Indole-based FLT3 inhibitors and related scaffolds as potential therapeutic agents for acute myeloid leukemia
Fms-like tyrosine kinase 3 (FLT3) mutation mechanisms are among the most common genetic abnormalities detected in about 30% of acute myeloid leukemia (AML) patients. These mutations are accompanied by poor cli... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - July 12, 2023 Category: Chemistry Authors: Hend A. A. Ezelarab, Taha F. S. Ali, Samar H. Abbas, Heba A. Hassan and Eman A. M. Beshr Tags: Review Source Type: research
Earth-friendly micellar UPLC technique for determination of four hypoglycemic drugs in different pharmaceutical dosage forms and spiked human plasma
A novel, sensitive, and green micellar UPLC method was proposed and validated for the simultaneous determination of four hypoglycemic agents used in type II diabetes mellitus treatment namely, pioglitazone, al... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - July 12, 2023 Category: Chemistry Authors: Manal S. Elmasry, Wafaa S. Hassan, Hanan A. Merey and Israa M. Nour Tags: Research Source Type: research
Biosynthesis approach of copper nanoparticles, physicochemical characterization, cefixime wastewater treatment, and antibacterial activities
The aim of this paper is the green synthesis of copper nanoparticles (Cu NPs) via Quinoa seed extract. X-ray diffraction (XRD) results confirmed the production of the pure crystalline face center cubic system of ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - July 9, 2023 Category: Chemistry Authors: Esraa Hassan, Ahmed A. Gahlan and Gamal A. Gouda Tags: Research Source Type: research
A study of the interaction space of two lactate dehydrogenase isoforms (LDHA and LDHB) and some of their inhibitors using proteochemometrics modeling
Lactate dehydrogenase (LDH) is a tetramer enzyme that converts pyruvate to lactate reversibly. This enzyme becomes important because it is associated with diseases such as cancers, heart disease, liver problem... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - July 6, 2023 Category: Chemistry Authors: Sedigheh Damavandi, Fereshteh Shiri, Abbasali Emamjomeh, Somayeh Pirhadi and Hamid Beyzaei Tags: Research Source Type: research
The mechanism of fluorescence quenching of naphthalimide A/C leak detector by copper (II)
Fluorescence quenching is an interesting phenomenon with the potential to be applied across various fields. The mechanism is commonly used across analytical applications for monitoring the concentration of tra... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - July 5, 2023 Category: Chemistry Authors: Ismail Badran and Najamus Sahar Riyaz Tags: Research Source Type: research
Contemporary methods for the extraction and isolation of natural products
Extraction is a vital step in obtaining pure bioactive natural compounds for medical, scientific and commercial use. Recently, interest in extracting natural products for applications across the food, pharmace... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 30, 2023 Category: Chemistry Authors: Milena Popova and Vassya Bankova Tags: Editorial Source Type: research
Repurposing Amphotericin B: anti-microbial, molecular docking and molecular dynamics simulation studies suggest inhibition potential of Amphotericin B against MRSA
Amphotericin B (AMPH) is an anti-fungal drug and this study, for the first time as best of our knowledge, reports the repurposing of the Amphotericin B. The drug was found to show significant antibacterial pot... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 29, 2023 Category: Chemistry Authors: Neha Farid, Khair Bux, Kashif Ali, Asma Bashir and Rahima Tahir Tags: Research Source Type: research
Synthesis, α-Glucosidase inhibitory activity and docking studies of Novel Ethyl 1,2,3-triazol-4-ylmethylthio-5,6-diphenylpyridazine-4-carboxylate derivatives
In this work, a novel series of pyridazine-triazole hybrid molecules were prepared and evaluated as inhibitors of rat intestinal α-glucosidase enzyme. Amongst all newly synthesized compounds, 10k showed good inhi... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 26, 2023 Category: Chemistry Authors: Loghman Firoozpour, Setareh Moghimi, Somayeh Salarinejad, Mahsa Toolabi, Mahdi Rafsanjani, Roya Pakrad, Farzaneh Salmani, Seyed Mohammad Shokrolahi, Seyed Esmail Sadat Ebrahimi, Saeed Karima and Alireza Foroumadi Tags: Research Source Type: research
Synthesis and tyrosinase inhibitory activities of novel isopropylquinazolinones
To find new anti-browning and whitening agents in this study, new series of isopropylquinazolinone derivatives were designed and synthesized. All derivatives were evaluated as possible tyrosinase inhibitors an... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 23, 2023 Category: Chemistry Authors: Arshia Hashemi, Milad Noori, Navid Dastyafteh, Seyed Esmaeil Sadat-Ebrahimi, Negin Fazelzadeh Haghighi, Katayoun Mehrpour, Elahe Sattarinezhad, Fatemeh Jalali Zafrei, Cambyz Irajie, Mohammad Ali Daneshmehr, Majid Heydari, Bagher Larijani, Aida Iraji and M Tags: Research Source Type: research
Three techniques for the determination of perindopril through derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
In addition to its pure form, three accurate, rapid, and simple methods have been established for determining perindopril (PRD) in its tablet form. At pH 9.0 using a borate buffer, developing the three designa... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 22, 2023 Category: Chemistry Authors: H. Askar, Mohammed E.-S. Metwally, M. M. Tolba, Fatma A. Ali and M. E. Fathy Tags: Research Source Type: research
6D-QSAR for predicting biological activity of human aldose reductase inhibitors using quasar receptor surface modeling
The application of QSAR analysis dates back a half-century ago and is currently continuously employed in any rational drug design. The multi-dimensional QSAR modeling can be a promising tool for researchers to... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 22, 2023 Category: Chemistry Authors: Babak Sokouti and Maryam Hamzeh-Mivehroud Tags: Research Source Type: research
Development and validation of an eco-friendly HPLC –UV method for determination of atorvastatin and vitamin D3 in pure form and pharmaceutical formulation
Statin-associated muscle symptoms are considered as obvious adverse effects of prolonged statin therapy such as myopathy, myalgia, and rhabdomyolysis. These side effects are associated with vitamin D3 deficiency ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 20, 2023 Category: Chemistry Authors: Khaled Maged, Magda M. El-Henawee and Soad S. Abd El-Hay Tags: Research Source Type: research
Synthesis, antimicrobial and antioxidant activity of triazole, pyrazole containing thiazole derivatives and molecular docking studies on COVID-19
New series of biologically active triazole and pyrazole compounds containing 2, 4-disubstituted thiazole analogues (12a-l) were synthesized from p-hydroxy benzaldehyde and phenyl hydrazine in excellent yields ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 17, 2023 Category: Chemistry Authors: Raghavender Matta, Jalapathi Pochampally, Bala Narsimha Dhoddi, Shankar Bhookya, Sampath Bitla and Anjini Gayatri Akkiraju Tags: Research Source Type: research
The first facile optical density-dependent approach for the analysis of doxorubicin, an oncogenic agent accompanied with the co-prescribed drug; paclitaxel
Doxorubicin (DRB) is an anthracycline oncogenic drug extracted from cultures of Streptomyces peucetius var. caesius. It is frequently recommended as an anti-neoplastic agent for the treatment of diverse malignanc... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 16, 2023 Category: Chemistry Authors: Ahmed Abdulhafez Hamad Tags: Research Source Type: research
Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents
The carbazole skeleton is an important structural motif occurring naturally or synthesized chemically and has antihistaminic, antioxidant, antitumor, antimicrobial, and anti-inflammatory activities. (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - June 16, 2023 Category: Chemistry Authors: İrfan Çapan, Mohammed Hawash, Nidal Jaradat, Yusuf Sert, Refik Servi and İrfan Koca Tags: Research Source Type: research
