Synthesis, anticancer evaluation, molecular docking and ADME study of novel pyrido[4 ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidines as potential tropomyosin receptor kinase A (TrKA) inhibitors

The starting compound 3-amino-1,7-dihydro-4H-pyrazolo[4,3-c]pyridine-4,6(5H)-dione (1) is reacted with each of diketone and β-ketoester, forming pyridopyrazolo[1,5-a]pyrimidines 4a,b and 14a,b, respectively. The ...

Source: Chemistry Central Journal - April 6, 2024 Category: Chemistry Authors: Nadia Hanafy Metwally, Emad Abdullah Deeb and Ibrahim Walid Hasani Tags: Research Source Type: research