Determination of Clomipramine using eco-friendly solid-contact ionophore-doped potentiometric sensor
Clomipramine is a tricyclic antidepressant acting as a serotonin reuptake inhibitor. Its maximum plasma concentration (Cmax) is 13 –310 ng/mL, the therapeutic range is 220–500 ng/mL and its toxic effect appears in... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 25, 2023 Category: Chemistry Authors: Adel M. Michael, Amr M. Mahmoud and Nesma M. Fahmy Tags: Research Source Type: research
Quality monitoring of Shenmai injection by HPLC pharmacodynamic fingerprinting
A probable problem of disconnection between chemical fingerprints and drug effects for TCMs would be contrary to the original intention of fingerprint research, and limits the development and application of fi... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 25, 2023 Category: Chemistry Authors: Geng Yang, Shuai Li, Xiaoyi Sun, Yuanyuan Lv and Hongxia Huang Tags: Research Source Type: research
Use of green fluorescent nano-sensors for the determination of furosemide in biological samples and pharmaceutical preparations
Carbon quantum dots (CQDs) are new class of carbon nanoparticles. Recently, they have been widely used as fluorescent probes due to their easy accessibility, optical properties and chemical inertness. Many ava... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 24, 2023 Category: Chemistry Authors: Mona H. Abo Zaid, Nahed El-Enany, Aziza E. Mostafa, Ghada M. Hadad and Fathalla Belal Tags: Research Source Type: research
Computer-aided drug design
Computer-Aided Drug Design tools are now an indispensable part of drug discovery that have made key contributions to the development of drugs. In this editorial, I briefly provide an overview of CADD emphasizi... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 24, 2023 Category: Chemistry Authors: Abdulilah Ece Tags: Editorial Source Type: research
The simultaneous measurement of quaternary mixture in over-the-counter cold medications using sequential spectrophotometric resolution approach enhanced with in-lab sample enrichment
A sequential spectrophotometric resolution technique (SSRT) was developed in this study without the use of systematic separation procedures to determine drug of a quaternary combination; caffeine (CAF), pseudo... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 22, 2023 Category: Chemistry Authors: Khadiga M. Kelani, Mohamed S. Emara, Ahmed W. Madkour, Hany A. Batakoushy and Rehab M. Tony Tags: Research Source Type: research
Green adherent degradation kinetics study of Nirmatrelvir, an oral anti-COVID-19: characterization of degradation products using LC –MS with insilico toxicity profile
The SARS-CoV-2 virus sets up a global catastrophe, and countries all around the world made significant efforts to halt the spread. Nirmatrelvir (NMV) was lately approved by the FDA as a safe and well-tolerated... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 17, 2023 Category: Chemistry Authors: Sara I. Aboras and Hadir M. Maher Tags: Research Source Type: research
Enantioseparation, quantification, molecular docking and molecular dynamics study of five β-adrenergic blockers on Lux-Cellulose-2 column
Enantioseparation of five β-adrenergic blockers was studied using two mobile phases on a cellulose tris(3‐chloro‐4‐methylphenylcarbamate) (Lux-Cellulose-2) chiral column in normal phase mode. The first mobile ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 16, 2023 Category: Chemistry Authors: Ola Ahmed Saleh, Amr Mohamed Badawey, Hassan Y. Aboul-Enein and Marwa Ahmed Fouad Tags: Research Source Type: research
HPLC-DAD technique for the quantification of a recently approved anti-diabetic triple combination along with two toxic official impurities: Toxicity confirmation aided by molecular docking application
Gliflozins and gliptins are two distinct groups of pharmacological drugs that reduce blood glucose levels in individuals with type II diabetes in various ways that may perform their functions harmoniously. Tri... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 15, 2023 Category: Chemistry Authors: Eman A. Bahgat, Hisham Hashem, Hanaa Saleh, Ebraam B. Kamel and Maya S. Eissa Tags: Research Source Type: research
Micellar eco-friendly HPLC method for simultaneous analysis of ternary combination of aspirin, atorvastatin and ramipril: application to content uniformity testing
Cardiovascular disease medications such as aspirin (ASP), statins like atorvastatin (ATR), and blood pressure-lowering drugs including ACE inhibitors like ramipril (RAM) have been included in the World Health ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 15, 2023 Category: Chemistry Authors: Nora A. Abdallah, Amina M. El-Brashy, Fawzia A. Ibrahim and Mohamed I. El-Awady Tags: Research Source Type: research
Comparative study of four innovative earth-friendly platforms for rapid analysis of daclatasvir dihydrochloride: Application on different matrices
Daclatasvir dihydrochloride has important roles not only in the management of COVID-19 pandemic symptoms but also in the treatment of chronic hepatitis C infection. (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 15, 2023 Category: Chemistry Authors: Rania A. Sayed, Ahmed R. Mohamed, Wafaa S. Hassan and Manal S. Elmasry Tags: Research Source Type: research
Synthesis and biological evaluation of [131I]iodocarvedilol as a potential radiopharmaceutical for heart imaging
The optimization of the radiolabeling yield of carvedilol with iodine-131 was described. Dependence of the labeling yield of [131I]iodocarvedilol on the concentration of carvedilol, chloramine-T content, pH of th... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 15, 2023 Category: Chemistry Authors: M. A. Motaleb, K M Attalah, H A Shweeta and I. T. Ibrahim Tags: Research Source Type: research
Insights of different analytical approaches for estimation of budesonide as COVID-19 replication inhibitor in its novel combinations: green assessment with AGREE and GAPI approaches
Simple, direct, rapid, and sensitive HPLC and spectrophotometric methods were established for simultaneous estimation of a novel combination of budesonide and azelastine (BUD/AZL) in their laboratory-prepared ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 14, 2023 Category: Chemistry Authors: Mohammed E. A. Hammouda, Amal A. El-Masry, Saadia M. El-Ashry and Dalia R. El-Wasseef Tags: Research Source Type: research
Three developed spectrophotometric methods for determination of a mixture of ofloxacin and ornidazole; application of greenness assessment tools
This work is dedicated to the greenness estimation of three proposed spectrophotometric techniques [e.g., ratio difference (RD), mean centering of ratio spectra (MCR) and continuous wavelet transform of ratio ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 13, 2023 Category: Chemistry Authors: Khadiga M. Kelani, Asmaa G. Gad, Yasmin M. Fayez, Amr M. Mahmoud and Ahmed M. Abdel-Raoof Tags: Research Source Type: research
Deep eutectic solvent-based manganese dioxide nanosheets composites for determination of DNA by a colorimetric method
Nucleic acid is the carrier of genetic information and the keymolecule in life science. It is important to establish a simple and feasible method for nucleic acid quantification in complex biological samples. (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 12, 2023 Category: Chemistry Authors: Jia Xu, Yuan Yang, Juan Du, Hui Lu, Wenqi Gao, Hongjian Gong and HanXiao Tags: Research Source Type: research
A novel heterogeneous acid –base nano-catalyst designed based on graphene oxide for synthesis of spiro-indoline-pyranochromene derivatives
Nano graphene oxide/3-aminopyridine has been introduced as a new, efficient and robust heterogeneous organic catalyst for synthesis of spiro-indoline-pyranochromene derivatives. Nano graphene oxide/3-aminopyri... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 10, 2023 Category: Chemistry Authors: Soghra Khabnadideh, Khashayar Khorshidi and Leila Amiri-Zirtol Tags: Research Source Type: research
