Bacteroides methylmalonyl-CoA mutase produces propionate that promotes intestinal goblet cell differentiation and homeostasis
Cell Host Microbe. 2023 Dec 1:S1931-3128(23)00455-9. doi: 10.1016/j.chom.2023.11.005. Online ahead of print.ABSTRACTPropionate is a short-chain fatty acid that is generated upon microbiome-mediated fiber fermentation in the intestine. By modulating immune and metabolic pathways, propionate exerts many health benefits. Key bacterial species, such as Bacteroides thetaiotaomicron, generate propionate, but the biochemical pathways and specific functions remain undetermined. We identified a gene operon-encoding methylmalonyl-CoA mutase (MCM) that contributes to propionate biosynthesis in B. thetaiotaomicron. Colonization of ger...
Source: Cell Host and Microbe - December 6, 2023 Category: Microbiology Authors: Xingyu Wang Zhongle Cai Qiaoling Wang Chao Wu Yingkai Sun Zhifeng Wang Xiaoqiang Xu Wenzhi Xue Zhiwen Cao Minchun Zhang Yinmeng Zhu Huibin Lin Yi Zhang Mingyang Yuan Yuxiao Zhao Aibo Gao Yuqiang Yu Yufang Bi Guang Ning Weiqing Wang Jiqiu Wang Ruixin Liu Source Type: research
Unveiling P. vivax invasion pathways in Duffy-negative individuals
Cell Host Microbe. 2023 Nov 29:S1931-3128(23)00457-2. doi: 10.1016/j.chom.2023.11.007. Online ahead of print.ABSTRACTVivax malaria has long been thought to be absent from sub-Saharan Africa owing to the high proportion of individuals lacking the Duffy antigen receptor for chemokines (DARC) in their erythrocytes. The interaction between P. vivax Duffy-binding protein (PvDBP) and DARC is assumed to be the main pathway used by merozoites to invade reticulocytes. However, the increasing number of reports of vivax malaria cases in genotypically Duffy-negative (DN) individuals has raised questions regarding the P. vivax invasion...
Source: Cell Host and Microbe - December 6, 2023 Category: Microbiology Authors: Isabelle Bouyssou Sara El Hoss C écile Doderer-Lang Matthieu Schoenhals Lova Tsikiniaina Rasoloharimanana In ès Vigan-Womas Ars ène Ratsimbasoa Andargie Abate Lemu Golassa Solenne Mabilotte Pascal Kessler Micheline Guillotte-Blisnick Francisco J Martin Source Type: research
Dietary environmental factors shape the immune defense against Cryptosporidium infection
Cell Host Microbe. 2023 Nov 28:S1931-3128(23)00458-4. doi: 10.1016/j.chom.2023.11.008. Online ahead of print.ABSTRACTCryptosporidium is a leading cause of diarrheal-related deaths in children, especially in resource-poor settings. It also targets the immunocompromised, chronically infecting people living with HIV and primary immunodeficiencies. There is no vaccine or effective treatment. Although it is known from human cases and animal models that CD4+ T cells play a role in curbing Cryptosporidium, the role of CD8+ T cells remains to be defined. Using a Cryptosporidium tyzzeri mouse model, we show that gut-resident CD8+ i...
Source: Cell Host and Microbe - December 5, 2023 Category: Microbiology Authors: Muralidhara Rao Maradana N Bishara Marzook Oscar E Diaz Tapoka Mkandawire Nicola Laura Diny Ying Li Anke Liebert Kathleen Shah Mauro Tolaini Martin Kv áč Brigitta Stockinger Adam Sateriale Source Type: research
Infant gut microbiota contributes to cognitive performance in mice
Cell Host Microbe. 2023 Nov 21:S1931-3128(23)00454-7. doi: 10.1016/j.chom.2023.11.004. Online ahead of print.ABSTRACTGut microbiota has been linked to infant neurodevelopment. Here, an association between infant composite cognition and gut microbiota composition is established as soon as 6 months. Higher diversity and evenness characterize microbial communities of infants with composite cognition above (Inf-aboveCC) versus below (Inf-belowCC) median values. Metaproteomic and metabolomic analyses establish an association between microbial histidine ammonia lyase and infant histidine metabolome with cognition. Fecal transpla...
Source: Cell Host and Microbe - December 5, 2023 Category: Microbiology Authors: Tom ás Cerdó Alicia Ruiz-Rodr íguez Inmaculada Acu ña Francisco Jos é Torres-Espínola Sergio Mench én-Márquez Fernando G ámiz Milagros Gallo Nico Jehmlich Sven-Bastiaan Haange Martin von Bergen Cristina Campoy Antonio Su árez Source Type: research
Dietary environmental factors shape the immune defense against Cryptosporidium infection
Cell Host Microbe. 2023 Nov 28:S1931-3128(23)00458-4. doi: 10.1016/j.chom.2023.11.008. Online ahead of print.ABSTRACTCryptosporidium is a leading cause of diarrheal-related deaths in children, especially in resource-poor settings. It also targets the immunocompromised, chronically infecting people living with HIV and primary immunodeficiencies. There is no vaccine or effective treatment. Although it is known from human cases and animal models that CD4+ T cells play a role in curbing Cryptosporidium, the role of CD8+ T cells remains to be defined. Using a Cryptosporidium tyzzeri mouse model, we show that gut-resident CD8+ i...
Source: Cell Host and Microbe - December 5, 2023 Category: Microbiology Authors: Muralidhara Rao Maradana N Bishara Marzook Oscar E Diaz Tapoka Mkandawire Nicola Laura Diny Ying Li Anke Liebert Kathleen Shah Mauro Tolaini Martin Kv áč Brigitta Stockinger Adam Sateriale Source Type: research
Infant gut microbiota contributes to cognitive performance in mice
Cell Host Microbe. 2023 Nov 21:S1931-3128(23)00454-7. doi: 10.1016/j.chom.2023.11.004. Online ahead of print.ABSTRACTGut microbiota has been linked to infant neurodevelopment. Here, an association between infant composite cognition and gut microbiota composition is established as soon as 6 months. Higher diversity and evenness characterize microbial communities of infants with composite cognition above (Inf-aboveCC) versus below (Inf-belowCC) median values. Metaproteomic and metabolomic analyses establish an association between microbial histidine ammonia lyase and infant histidine metabolome with cognition. Fecal transpla...
Source: Cell Host and Microbe - December 5, 2023 Category: Microbiology Authors: Tom ás Cerdó Alicia Ruiz-Rodr íguez Inmaculada Acu ña Francisco Jos é Torres-Espínola Sergio Mench én-Márquez Fernando G ámiz Milagros Gallo Nico Jehmlich Sven-Bastiaan Haange Martin von Bergen Cristina Campoy Antonio Su árez Source Type: research
Characterization of a unique repression system present in arbitrium phages of the SPbeta family
Cell Host Microbe. 2023 Nov 21:S1931-3128(23)00453-5. doi: 10.1016/j.chom.2023.11.003. Online ahead of print.ABSTRACTArbitrium-coding phages use peptides to communicate and coordinate the decision between lysis and lysogeny. However, the mechanism by which these phages establish lysogeny remains unknown. Here, focusing on the SPbeta phage family's model phages phi3T and SPβ, we report that a six-gene operon called the "SPbeta phages repressor operon" (sro) expresses not one but two master repressors, SroE and SroF, the latter of which folds like a classical phage integrase. To promote lysogeny, these repressors bind to mu...
Source: Cell Host and Microbe - November 30, 2023 Category: Microbiology Authors: Aisling Brady Elena Cabello-Yeves Francisca Gallego Del Sol Cora Chmielowska Javier Manche ño-Bonillo Sara Zamora-Caballero Shira Bendori Omer Manuela Torres-Puente Avigdor Eldar Nuria Quiles-Puchalt Alberto Marina Jos é R Penadés Source Type: research
Characterization of a unique repression system present in arbitrium phages of the SPbeta family
Cell Host Microbe. 2023 Nov 21:S1931-3128(23)00453-5. doi: 10.1016/j.chom.2023.11.003. Online ahead of print.ABSTRACTArbitrium-coding phages use peptides to communicate and coordinate the decision between lysis and lysogeny. However, the mechanism by which these phages establish lysogeny remains unknown. Here, focusing on the SPbeta phage family's model phages phi3T and SPβ, we report that a six-gene operon called the "SPbeta phages repressor operon" (sro) expresses not one but two master repressors, SroE and SroF, the latter of which folds like a classical phage integrase. To promote lysogeny, these repressors bind to mu...
Source: Cell Host and Microbe - November 30, 2023 Category: Microbiology Authors: Aisling Brady Elena Cabello-Yeves Francisca Gallego Del Sol Cora Chmielowska Javier Manche ño-Bonillo Sara Zamora-Caballero Shira Bendori Omer Manuela Torres-Puente Avigdor Eldar Nuria Quiles-Puchalt Alberto Marina Jos é R Penadés Source Type: research
Characterization of a unique repression system present in arbitrium phages of the SPbeta family
Cell Host Microbe. 2023 Nov 21:S1931-3128(23)00453-5. doi: 10.1016/j.chom.2023.11.003. Online ahead of print.ABSTRACTArbitrium-coding phages use peptides to communicate and coordinate the decision between lysis and lysogeny. However, the mechanism by which these phages establish lysogeny remains unknown. Here, focusing on the SPbeta phage family's model phages phi3T and SPβ, we report that a six-gene operon called the "SPbeta phages repressor operon" (sro) expresses not one but two master repressors, SroE and SroF, the latter of which folds like a classical phage integrase. To promote lysogeny, these repressors bind to mu...
Source: Cell Host and Microbe - November 30, 2023 Category: Microbiology Authors: Aisling Brady Elena Cabello-Yeves Francisca Gallego Del Sol Cora Chmielowska Javier Manche ño-Bonillo Sara Zamora-Caballero Shira Bendori Omer Manuela Torres-Puente Avigdor Eldar Nuria Quiles-Puchalt Alberto Marina Jos é R Penadés Source Type: research
Characterization of a unique repression system present in arbitrium phages of the SPbeta family
Cell Host Microbe. 2023 Nov 21:S1931-3128(23)00453-5. doi: 10.1016/j.chom.2023.11.003. Online ahead of print.ABSTRACTArbitrium-coding phages use peptides to communicate and coordinate the decision between lysis and lysogeny. However, the mechanism by which these phages establish lysogeny remains unknown. Here, focusing on the SPbeta phage family's model phages phi3T and SPβ, we report that a six-gene operon called the "SPbeta phages repressor operon" (sro) expresses not one but two master repressors, SroE and SroF, the latter of which folds like a classical phage integrase. To promote lysogeny, these repressors bind to mu...
Source: Cell Host and Microbe - November 30, 2023 Category: Microbiology Authors: Aisling Brady Elena Cabello-Yeves Francisca Gallego Del Sol Cora Chmielowska Javier Manche ño-Bonillo Sara Zamora-Caballero Shira Bendori Omer Manuela Torres-Puente Avigdor Eldar Nuria Quiles-Puchalt Alberto Marina Jos é R Penadés Source Type: research
Characterization of a unique repression system present in arbitrium phages of the SPbeta family
Cell Host Microbe. 2023 Nov 21:S1931-3128(23)00453-5. doi: 10.1016/j.chom.2023.11.003. Online ahead of print.ABSTRACTArbitrium-coding phages use peptides to communicate and coordinate the decision between lysis and lysogeny. However, the mechanism by which these phages establish lysogeny remains unknown. Here, focusing on the SPbeta phage family's model phages phi3T and SPβ, we report that a six-gene operon called the "SPbeta phages repressor operon" (sro) expresses not one but two master repressors, SroE and SroF, the latter of which folds like a classical phage integrase. To promote lysogeny, these repressors bind to mu...
Source: Cell Host and Microbe - November 30, 2023 Category: Microbiology Authors: Aisling Brady Elena Cabello-Yeves Francisca Gallego Del Sol Cora Chmielowska Javier Manche ño-Bonillo Sara Zamora-Caballero Shira Bendori Omer Manuela Torres-Puente Avigdor Eldar Nuria Quiles-Puchalt Alberto Marina Jos é R Penadés Source Type: research
Conspecific versus heterospecific transmission shapes host specialization of the phyllosphere microbiome
Cell Host Microbe. 2023 Nov 22:S1931-3128(23)00452-3. doi: 10.1016/j.chom.2023.11.002. Online ahead of print.ABSTRACTIn disease ecology, pathogen transmission among conspecific versus heterospecific hosts is known to shape pathogen specialization and virulence, but we do not yet know if similar effects occur at the microbiome level. We tested this idea by experimentally passaging leaf-associated microbiomes either within conspecific or across heterospecific plant hosts. Although conspecific transmission results in persistent host-filtering effects and more within-microbiome network connections, heterospecific transmission ...
Source: Cell Host and Microbe - November 29, 2023 Category: Microbiology Authors: Kyle M Meyer Isabella E Muscettola Ana Luisa S Vasconcelos Julia K Sherman C Jessica E Metcalf Steven E Lindow Britt Koskella Source Type: research
Enhanced neutralization of SARS-CoV-2 variant BA.2.86 and XBB sub-lineages by a tetravalent COVID-19 vaccine booster
Cell Host Microbe. 2023 Nov 22:S1931-3128(23)00462-6. doi: 10.1016/j.chom.2023.11.012. Online ahead of print.ABSTRACTEmerging SARS-CoV-2 sub-lineages like XBB.1.5, XBB.1.16, EG.5, HK.3 (FLip), and XBB.2.3 and the variant BA.2.86 have recently been identified. Understanding the efficacy of current vaccines on these emerging variants is critical. We evaluate the serum neutralization activities of participants who received COVID-19 inactivated vaccine (CoronaVac), those who received the recently approved tetravalent protein vaccine (SCTV01E), or those who had contracted a breakthrough infection with BA.5/BF.7/XBB virus. Neutr...
Source: Cell Host and Microbe - November 29, 2023 Category: Microbiology Authors: Xun Wang Shujun Jiang Wentai Ma Xiangnan Li Kaifeng Wei Faren Xie Chaoyue Zhao Xiaoyu Zhao Shidi Wang Chen Li Rui Qiao Yuchen Cui Yanjia Chen Jiayan Li Guonan Cai Changyi Liu Jizhen Yu Jixi Li Zixin Hu Wenhong Zhang Shibo Jiang Mingkun Li Yanliang Zhang P Source Type: research
A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation
Cell Host Microbe. 2023 Nov 17:S1931-3128(23)00415-8. doi: 10.1016/j.chom.2023.10.011. Online ahead of print.ABSTRACTImpaired gastrointestinal motility is associated with gut dysbiosis. Probiotics, such as Bifidobacteria, can improve this bowel disorder; however, efficacy is strain-dependent. We determine that a genetic factor, the abfA cluster governing arabinan utilization, in Bifidobacterium longum impacts treatment efficacy against functional constipation (FC). In mice with FC, B. longum, but not an abfA mutant, improved gastrointestinal transit time, an affect that was dependent upon dietary arabinan. abfA genes were ...
Source: Cell Host and Microbe - November 22, 2023 Category: Microbiology Authors: Chengcheng Zhang Leilei Yu Chenchen Ma Shuaiming Jiang Yufeng Zhang Shunhe Wang Fengwei Tian Yuzheng Xue Jianxin Zhao Hao Zhang Liming Liu Wei Chen Shi Huang Jiachao Zhang Qixiao Zhai Source Type: research
A key genetic factor governing arabinan utilization in the gut microbiome alleviates constipation
Cell Host Microbe. 2023 Nov 17:S1931-3128(23)00415-8. doi: 10.1016/j.chom.2023.10.011. Online ahead of print.ABSTRACTImpaired gastrointestinal motility is associated with gut dysbiosis. Probiotics, such as Bifidobacteria, can improve this bowel disorder; however, efficacy is strain-dependent. We determine that a genetic factor, the abfA cluster governing arabinan utilization, in Bifidobacterium longum impacts treatment efficacy against functional constipation (FC). In mice with FC, B. longum, but not an abfA mutant, improved gastrointestinal transit time, an affect that was dependent upon dietary arabinan. abfA genes were ...
Source: Cell Host and Microbe - November 22, 2023 Category: Microbiology Authors: Chengcheng Zhang Leilei Yu Chenchen Ma Shuaiming Jiang Yufeng Zhang Shunhe Wang Fengwei Tian Yuzheng Xue Jianxin Zhao Hao Zhang Liming Liu Wei Chen Shi Huang Jiachao Zhang Qixiao Zhai Source Type: research
