Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications
Cell Immunol. 2023 Aug 9;391-392:104756. doi: 10.1016/j.cellimm.2023.104756. Online ahead of print.NO ABSTRACTPMID:37603955 | DOI:10.1016/j.cellimm.2023.104756 (Source: Cellular Immunology)
Source: Cellular Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Eddie A James Source Type: research
Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications
Cell Immunol. 2023 Aug 9;391-392:104756. doi: 10.1016/j.cellimm.2023.104756. Online ahead of print.NO ABSTRACTPMID:37603955 | DOI:10.1016/j.cellimm.2023.104756 (Source: Cellular Immunology)
Source: Cellular Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Eddie A James Source Type: research
Editorial: Processing, presentation, and recognition of T cell determinants: From molecular insights to clinical applications
Cell Immunol. 2023 Aug 9;391-392:104756. doi: 10.1016/j.cellimm.2023.104756. Online ahead of print.NO ABSTRACTPMID:37603955 | DOI:10.1016/j.cellimm.2023.104756 (Source: Cellular Immunology)
Source: Cellular Immunology - August 21, 2023 Category: Allergy & Immunology Authors: Eddie A James Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
HIF-1 α regulates the expression of the non-conventional isoform of the cd5 gene in T cells under the hypoxic condition: A potential mechanism for CD5 < sup > neg/low < /sup > phenotype of infiltrating cells in solid tumors
Cell Immunol. 2023 Aug 1;391-392:104755. doi: 10.1016/j.cellimm.2023.104755. Online ahead of print.ABSTRACTCD5, a T-cell receptor (TCR) negative regulator, is reduced on the surface of CD8+ lymphocytes in the tumor microenvironment (TME). Reduced surface CD5 expression (sCD5) occurs due to the preferential transcription of HERV-E derived exon E1B, i.e., anon-conventional formofthe cd5gene instead of its conventional exon E1A. A tumor employs several mechanisms to evade anti-tumor response, and hypoxia is one such mechanism that prevails in the TME and modulates the infiltrated T lymphocytes. We identified hypoxia response ...
Source: Cellular Immunology - August 6, 2023 Category: Allergy & Immunology Authors: Smita Kumari Srishti Sahu Bharat Singh Swarnima Gupta Amit Kumar Kureel Ankit Srivastava Deeksha Rikhari Sameer Srivastava Ambak Kumar Rai Source Type: research
Haploinsufficiency of A20 caused by a novel pathogenic missense variant of TNFAIP3 and successfully treated with anti-TNF and immunosuppressive therapies
This study reports one Chinese child with HA20 and explores the genetic etiology of TNFAIP3 variant. The patient exhibited transient recurrent episodes of fever, intermittent signs of arthritis, gastrointestinal symptoms and multiple colonic ulcers. Laboratory tests revealed elevated inflammatory indicators and mild to moderate anemia. Genetic analysis identified a heterozygous de novo variant in his TNFAIP3 gene (c.740C＞T, p. P247L), which had never been reported before. The novel missense variation was validated to be pathogenic through causing insufficient expression of A20, over-activation of NF-κB signaling pathway...
Source: Cellular Immunology - August 3, 2023 Category: Allergy & Immunology Authors: Sun Lina Han Ya'nan Yang Ying Wang Fengfan Hou Xin Ren Xiaoxia Fang Ying Source Type: research
