Iso-mukaadial acetate and ursolic acid acetate bind to Plasmodium Falciparum heat shock protein 70: towards targeting parasite protein folding pathway
Plasmodium falciparum is the most lethal malaria parasite. P. falciparum Hsp70 (PfHsp70) is an essential molecular chaperone (facilitates protein folding) and is deemed a prospective antimalarial drug target. The... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 18, 2024 Category: Chemistry Authors: Francis Opoku, Penny Govender, Addmore Shonhai and Mthokozisi BC Simelane Tags: Research Source Type: research
Simultaneous determination of bromoxynil and MCPA in commercial samples and raw materials using reversed phase high performance liquid chromatography
This study encompasses a quick, efficient, repeatable and reproducible analytical method for simultaneous determination of Bromoxynil (3, 5-Dibromo-4-hydroxybenzonitrile) and MCPA (2-methyl-4-chlorophenoxyacet... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 16, 2024 Category: Chemistry Authors: Ahmed Yar, Tariq Mahmood Ansari, Faariah Rehman, Asad Raza, Umair Riaz, Rashid Iqbal, Amal M. Al-Mohaimeed, Wedad A. Al-onazi and Muhammad Rizwan Tags: Research Source Type: research
New thiazole, thiophene and 2-pyridone compounds incorporating dimethylaniline moiety: synthesis, cytotoxicity, ADME and molecular docking studies
Various sets of thiazole, thiophene, and 2-pyridone ring structures containing a dimethylaniline component were synthesized. Substituted thiazoles 2 –3 and thiophenes 5–7 were produced by reacting thiocarbamoyl co... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 14, 2024 Category: Chemistry Authors: Heba M. Metwally, Norhan M. Younis, Ehab Abdel-Latif and Ali El-Rayyes Tags: Research Source Type: research
Thermodynamic investigation on the aqueous mixtures of choline chloride/propylene glycol deep eutectic solvent at T = (293.15 to 313.15) K
This work focuses on physicochemical features of the choline chloride/propylene glycol deep eutectic solvent (DES) + water mixtures by determining their density values in mono- and mixed- states over various t... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 13, 2024 Category: Chemistry Authors: Aynaz Zarghampour, Parisa Jafari, Elaheh Rahimpour and Abolghasem Jouyban Tags: Research Source Type: research
Utility of sustainable ratio derivative spectrophotometry for the concurrent assay of synergistic repurposed drugs for COVID-19 infections; Insilico pharmacokinetics proof
The cutting-edge combination of fluvoxamine (FVM) and ivermectin (IVM) has been presented as a proposed dosage form for the treatment of COVID-19 infections in early diagnosed patients. The main objective of t... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 7, 2024 Category: Chemistry Authors: Sara I. Aboras, Ahmed A. Megahed, Fawzy El-Yazbi and Hadir M. Maher Tags: Research Source Type: research
Preparation and property analysis of antioxidant of carbazole derivatives
Carbazole derivatives can be used as antioxidants in the lubricating oil industry. The alkylation of carbazole with 2-chloro-2-methylpropane and 2-bromopropane catalyzed by anhydrous aluminum chloride was stud... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 7, 2024 Category: Chemistry Authors: Zhi-quan Zhang, Bao-wei Zhu, Jing-yu Zhang and Hong Chen Tags: Research Source Type: research
Sulfonate derivatives bearing an amide unit: design, synthesis and biological activity studies
Pest disasters which occurs on crops is a serious problem that not only cause crop yield loss or even crop failure but can also spread a number of plant diseases.Sulfonate derivatives have been widely used in ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 6, 2024 Category: Chemistry Authors: You-hua Liu, Chang-kun Li, Mao-yu Nie, Fa-li Wang, Xiao-li Ren, Lin-hong Jin and Xia Zhou Tags: Research Source Type: research
Exploration of newly synthesized azo-thiohydantoins as the potential alkaline phosphatase inhibitors via advanced biochemical characterization and molecular modeling approaches
In the current study, Azo-Thiohydantoins derivatives were synthesized and characterized by using various spectroscopic techniques including FTIR, 1H-NMR, 13C-NMR, elemental and HRMS analysis. The compounds were e... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 6, 2024 Category: Chemistry Authors: Hafiz Muhammad Attaullah, Syeda Abida Ejaz, Pervaiz Ali Channar, Aamer Saeed, Rabail Ujan, Seema Zargar, Sajid Ali Channar, Reshma Sahito, Tanveer A. Wani and Qamar Abbas Tags: Research Source Type: research
Voltammetric analysis of pholcodine on graphene-modified GNPs/PTs with green assessment
Pholcodine, an anti-tussive medication widely used as an over-the-counter, OTC drug, has recently faced restrictions in several countries. This paper presents a sensitive electrochemical approach for pholcodin... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 6, 2024 Category: Chemistry Authors: Nahla A. Abdelshafi, Hany W. Darwish, Ashwag S. Alanazi, Ibrahim A. Naguib, Hadeer H. Elkhouly, Nehal S. Khodary and Ekram H. Mohamed Tags: Research Source Type: research
In silico evaluation of a new compound incorporating 4(3H)-quinazolinone and sulfonamide as a potential inhibitor of a human carbonic anhydrase
The present study investigates the potential of a new compound containing sulfonamide and 4(3H)-quinazolinone to inhibit the hCA-IIX enzyme using in silico methods. Density functional theory-based calculations... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 4, 2024 Category: Chemistry Authors: Ahmed M. Alkaoud, Abbas I. Alakhras, Moez A. Ibrahim, S. K. Alghamdi and Rageh K. Hussein Tags: Research Source Type: research
Application of smart chemometric models for spectra resolution and determination of challenging multi-action quaternary mixture: statistical comparison with greenness assessment
A multivariate spectrophotometric method is a potential approach that enables discrimination of spectra of components in complex matrices (e.g., pharmaceutical formulation) serving as a substitution method for... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 2, 2024 Category: Chemistry Authors: Aya A. Mouhamed, Ahmed H. Nadim, Nadia M. Mostafa and Basma M. Eltanany Tags: Research Source Type: research
Receptor-based pharmacophore modeling, molecular docking, synthesis and biological evaluation of novel VEGFR-2, FGFR-1, and BRAF multi-kinase inhibitors
A receptor-based pharmacophore model describing the binding features required for the multi-kinase inhibition of the target kinases (VEGFR-2, FGFR-1, and BRAF) were constructed and validated. It showed a good ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 23, 2024 Category: Chemistry Authors: Heba T. Abdel-Mohsen, Marwa A. Ibrahim, Amira M. Nageeb and Ahmed M. El Kerdawy Tags: Research Source Type: research
Vancomycin and nisin-modified magnetic Fe3O4@SiO2 nanostructures coated with chitosan to enhance antibacterial efficiency against methicillin resistant Staphylococcus aureus (MRSA) infection in a murine superficial wound model
The objective of this research was to prepare some Fe3O4@SiO2@Chitosan (CS) magnetic nanocomposites coupled with nisin, and vancomycin to evaluate their antibacterial efficacy under both in vitro and in vivo agai... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 23, 2024 Category: Chemistry Authors: Mona Nasaj, Abbas Farmany, Leili Shokoohizadeh, Farid Aziz Jalilian, Reza Mahjoub, Ghodratollah Roshanaei, Alireza Nourian, Omid Heydari Shayesteh and Mohammadreza Arabestani Tags: Research Source Type: research
Design, synthesis, and molecular dynamics simulation studies of some novel kojic acid fused 2-amino-3-cyano-4H-pyran derivatives as tyrosinase inhibitors
A novel series of kojic acid fused 2-amino-3-cyano-4H-pyran derivatives were synthesized via a multicomponent reaction involving kojic acid, benzyloxy benzaldehyde, and malonitrile as tyrosinase inhibitors. Su... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 22, 2024 Category: Chemistry Authors: Zahra Najafi, Maryam Zandi Haramabadi, Gholamabbas Chehardoli, Ahmad Ebadi and Aida Iraji Tags: Research Source Type: research
Computational design of anti-cancer peptides tailored to target specific tumor markers
In this study, we designed ACPs to target recept... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 22, 2024 Category: Chemistry Authors: Aisha Naeem, Nighat Noureen, Shaikha Khalid Al-Naemi, Jawaher Ahmed Al-Emadi and Muhammad Jawad Khan Tags: Research Source Type: research
