Crafty mimicry grants nuclear pore entry to HIV
Cell Host Microbe. 2024 Apr 10;32(4):441-442. doi: 10.1016/j.chom.2024.03.004.ABSTRACTThe size of the nuclear pore should, in principle, prevent HIV-1 entry. However, HIV-1 capsid is able to gain nuclear pore entry. In a recent issue of Nature, Fu et al. and Dickson et al. demonstrate that the HIV-1 capsid mimics the nuclear transport protein karyopherins to access host nuclei.PMID:38604120 | DOI:10.1016/j.chom.2024.03.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - April 11, 2024 Category: Microbiology Authors: Keesiang Lim Masaharu Hazawa Richard W Wong Source Type: research
Fusobacterium nucleatum subsp. animalis comes to the spotlight in oral diseases
Cell Host Microbe. 2024 Apr 10;32(4):443-444. doi: 10.1016/j.chom.2024.03.009.ABSTRACTKrieger et al.'s study in this issue of Cell Host & Microbe reveals that Fusobacterium nucleatum subsp. animalis strains, previously underestimated, are significant in disease-affected oral areas. This challenges the long-held notion of the dominance of Fusobacterium nucleatum subsp. nucleatum, reshaping our understanding of Fusobacterium distribution in the oral microbiome.PMID:38604121 | DOI:10.1016/j.chom.2024.03.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - April 11, 2024 Category: Microbiology Authors: Bibek G C Peng Zhou Chenggang Wu Source Type: research
Spatially distributed metabolites SWEETen the root for microbes
Cell Host Microbe. 2024 Apr 10;32(4):445-447. doi: 10.1016/j.chom.2024.03.006.ABSTRACTLimited understanding exists on the spatial configuration of underground plant-microbe interactions. In this issue of Cell Host & Microbe, Loo et al. illustrate the sugar transporter-involved interdependent interaction between root metabolites and microbial spatial colonization, providing insights into metabolic-associated organization of plant-microbe interactions.PMID:38604122 | DOI:10.1016/j.chom.2024.03.006 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - April 11, 2024 Category: Microbiology Authors: Xiaoyan Fan An-Hui Ge Ertao Wang Source Type: research
A layered effect in bacterial defense
Cell Host Microbe. 2024 Apr 10;32(4):447-449. doi: 10.1016/j.chom.2024.03.007.ABSTRACTDefense systems that protect bacteria from invaders, such as viruses, are believed to be multi-layered and driven by interactions. In this issue of Cell Host & Microbe, Wu, Garushyants et al.1 delve into the dynamics between these safeguard mechanisms and unravel synergistic interactions.PMID:38604123 | DOI:10.1016/j.chom.2024.03.007 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - April 11, 2024 Category: Microbiology Authors: Karina Ilchenko Eugen Pfeifer Source Type: research
GOSpel for tiny allies
Cell Host Microbe. 2024 Apr 10;32(4):450-452. doi: 10.1016/j.chom.2024.03.008.ABSTRACTInfant formulas are often supplemented to foster the development of a healthy gut microbiota. In this issue of Cell Host & Microbe, Heppner et al. present an elaborate clinical trial examining the impact of formula supplementation on the development and circadian rhythmicity of the microbiota during the first year of life.PMID:38604124 | DOI:10.1016/j.chom.2024.03.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - April 11, 2024 Category: Microbiology Authors: Wei Hu Xiaofei Yu Source Type: research
Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host
Cell Host Microbe. 2024 Apr 2:S1931-3128(24)00090-8. doi: 10.1016/j.chom.2024.03.010. Online ahead of print.ABSTRACTMany, if not all, bacteria use quorum sensing (QS) to control collective behaviors, and more recently, QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or "listen in" on the host's communication processes, to switch between lytic and lysogenic modes of infection. Here, we study the interaction of Vibrio cholerae with the lysogenic phage VP882, which is activated by the QS molecule DPO. We discover that induction of VP882 results in the binding of...
Source: Cell Host and Microbe - April 5, 2024 Category: Microbiology Authors: Marcel Sprenger Malte Siemers Sebastian Krautwurst Kai Papenfort Source Type: research
Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host
Cell Host Microbe. 2024 Apr 2:S1931-3128(24)00090-8. doi: 10.1016/j.chom.2024.03.010. Online ahead of print.ABSTRACTMany, if not all, bacteria use quorum sensing (QS) to control collective behaviors, and more recently, QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or "listen in" on the host's communication processes, to switch between lytic and lysogenic modes of infection. Here, we study the interaction of Vibrio cholerae with the lysogenic phage VP882, which is activated by the QS molecule DPO. We discover that induction of VP882 results in the binding of...
Source: Cell Host and Microbe - April 5, 2024 Category: Microbiology Authors: Marcel Sprenger Malte Siemers Sebastian Krautwurst Kai Papenfort Source Type: research
Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host
Cell Host Microbe. 2024 Apr 2:S1931-3128(24)00090-8. doi: 10.1016/j.chom.2024.03.010. Online ahead of print.ABSTRACTMany, if not all, bacteria use quorum sensing (QS) to control collective behaviors, and more recently, QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or "listen in" on the host's communication processes, to switch between lytic and lysogenic modes of infection. Here, we study the interaction of Vibrio cholerae with the lysogenic phage VP882, which is activated by the QS molecule DPO. We discover that induction of VP882 results in the binding of...
Source: Cell Host and Microbe - April 5, 2024 Category: Microbiology Authors: Marcel Sprenger Malte Siemers Sebastian Krautwurst Kai Papenfort Source Type: research
Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host
Cell Host Microbe. 2024 Apr 2:S1931-3128(24)00090-8. doi: 10.1016/j.chom.2024.03.010. Online ahead of print.ABSTRACTMany, if not all, bacteria use quorum sensing (QS) to control collective behaviors, and more recently, QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or "listen in" on the host's communication processes, to switch between lytic and lysogenic modes of infection. Here, we study the interaction of Vibrio cholerae with the lysogenic phage VP882, which is activated by the QS molecule DPO. We discover that induction of VP882 results in the binding of...
Source: Cell Host and Microbe - April 5, 2024 Category: Microbiology Authors: Marcel Sprenger Malte Siemers Sebastian Krautwurst Kai Papenfort Source Type: research
Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host
Cell Host Microbe. 2024 Apr 2:S1931-3128(24)00090-8. doi: 10.1016/j.chom.2024.03.010. Online ahead of print.ABSTRACTMany, if not all, bacteria use quorum sensing (QS) to control collective behaviors, and more recently, QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or "listen in" on the host's communication processes, to switch between lytic and lysogenic modes of infection. Here, we study the interaction of Vibrio cholerae with the lysogenic phage VP882, which is activated by the QS molecule DPO. We discover that induction of VP882 results in the binding of...
Source: Cell Host and Microbe - April 5, 2024 Category: Microbiology Authors: Marcel Sprenger Malte Siemers Sebastian Krautwurst Kai Papenfort Source Type: research
Small RNAs direct attack and defense mechanisms in a quorum sensing phage and its host
Cell Host Microbe. 2024 Apr 2:S1931-3128(24)00090-8. doi: 10.1016/j.chom.2024.03.010. Online ahead of print.ABSTRACTMany, if not all, bacteria use quorum sensing (QS) to control collective behaviors, and more recently, QS has also been discovered in bacteriophages (phages). Phages can produce communication molecules of their own, or "listen in" on the host's communication processes, to switch between lytic and lysogenic modes of infection. Here, we study the interaction of Vibrio cholerae with the lysogenic phage VP882, which is activated by the QS molecule DPO. We discover that induction of VP882 results in the binding of...
Source: Cell Host and Microbe - April 5, 2024 Category: Microbiology Authors: Marcel Sprenger Malte Siemers Sebastian Krautwurst Kai Papenfort Source Type: research
Diurnal rhythmicity of infant fecal microbiota and metabolites: A randomized controlled interventional trial with infant formula
Cell Host Microbe. 2024 Mar 12:S1931-3128(24)00058-1. doi: 10.1016/j.chom.2024.02.015. Online ahead of print.ABSTRACTMicrobiota assembly in the infant gut is influenced by diet. Breastfeeding and human breastmilk oligosaccharides promote the colonization of beneficial bifidobacteria. Infant formulas are supplemented with bifidobacteria or complex oligosaccharides, notably galacto-oligosaccharides (GOS), to mimic breast milk. To compare microbiota development across feeding modes, this randomized controlled intervention study (German Clinical Trial DRKS00012313) longitudinally sampled infant stool during the first year of l...
Source: Cell Host and Microbe - April 3, 2024 Category: Microbiology Authors: Nina Heppner Sandra Reitmeier Marjolein Heddes Michael Vig Merino Leon Schwartz Alexander Dietrich Markus List Michael Gigl Chen Meng Daan R van der Veen Melanie Schirmer Karin Kleigrewe H élène Omer Silke Kiessling Dirk Haller Source Type: research
Diurnal rhythmicity of infant fecal microbiota and metabolites: A randomized controlled interventional trial with infant formula
Cell Host Microbe. 2024 Mar 12:S1931-3128(24)00058-1. doi: 10.1016/j.chom.2024.02.015. Online ahead of print.ABSTRACTMicrobiota assembly in the infant gut is influenced by diet. Breastfeeding and human breastmilk oligosaccharides promote the colonization of beneficial bifidobacteria. Infant formulas are supplemented with bifidobacteria or complex oligosaccharides, notably galacto-oligosaccharides (GOS), to mimic breast milk. To compare microbiota development across feeding modes, this randomized controlled intervention study (German Clinical Trial DRKS00012313) longitudinally sampled infant stool during the first year of l...
Source: Cell Host and Microbe - April 3, 2024 Category: Microbiology Authors: Nina Heppner Sandra Reitmeier Marjolein Heddes Michael Vig Merino Leon Schwartz Alexander Dietrich Markus List Michael Gigl Chen Meng Daan R van der Veen Melanie Schirmer Karin Kleigrewe H élène Omer Silke Kiessling Dirk Haller Source Type: research
A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota
Cell Host Microbe. 2024 Mar 21:S1931-3128(24)00085-4. doi: 10.1016/j.chom.2024.03.005. Online ahead of print.ABSTRACTInsertion sequence (IS) elements are mobile genetic elements in bacterial genomes that support adaptation. We developed a database of IS elements coupled to a computational pipeline that identifies IS element insertions in the microbiota. We discovered that diverse IS elements insert into the genomes of intestinal bacteria regardless of human host lifestyle. These insertions target bacterial accessory genes that aid in their adaptation to unique environmental conditions. Using IS expansion in Bacteroides, we...
Source: Cell Host and Microbe - April 2, 2024 Category: Microbiology Authors: Joshua M Kirsch Andrew J Hryckowian Breck A Duerkop Source Type: research
A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota
Cell Host Microbe. 2024 Mar 21:S1931-3128(24)00085-4. doi: 10.1016/j.chom.2024.03.005. Online ahead of print.ABSTRACTInsertion sequence (IS) elements are mobile genetic elements in bacterial genomes that support adaptation. We developed a database of IS elements coupled to a computational pipeline that identifies IS element insertions in the microbiota. We discovered that diverse IS elements insert into the genomes of intestinal bacteria regardless of human host lifestyle. These insertions target bacterial accessory genes that aid in their adaptation to unique environmental conditions. Using IS expansion in Bacteroides, we...
Source: Cell Host and Microbe - April 2, 2024 Category: Microbiology Authors: Joshua M Kirsch Andrew J Hryckowian Breck A Duerkop Source Type: research
