Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell models
Cancer is a deadly illness with a convoluted pathogenesis. The most prevalent restrictions that frequently result in treatment failure for cancer chemotherapy include lack of selectivity, cytotoxicity, and mul... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 10, 2024 Category: Chemistry Authors: Amna H. Faid and Marwa A. Ramadan Tags: Research Source Type: research
Amino-7,8-dihydro-4H-chromenone derivatives as potential inhibitors of acetylcholinesterase and butyrylcholinesterase for Alzheimer ’s disease management; in vitro and in silico study
In this article, we present the design and synthesis of amino-7,8-dihydro-4H-chromenone derivatives as possible inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for the management of ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 10, 2024 Category: Chemistry Authors: Ali Asadipour, Yaghoub Pourshojaei, Moein Mansouri, Elham Mahdavizadeh, Cambyz Irajie, Javad Mottaghipisheh, Ehsan Faghih-Mirzaei, Mohammad Mahdavi and Aida Iraji Tags: Research Source Type: research
Synthesis, anticancer evaluation, molecular docking and ADME study of novel pyrido[4 ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidines as potential tropomyosin receptor kinase A (TrKA) inhibitors
The starting compound 3-amino-1,7-dihydro-4H-pyrazolo[4,3-c]pyridine-4,6(5H)-dione (1) is reacted with each of diketone and β-ketoester, forming pyridopyrazolo[1,5-a]pyrimidines 4a,b and 14a,b, respectively. The ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 6, 2024 Category: Chemistry Authors: Nadia Hanafy Metwally, Emad Abdullah Deeb and Ibrahim Walid Hasani Tags: Research Source Type: research
Green chemometric-assisted UV-spectrophotometric methods for the determination of favipiravir, cefixime and moxifloxacin hydrochloride as an effective therapeutic combination for COVID-19; application in pharmaceutical form and spiked human plasma
As pharmaceutical analysis progresses towards environmental sustainability, there is a growing need to enhance the safety and health conditions for analysts. Consequently, the incorporation of chemometrics int... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 5, 2024 Category: Chemistry Authors: Eman A. Madbouly, Abdalla A. El-Shanawani, Sobhy M. El-adl and Ahmed S. Abdelkhalek Tags: Research Source Type: research
Therapeutic drug monitoring of six contraindicated/co-administered drugs by simple and green RP-HPLC-PDA; application to spiked human plasma
Therapeutic drug monitoring is an important clinical testing of the drugs to monitor their concentrations in plasma in order to guarantee their optimal impact, and to avoid any side effects resulting from drug... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 5, 2024 Category: Chemistry Authors: Nada Hesham, Maha A. Hegazy and Hebatallah A. Wagdy Tags: Research Source Type: research
Nitrophenylpiperazine derivatives as novel tyrosinase inhibitors: design, synthesis, and in silico evaluations
A novel series of 4-nitrophenylpiperazine derivatives (4a –m) was designed and synthesized as potential tyrosinase inhibitors. Comprehensive characterization using 1H-NMR, 13C-NMR, CNH, and IR techniques was perfo... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 5, 2024 Category: Chemistry Authors: Mehdi Asadi, Fahime Fayazi, Aida Iraji, Reyhaneh Sabourian, Homa Azizian, Mannan Hajimahmoodi, Bagher Larijani, Mohammad Mahdavi and Massoud Amanlou Tags: Research Source Type: research
Anticholinesterase activities of novel isoindolin-1,3-dione-based acetohydrazide derivatives: design, synthesis, biological evaluation, molecular dynamic study
In pursuit of developing novel cholinesterase (ChE) inhibitors through molecular hybridization theory, a novel series of isoindolin-1,3-dione-based acetohydrazides (compounds 8a –h) was designed, synthesized, and ... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - April 1, 2024 Category: Chemistry Authors: Ahmad Nazarian, Fahime Abedinifar, Haleh Hamedifar, Mohammad Hashem Hashempur, Mohammad Mahdavi, Nima Sepehri and Aida Iraji Tags: Research Source Type: research
QSAR analysis of VEGFR-2 inhibitors based on machine learning, Topomer CoMFA and molecule docking
VEGFR-2 kinase inhibitors are clinically approved drugs that can effectively target cancer angiogenesis. However, such inhibitors have adverse effects such as skin toxicity, gastrointestinal reactions and hepa... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 30, 2024 Category: Chemistry Authors: Hao Ding, Fei Xing, Lin Zou and Liang Zhao Tags: Research Source Type: research
Determination of indoxyl sulfate by spectrofluorimetric method in human plasma through extraction with deep eutectic solvent
A rapid and efficient analytical method was established to quantify indoxyl sulfate (IS) in plasma through extraction technique with a deep eutectic solvent (DES) and spectrofluorimetric method. DES (choline c... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 30, 2024 Category: Chemistry Authors: Samira Shafiee, Siavoush Dastmalchi, Afshin Gharekhani and Ali Shayanfar Tags: Research Source Type: research
Enhancing the efficacy of nano-curcumin on cancer cells through mixture design optimization of three emulsifiers
Curcumin, a vital bioactive compound found naturally, has diverse biological applications. However, a major limitation of curcumin is its low bioavailability caused by its limited solubility in water. Hence, i... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 30, 2024 Category: Chemistry Authors: Zahra Sayyar and Hoda Jafarizadeh-Malmiri Tags: Research Source Type: research
Application of a magnetically separable Zr-MOF for fast extraction of palladium before its spectrophotometric detection
In this research, a novel magnetic zirconium-based metal-organic framework (Fe3O4@SiO2@MIP-202, MMOF), was fabricated, fully characterized, and applied for the batch-mode solid phase extraction of trace amounts o... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 30, 2024 Category: Chemistry Authors: Amin Piri, Massoud Kaykhaii, Mostafa Khajeh and Ali Reza Oveisi Tags: Research Source Type: research
Novel synthesis of new triazine sulfonamides with antitumor, anti-microbial and anti-SARS-CoV-2 activities
Novel approach for synthesizing triazine sulfonamide derivatives is accomplished via reacting the sulfaguanidine derivatives with N-cyanodithioiminocarbonate. Further reaction of the novel triazine sulfonamide an... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 26, 2024 Category: Chemistry Authors: Reham A. Mohamed-Ezzat and Galal H. Elgemeie Tags: Research Source Type: research
Prospective virtual screening combined with bio-molecular simulation enabled identification of new inhibitors for the KRAS drug target
Lung cancer is a disease with a high mortality rate and it is the number one cause of cancer death globally. Approximately 12 –14% of non-small cell lung cancers are caused by mutations in KRASG12C. The KRASG12C i... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 25, 2024 Category: Chemistry Authors: Amar Ajmal, Hind A Alkhatabi, Roaa M. Alreemi, Mubarak A. Alamri, Asaad Khalid, Ashraf N. Abdalla, Bader S. Alotaibi and Abdul Wadood Tags: Research Source Type: research
Comparing silver and gold nanoislands ’ surface plasmon resonance for bisacodyl and its metabolite quantification in human plasma
Gold and silver nanoparticles have witnessed increased scientific interest due to their colourful colloidal solutions and exceptional applications. Comparing the localized surface plasmon resonance (LSPR) of g... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 23, 2024 Category: Chemistry Authors: Khadiga M. Kelani, Maha M. Ibrahim, Nesreen K. Ramadan, Eman S. Elzanfaly and Sherif M. Eid Tags: Research Source Type: research
Four chemometric models enhanced by Latin hypercube sampling design for quantification of anti-COVID drugs: sustainability profiling through multiple greenness, carbon footprint, blueness, and whiteness metrics
Montelukast sodium (MLK) and Levocetirizine dihydrochloride (LCZ) are widely prescribed medications with promising therapeutic potential against COVID-19. However, existing analytical methods for their quantif... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - March 18, 2024 Category: Chemistry Authors: Noha S. Katamesh, Ahmed Emad F. Abbas and Shimaa A. Mahmoud Tags: Research Source Type: research
