Potential role for oral tolerance in gene therapy

Cell Immunol. 2023 Jun 28:104742. doi: 10.1016/j.cellimm.2023.104742. Online ahead of print.ABSTRACTOral immunotherapies are being developed for various autoimmune diseases and allergies to suppress immune responses in an antigen-specific manner. Previous studies have shown that anti-drug antibody (inhibitor) formation in protein replacement therapy for the inherited bleeding disorder hemophilia can be prevented by repeated oral delivery of coagulation factor antigens bioencapsulated in transplastomic lettuce cells. Here, we find that this approach substantially reduces antibody development against factor VIII in hemophilia A mice treated with adeno-associated viral gene transfer. We propose that the concept of oral tolerance can be applied to prevent immune responses against therapeutic transgene products expressed in gene therapy.PMID:37423874 | DOI:10.1016/j.cellimm.2023.104742

Source: Cellular Immunology - July 9, 2023 Category: Allergy & Immunology Authors: John S S Butterfield Xin Li Sreevani Arisa Kwang-Chul Kwon Henry Daniell Roland W Herzog Source Type: research