Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells
CONCLUSION: Paeonol, a herb-derived phenolic compound, can provide drug candidate for developing new drug in treatment of skin disease such as urticaria.SIGNIFICANCE STATEMENT: In this study, we primarily examined the effect of Paeonol in the treatment of chronic urticaria and its mechanism of action in mast cells. Interestingly, Paeonol was found to regulate Src kinase activity downstream of MRGPRX2 triggered signaling cascade in mast cells. Therefore, this plant-derived phenolic compound may provide a therapeutic option for the treatment of chronic urticaria.PMID:37224634 | DOI:10.1016/j.cellimm.2023.104728 (Source: Cellular Immunology)
Source: Cellular Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Yuanyuan Ding Baowen Dang Yonghui Zhang Shiting Hu Yuejin Wang Chenrui Zhao Tao Zhang Zijun Gao Source Type: research
Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells
CONCLUSION: Paeonol, a herb-derived phenolic compound, can provide drug candidate for developing new drug in treatment of skin disease such as urticaria.SIGNIFICANCE STATEMENT: In this study, we primarily examined the effect of Paeonol in the treatment of chronic urticaria and its mechanism of action in mast cells. Interestingly, Paeonol was found to regulate Src kinase activity downstream of MRGPRX2 triggered signaling cascade in mast cells. Therefore, this plant-derived phenolic compound may provide a therapeutic option for the treatment of chronic urticaria.PMID:37224634 | DOI:10.1016/j.cellimm.2023.104728 (Source: Cellular Immunology)
Source: Cellular Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Yuanyuan Ding Baowen Dang Yonghui Zhang Shiting Hu Yuejin Wang Chenrui Zhao Tao Zhang Zijun Gao Source Type: research
Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells
CONCLUSION: Paeonol, a herb-derived phenolic compound, can provide drug candidate for developing new drug in treatment of skin disease such as urticaria.SIGNIFICANCE STATEMENT: In this study, we primarily examined the effect of Paeonol in the treatment of chronic urticaria and its mechanism of action in mast cells. Interestingly, Paeonol was found to regulate Src kinase activity downstream of MRGPRX2 triggered signaling cascade in mast cells. Therefore, this plant-derived phenolic compound may provide a therapeutic option for the treatment of chronic urticaria.PMID:37224634 | DOI:10.1016/j.cellimm.2023.104728 (Source: Cellular Immunology)
Source: Cellular Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Yuanyuan Ding Baowen Dang Yonghui Zhang Shiting Hu Yuejin Wang Chenrui Zhao Tao Zhang Zijun Gao Source Type: research
Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells
CONCLUSION: Paeonol, a herb-derived phenolic compound, can provide drug candidate for developing new drug in treatment of skin disease such as urticaria.SIGNIFICANCE STATEMENT: In this study, we primarily examined the effect of Paeonol in the treatment of chronic urticaria and its mechanism of action in mast cells. Interestingly, Paeonol was found to regulate Src kinase activity downstream of MRGPRX2 triggered signaling cascade in mast cells. Therefore, this plant-derived phenolic compound may provide a therapeutic option for the treatment of chronic urticaria.PMID:37224634 | DOI:10.1016/j.cellimm.2023.104728 (Source: Cellular Immunology)
Source: Cellular Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Yuanyuan Ding Baowen Dang Yonghui Zhang Shiting Hu Yuejin Wang Chenrui Zhao Tao Zhang Zijun Gao Source Type: research
Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells
CONCLUSION: Paeonol, a herb-derived phenolic compound, can provide drug candidate for developing new drug in treatment of skin disease such as urticaria.SIGNIFICANCE STATEMENT: In this study, we primarily examined the effect of Paeonol in the treatment of chronic urticaria and its mechanism of action in mast cells. Interestingly, Paeonol was found to regulate Src kinase activity downstream of MRGPRX2 triggered signaling cascade in mast cells. Therefore, this plant-derived phenolic compound may provide a therapeutic option for the treatment of chronic urticaria.PMID:37224634 | DOI:10.1016/j.cellimm.2023.104728 (Source: Cellular Immunology)
Source: Cellular Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Yuanyuan Ding Baowen Dang Yonghui Zhang Shiting Hu Yuejin Wang Chenrui Zhao Tao Zhang Zijun Gao Source Type: research
Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells
CONCLUSION: Paeonol, a herb-derived phenolic compound, can provide drug candidate for developing new drug in treatment of skin disease such as urticaria.SIGNIFICANCE STATEMENT: In this study, we primarily examined the effect of Paeonol in the treatment of chronic urticaria and its mechanism of action in mast cells. Interestingly, Paeonol was found to regulate Src kinase activity downstream of MRGPRX2 triggered signaling cascade in mast cells. Therefore, this plant-derived phenolic compound may provide a therapeutic option for the treatment of chronic urticaria.PMID:37224634 | DOI:10.1016/j.cellimm.2023.104728 (Source: Cellular Immunology)
Source: Cellular Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Yuanyuan Ding Baowen Dang Yonghui Zhang Shiting Hu Yuejin Wang Chenrui Zhao Tao Zhang Zijun Gao Source Type: research
Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells
CONCLUSION: Paeonol, a herb-derived phenolic compound, can provide drug candidate for developing new drug in treatment of skin disease such as urticaria.SIGNIFICANCE STATEMENT: In this study, we primarily examined the effect of Paeonol in the treatment of chronic urticaria and its mechanism of action in mast cells. Interestingly, Paeonol was found to regulate Src kinase activity downstream of MRGPRX2 triggered signaling cascade in mast cells. Therefore, this plant-derived phenolic compound may provide a therapeutic option for the treatment of chronic urticaria.PMID:37224634 | DOI:10.1016/j.cellimm.2023.104728 (Source: Cellular Immunology)
Source: Cellular Immunology - May 24, 2023 Category: Allergy & Immunology Authors: Yuanyuan Ding Baowen Dang Yonghui Zhang Shiting Hu Yuejin Wang Chenrui Zhao Tao Zhang Zijun Gao Source Type: research
Downregulation of HHLA2 inhibits ovarian cancer progression via the NF- κB signaling pathway and suppresses the expression of CA9
Cell Immunol. 2023 May 16;388-389:104730. doi: 10.1016/j.cellimm.2023.104730. Online ahead of print.ABSTRACTHHLA2 has been recently demonstrated to play multifaceted roles in several types of cancers. However, its underlying mechanism in the progression of human ovarian cancer (OC) remains largely unexplored. In the present study, we aimed to determine whether downregulation of HHLA2 inhibited malignant phenotypes of human OC cells and explore its specific mechanism. Our results revealed that downregulation of HHLA2 by transfection with a lentiviral vector significantly suppressed the viability, invasion, and migration of ...
Source: Cellular Immunology - May 21, 2023 Category: Allergy & Immunology Authors: Yuanyuan Fu Panpan Zheng Xiao Zheng Lujun Chen Caixia Kong Wenzhi Liu Shuping Li Jingting Jiang Source Type: research
Downregulation of HHLA2 inhibits ovarian cancer progression via the NF- κB signaling pathway and suppresses the expression of CA9
Cell Immunol. 2023 May 16;388-389:104730. doi: 10.1016/j.cellimm.2023.104730. Online ahead of print.ABSTRACTHHLA2 has been recently demonstrated to play multifaceted roles in several types of cancers. However, its underlying mechanism in the progression of human ovarian cancer (OC) remains largely unexplored. In the present study, we aimed to determine whether downregulation of HHLA2 inhibited malignant phenotypes of human OC cells and explore its specific mechanism. Our results revealed that downregulation of HHLA2 by transfection with a lentiviral vector significantly suppressed the viability, invasion, and migration of ...
Source: Cellular Immunology - May 21, 2023 Category: Allergy & Immunology Authors: Yuanyuan Fu Panpan Zheng Xiao Zheng Lujun Chen Caixia Kong Wenzhi Liu Shuping Li Jingting Jiang Source Type: research
Downregulation of HHLA2 inhibits ovarian cancer progression via the NF- κB signaling pathway and suppresses the expression of CA9
Cell Immunol. 2023 May 16;388-389:104730. doi: 10.1016/j.cellimm.2023.104730. Online ahead of print.ABSTRACTHHLA2 has been recently demonstrated to play multifaceted roles in several types of cancers. However, its underlying mechanism in the progression of human ovarian cancer (OC) remains largely unexplored. In the present study, we aimed to determine whether downregulation of HHLA2 inhibited malignant phenotypes of human OC cells and explore its specific mechanism. Our results revealed that downregulation of HHLA2 by transfection with a lentiviral vector significantly suppressed the viability, invasion, and migration of ...
Source: Cellular Immunology - May 21, 2023 Category: Allergy & Immunology Authors: Yuanyuan Fu Panpan Zheng Xiao Zheng Lujun Chen Caixia Kong Wenzhi Liu Shuping Li Jingting Jiang Source Type: research
Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation
Cell Immunol. 2023 Apr 26;388-389:104719. doi: 10.1016/j.cellimm.2023.104719. Online ahead of print.ABSTRACTGraft-versus-leukemia (GvL) effects are critical to prevent relapses after allogeneic hematopoietic cell transplantation (allo-HCT). However, the success of allo-HCT is limited by graft-versus-host disease (GvHD). Both, CD4+ and CD8+ T cells contribute to GvHD and GvL. The sphingosine-1-phosphate receptor (S1PR) signaling plays a crucial role in lymphocyte trafficking. Mocravimod is an S1PR modulator and its administration leads to blocking lymphocyte egress from lymphoid organs. We hypothesized that this applies to ...
Source: Cellular Immunology - May 4, 2023 Category: Allergy & Immunology Authors: Simone Dertschnig Jakob Passweg Christoph Bucher Michael Medinger Alexandar Tzankov Source Type: research
Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation
Cell Immunol. 2023 Apr 26;388-389:104719. doi: 10.1016/j.cellimm.2023.104719. Online ahead of print.ABSTRACTGraft-versus-leukemia (GvL) effects are critical to prevent relapses after allogeneic hematopoietic cell transplantation (allo-HCT). However, the success of allo-HCT is limited by graft-versus-host disease (GvHD). Both, CD4+ and CD8+ T cells contribute to GvHD and GvL. The sphingosine-1-phosphate receptor (S1PR) signaling plays a crucial role in lymphocyte trafficking. Mocravimod is an S1PR modulator and its administration leads to blocking lymphocyte egress from lymphoid organs. We hypothesized that this applies to ...
Source: Cellular Immunology - May 4, 2023 Category: Allergy & Immunology Authors: Simone Dertschnig Jakob Passweg Christoph Bucher Michael Medinger Alexandar Tzankov Source Type: research
Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation
Cell Immunol. 2023 Apr 26;388-389:104719. doi: 10.1016/j.cellimm.2023.104719. Online ahead of print.ABSTRACTGraft-versus-leukemia (GvL) effects are critical to prevent relapses after allogeneic hematopoietic cell transplantation (allo-HCT). However, the success of allo-HCT is limited by graft-versus-host disease (GvHD). Both, CD4+ and CD8+ T cells contribute to GvHD and GvL. The sphingosine-1-phosphate receptor (S1PR) signaling plays a crucial role in lymphocyte trafficking. Mocravimod is an S1PR modulator and its administration leads to blocking lymphocyte egress from lymphoid organs. We hypothesized that this applies to ...
Source: Cellular Immunology - May 4, 2023 Category: Allergy & Immunology Authors: Simone Dertschnig Jakob Passweg Christoph Bucher Michael Medinger Alexandar Tzankov Source Type: research
Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation
Cell Immunol. 2023 Apr 26;388-389:104719. doi: 10.1016/j.cellimm.2023.104719. Online ahead of print.ABSTRACTGraft-versus-leukemia (GvL) effects are critical to prevent relapses after allogeneic hematopoietic cell transplantation (allo-HCT). However, the success of allo-HCT is limited by graft-versus-host disease (GvHD). Both, CD4+ and CD8+ T cells contribute to GvHD and GvL. The sphingosine-1-phosphate receptor (S1PR) signaling plays a crucial role in lymphocyte trafficking. Mocravimod is an S1PR modulator and its administration leads to blocking lymphocyte egress from lymphoid organs. We hypothesized that this applies to ...
Source: Cellular Immunology - May 4, 2023 Category: Allergy & Immunology Authors: Simone Dertschnig Jakob Passweg Christoph Bucher Michael Medinger Alexandar Tzankov Source Type: research
Mocravimod, a S1P receptor modulator, increases T cell counts in bone marrow biopsies from patients undergoing allogeneic hematopoietic stem cell transplantation
Cell Immunol. 2023 Apr 26;388-389:104719. doi: 10.1016/j.cellimm.2023.104719. Online ahead of print.ABSTRACTGraft-versus-leukemia (GvL) effects are critical to prevent relapses after allogeneic hematopoietic cell transplantation (allo-HCT). However, the success of allo-HCT is limited by graft-versus-host disease (GvHD). Both, CD4+ and CD8+ T cells contribute to GvHD and GvL. The sphingosine-1-phosphate receptor (S1PR) signaling plays a crucial role in lymphocyte trafficking. Mocravimod is an S1PR modulator and its administration leads to blocking lymphocyte egress from lymphoid organs. We hypothesized that this applies to ...
Source: Cellular Immunology - May 4, 2023 Category: Allergy & Immunology Authors: Simone Dertschnig Jakob Passweg Christoph Bucher Michael Medinger Alexandar Tzankov Source Type: research
