Conquering homocystinuria with engineered probiotics
Cell Host Microbe. 2024 Mar 13;32(3):298-300. doi: 10.1016/j.chom.2024.02.008.ABSTRACTPyridoxine-unresponsive homocystinuria has lifelong implications for health. In this issue, Perreault and colleagues present evidence that orally delivered engineered probiotic Escherichia Coli Nissle SYNB1353 is a promising candidate in reducing homocysteine, with successful trials in mice, monkeys, and humans. However, further probiotic optimization and safety assessments are required.PMID:38484708 | DOI:10.1016/j.chom.2024.02.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Skye R S Fishbein Esse M Evbuomwan Gautam Dantas Source Type: research
Invade to evade: E. coli's gutsy survival strategies
Cell Host Microbe. 2024 Mar 13;32(3):300-301. doi: 10.1016/j.chom.2024.02.006.ABSTRACTAntibiotic resistance is often studied in vitro, limiting the understanding of in vivo mechanisms that affect antibiotic treatment. In this issue of Cell Host & Microbe, Rodrigues et al. show that specific mutations allow bacteria to invade intestinal cells in a mouse model, thereby evading antibiotic treatment.PMID:38484709 | DOI:10.1016/j.chom.2024.02.006 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Yuval Mulla Tobias Bollenbach Source Type: research
Plant cellular messengers mobilized to defend
Cell Host Microbe. 2024 Mar 13;32(3):302-303. doi: 10.1016/j.chom.2024.02.005.ABSTRACTPhosphatidic acid (PA) and reactive oxygen species (ROS) are cellular messengers that relay signals to regulate diverse biological processes. In recent issues of Cell Host & Microbe and Cell, Qi et al. and Kong et al., respectively, investigate diacylglycerol kinase 5-mediated PA in regulating ROS signaling and plant immunity.PMID:38484710 | DOI:10.1016/j.chom.2024.02.005 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Lifan Sun Jie Zhang Source Type: research
A tough act to swallow: Streptococcusanginosus and gastric cancer
Cell Host Microbe. 2024 Mar 13;32(3):291-293. doi: 10.1016/j.chom.2024.02.004.ABSTRACTGastric cancer is a deadly global malignancy caused by Helicobacter pylori infection. In a recent issue of Cell, Fu et al. identify Streptococcus anginosus, a bacterium normally residing in the oral cavity, as an additional contributor to gastric carcinogenesis.PMID:38484705 | DOI:10.1016/j.chom.2024.02.004 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Sunny Wong Patrick Tan Source Type: research
A new piece of the microbiota pie: Mining 'omics for DNA inversion states
Cell Host Microbe. 2024 Mar 13;32(3):293-295. doi: 10.1016/j.chom.2024.02.009.ABSTRACTIn this issue of Cell Host & Microbe, Carasso et al. survey invertible DNA sites in Bacteroidales from patients with inflammatory bowel disease (IBD) and healthy control individuals. They identify complex functional interactions between Bacteroides fragilis, an invertible promoter, a capsular polysaccharide, a bacteriophage, and the human host. The establishment of 'omics approaches to characterizing genomic targets and functional roles is still required.PMID:38484706 | DOI:10.1016/j.chom.2024.02.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Danielle E Campbell Megan T Baldridge Source Type: research
Gut microbe guides alveolar macrophages to fight flu
Cell Host Microbe. 2024 Mar 13;32(3):296-298. doi: 10.1016/j.chom.2024.02.007.ABSTRACTThe intestinal microbiota is associated with defense against respiratory viral infections. In this issue of Cell Host & Microbe, Ngo and colleagues1 show that intestinal commensal segmented filamentous bacteria reprogram alveolar macrophages with improved influenza-viral-neutralizing and phagocytic functions while maintaining inflammatory anergy to better protect the lung.PMID:38484707 | DOI:10.1016/j.chom.2024.02.007 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Tao Wang Yanling Wang Yushi Yao Source Type: research
Conquering homocystinuria with engineered probiotics
Cell Host Microbe. 2024 Mar 13;32(3):298-300. doi: 10.1016/j.chom.2024.02.008.ABSTRACTPyridoxine-unresponsive homocystinuria has lifelong implications for health. In this issue, Perreault and colleagues present evidence that orally delivered engineered probiotic Escherichia Coli Nissle SYNB1353 is a promising candidate in reducing homocysteine, with successful trials in mice, monkeys, and humans. However, further probiotic optimization and safety assessments are required.PMID:38484708 | DOI:10.1016/j.chom.2024.02.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Skye R S Fishbein Esse M Evbuomwan Gautam Dantas Source Type: research
Invade to evade: E. coli's gutsy survival strategies
Cell Host Microbe. 2024 Mar 13;32(3):300-301. doi: 10.1016/j.chom.2024.02.006.ABSTRACTAntibiotic resistance is often studied in vitro, limiting the understanding of in vivo mechanisms that affect antibiotic treatment. In this issue of Cell Host & Microbe, Rodrigues et al. show that specific mutations allow bacteria to invade intestinal cells in a mouse model, thereby evading antibiotic treatment.PMID:38484709 | DOI:10.1016/j.chom.2024.02.006 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Yuval Mulla Tobias Bollenbach Source Type: research
Plant cellular messengers mobilized to defend
Cell Host Microbe. 2024 Mar 13;32(3):302-303. doi: 10.1016/j.chom.2024.02.005.ABSTRACTPhosphatidic acid (PA) and reactive oxygen species (ROS) are cellular messengers that relay signals to regulate diverse biological processes. In recent issues of Cell Host & Microbe and Cell, Qi et al. and Kong et al., respectively, investigate diacylglycerol kinase 5-mediated PA in regulating ROS signaling and plant immunity.PMID:38484710 | DOI:10.1016/j.chom.2024.02.005 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - March 14, 2024 Category: Microbiology Authors: Lifan Sun Jie Zhang Source Type: research
Stratification of Fusobacterium nucleatum by local health status in the oral cavity defines its subspecies disease association
Cell Host Microbe. 2024 Mar 8:S1931-3128(24)00053-2. doi: 10.1016/j.chom.2024.02.010. Online ahead of print.ABSTRACTThe ubiquitous inflammophilic oral pathobiont Fusobacterium nucleatum (Fn) is widely recognized for its strong association with inflammatory dysbiotic diseases and cancer. Fn is subdivided into four subspecies, which are historically considered functionally interchangeable in the oral cavity. To test this assumption, we analyzed patient-matched dental plaque and odontogenic abscess clinical specimens and examined whether an inflammatory environment selects for/against particular Fn subspecies. Dental plaque h...
Source: Cell Host and Microbe - March 13, 2024 Category: Microbiology Authors: Madeline Krieger Yasser M AbdelRahman Dongseok Choi Elizabeth A Palmer Anna Yoo Sean McGuire Jens Kreth Justin Merritt Source Type: research
Sugar transporters spatially organize microbiota colonization along the longitudinal root axis of Arabidopsis
Cell Host Microbe. 2024 Mar 8:S1931-3128(24)00057-X. doi: 10.1016/j.chom.2024.02.014. Online ahead of print.ABSTRACTPlant roots are functionally heterogeneous in cellular architecture, transcriptome profile, metabolic state, and microbial immunity. We hypothesized that axial differentiation may also impact spatial colonization by root microbiota along the root axis. We developed two growth systems, ArtSoil and CD-Rhizotron, to grow and then dissect Arabidopsis thaliana roots into three segments. We demonstrate that distinct endospheric and rhizosphere bacterial communities colonize the segments, supporting the hypothesis o...
Source: Cell Host and Microbe - March 13, 2024 Category: Microbiology Authors: Eliza P-I Loo Paloma Dur án Tin Yau Pang Philipp Westhoff Chen Deng Carlos Dur án Martin Lercher Ruben Garrido-Oter Wolf B Frommer Source Type: research
Human cytomegalovirus degrades DMXL1 to inhibit autophagy, lysosomal acidification, and viral assembly
Cell Host Microbe. 2024 Mar 5:S1931-3128(24)00055-6. doi: 10.1016/j.chom.2024.02.013. Online ahead of print.ABSTRACTHuman cytomegalovirus (HCMV) is an important human pathogen that regulates host immunity and hijacks host compartments, including lysosomes, to assemble virions. We combined a quantitative proteomic analysis of HCMV infection with a database of proteins involved in vacuolar acidification, revealing Dmx-like protein-1 (DMXL1) as the only protein that acidifies vacuoles yet is degraded by HCMV. Systematic comparison of viral deletion mutants reveals the uncharacterized 7 kDa US33A protein as necessary and suffi...
Source: Cell Host and Microbe - March 13, 2024 Category: Microbiology Authors: Hanqi Li Alice Fletcher-Etherington Leah M Hunter Swati Keshri Ceri A Fielding Katie Nightingale Benjamin Ravenhill Luis Nobre Martin Potts Robin Antrobus Colin M Crump David C Rubinsztein Richard J Stanton Michael P Weekes Source Type: research
Pathophysiology of chikungunya virus infection associated with fatal outcomes
Cell Host Microbe. 2024 Mar 8:S1931-3128(24)00054-4. doi: 10.1016/j.chom.2024.02.011. Online ahead of print.ABSTRACTChikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes acute, subacute, and chronic human arthritogenic diseases and, in rare instances, can lead to neurological complications and death. Here, we combined epidemiological, virological, histopathological, cytokine, molecular dynamics, metabolomic, proteomic, and genomic analyses to investigate viral and host factors that contribute to chikungunya-associated (CHIK) death. Our results indicate that CHIK deaths are associated with multi-organ infecti...
Source: Cell Host and Microbe - March 13, 2024 Category: Microbiology Authors: William M de Souza Marcilio J Fumagalli Shirlene T S de Lima Pierina L Parise Deyse C M Carvalho Cristian Hernandez Ronaldo de Jesus Jeany Delafiori Darlan S Candido Victor C Carregari Stefanie P Muraro Gabriela F Souza Leda M Sim ões Mello Ingra M Claro Source Type: research
Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease
Cell Host Microbe. 2024 Mar 8:S1931-3128(24)00056-8. doi: 10.1016/j.chom.2024.02.012. Online ahead of print.ABSTRACTTo understand the dynamic interplay between the human microbiome and host during health and disease, we analyzed the microbial composition, temporal dynamics, and associations with host multi-omics, immune, and clinical markers of microbiomes from four body sites in 86 participants over 6 years. We found that microbiome stability and individuality are body-site specific and heavily influenced by the host. The stool and oral microbiome are more stable than the skin and nasal microbiomes, possibly due to their ...
Source: Cell Host and Microbe - March 13, 2024 Category: Microbiology Authors: Xin Zhou Xiaotao Shen Jethro S Johnson Daniel J Spakowicz Melissa Agnello Wenyu Zhou Monica Avina Alexander Honkala Faye Chleilat Shirley Jingyi Chen Kexin Cha Shana Leopold Chenchen Zhu Lei Chen Lin Lyu Daniel Hornburg Si Wu Xinyue Zhang Chao Jiang Liuyi Source Type: research
Stratification of Fusobacterium nucleatum by local health status in the oral cavity defines its subspecies disease association
Cell Host Microbe. 2024 Mar 8:S1931-3128(24)00053-2. doi: 10.1016/j.chom.2024.02.010. Online ahead of print.ABSTRACTThe ubiquitous inflammophilic oral pathobiont Fusobacterium nucleatum (Fn) is widely recognized for its strong association with inflammatory dysbiotic diseases and cancer. Fn is subdivided into four subspecies, which are historically considered functionally interchangeable in the oral cavity. To test this assumption, we analyzed patient-matched dental plaque and odontogenic abscess clinical specimens and examined whether an inflammatory environment selects for/against particular Fn subspecies. Dental plaque h...
Source: Cell Host and Microbe - March 13, 2024 Category: Microbiology Authors: Madeline Krieger Yasser M AbdelRahman Dongseok Choi Elizabeth A Palmer Anna Yoo Sean McGuire Jens Kreth Justin Merritt Source Type: research
