Determination of antihistaminic drugs alcaftadine and olopatadine hydrochloride via ion-pairing with eosin Y as a spectrofluorimetric and spectrophotometric probe: application to dosage forms
Four sensitive and fast analytical approaches relied on ion pairing with eosin Y were built up and evaluated using spectroscopy for determination of Alcaftadine and Olopatadine hydrochloride with high sensitiv... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 22, 2024 Category: Chemistry Authors: Sayed M. Derayea, Khalid M. Badr El-din, Ahmed S. Ahmed, Ahmed A. Khorshed and Mohamed Oraby Tags: Research Source Type: research
Application of α-bromination reaction on acetophenone derivatives in experimental teaching: a chemical innovation experiment engaging junior undergraduates
The α-bromination reaction of carbonyl compounds is a significant topic in the field of organic chemistry. However, due to the lack of suitable brominating reagents, the application of this reaction in undergr... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 21, 2024 Category: Chemistry Authors: Yongguang Gao, Na Chen, Xiaoye Jiang and Xiaochun Yang Tags: Research Source Type: research
Development of an UPLC-MS/MS method for quantitative analysis of abexinostat levels in rat plasma and application of pharmacokinetics
Broad-spectrum histone deacetylase inhibitors (HDACi) have excellent anti-tumor effects, such as abexinostat, which was a novel oral HDACi that was widely used in clinical treatment. The purpose of this study ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 20, 2024 Category: Chemistry Authors: Yige Yu, Jinyu Hu, Xiaohai Chen, Hua-lu Wu, Anzhou Wang and Congrong Tang Tags: Research Source Type: research
Spectrophotometric resolution for quantitative analysis of aspirin and rivaroxaban combination therapy in biological fluids using simple and eco-friendly procedure
Patients diagnosed with symptomatic peripheral artery disease (PAD) in the lower extremities have a higher likelihood of suffering from major vascular events. Recently, FDA has approved the combination therapy... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 19, 2024 Category: Chemistry Authors: Heba M. Mohamed and Hebatallah M. Essam Tags: Research Source Type: research
Synthesis and biological evaluation of titanium dioxide/thiopolyurethane composite: anticancer and antibacterial effects
Nanocomposites incorporating titanium dioxide (TiO2) have a significant potential for various industrial and medical applications. These nanocomposites exhibit selectivity as antimicrobial and anticancer agents. ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 17, 2024 Category: Chemistry Authors: Rana R. El Sadda, Mai S. Eissa, Rokaya K. Elafndi, Elhossein A. Moawed, Mohamed M. El-Zahed and Hoda R. Saad Tags: Research Source Type: research
Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties
In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines based on 4-(N,N-dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 16, 2024 Category: Chemistry Authors: Eman M. Sayed, Etify A. Bakhite, Reda Hassanien, Nasser Farhan, Hanan F. Aly, Salma G. Morsy and Nivin A. Hassan Tags: Research Source Type: research
Iron oxide nanoparticles coated with Glucose and conjugated with Safranal (Fe3O4@Glu-Safranal NPs) inducing apoptosis in liver cancer cell line (HepG2)
Magnetic nanoparticles can be considered a reliable tool for targeted drug delivery to cancer tissues. Based on this, in this study, the anticancer effect of iron oxide nanoparticles coated with glucose and co... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 15, 2024 Category: Chemistry Authors: Somayeh Mikaeili Ghezeljeh, Ali Salehzadeh and Somayeh Ataei-e Jaliseh Tags: Research Source Type: research
Synthesis and characterization of Cu-Doped ZnO nanostructures for UV sensing application
In this work, Fabrication, and characterization of Cu-doped ZnO thin films deposited on porous silicon (PSi) substrates have been reported using electrochemical deposition (ECD) technique. The influence of Cu-... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 14, 2024 Category: Chemistry Authors: K. Al-heuseen, A. I. Aljameel and R. K. Hussein Tags: Research Source Type: research
An immunoinformatics and structural vaccinology approach to design a novel and potent multi-epitope base vaccine targeting Zika virus
Zika virus is an infectious virus, that belongs to Flaviviridae family, which is transferred to humans through mosquito vectors and severely threatens human health; but, apart from available resources, no effecti... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 13, 2024 Category: Chemistry Authors: Mohammed Ageeli Hakami Tags: Research Source Type: research
Discovery of dual kinase inhibitors targeting VEGFR2 and FAK: structure-based pharmacophore modeling, virtual screening, and molecular docking studies
VEGFR2 and FAK signaling pathways are interconnected and have synergistic effects on tumor angiogenesis, growth, and metastasis. Thus, instead of the conventional targeting of each of these proteins individual... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 12, 2024 Category: Chemistry Authors: Marwa A. Fouad, Alaa A. Osman, Noha M. Abdelhamid, Mai W. Rashad, Ashrakat Y. Nabawy and Ahmed M. El Kerdawy Tags: Research Source Type: research
Novel quinazolines bearing 1,3,4-thiadiazole-aryl urea derivative as anticancer agents: design, synthesis, molecular docking, DFT and bioactivity evaluations
A novel series of 1-(5-((6-nitroquinazoline-4-yl)thio)-1,3,4-thiadiazol-2-yl)-3-phenylurea derivatives 8 were designed and synthesized to evaluate their cytotoxic potencies. The structures of these obtained compo... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 12, 2024 Category: Chemistry Authors: Sara Masoudinia, Marjaneh Samadizadeh, Maliheh Safavi, Hamid Reza Bijanzadeh and Alireza Foroumadi Tags: Research Source Type: research
Electroreduction of divanillin to polyvanillin in an electrochemical flow reactor
The electrochemical conversion of biobased intermediates offers an attractive and sustainable process for the production of green chemicals. One promising synthesis route is the production of the total vanilli... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 8, 2024 Category: Chemistry Authors: Robin Kunkel, Maximilian Fath, Detlef Schmiedl, Volkmar M. Schmidt and Jens T übke Tags: Research Source Type: research
Eco-friendly, sensitive and inventive first derivative synchronous spectrofluorimetric determination of ciprofloxacin and phenylephrine in their pure form, single and combined eye drops
A facile, sensitive, accurate and green spectrofluorimetric method was evolved for the assay of ciprofloxacin hydrochloride (CFX) and phenylephrine hydrochloride (PLN) in their co-formulated eye drops with the... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 5, 2024 Category: Chemistry Authors: Neamat T. Barakat, Amina M. El-Brashy and Mona E. Fathy Tags: Research Source Type: research
Cluster energy prediction based on multiple strategy fusion whale optimization algorithm and light gradient boosting machine
Clusters, a novel hierarchical material structure that emerges from atoms or molecules, possess unique reactivity and catalytic properties, crucial in catalysis, biomedicine, and optoelectronics. Predicting cl... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - January 30, 2024 Category: Chemistry Authors: Wu Wei, Li Mengshan, Wu Yan and Guan Lixin Tags: Research Source Type: research
Stability indicating eco-friendly quantitation of terbutaline and its pro-drug bambuterol using quantitative proton nuclear magnetic spectroscopy
This study used NMR spectroscopy to assay the bronchodilator drug terbutaline sulfate and its pro-drug bambuterol... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - January 30, 2024 Category: Chemistry Authors: Asmaa El-Sayed, Mohamed A. Sabry, Heba Elmansi, Manal Eid and Shereen Shalan Tags: Research Source Type: research
