A mAb to SIRP α downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia
In this study, we show that there was a low expression state of SIRPα on the surface of monocytes. Treatment of cells culture from ITP patients with a mAb to SIRPα that blocks the binding of SIRPα to CD47 downregulated the ITP response. The abilities of monocytes from ITP patients to stimulate an allogenic MLR were reduced. The proliferation of, and production of IL-2, by CD4 + T cells from ITP patients were inhibited, the Treg cell numbers and the production of IL-10 pairs were upregulated, and the production of TGF-β not was inhibited, by a mAb to SIRPα. Moreover, a mAb to SIRPα, the expression of HLA-DR and CD86 w...
Source: Cellular Immunology - September 3, 2023 Category: Allergy & Immunology Authors: Dongmei Xie Zhihui Feng Wen Yang Yacan Wang Renxia Li Shiqi Zhang Zeping Zhou Source Type: research
Tandem CAR-T cells targeting MUC1 and PSCA combined with anti-PD-1 antibody exhibit potent preclinical activity against non-small cell lung cancer
Cell Immunol. 2023 Aug 29;391-392:104760. doi: 10.1016/j.cellimm.2023.104760. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR)-T cells encounter many issues when treating solid tumors, including tumor antigen heterogeneity and immunosuppression. United targeting of two tumor-associated antigens (TAAs) and blocking of PD-1 may solve this problem and enhance the function of CAR-T. Mucin 1 (MUC1) and prostate stem cell antigen (PSCA) are overexpressed in non-small cell lung cancer (NSCLC). Here, we constructed a bivalent tandem CAR-T (Tan CAR-T), which can simultaneously target MUC1 and PSCA and evaluated its eff...
Source: Cellular Immunology - September 3, 2023 Category: Allergy & Immunology Authors: Aying Wang Tangfeng Lv Yong Song Source Type: research
A mAb to SIRP α downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia
In this study, we show that there was a low expression state of SIRPα on the surface of monocytes. Treatment of cells culture from ITP patients with a mAb to SIRPα that blocks the binding of SIRPα to CD47 downregulated the ITP response. The abilities of monocytes from ITP patients to stimulate an allogenic MLR were reduced. The proliferation of, and production of IL-2, by CD4 + T cells from ITP patients were inhibited, the Treg cell numbers and the production of IL-10 pairs were upregulated, and the production of TGF-β not was inhibited, by a mAb to SIRPα. Moreover, a mAb to SIRPα, the expression of HLA-DR and CD86 w...
Source: Cellular Immunology - September 3, 2023 Category: Allergy & Immunology Authors: Dongmei Xie Zhihui Feng Wen Yang Yacan Wang Renxia Li Shiqi Zhang Zeping Zhou Source Type: research
Tandem CAR-T cells targeting MUC1 and PSCA combined with anti-PD-1 antibody exhibit potent preclinical activity against non-small cell lung cancer
Cell Immunol. 2023 Aug 29;391-392:104760. doi: 10.1016/j.cellimm.2023.104760. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR)-T cells encounter many issues when treating solid tumors, including tumor antigen heterogeneity and immunosuppression. United targeting of two tumor-associated antigens (TAAs) and blocking of PD-1 may solve this problem and enhance the function of CAR-T. Mucin 1 (MUC1) and prostate stem cell antigen (PSCA) are overexpressed in non-small cell lung cancer (NSCLC). Here, we constructed a bivalent tandem CAR-T (Tan CAR-T), which can simultaneously target MUC1 and PSCA and evaluated its eff...
Source: Cellular Immunology - September 3, 2023 Category: Allergy & Immunology Authors: Aying Wang Tangfeng Lv Yong Song Source Type: research
A mAb to SIRP α downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia
In this study, we show that there was a low expression state of SIRPα on the surface of monocytes. Treatment of cells culture from ITP patients with a mAb to SIRPα that blocks the binding of SIRPα to CD47 downregulated the ITP response. The abilities of monocytes from ITP patients to stimulate an allogenic MLR were reduced. The proliferation of, and production of IL-2, by CD4 + T cells from ITP patients were inhibited, the Treg cell numbers and the production of IL-10 pairs were upregulated, and the production of TGF-β not was inhibited, by a mAb to SIRPα. Moreover, a mAb to SIRPα, the expression of HLA-DR and CD86 w...
Source: Cellular Immunology - September 3, 2023 Category: Allergy & Immunology Authors: Dongmei Xie Zhihui Feng Wen Yang Yacan Wang Renxia Li Shiqi Zhang Zeping Zhou Source Type: research
Tandem CAR-T cells targeting MUC1 and PSCA combined with anti-PD-1 antibody exhibit potent preclinical activity against non-small cell lung cancer
Cell Immunol. 2023 Aug 29;391-392:104760. doi: 10.1016/j.cellimm.2023.104760. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR)-T cells encounter many issues when treating solid tumors, including tumor antigen heterogeneity and immunosuppression. United targeting of two tumor-associated antigens (TAAs) and blocking of PD-1 may solve this problem and enhance the function of CAR-T. Mucin 1 (MUC1) and prostate stem cell antigen (PSCA) are overexpressed in non-small cell lung cancer (NSCLC). Here, we constructed a bivalent tandem CAR-T (Tan CAR-T), which can simultaneously target MUC1 and PSCA and evaluated its eff...
Source: Cellular Immunology - September 3, 2023 Category: Allergy & Immunology Authors: Aying Wang Tangfeng Lv Yong Song Source Type: research
A mAb to SIRP α downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia
In this study, we show that there was a low expression state of SIRPα on the surface of monocytes. Treatment of cells culture from ITP patients with a mAb to SIRPα that blocks the binding of SIRPα to CD47 downregulated the ITP response. The abilities of monocytes from ITP patients to stimulate an allogenic MLR were reduced. The proliferation of, and production of IL-2, by CD4 + T cells from ITP patients were inhibited, the Treg cell numbers and the production of IL-10 pairs were upregulated, and the production of TGF-β not was inhibited, by a mAb to SIRPα. Moreover, a mAb to SIRPα, the expression of HLA-DR and CD86 w...
Source: Cellular Immunology - September 3, 2023 Category: Allergy & Immunology Authors: Dongmei Xie Zhihui Feng Wen Yang Yacan Wang Renxia Li Shiqi Zhang Zeping Zhou Source Type: research
PD-1 negatively tunes macrophage immune activation by turning off JNK and STAT1 signaling: Exploited by Leishmania for its intra-macrophage survival
Cell Immunol. 2023 Aug 22;391-392:104758. doi: 10.1016/j.cellimm.2023.104758. Online ahead of print.ABSTRACTThe anti-inflammatory role of the programmed death-1 receptor (PD-1) is well appreciated. However, the mechanism of how PD-1 signaling inhibits the pro-inflammatory cytokine responses in macrophages, which is further exploited by Leishmania to foster their intracellular survival, was unknown. We found that among three major MAP kinases regulating immune activation, PD-1 signaling decreased only JNK phosphorylation without perturbing p38 and ERK. Inflammatory transcription factor STAT1 was also inhibited by PD-1. Asso...
Source: Cellular Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Shalini Roy Anand K Gupta Madhurima Banerjee Pijush K Das Anindita Ukil Source Type: research
PD-1 negatively tunes macrophage immune activation by turning off JNK and STAT1 signaling: Exploited by Leishmania for its intra-macrophage survival
Cell Immunol. 2023 Aug 22;391-392:104758. doi: 10.1016/j.cellimm.2023.104758. Online ahead of print.ABSTRACTThe anti-inflammatory role of the programmed death-1 receptor (PD-1) is well appreciated. However, the mechanism of how PD-1 signaling inhibits the pro-inflammatory cytokine responses in macrophages, which is further exploited by Leishmania to foster their intracellular survival, was unknown. We found that among three major MAP kinases regulating immune activation, PD-1 signaling decreased only JNK phosphorylation without perturbing p38 and ERK. Inflammatory transcription factor STAT1 was also inhibited by PD-1. Asso...
Source: Cellular Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Shalini Roy Anand K Gupta Madhurima Banerjee Pijush K Das Anindita Ukil Source Type: research
PD-1 negatively tunes macrophage immune activation by turning off JNK and STAT1 signaling: Exploited by Leishmania for its intra-macrophage survival
Cell Immunol. 2023 Aug 22;391-392:104758. doi: 10.1016/j.cellimm.2023.104758. Online ahead of print.ABSTRACTThe anti-inflammatory role of the programmed death-1 receptor (PD-1) is well appreciated. However, the mechanism of how PD-1 signaling inhibits the pro-inflammatory cytokine responses in macrophages, which is further exploited by Leishmania to foster their intracellular survival, was unknown. We found that among three major MAP kinases regulating immune activation, PD-1 signaling decreased only JNK phosphorylation without perturbing p38 and ERK. Inflammatory transcription factor STAT1 was also inhibited by PD-1. Asso...
Source: Cellular Immunology - August 31, 2023 Category: Allergy & Immunology Authors: Shalini Roy Anand K Gupta Madhurima Banerjee Pijush K Das Anindita Ukil Source Type: research
Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications
Cell Immunol. 2023 Aug 9;391-392:104756. doi: 10.1016/j.cellimm.2023.104756. Online ahead of print.NO ABSTRACTPMID:37603955 | DOI:10.1016/j.cellimm.2023.104756 (Source: Cellular Immunology)
Source: Cellular Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Eddie A James Source Type: research
Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications
Cell Immunol. 2023 Aug 9;391-392:104756. doi: 10.1016/j.cellimm.2023.104756. Online ahead of print.NO ABSTRACTPMID:37603955 | DOI:10.1016/j.cellimm.2023.104756 (Source: Cellular Immunology)
Source: Cellular Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Eddie A James Source Type: research
Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications
Cell Immunol. 2023 Aug 9;391-392:104756. doi: 10.1016/j.cellimm.2023.104756. Online ahead of print.NO ABSTRACTPMID:37603955 | DOI:10.1016/j.cellimm.2023.104756 (Source: Cellular Immunology)
Source: Cellular Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Eddie A James Source Type: research
Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications
Cell Immunol. 2023 Aug 9;391-392:104756. doi: 10.1016/j.cellimm.2023.104756. Online ahead of print.NO ABSTRACTPMID:37603955 | DOI:10.1016/j.cellimm.2023.104756 (Source: Cellular Immunology)
Source: Cellular Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Eddie A James Source Type: research
Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications
Cell Immunol. 2023 Aug 9;391-392:104756. doi: 10.1016/j.cellimm.2023.104756. Online ahead of print.NO ABSTRACTPMID:37603955 | DOI:10.1016/j.cellimm.2023.104756 (Source: Cellular Immunology)
Source: Cellular Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Eddie A James Source Type: research
