Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells

CONCLUSION: Paeonol, a herb-derived phenolic compound, can provide drug candidate for developing new drug in treatment of skin disease such as urticaria.SIGNIFICANCE STATEMENT: In this study, we primarily examined the effect of Paeonol in the treatment of chronic urticaria and its mechanism of action in mast cells. Interestingly, Paeonol was found to regulate Src kinase activity downstream of MRGPRX2 triggered signaling cascade in mast cells. Therefore, this plant-derived phenolic compound may provide a therapeutic option for the treatment of chronic urticaria.PMID:37224634 | DOI:10.1016/j.cellimm.2023.104728
Source: Cellular Immunology - Category: Allergy & Immunology Authors: Source Type: research