Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
Identification of the major immune differences in severe asthmatic children according to their atopic dermatitis status
In conclusion, this study shows the major immune differences between cwSA with and without AD in BAL and blood suggesting that distinct endotypes may be implicated in the inflammatory responses observed in these pediatric patients.PMID:38428350 | DOI:10.1016/j.cellimm.2024.104815 (Source: Cellular Immunology)
Source: Cellular Immunology - March 1, 2024 Category: Allergy & Immunology Authors: Guillaume Lezmi Cl ément Poirault Marta Grauso C éline Dietrich Karine Adel-Patient Maria Leite-de-Moraes Source Type: research
MALT1 inhibition suppresses antigen-specific T cell responses
Cell Immunol. 2024 Feb 24;397-398:104814. doi: 10.1016/j.cellimm.2024.104814. Online ahead of print.ABSTRACTThe aim of this study was to assess the potential use of a selective small molecule MALT1 inhibitor in solid tumor treatment as an immunotherapy targeting regulatory T-cells (Tregs). In vitro, MALT1 inhibition suppressed the proteolytic cleavage of the MALT1-substrate HOIL1 and blocked IL-2 secretion in Jurkat cells. It selectively suppressed the proliferation of PBMC-derived Tregs, with no effect on conventional CD4+T-cells. In vivo, however, no evident anti-tumor effect was achieved by MALT1 inhibition monotherapy ...
Source: Cellular Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Iliana K Kerzeli Aikaterini Nasi Erika Fletcher Aikaterini Chourlia Anders Kallin Niklas Finnberg Karolina Ersmark Maria Lampinen Mark Albertella Fredrik Öberg Sara M Mangsbo Source Type: research
MALT1 inhibition suppresses antigen-specific T cell responses
Cell Immunol. 2024 Feb 24;397-398:104814. doi: 10.1016/j.cellimm.2024.104814. Online ahead of print.ABSTRACTThe aim of this study was to assess the potential use of a selective small molecule MALT1 inhibitor in solid tumor treatment as an immunotherapy targeting regulatory T-cells (Tregs). In vitro, MALT1 inhibition suppressed the proteolytic cleavage of the MALT1-substrate HOIL1 and blocked IL-2 secretion in Jurkat cells. It selectively suppressed the proliferation of PBMC-derived Tregs, with no effect on conventional CD4+T-cells. In vivo, however, no evident anti-tumor effect was achieved by MALT1 inhibition monotherapy ...
Source: Cellular Immunology - February 29, 2024 Category: Allergy & Immunology Authors: Iliana K Kerzeli Aikaterini Nasi Erika Fletcher Aikaterini Chourlia Anders Kallin Niklas Finnberg Karolina Ersmark Maria Lampinen Mark Albertella Fredrik Öberg Sara M Mangsbo Source Type: research
Therapeutic potential of mesenchymal stem cell-derived exosomes for allergic airway inflammation
Cell Immunol. 2024 Feb 15;397-398:104813. doi: 10.1016/j.cellimm.2024.104813. Online ahead of print.ABSTRACTDue to their immunomodulatory capacities, mesenchymal stem cells (MSCs) have been extensively used as therapeutic approaches in cell-based therapy for various inflammatory diseases. Several lines of studies have shown that the most beneficial effects of MSCs are associated with MSC-derived exosomes. Exosomes are nanoscale extracellular vesicles that contain important biomolecules such as RNA, microRNAs (miRNAs), DNA, growth factors, enzymes, chemokines, and cytokines that regulate immune cell functions and parenchyma...
Source: Cellular Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Mahvash Sadeghi Mojgan Mohammadi Jalil Tavakol Afshari Sara Iranparast Bahareh Ansari Sajad Dehnavi Source Type: research
Therapeutic potential of mesenchymal stem cell-derived exosomes for allergic airway inflammation
Cell Immunol. 2024 Feb 15;397-398:104813. doi: 10.1016/j.cellimm.2024.104813. Online ahead of print.ABSTRACTDue to their immunomodulatory capacities, mesenchymal stem cells (MSCs) have been extensively used as therapeutic approaches in cell-based therapy for various inflammatory diseases. Several lines of studies have shown that the most beneficial effects of MSCs are associated with MSC-derived exosomes. Exosomes are nanoscale extracellular vesicles that contain important biomolecules such as RNA, microRNAs (miRNAs), DNA, growth factors, enzymes, chemokines, and cytokines that regulate immune cell functions and parenchyma...
Source: Cellular Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Mahvash Sadeghi Mojgan Mohammadi Jalil Tavakol Afshari Sara Iranparast Bahareh Ansari Sajad Dehnavi Source Type: research
Therapeutic potential of mesenchymal stem cell-derived exosomes for allergic airway inflammation
Cell Immunol. 2024 Feb 15;397-398:104813. doi: 10.1016/j.cellimm.2024.104813. Online ahead of print.ABSTRACTDue to their immunomodulatory capacities, mesenchymal stem cells (MSCs) have been extensively used as therapeutic approaches in cell-based therapy for various inflammatory diseases. Several lines of studies have shown that the most beneficial effects of MSCs are associated with MSC-derived exosomes. Exosomes are nanoscale extracellular vesicles that contain important biomolecules such as RNA, microRNAs (miRNAs), DNA, growth factors, enzymes, chemokines, and cytokines that regulate immune cell functions and parenchyma...
Source: Cellular Immunology - February 16, 2024 Category: Allergy & Immunology Authors: Mahvash Sadeghi Mojgan Mohammadi Jalil Tavakol Afshari Sara Iranparast Bahareh Ansari Sajad Dehnavi Source Type: research
