Clinical & amp; Experimental Immunology: Highlights of 2023
Clin Exp Immunol. 2024 Feb 27:uxae017. doi: 10.1093/cei/uxae017. Online ahead of print.NO ABSTRACTPMID:38412337 | DOI:10.1093/cei/uxae017 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 27, 2024 Category: Allergy & Immunology Authors: Leonie S Taams Sevda Dogan Source Type: research

The balance between memory and regulatory cell populations in kidney transplant recipients with operational tolerance
In conclusion, monitoring the balance between circulating CD8+ TEMRA T cells and regulatory cell subsets and their transcripts may help to distinguish transplant recipients with operational tolerance from recipients at risk of graft loss.PMID:38393856 | DOI:10.1093/cei/uxae018 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Caner S üsal Cristiam M Alvarez Louise Benning Volker Daniel Martin Zeier Matthias Schaier Christian Morath Claudius Speer Source Type: research

The balance between memory and regulatory cell populations in kidney transplant recipients with operational tolerance
In conclusion, monitoring the balance between circulating CD8+ TEMRA T cells and regulatory cell subsets and their transcripts may help to distinguish transplant recipients with operational tolerance from recipients at risk of graft loss.PMID:38393856 | DOI:10.1093/cei/uxae018 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Caner S üsal Cristiam M Alvarez Louise Benning Volker Daniel Martin Zeier Matthias Schaier Christian Morath Claudius Speer Source Type: research

The balance between memory and regulatory cell populations in kidney transplant recipients with operational tolerance
In conclusion, monitoring the balance between circulating CD8+ TEMRA T cells and regulatory cell subsets and their transcripts may help to distinguish transplant recipients with operational tolerance from recipients at risk of graft loss.PMID:38393856 | DOI:10.1093/cei/uxae018 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Caner S üsal Cristiam M Alvarez Louise Benning Volker Daniel Martin Zeier Matthias Schaier Christian Morath Claudius Speer Source Type: research

The balance between memory and regulatory cell populations in kidney transplant recipients with operational tolerance
In conclusion, monitoring the balance between circulating CD8+ TEMRA T cells and regulatory cell subsets and their transcripts may help to distinguish transplant recipients with operational tolerance from recipients at risk of graft loss.PMID:38393856 | DOI:10.1093/cei/uxae018 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 23, 2024 Category: Allergy & Immunology Authors: Caner S üsal Cristiam M Alvarez Louise Benning Volker Daniel Martin Zeier Matthias Schaier Christian Morath Claudius Speer Source Type: research

Regulatory T cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction
This study aimed to analyze, by flow cytometry, the circulating levels of CD69+ regulatory T cells and CD4+ CD25hi Foxp3+ cells, its IL-10+ production as well as their function in patients with acute myocardial infarction (AMI), and its possible relation with ventricular dysfunction. We found a significant difference in the percentage of CD4+ CD25hi Foxp3+ cells and IL-10+ MFI in patients with AMI at 72 hours compared with the healthy control group, and the levels of these cells were reduced six months post-AMI. Regarding the suppressive function of CD4+ CD25+ regulatory cells, they were dysfunctional at three- and six-mon...
Source: Clinical and Developmental Immunology - February 22, 2024 Category: Allergy & Immunology Authors: Elena Berenice Mart ínez-Shio Sherell Mar ín-Jáuregui Alma Celeste Rodr íguez Ortega Lesly Marsol Don íz Padilla Roberto Gonz ález-Amaro Carlos David Escobedo-Uribe Adriana Elizabeth Monsiv áis-Urenda Source Type: research

Altered CD226/TIGIT expressions were associated with activated NK phenotypes in primary anti-phospholipid syndrome and affected by IL-4/JAK pathway
Conclusion: Our data revealed significant imbalanced CD226/TIGIT expressions on NK cells in pAPS, which closely associated with activated NK subsets phenotypes and more complicated autoantibody status. CD226/TIGIT imbalanced may be affected by IL-4/JAK pathway activation.PMID:38386917 | DOI:10.1093/cei/uxae016 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 22, 2024 Category: Allergy & Immunology Authors: Yan Long Ke-Jia Lu Chang-Sheng Xia Jing-Hong Feng Wen-Yi Li Yin-Ting Ma Yuan-Yuan Sun Chun-Hong Fan Chun Li Source Type: research

Chronic malaria exposure is associated with inhibitory markers on T cells that correlate with atypical memory and marginal zone-like B cells
Clin Exp Immunol. 2024 Feb 22:uxae015. doi: 10.1093/cei/uxae015. Online ahead of print.ABSTRACTChronic immune activation from persistent malaria infections can induce immunophenotypic changes associated with T cell exhaustion. However, associations between T and B cells during chronic exposure remain undefined. We analyzed peripheral blood mononuclear cells from malaria-exposed pregnant women from Papua New Guinea and Spanish malaria-naïve individuals using flow cytometry to profile T cell exhaustion markers phenotypically. T cell lineage (CD3, CD4, CD8), inhibitory (PD1, TIM3, LAG3, CTLA4, 2B4) and senescence (CD28-) mar...
Source: Clinical and Developmental Immunology - February 22, 2024 Category: Allergy & Immunology Authors: Robert A Mitchell Itziar Ubillos Pilar Requena Joseph J Campo Maria Ome-Kaius Sarah Hanieh Alexandra Umbers Paula Samol Diana Barrios Alfons Jim énez Azucena Bardaj í Ivo Mueller Clara Men éndez Stephen Rogerson Carlota Doba ño Gemma Moncunill Source Type: research

Splenectomy at Early stage of Autoimmune Arthritis Delayed Inflammatory Response and Reduced Joint Deterioration in Mice
In conclusion, splenectomy in early stages of GIA delayed the inflammatory response, suggesting a protective effect against the development and progression of severe destructive arthritis.PMID:38363980 | DOI:10.1093/cei/uxae013 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Esam Khanfar Katalin Olasz Szonja G ál Erzs ébet Gajdócsi B éla Kajtár Tam ás Kiss P éter Balogh Timea Berki Ferenc Boldizs ár Source Type: research

Splenectomy at Early stage of Autoimmune Arthritis Delayed Inflammatory Response and Reduced Joint Deterioration in Mice
In conclusion, splenectomy in early stages of GIA delayed the inflammatory response, suggesting a protective effect against the development and progression of severe destructive arthritis.PMID:38363980 | DOI:10.1093/cei/uxae013 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Esam Khanfar Katalin Olasz Szonja G ál Erzs ébet Gajdócsi B éla Kajtár Tam ás Kiss P éter Balogh Timea Berki Ferenc Boldizs ár Source Type: research

Splenectomy at Early stage of Autoimmune Arthritis Delayed Inflammatory Response and Reduced Joint Deterioration in Mice
In conclusion, splenectomy in early stages of GIA delayed the inflammatory response, suggesting a protective effect against the development and progression of severe destructive arthritis.PMID:38363980 | DOI:10.1093/cei/uxae013 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Esam Khanfar Katalin Olasz Szonja G ál Erzs ébet Gajdócsi B éla Kajtár Tam ás Kiss P éter Balogh Timea Berki Ferenc Boldizs ár Source Type: research

Splenectomy at Early stage of Autoimmune Arthritis Delayed Inflammatory Response and Reduced Joint Deterioration in Mice
In conclusion, splenectomy in early stages of GIA delayed the inflammatory response, suggesting a protective effect against the development and progression of severe destructive arthritis.PMID:38363980 | DOI:10.1093/cei/uxae013 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Esam Khanfar Katalin Olasz Szonja G ál Erzs ébet Gajdócsi B éla Kajtár Tam ás Kiss P éter Balogh Timea Berki Ferenc Boldizs ár Source Type: research

Splenectomy at Early stage of Autoimmune Arthritis Delayed Inflammatory Response and Reduced Joint Deterioration in Mice
In conclusion, splenectomy in early stages of GIA delayed the inflammatory response, suggesting a protective effect against the development and progression of severe destructive arthritis.PMID:38363980 | DOI:10.1093/cei/uxae013 (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Esam Khanfar Katalin Olasz Szonja G ál Erzs ébet Gajdócsi B éla Kajtár Tam ás Kiss P éter Balogh Timea Berki Ferenc Boldizs ár Source Type: research

Albumin influences leucocyte FcRn expression in the early days of kidney transplantation
Clin Exp Immunol. 2024 Feb 13:uxae011. doi: 10.1093/cei/uxae011. Online ahead of print.ABSTRACTFcRn, a receptor originally known for its involvement in IgG and albumin transcytosis and recycling, is also important in the establishment of the innate and adaptive immune response. Dysregulation of the immune response has been associated with variations in FcRn expression, as observed in cancer. Recently, a link between autophagy and FcRn expression has been demonstrated. Knowing that autophagy is strongly involved in the development of reperfusion injury in kidney transplantation and that albuminemia is transiently decreased ...
Source: Clinical and Developmental Immunology - February 14, 2024 Category: Allergy & Immunology Authors: Pierre Boulard Nicolas Azzopardi Romain Levard Jean-Marie Cornec Juliette Lamamy B érénice Prieur Marie-V éronique Demattei Herv é Watier Philippe Gatault Val érie Gouilleux-Gruart Source Type: research

Albumin influences leucocyte FcRn expression in the early days of kidney transplantation
Clin Exp Immunol. 2024 Feb 13:uxae011. doi: 10.1093/cei/uxae011. Online ahead of print.ABSTRACTFcRn, a receptor originally known for its involvement in IgG and albumin transcytosis and recycling, is also important in the establishment of the innate and adaptive immune response. Dysregulation of the immune response has been associated with variations in FcRn expression, as observed in cancer. Recently, a link between autophagy and FcRn expression has been demonstrated. Knowing that autophagy is strongly involved in the development of reperfusion injury in kidney transplantation and that albuminemia is transiently decreased ...
Source: Clinical and Developmental Immunology - February 14, 2024 Category: Allergy & Immunology Authors: Pierre Boulard Nicolas Azzopardi Romain Levard Jean-Marie Cornec Juliette Lamamy B érénice Prieur Marie-V éronique Demattei Herv é Watier Philippe Gatault Val érie Gouilleux-Gruart Source Type: research