Maternal immune factors involved in the prevention or facilitation of neonatal bacterial infections
Cell Immunol. 2023 Dec 7;395-396:104796. doi: 10.1016/j.cellimm.2023.104796. Online ahead of print.ABSTRACTNewborns, whether born prematurely or at term, have a fully formed but naive immune system that must adapt to the extra-uterine environment to prevent infections. Maternal immunity, transmitted through the placenta and breast milk, protects newborns against infections, primarily via immunoglobulins (IgG and IgA) and certain maternal immune cells also known as microchimeric cells. Recently, it also appeared that the maternal gut microbiota played a vital role in neonatal immune maturation via microbial compounds impact...
Source: Cellular Immunology - December 17, 2023 Category: Allergy & Immunology Authors: Youssouf Sereme Eya Toumi Estelle Saifi Hel ène Faury David Skurnik Source Type: research
Development of a highly cytotoxic, clinical-grade virus-specific T cell product for adoptive T cell therapy
This study targeted cytomegalovirus (CMV) for the development of an innovative approach for generating a very specific VST product following Good Manufacturing Practices (GMP) guidelines. We used a sterile disposable compartment named the Leukoreduction System Chamber (LRS-chamber) from the apheresis platelet donation kit as the starting material, which has demonstrated high levels of T cells. Using a combination of IL-2 and IL-7 we could improve expansion of CMV-specific T cells. Moreover, by developing and establishing a new product protocol, we were able to stimulate VST proliferation and favors T cell effector memory p...
Source: Cellular Immunology - December 15, 2023 Category: Allergy & Immunology Authors: Fernanda Agostini Rocha Caio Raony Farina Silveira Anc ély Ferreira Dos Santos Ana Carolina Buzzo Stefanini Nelson Hamerschlak Luciana Cavalheiro Marti Source Type: research
Development of a highly cytotoxic, clinical-grade virus-specific T cell product for adoptive T cell therapy
This study targeted cytomegalovirus (CMV) for the development of an innovative approach for generating a very specific VST product following Good Manufacturing Practices (GMP) guidelines. We used a sterile disposable compartment named the Leukoreduction System Chamber (LRS-chamber) from the apheresis platelet donation kit as the starting material, which has demonstrated high levels of T cells. Using a combination of IL-2 and IL-7 we could improve expansion of CMV-specific T cells. Moreover, by developing and establishing a new product protocol, we were able to stimulate VST proliferation and favors T cell effector memory p...
Source: Cellular Immunology - December 15, 2023 Category: Allergy & Immunology Authors: Fernanda Agostini Rocha Caio Raony Farina Silveira Anc ély Ferreira Dos Santos Ana Carolina Buzzo Stefanini Nelson Hamerschlak Luciana Cavalheiro Marti Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
Response to "Letter to the Editor: SMAC mimetics inhibit human T cell proliferation and fail to augment type 1 cytokine responses"
Cell Immunol. 2023 Nov 10:104785. doi: 10.1016/j.cellimm.2023.104785. Online ahead of print.NO ABSTRACTPMID:38016882 | DOI:10.1016/j.cellimm.2023.104785 (Source: Cellular Immunology)
Source: Cellular Immunology - November 28, 2023 Category: Allergy & Immunology Authors: Susan Murray Source Type: research
