The effects of age, origin, and biological sex on rodent mast cell (BMMC and MC/9) and basophil (RBL-2H3) phenotype and function
In this study, we have compared the response of BMMC (derived from C57BL/6 male or female mice), two sources of RBL-2H3 (purchased directly from ATCC and a lab curated culture), and MC/9 (ATCC) at several critical stages to some common stimuli (IgE/Ag, A23187) and analyzed mast cell morphology, expression level of common mast cell surface markers (CD117 and FcεRI), protease expression, and function (growth kinetics, viability, ROS production, degranulation, cytokine release and FcεRI signaling). The objective of this study was to provide insight into the effects of culture conditions, biological sex, and age of the cells...
Source: Cellular Immunology - July 22, 2023 Category: Allergy & Immunology Authors: Ashley Wagner Syed Benazir Alam M Kulka Source Type: research
The effects of age, origin, and biological sex on rodent mast cell (BMMC and MC/9) and basophil (RBL-2H3) phenotype and function
In this study, we have compared the response of BMMC (derived from C57BL/6 male or female mice), two sources of RBL-2H3 (purchased directly from ATCC and a lab curated culture), and MC/9 (ATCC) at several critical stages to some common stimuli (IgE/Ag, A23187) and analyzed mast cell morphology, expression level of common mast cell surface markers (CD117 and FcεRI), protease expression, and function (growth kinetics, viability, ROS production, degranulation, cytokine release and FcεRI signaling). The objective of this study was to provide insight into the effects of culture conditions, biological sex, and age of the cells...
Source: Cellular Immunology - July 22, 2023 Category: Allergy & Immunology Authors: Ashley Wagner Syed Benazir Alam M Kulka Source Type: research
IL-1 in Abdominal Aortic Aneurysms
J Cell Immunol. 2023;5(2):22-31. doi: 10.33696/immunology.5.163.ABSTRACTAbdominal Aortic Aneurysms (AAA) remain a clinically devastating disease with no effective medical treatment therapy. AAAs are characterized by immune cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. Interleukin-1 (IL-1) has been shown to play role in AAA associated inflammation through immune cell recruitment and activation, endothelial dysfunction, production of reactive oxygen species (ROS), and regulation of transcription factors of additional inflammatory mediators. In this review, we will discuss the principl...
Source: Cellular Immunology - July 21, 2023 Category: Allergy & Immunology Authors: Jessica Millar Elias Nasser Gorav Ailawadi Morgan Salmon Source Type: research
IL-1 in Abdominal Aortic Aneurysms
J Cell Immunol. 2023;5(2):22-31. doi: 10.33696/immunology.5.163.ABSTRACTAbdominal Aortic Aneurysms (AAA) remain a clinically devastating disease with no effective medical treatment therapy. AAAs are characterized by immune cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. Interleukin-1 (IL-1) has been shown to play role in AAA associated inflammation through immune cell recruitment and activation, endothelial dysfunction, production of reactive oxygen species (ROS), and regulation of transcription factors of additional inflammatory mediators. In this review, we will discuss the principl...
Source: Cellular Immunology - July 21, 2023 Category: Allergy & Immunology Authors: Jessica Millar Elias Nasser Gorav Ailawadi Morgan Salmon Source Type: research
Crosstalk between peripheral immunity and central nervous system in Alzheimer's disease
Cell Immunol. 2023 Jul 8:104743. doi: 10.1016/j.cellimm.2023.104743. Online ahead of print.ABSTRACTThe significance of peripheral immunity in the pathogenesis and progression of Alzheimer's diseases (AD) has been recognized. Brain-infiltrated peripheral immune components transporting across the blood-brain barrier (BBB) may reshape the central immune environment. However, mechanisms of how these components open the BBB for AD occurrence and development and correlations between peripheral and central immunity have not been fully explored. Herein, we formulate a hypothesis whereby peripheral immunity as a critical factor all...
Source: Cellular Immunology - July 14, 2023 Category: Allergy & Immunology Authors: Hanchen Yang Qi Qin Meng Wang Yunsi Yin Ruiyang Li Yi Tang Source Type: research
Crosstalk between peripheral immunity and central nervous system in Alzheimer's disease
Cell Immunol. 2023 Jul 8:104743. doi: 10.1016/j.cellimm.2023.104743. Online ahead of print.ABSTRACTThe significance of peripheral immunity in the pathogenesis and progression of Alzheimer's diseases (AD) has been recognized. Brain-infiltrated peripheral immune components transporting across the blood-brain barrier (BBB) may reshape the central immune environment. However, mechanisms of how these components open the BBB for AD occurrence and development and correlations between peripheral and central immunity have not been fully explored. Herein, we formulate a hypothesis whereby peripheral immunity as a critical factor all...
Source: Cellular Immunology - July 14, 2023 Category: Allergy & Immunology Authors: Hanchen Yang Qi Qin Meng Wang Yunsi Yin Ruiyang Li Yi Tang Source Type: research
Crosstalk between peripheral immunity and central nervous system in Alzheimer's disease
Cell Immunol. 2023 Jul 8:104743. doi: 10.1016/j.cellimm.2023.104743. Online ahead of print.ABSTRACTThe significance of peripheral immunity in the pathogenesis and progression of Alzheimer's diseases (AD) has been recognized. Brain-infiltrated peripheral immune components transporting across the blood-brain barrier (BBB) may reshape the central immune environment. However, mechanisms of how these components open the BBB for AD occurrence and development and correlations between peripheral and central immunity have not been fully explored. Herein, we formulate a hypothesis whereby peripheral immunity as a critical factor all...
Source: Cellular Immunology - July 14, 2023 Category: Allergy & Immunology Authors: Hanchen Yang Qi Qin Meng Wang Yunsi Yin Ruiyang Li Yi Tang Source Type: research
Crosstalk between peripheral immunity and central nervous system in Alzheimer's disease
Cell Immunol. 2023 Jul 8:104743. doi: 10.1016/j.cellimm.2023.104743. Online ahead of print.ABSTRACTThe significance of peripheral immunity in the pathogenesis and progression of Alzheimer's diseases (AD) has been recognized. Brain-infiltrated peripheral immune components transporting across the blood-brain barrier (BBB) may reshape the central immune environment. However, mechanisms of how these components open the BBB for AD occurrence and development and correlations between peripheral and central immunity have not been fully explored. Herein, we formulate a hypothesis whereby peripheral immunity as a critical factor all...
Source: Cellular Immunology - July 14, 2023 Category: Allergy & Immunology Authors: Hanchen Yang Qi Qin Meng Wang Yunsi Yin Ruiyang Li Yi Tang Source Type: research
Crosstalk between peripheral immunity and central nervous system in Alzheimer's disease
Cell Immunol. 2023 Jul 8:104743. doi: 10.1016/j.cellimm.2023.104743. Online ahead of print.ABSTRACTThe significance of peripheral immunity in the pathogenesis and progression of Alzheimer's diseases (AD) has been recognized. Brain-infiltrated peripheral immune components transporting across the blood-brain barrier (BBB) may reshape the central immune environment. However, mechanisms of how these components open the BBB for AD occurrence and development and correlations between peripheral and central immunity have not been fully explored. Herein, we formulate a hypothesis whereby peripheral immunity as a critical factor all...
Source: Cellular Immunology - July 14, 2023 Category: Allergy & Immunology Authors: Hanchen Yang Qi Qin Meng Wang Yunsi Yin Ruiyang Li Yi Tang Source Type: research
Potential role for oral tolerance in gene therapy
Cell Immunol. 2023 Jun 28:104742. doi: 10.1016/j.cellimm.2023.104742. Online ahead of print.ABSTRACTOral immunotherapies are being developed for various autoimmune diseases and allergies to suppress immune responses in an antigen-specific manner. Previous studies have shown that anti-drug antibody (inhibitor) formation in protein replacement therapy for the inherited bleeding disorder hemophilia can be prevented by repeated oral delivery of coagulation factor antigens bioencapsulated in transplastomic lettuce cells. Here, we find that this approach substantially reduces antibody development against factor VIII in hemophili...
Source: Cellular Immunology - July 9, 2023 Category: Allergy & Immunology Authors: John S S Butterfield Xin Li Sreevani Arisa Kwang-Chul Kwon Henry Daniell Roland W Herzog Source Type: research
Potential role for oral tolerance in gene therapy
Cell Immunol. 2023 Jun 28:104742. doi: 10.1016/j.cellimm.2023.104742. Online ahead of print.ABSTRACTOral immunotherapies are being developed for various autoimmune diseases and allergies to suppress immune responses in an antigen-specific manner. Previous studies have shown that anti-drug antibody (inhibitor) formation in protein replacement therapy for the inherited bleeding disorder hemophilia can be prevented by repeated oral delivery of coagulation factor antigens bioencapsulated in transplastomic lettuce cells. Here, we find that this approach substantially reduces antibody development against factor VIII in hemophili...
Source: Cellular Immunology - July 9, 2023 Category: Allergy & Immunology Authors: John S S Butterfield Xin Li Sreevani Arisa Kwang-Chul Kwon Henry Daniell Roland W Herzog Source Type: research
Potential role for oral tolerance in gene therapy
Cell Immunol. 2023 Jun 28:104742. doi: 10.1016/j.cellimm.2023.104742. Online ahead of print.ABSTRACTOral immunotherapies are being developed for various autoimmune diseases and allergies to suppress immune responses in an antigen-specific manner. Previous studies have shown that anti-drug antibody (inhibitor) formation in protein replacement therapy for the inherited bleeding disorder hemophilia can be prevented by repeated oral delivery of coagulation factor antigens bioencapsulated in transplastomic lettuce cells. Here, we find that this approach substantially reduces antibody development against factor VIII in hemophili...
Source: Cellular Immunology - July 9, 2023 Category: Allergy & Immunology Authors: John S S Butterfield Xin Li Sreevani Arisa Kwang-Chul Kwon Henry Daniell Roland W Herzog Source Type: research
Potential role for oral tolerance in gene therapy
Cell Immunol. 2023 Jun 28:104742. doi: 10.1016/j.cellimm.2023.104742. Online ahead of print.ABSTRACTOral immunotherapies are being developed for various autoimmune diseases and allergies to suppress immune responses in an antigen-specific manner. Previous studies have shown that anti-drug antibody (inhibitor) formation in protein replacement therapy for the inherited bleeding disorder hemophilia can be prevented by repeated oral delivery of coagulation factor antigens bioencapsulated in transplastomic lettuce cells. Here, we find that this approach substantially reduces antibody development against factor VIII in hemophili...
Source: Cellular Immunology - July 9, 2023 Category: Allergy & Immunology Authors: John S S Butterfield Xin Li Sreevani Arisa Kwang-Chul Kwon Henry Daniell Roland W Herzog Source Type: research
Potential role for oral tolerance in gene therapy
Cell Immunol. 2023 Jun 28:104742. doi: 10.1016/j.cellimm.2023.104742. Online ahead of print.ABSTRACTOral immunotherapies are being developed for various autoimmune diseases and allergies to suppress immune responses in an antigen-specific manner. Previous studies have shown that anti-drug antibody (inhibitor) formation in protein replacement therapy for the inherited bleeding disorder hemophilia can be prevented by repeated oral delivery of coagulation factor antigens bioencapsulated in transplastomic lettuce cells. Here, we find that this approach substantially reduces antibody development against factor VIII in hemophili...
Source: Cellular Immunology - July 9, 2023 Category: Allergy & Immunology Authors: John S S Butterfield Xin Li Sreevani Arisa Kwang-Chul Kwon Henry Daniell Roland W Herzog Source Type: research
Chronic IFN α treatment induces leukopoiesis, increased plasma succinate and immune cell metabolic rewiring
Cell Immunol. 2023 Jun 20;390:104741. doi: 10.1016/j.cellimm.2023.104741. Online ahead of print.ABSTRACTAlthough clinically effective, the actions of IFNα, either produced endogenously or by therapeutic delivery, remain poorly understood. Emblematic of this research gap is the disparate array of notable side effects that occur in susceptible individuals, such as neuropsychiatric consequences, autoimmune phenomena, and infectious complications. We hypothesised that these complications are driven at least in part by dysregulated cellular metabolism. Male Wistar rats were treated with either 170,000 IU/kg human recombinant I...
Source: Cellular Immunology - June 25, 2023 Category: Allergy & Immunology Authors: Anjali S Yennemadi Gr áinne Jameson Mary Glass Carolina De Pasquale Joseph Keane Massimiliano Bianchi Gina Leisching Source Type: research
