A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy
Cell Host Microbe. 2024 Mar 18:S1931-3128(24)00075-1. doi: 10.1016/j.chom.2024.03.002. Online ahead of print.ABSTRACTImmunotherapy has revolutionized cancer treatment, but inconsistent responses persist. Our study delves into the intriguing phenomenon of enhanced immunotherapy sensitivity in older individuals with cancers. Through a meta-analysis encompassing 25 small-to-mid-sized trials of immune checkpoint blockade (ICB), we demonstrate that older individuals exhibit heightened responsiveness to ICB therapy. To understand the underlying mechanism, we reanalyze single-cell RNA sequencing (scRNA-seq) data from multiple stu...
Source: Cell Host and Microbe - March 21, 2024 Category: Microbiology Authors: Xiaoqiang Zhu Xiaowen Huang Muni Hu Rongrong Sun Jiantao Li Hai Wang Xuefeng Pan Yanru Ma Lijun Ning Tianying Tong Yilu Zhou Jinmei Ding Ying Zhao Baoqin Xuan Jing-Yuan Fang Jie Hong Jason Wing Hon Wong Youwei Zhang Haoyan Chen Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
A new piece of the microbiota pie: Mining 'omics for DNA inversion states
Cell Host Microbe. 2024 Mar 13;32(3):293-295. doi: 10.1016/j.chom.2024.02.009.ABSTRACTIn this issue of Cell Host & Microbe, Carasso et al. survey invertible DNA sites in Bacteroidales from patients with inflammatory bowel disease (IBD) and healthy control individuals. They identify complex functional interactions between Bacteroides fragilis, an invertible promoter, a capsular polysaccharide, a bacteriophage, and the human host. The establishment of 'omics approaches to characterizing genomic targets and functional roles is still required.PMID:38484706 | DOI:10.1016/j.chom.2024.02.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Danielle E Campbell Megan T Baldridge Source Type: research
Gut microbe guides alveolar macrophages to fight flu
Cell Host Microbe. 2024 Mar 13;32(3):296-298. doi: 10.1016/j.chom.2024.02.007.ABSTRACTThe intestinal microbiota is associated with defense against respiratory viral infections. In this issue of Cell Host & Microbe, Ngo and colleagues1 show that intestinal commensal segmented filamentous bacteria reprogram alveolar macrophages with improved influenza-viral-neutralizing and phagocytic functions while maintaining inflammatory anergy to better protect the lung.PMID:38484707 | DOI:10.1016/j.chom.2024.02.007 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Tao Wang Yanling Wang Yushi Yao Source Type: research
Conquering homocystinuria with engineered probiotics
Cell Host Microbe. 2024 Mar 13;32(3):298-300. doi: 10.1016/j.chom.2024.02.008.ABSTRACTPyridoxine-unresponsive homocystinuria has lifelong implications for health. In this issue, Perreault and colleagues present evidence that orally delivered engineered probiotic Escherichia Coli Nissle SYNB1353 is a promising candidate in reducing homocysteine, with successful trials in mice, monkeys, and humans. However, further probiotic optimization and safety assessments are required.PMID:38484708 | DOI:10.1016/j.chom.2024.02.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Skye R S Fishbein Esse M Evbuomwan Gautam Dantas Source Type: research
Invade to evade: E. coli's gutsy survival strategies
Cell Host Microbe. 2024 Mar 13;32(3):300-301. doi: 10.1016/j.chom.2024.02.006.ABSTRACTAntibiotic resistance is often studied in vitro, limiting the understanding of in vivo mechanisms that affect antibiotic treatment. In this issue of Cell Host & Microbe, Rodrigues et al. show that specific mutations allow bacteria to invade intestinal cells in a mouse model, thereby evading antibiotic treatment.PMID:38484709 | DOI:10.1016/j.chom.2024.02.006 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Yuval Mulla Tobias Bollenbach Source Type: research
Plant cellular messengers mobilized to defend
Cell Host Microbe. 2024 Mar 13;32(3):302-303. doi: 10.1016/j.chom.2024.02.005.ABSTRACTPhosphatidic acid (PA) and reactive oxygen species (ROS) are cellular messengers that relay signals to regulate diverse biological processes. In recent issues of Cell Host & Microbe and Cell, Qi et al. and Kong et al., respectively, investigate diacylglycerol kinase 5-mediated PA in regulating ROS signaling and plant immunity.PMID:38484710 | DOI:10.1016/j.chom.2024.02.005 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Lifan Sun Jie Zhang Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
A new piece of the microbiota pie: Mining 'omics for DNA inversion states
Cell Host Microbe. 2024 Mar 13;32(3):293-295. doi: 10.1016/j.chom.2024.02.009.ABSTRACTIn this issue of Cell Host & Microbe, Carasso et al. survey invertible DNA sites in Bacteroidales from patients with inflammatory bowel disease (IBD) and healthy control individuals. They identify complex functional interactions between Bacteroides fragilis, an invertible promoter, a capsular polysaccharide, a bacteriophage, and the human host. The establishment of 'omics approaches to characterizing genomic targets and functional roles is still required.PMID:38484706 | DOI:10.1016/j.chom.2024.02.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Danielle E Campbell Megan T Baldridge Source Type: research
Gut microbe guides alveolar macrophages to fight flu
Cell Host Microbe. 2024 Mar 13;32(3):296-298. doi: 10.1016/j.chom.2024.02.007.ABSTRACTThe intestinal microbiota is associated with defense against respiratory viral infections. In this issue of Cell Host & Microbe, Ngo and colleagues1 show that intestinal commensal segmented filamentous bacteria reprogram alveolar macrophages with improved influenza-viral-neutralizing and phagocytic functions while maintaining inflammatory anergy to better protect the lung.PMID:38484707 | DOI:10.1016/j.chom.2024.02.007 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Tao Wang Yanling Wang Yushi Yao Source Type: research
Conquering homocystinuria with engineered probiotics
Cell Host Microbe. 2024 Mar 13;32(3):298-300. doi: 10.1016/j.chom.2024.02.008.ABSTRACTPyridoxine-unresponsive homocystinuria has lifelong implications for health. In this issue, Perreault and colleagues present evidence that orally delivered engineered probiotic Escherichia Coli Nissle SYNB1353 is a promising candidate in reducing homocysteine, with successful trials in mice, monkeys, and humans. However, further probiotic optimization and safety assessments are required.PMID:38484708 | DOI:10.1016/j.chom.2024.02.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Skye R S Fishbein Esse M Evbuomwan Gautam Dantas Source Type: research
Invade to evade: E. coli's gutsy survival strategies
Cell Host Microbe. 2024 Mar 13;32(3):300-301. doi: 10.1016/j.chom.2024.02.006.ABSTRACTAntibiotic resistance is often studied in vitro, limiting the understanding of in vivo mechanisms that affect antibiotic treatment. In this issue of Cell Host & Microbe, Rodrigues et al. show that specific mutations allow bacteria to invade intestinal cells in a mouse model, thereby evading antibiotic treatment.PMID:38484709 | DOI:10.1016/j.chom.2024.02.006 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Yuval Mulla Tobias Bollenbach Source Type: research
Plant cellular messengers mobilized to defend
Cell Host Microbe. 2024 Mar 13;32(3):302-303. doi: 10.1016/j.chom.2024.02.005.ABSTRACTPhosphatidic acid (PA) and reactive oxygen species (ROS) are cellular messengers that relay signals to regulate diverse biological processes. In recent issues of Cell Host & Microbe and Cell, Qi et al. and Kong et al., respectively, investigate diacylglycerol kinase 5-mediated PA in regulating ROS signaling and plant immunity.PMID:38484710 | DOI:10.1016/j.chom.2024.02.005 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Lifan Sun Jie Zhang Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
A new piece of the microbiota pie: Mining 'omics for DNA inversion states
Cell Host Microbe. 2024 Mar 13;32(3):293-295. doi: 10.1016/j.chom.2024.02.009.ABSTRACTIn this issue of Cell Host & Microbe, Carasso et al. survey invertible DNA sites in Bacteroidales from patients with inflammatory bowel disease (IBD) and healthy control individuals. They identify complex functional interactions between Bacteroides fragilis, an invertible promoter, a capsular polysaccharide, a bacteriophage, and the human host. The establishment of 'omics approaches to characterizing genomic targets and functional roles is still required.PMID:38484706 | DOI:10.1016/j.chom.2024.02.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Danielle E Campbell Megan T Baldridge Source Type: research
