Concomitant assessment of PD-1 and CD56 expression identifies subsets of resting cord blood V δ2 T cells with disparate cytotoxic potential
Cell Immunol. 2023 Dec 23;395-396:104797. doi: 10.1016/j.cellimm.2023.104797. Online ahead of print.ABSTRACTVγ9Vδ2 T lymphocytes are programmed for broad antimicrobial responses with rapid production of Th1 cytokines even before birth, and thus thought to play key roles against pathogens in infants. The process regulating Vδ2 cell acquisition of cytotoxic potential shortly after birth remains understudied. We observed that perforin production in cord blood Vδ2 cells correlates with phenotypes defined by the concomitant assessment of PD-1 and CD56. Bulk RNA sequencing of sorted Vδ2 cell fractions indicated that transcr...
Source: Cellular Immunology - December 29, 2023 Category: Allergy & Immunology Authors: Haoting Hsu Claudio Zanettini Modupe Coker Sarah Boudova David Rach Godfrey Mvula Titus H Divala Randy G Mungwira Francesca Boldrin Giulia Degiacomi Laura Cioetto Mazzab ò Riccardo Manganelli Miriam K Laufer Yuji Zhang Luigi Marchionni Cristiana Cairo Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Development of a highly cytotoxic, clinical-grade virus-specific T cell product for adoptive T cell therapy
This study targeted cytomegalovirus (CMV) for the development of an innovative approach for generating a very specific VST product following Good Manufacturing Practices (GMP) guidelines. We used a sterile disposable compartment named the Leukoreduction System Chamber (LRS-chamber) from the apheresis platelet donation kit as the starting material, which has demonstrated high levels of T cells. Using a combination of IL-2 and IL-7 we could improve expansion of CMV-specific T cells. Moreover, by developing and establishing a new product protocol, we were able to stimulate VST proliferation and favors T cell effector memory p...
Source: Cellular Immunology - December 15, 2023 Category: Allergy & Immunology Authors: Fernanda Agostini Rocha Caio Raony Farina Silveira Anc ély Ferreira Dos Santos Ana Carolina Buzzo Stefanini Nelson Hamerschlak Luciana Cavalheiro Marti Source Type: research
Development of a highly cytotoxic, clinical-grade virus-specific T cell product for adoptive T cell therapy
This study targeted cytomegalovirus (CMV) for the development of an innovative approach for generating a very specific VST product following Good Manufacturing Practices (GMP) guidelines. We used a sterile disposable compartment named the Leukoreduction System Chamber (LRS-chamber) from the apheresis platelet donation kit as the starting material, which has demonstrated high levels of T cells. Using a combination of IL-2 and IL-7 we could improve expansion of CMV-specific T cells. Moreover, by developing and establishing a new product protocol, we were able to stimulate VST proliferation and favors T cell effector memory p...
Source: Cellular Immunology - December 15, 2023 Category: Allergy & Immunology Authors: Fernanda Agostini Rocha Caio Raony Farina Silveira Anc ély Ferreira Dos Santos Ana Carolina Buzzo Stefanini Nelson Hamerschlak Luciana Cavalheiro Marti Source Type: research
