Loss of B1 and marginal zone B cells during ovarian cancer
Cell Immunol. 2023 Nov 22;395-396:104788. doi: 10.1016/j.cellimm.2023.104788. Online ahead of print.ABSTRACTRecent advances in immunotherapy have not addressed the challenge presented by ovarian cancer. Although the peritoneum is an "accessible" locus for this disease there has been limited characterization of the immunobiology therein. We investigated the ID8-C57BL/6J ovarian cancer model and found marked depletion of B1 cells from the ascites of the peritoneal cavity. There was also selective loss of the B1 and marginal zone B cell subsets from the spleen. Immunity to antigens that activate these subsets validated their ...
Source: Cellular Immunology - November 24, 2023 Category: Allergy & Immunology Authors: Jeffrey Maslanka Gretel Torres Jennifer Londregan Naomi Goldman Daniel Silberman John Somerville James E Riggs Source Type: research
Loss of B1 and marginal zone B cells during ovarian cancer
Cell Immunol. 2023 Nov 22;395-396:104788. doi: 10.1016/j.cellimm.2023.104788. Online ahead of print.ABSTRACTRecent advances in immunotherapy have not addressed the challenge presented by ovarian cancer. Although the peritoneum is an "accessible" locus for this disease there has been limited characterization of the immunobiology therein. We investigated the ID8-C57BL/6J ovarian cancer model and found marked depletion of B1 cells from the ascites of the peritoneal cavity. There was also selective loss of the B1 and marginal zone B cell subsets from the spleen. Immunity to antigens that activate these subsets validated their ...
Source: Cellular Immunology - November 24, 2023 Category: Allergy & Immunology Authors: Jeffrey Maslanka Gretel Torres Jennifer Londregan Naomi Goldman Daniel Silberman John Somerville James E Riggs Source Type: research
Loss of B1 and marginal zone B cells during ovarian cancer
Cell Immunol. 2023 Nov 22;395-396:104788. doi: 10.1016/j.cellimm.2023.104788. Online ahead of print.ABSTRACTRecent advances in immunotherapy have not addressed the challenge presented by ovarian cancer. Although the peritoneum is an "accessible" locus for this disease there has been limited characterization of the immunobiology therein. We investigated the ID8-C57BL/6J ovarian cancer model and found marked depletion of B1 cells from the ascites of the peritoneal cavity. There was also selective loss of the B1 and marginal zone B cell subsets from the spleen. Immunity to antigens that activate these subsets validated their ...
Source: Cellular Immunology - November 24, 2023 Category: Allergy & Immunology Authors: Jeffrey Maslanka Gretel Torres Jennifer Londregan Naomi Goldman Daniel Silberman John Somerville James E Riggs Source Type: research
Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses
Cell Immunol. 2023 Sep 30:104772. doi: 10.1016/j.cellimm.2023.104772. Online ahead of print.NO ABSTRACTPMID:37996259 | DOI:10.1016/j.cellimm.2023.104772 (Source: Cellular Immunology)
Source: Cellular Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Jean Bourhis Xu-Shan Sun Yungan Tao Source Type: research
Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses
Cell Immunol. 2023 Sep 30:104772. doi: 10.1016/j.cellimm.2023.104772. Online ahead of print.NO ABSTRACTPMID:37996259 | DOI:10.1016/j.cellimm.2023.104772 (Source: Cellular Immunology)
Source: Cellular Immunology - November 23, 2023 Category: Allergy & Immunology Authors: Jean Bourhis Xu-Shan Sun Yungan Tao Source Type: research
Immunomodulatory action of synbiotic comprising of newly isolated lactic acid producing bacterial strains against allergic asthma in mice
Cell Immunol. 2023 Nov 10;393-394:104786. doi: 10.1016/j.cellimm.2023.104786. Online ahead of print.ABSTRACTGiven the reported role of gut-microbiota in asthma pathogenesis, the present work was carried to evaluate immunomodulatory action of newly isolated lactic acid producing bacterial strains Bifidobacterium breve Bif11 and Lactiplantibacillus plantarum LAB31 against asthma using ovalbumin (OVA) based mouse model. Our results show that both strains modulate Th2 immune response potentially through production of short chain fatty acids (SCFAs), resulting in suppression of OVA-induced airway inflammation. Furthermore, synb...
Source: Cellular Immunology - November 20, 2023 Category: Allergy & Immunology Authors: Naina Monga Shikha Sharma Ruchika Bhatia Mahendra Bishnoi Kanthi Kiran Kondepudi Amarjit S Naura Source Type: research
One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8 < sup > + < /sup > T cell activation and proliferation
In conclusion, this study describes a time-saving and low-cost method to isolate tumour antigen peptide MHC complexs, helping tumor antigen-specific T cell enrichment, activation, and proliferation.PMID:37984278 | DOI:10.1016/j.cellimm.2023.104784 (Source: Cellular Immunology)
Source: Cellular Immunology - November 20, 2023 Category: Allergy & Immunology Authors: Lili Liu Yateng Li Yu Song Zhen Sun Wenjing Li Bin Li Yongjie Wang Haibo Wang Bin Wang Source Type: research
Immunomodulatory action of synbiotic comprising of newly isolated lactic acid producing bacterial strains against allergic asthma in mice
Cell Immunol. 2023 Nov 10;393-394:104786. doi: 10.1016/j.cellimm.2023.104786. Online ahead of print.ABSTRACTGiven the reported role of gut-microbiota in asthma pathogenesis, the present work was carried to evaluate immunomodulatory action of newly isolated lactic acid producing bacterial strains Bifidobacterium breve Bif11 and Lactiplantibacillus plantarum LAB31 against asthma using ovalbumin (OVA) based mouse model. Our results show that both strains modulate Th2 immune response potentially through production of short chain fatty acids (SCFAs), resulting in suppression of OVA-induced airway inflammation. Furthermore, synb...
Source: Cellular Immunology - November 20, 2023 Category: Allergy & Immunology Authors: Naina Monga Shikha Sharma Ruchika Bhatia Mahendra Bishnoi Kanthi Kiran Kondepudi Amarjit S Naura Source Type: research
One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8 < sup > + < /sup > T cell activation and proliferation
In conclusion, this study describes a time-saving and low-cost method to isolate tumour antigen peptide MHC complexs, helping tumor antigen-specific T cell enrichment, activation, and proliferation.PMID:37984278 | DOI:10.1016/j.cellimm.2023.104784 (Source: Cellular Immunology)
Source: Cellular Immunology - November 20, 2023 Category: Allergy & Immunology Authors: Lili Liu Yateng Li Yu Song Zhen Sun Wenjing Li Bin Li Yongjie Wang Haibo Wang Bin Wang Source Type: research
Immunomodulatory action of synbiotic comprising of newly isolated lactic acid producing bacterial strains against allergic asthma in mice
Cell Immunol. 2023 Nov 10;393-394:104786. doi: 10.1016/j.cellimm.2023.104786. Online ahead of print.ABSTRACTGiven the reported role of gut-microbiota in asthma pathogenesis, the present work was carried to evaluate immunomodulatory action of newly isolated lactic acid producing bacterial strains Bifidobacterium breve Bif11 and Lactiplantibacillus plantarum LAB31 against asthma using ovalbumin (OVA) based mouse model. Our results show that both strains modulate Th2 immune response potentially through production of short chain fatty acids (SCFAs), resulting in suppression of OVA-induced airway inflammation. Furthermore, synb...
Source: Cellular Immunology - November 20, 2023 Category: Allergy & Immunology Authors: Naina Monga Shikha Sharma Ruchika Bhatia Mahendra Bishnoi Kanthi Kiran Kondepudi Amarjit S Naura Source Type: research
One-step shotgun approach for antigenic specific pMHCs capture stimulated CD8 < sup > + < /sup > T cell activation and proliferation
In conclusion, this study describes a time-saving and low-cost method to isolate tumour antigen peptide MHC complexs, helping tumor antigen-specific T cell enrichment, activation, and proliferation.PMID:37984278 | DOI:10.1016/j.cellimm.2023.104784 (Source: Cellular Immunology)
Source: Cellular Immunology - November 20, 2023 Category: Allergy & Immunology Authors: Lili Liu Yateng Li Yu Song Zhen Sun Wenjing Li Bin Li Yongjie Wang Haibo Wang Bin Wang Source Type: research
Anti-CD19/CD8 bispecific T cell engager for the potential treatment of B cell malignancies
The objective of this study was to produce and evaluate a novel αCD8/CD19 BiTE (αCD8/CD19) with the potency to directly target CD8+T-cells. In-silico studies were utilized for determining proper folding, receptor binding, and structural stability of αCD8/CD19 protein. Western blotting and indirect surface staining were used to evaluate the size accuracy and binding potency of the purified protein. Functionality was assessed for granzyme B production, cytotoxicity, and proliferation. TheαCD8/CD19recombinant protein was produced in the CHO-K1 cell line with a final concentration of 1.94 mg/l. The αCD8/CD19 bound to CD8+...
Source: Cellular Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Nafiseh Maghsoodi Mohammadrasul Zareinejad Ali Golestan Elham Mahmoudi Maymand Amin Ramezani Source Type: research
Anti-CD19/CD8 bispecific T cell engager for the potential treatment of B cell malignancies
The objective of this study was to produce and evaluate a novel αCD8/CD19 BiTE (αCD8/CD19) with the potency to directly target CD8+T-cells. In-silico studies were utilized for determining proper folding, receptor binding, and structural stability of αCD8/CD19 protein. Western blotting and indirect surface staining were used to evaluate the size accuracy and binding potency of the purified protein. Functionality was assessed for granzyme B production, cytotoxicity, and proliferation. TheαCD8/CD19recombinant protein was produced in the CHO-K1 cell line with a final concentration of 1.94 mg/l. The αCD8/CD19 bound to CD8+...
Source: Cellular Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Nafiseh Maghsoodi Mohammadrasul Zareinejad Ali Golestan Elham Mahmoudi Maymand Amin Ramezani Source Type: research
Anti-CD19/CD8 bispecific T cell engager for the potential treatment of B cell malignancies
The objective of this study was to produce and evaluate a novel αCD8/CD19 BiTE (αCD8/CD19) with the potency to directly target CD8+T-cells. In-silico studies were utilized for determining proper folding, receptor binding, and structural stability of αCD8/CD19 protein. Western blotting and indirect surface staining were used to evaluate the size accuracy and binding potency of the purified protein. Functionality was assessed for granzyme B production, cytotoxicity, and proliferation. TheαCD8/CD19recombinant protein was produced in the CHO-K1 cell line with a final concentration of 1.94 mg/l. The αCD8/CD19 bound to CD8+...
Source: Cellular Immunology - November 17, 2023 Category: Allergy & Immunology Authors: Nafiseh Maghsoodi Mohammadrasul Zareinejad Ali Golestan Elham Mahmoudi Maymand Amin Ramezani Source Type: research
Designing Anti-Viral Vaccines that Harness Intrastructural Help from Prior BCG Vaccination
J Cell Immunol. 2023;5(4):97-102. doi: 10.33696/immunology.5.174.ABSTRACTVaccines are among the most effective tools for combatting the impact and spread of infectious diseases. However, the effectiveness of a vaccine can be diminished by vaccine inequality, particularly during severe outbreaks of infectious diseases in resource-poor areas. As seen in many developing countries that lack adequate healthcare infrastructure and economic resources, the acquisition and distribution of potentially life-saving vaccines may be limited, leading to prolonged suffering and increased deaths. To improve vaccine equity, vaccine design m...
Source: Cellular Immunology - November 10, 2023 Category: Allergy & Immunology Authors: Tony W Ng Steven A Porcelli Source Type: research
