3 expression in IBD patients were examined. Afterwards we generated the mice line with IECs-specific deletion of Mettl3 verified by various experiments. We continuously recorded and compared the physiological status inc...
Source: Clinical and Developmental Immunology - March 20, 2024 Category: Allergy & Immunology Authors: Miao Fang Jie Yao Haifeng Zhang Jiahui Sun Yiping Yin Hongzhou Shi Guangqing Jiang Xin Shi Source Type: research

Prophylaxis in hereditary angioedema: a United Kingdom Delphi consensus
Clin Exp Immunol. 2024 Mar 8:uxae020. doi: 10.1093/cei/uxae020. Online ahead of print.ABSTRACTHereditary angioedema (HAE) is a rare inherited disorder causing recurrent of episodes of swelling that can be potentially life threatening. Treatment of HAE can be divided into on-demand treatment for swelling, and prophylaxis. The last UK consensus on HAE was in 2014 and since then, new medications for prophylaxis have been developed, with more drugs in the pipeline. International guidelines currently recommend the use of long-term prophylaxis (LTP) as the only way of achieving disease control and normalising patient lives. Mode...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Patrick F K Yong Rachel Annals Lavanya Diwakar Shuayb Elkhalifa Mark Gompels Rashmi Jain M Yousuf Karim Sujoy Khan Angela Metcalfe Sadia Noorani Cathal Steele Sorena Kiani-Alikhan Tomaz Garcez Source Type: research

Quantifying Microglial Morphology: An Insight into Function
Clin Exp Immunol. 2024 Mar 8:uxae023. doi: 10.1093/cei/uxae023. Online ahead of print.ABSTRACTMicroglia are specialized immune cells unique to the central nervous system (CNS). Microglia have a highly plastic morphology that changes rapidly in response to injury or infection. Qualitative and quantitative measurements of ever-changing microglial morphology are considered a cornerstone of many microglia-centric research studies. The distinctive morphological variations seen in microglia are a useful marker of inflammation and severity of tissue damage. Although a wide array of damage-associated microglial morphologies has be...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Tabitha R F Green Rachel K Rowe Source Type: research

α2-antiplasmin is associated with macrophage activation and fibrin in a macrophage activation syndrome mouse model
In this study, we investigated that the roles of α2-antiplasmin (α2AP) in the progression of MAS using fulminant MAS mouse model induced by Toll-like receptor-9 (TLR-9) agonist (CpG) and d-galactosamine (DG). α2AP deficiency attenuated macrophage accumulation, liver injury, and fibrin deposition in the MAS model mice. Interferon-γ (IFN-γ) is associated with macrophage activation, including migration, and plays a pivotal role in MAS progression. α2AP enhanced the IFN-γ-induced migration, and tissue factor (TF) production. Additionally, we showed that fibrin induced macrophage activation and tumor necrosis factor-α (...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Yosuke Kanno Kinomi Toyama Haruna Shibata Osamu Matsuo Kei-Ichi Ozaki Source Type: research

Prophylaxis in hereditary angioedema: a United Kingdom Delphi consensus
Clin Exp Immunol. 2024 Mar 8:uxae020. doi: 10.1093/cei/uxae020. Online ahead of print.ABSTRACTHereditary angioedema (HAE) is a rare inherited disorder causing recurrent of episodes of swelling that can be potentially life threatening. Treatment of HAE can be divided into on-demand treatment for swelling, and prophylaxis. The last UK consensus on HAE was in 2014 and since then, new medications for prophylaxis have been developed, with more drugs in the pipeline. International guidelines currently recommend the use of long-term prophylaxis (LTP) as the only way of achieving disease control and normalising patient lives. Mode...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Patrick F K Yong Rachel Annals Lavanya Diwakar Shuayb Elkhalifa Mark Gompels Rashmi Jain M Yousuf Karim Sujoy Khan Angela Metcalfe Sadia Noorani Cathal Steele Sorena Kiani-Alikhan Tomaz Garcez Source Type: research

Quantifying Microglial Morphology: An Insight into Function
Clin Exp Immunol. 2024 Mar 8:uxae023. doi: 10.1093/cei/uxae023. Online ahead of print.ABSTRACTMicroglia are specialized immune cells unique to the central nervous system (CNS). Microglia have a highly plastic morphology that changes rapidly in response to injury or infection. Qualitative and quantitative measurements of ever-changing microglial morphology are considered a cornerstone of many microglia-centric research studies. The distinctive morphological variations seen in microglia are a useful marker of inflammation and severity of tissue damage. Although a wide array of damage-associated microglial morphologies has be...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Tabitha R F Green Rachel K Rowe Source Type: research

α2-antiplasmin is associated with macrophage activation and fibrin in a macrophage activation syndrome mouse model
In this study, we investigated that the roles of α2-antiplasmin (α2AP) in the progression of MAS using fulminant MAS mouse model induced by Toll-like receptor-9 (TLR-9) agonist (CpG) and d-galactosamine (DG). α2AP deficiency attenuated macrophage accumulation, liver injury, and fibrin deposition in the MAS model mice. Interferon-γ (IFN-γ) is associated with macrophage activation, including migration, and plays a pivotal role in MAS progression. α2AP enhanced the IFN-γ-induced migration, and tissue factor (TF) production. Additionally, we showed that fibrin induced macrophage activation and tumor necrosis factor-α (...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Yosuke Kanno Kinomi Toyama Haruna Shibata Osamu Matsuo Kei-Ichi Ozaki Source Type: research

Prophylaxis in hereditary angioedema: a United Kingdom Delphi consensus
Clin Exp Immunol. 2024 Mar 8:uxae020. doi: 10.1093/cei/uxae020. Online ahead of print.ABSTRACTHereditary angioedema (HAE) is a rare inherited disorder causing recurrent of episodes of swelling that can be potentially life threatening. Treatment of HAE can be divided into on-demand treatment for swelling, and prophylaxis. The last UK consensus on HAE was in 2014 and since then, new medications for prophylaxis have been developed, with more drugs in the pipeline. International guidelines currently recommend the use of long-term prophylaxis (LTP) as the only way of achieving disease control and normalising patient lives. Mode...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Patrick F K Yong Rachel Annals Lavanya Diwakar Shuayb Elkhalifa Mark Gompels Rashmi Jain M Yousuf Karim Sujoy Khan Angela Metcalfe Sadia Noorani Cathal Steele Sorena Kiani-Alikhan Tomaz Garcez Source Type: research

Quantifying Microglial Morphology: An Insight into Function
Clin Exp Immunol. 2024 Mar 8:uxae023. doi: 10.1093/cei/uxae023. Online ahead of print.ABSTRACTMicroglia are specialized immune cells unique to the central nervous system (CNS). Microglia have a highly plastic morphology that changes rapidly in response to injury or infection. Qualitative and quantitative measurements of ever-changing microglial morphology are considered a cornerstone of many microglia-centric research studies. The distinctive morphological variations seen in microglia are a useful marker of inflammation and severity of tissue damage. Although a wide array of damage-associated microglial morphologies has be...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Tabitha R F Green Rachel K Rowe Source Type: research

α2-antiplasmin is associated with macrophage activation and fibrin in a macrophage activation syndrome mouse model
In this study, we investigated that the roles of α2-antiplasmin (α2AP) in the progression of MAS using fulminant MAS mouse model induced by Toll-like receptor-9 (TLR-9) agonist (CpG) and d-galactosamine (DG). α2AP deficiency attenuated macrophage accumulation, liver injury, and fibrin deposition in the MAS model mice. Interferon-γ (IFN-γ) is associated with macrophage activation, including migration, and plays a pivotal role in MAS progression. α2AP enhanced the IFN-γ-induced migration, and tissue factor (TF) production. Additionally, we showed that fibrin induced macrophage activation and tumor necrosis factor-α (...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Yosuke Kanno Kinomi Toyama Haruna Shibata Osamu Matsuo Kei-Ichi Ozaki Source Type: research

Prophylaxis in hereditary angioedema: a United Kingdom Delphi consensus
Clin Exp Immunol. 2024 Mar 8:uxae020. doi: 10.1093/cei/uxae020. Online ahead of print.ABSTRACTHereditary angioedema (HAE) is a rare inherited disorder causing recurrent of episodes of swelling that can be potentially life threatening. Treatment of HAE can be divided into on-demand treatment for swelling, and prophylaxis. The last UK consensus on HAE was in 2014 and since then, new medications for prophylaxis have been developed, with more drugs in the pipeline. International guidelines currently recommend the use of long-term prophylaxis (LTP) as the only way of achieving disease control and normalising patient lives. Mode...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Patrick F K Yong Rachel Annals Lavanya Diwakar Shuayb Elkhalifa Mark Gompels Rashmi Jain M Yousuf Karim Sujoy Khan Angela Metcalfe Sadia Noorani Cathal Steele Sorena Kiani-Alikhan Tomaz Garcez Source Type: research

Quantifying Microglial Morphology: An Insight into Function
Clin Exp Immunol. 2024 Mar 8:uxae023. doi: 10.1093/cei/uxae023. Online ahead of print.ABSTRACTMicroglia are specialized immune cells unique to the central nervous system (CNS). Microglia have a highly plastic morphology that changes rapidly in response to injury or infection. Qualitative and quantitative measurements of ever-changing microglial morphology are considered a cornerstone of many microglia-centric research studies. The distinctive morphological variations seen in microglia are a useful marker of inflammation and severity of tissue damage. Although a wide array of damage-associated microglial morphologies has be...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Tabitha R F Green Rachel K Rowe Source Type: research

α2-antiplasmin is associated with macrophage activation and fibrin in a macrophage activation syndrome mouse model
In this study, we investigated that the roles of α2-antiplasmin (α2AP) in the progression of MAS using fulminant MAS mouse model induced by Toll-like receptor-9 (TLR-9) agonist (CpG) and d-galactosamine (DG). α2AP deficiency attenuated macrophage accumulation, liver injury, and fibrin deposition in the MAS model mice. Interferon-γ (IFN-γ) is associated with macrophage activation, including migration, and plays a pivotal role in MAS progression. α2AP enhanced the IFN-γ-induced migration, and tissue factor (TF) production. Additionally, we showed that fibrin induced macrophage activation and tumor necrosis factor-α (...
Source: Clinical and Developmental Immunology - March 8, 2024 Category: Allergy & Immunology Authors: Yosuke Kanno Kinomi Toyama Haruna Shibata Osamu Matsuo Kei-Ichi Ozaki Source Type: research