Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines based on 4-(N,N-dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The...

Source: Chemistry Central Journal - February 16, 2024 Category: Chemistry Authors: Eman M. Sayed, Etify A. Bakhite, Reda Hassanien, Nasser Farhan, Hanan F. Aly, Salma G. Morsy and Nivin A. Hassan Tags: Research Source Type: research