XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1
Cell Host Microbe. 2024 Feb 10:S1931-3128(24)00018-0. doi: 10.1016/j.chom.2024.01.014. Online ahead of print.ABSTRACTCOVID-19 vaccines have recently been updated to specifically encode or contain the spike protein of the SARS-CoV-2 XBB.1.5 subvariant, but their immunogenicity in humans has yet to be fully evaluated and reported, particularly against emergent viruses that are rapidly expanding. We now report that administration of an updated monovalent mRNA vaccine booster (XBB.1.5 MV) to previously uninfected individuals boosted serum virus-neutralizing antibodies significantly against not only XBB.1.5 (27.0-fold increase)...
Source: Cell Host and Microbe - February 20, 2024 Category: Microbiology Authors: Qian Wang Yicheng Guo Anthony Bowen Ian A Mellis Riccardo Valdez Carmen Gherasim Aubree Gordon Lihong Liu David D Ho Source Type: research
XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against XBB subvariants and JN.1
Cell Host Microbe. 2024 Feb 10:S1931-3128(24)00018-0. doi: 10.1016/j.chom.2024.01.014. Online ahead of print.ABSTRACTCOVID-19 vaccines have recently been updated to specifically encode or contain the spike protein of the SARS-CoV-2 XBB.1.5 subvariant, but their immunogenicity in humans has yet to be fully evaluated and reported, particularly against emergent viruses that are rapidly expanding. We now report that administration of an updated monovalent mRNA vaccine booster (XBB.1.5 MV) to previously uninfected individuals boosted serum virus-neutralizing antibodies significantly against not only XBB.1.5 (27.0-fold increase)...
Source: Cell Host and Microbe - February 20, 2024 Category: Microbiology Authors: Qian Wang Yicheng Guo Anthony Bowen Ian A Mellis Riccardo Valdez Carmen Gherasim Aubree Gordon Lihong Liu David D Ho Source Type: research
Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome
Cell Host Microbe. 2024 Feb 12:S1931-3128(24)00017-9. doi: 10.1016/j.chom.2024.01.013. Online ahead of print.ABSTRACTStudies on fecal microbiota transplantation (FMT) have reported inconsistent connections between clinical outcomes and donor strain engraftment. Analyses of subspecies-level crosstalk and its influences on lineage transfer in metagenomic FMT datasets have proved challenging, as single-nucleotide polymorphisms (SNPs) are generally not linked and are often absent. Here, we utilized species genome bin (SGB), which employs co-abundance binning, to investigate subspecies-level microbiome dynamics in patients with...
Source: Cell Host and Microbe - February 17, 2024 Category: Microbiology Authors: Qiyi Chen Chunyan Wu Jinfeng Xu Chen Ye Xiang Chen Hongliang Tian Naixin Zong Shaoyi Zhang Long Li Yuan Gao Di Zhao Xiaoqiong Lv Qilin Yang Le Wang Jiaqu Cui Zhiliang Lin Jubao Lu Rong Yang Fang Yin Nan Qin Ning Li Qian Xu Huanlong Qin Source Type: research
Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome
Cell Host Microbe. 2024 Feb 12:S1931-3128(24)00017-9. doi: 10.1016/j.chom.2024.01.013. Online ahead of print.ABSTRACTStudies on fecal microbiota transplantation (FMT) have reported inconsistent connections between clinical outcomes and donor strain engraftment. Analyses of subspecies-level crosstalk and its influences on lineage transfer in metagenomic FMT datasets have proved challenging, as single-nucleotide polymorphisms (SNPs) are generally not linked and are often absent. Here, we utilized species genome bin (SGB), which employs co-abundance binning, to investigate subspecies-level microbiome dynamics in patients with...
Source: Cell Host and Microbe - February 17, 2024 Category: Microbiology Authors: Qiyi Chen Chunyan Wu Jinfeng Xu Chen Ye Xiang Chen Hongliang Tian Naixin Zong Shaoyi Zhang Long Li Yuan Gao Di Zhao Xiaoqiong Lv Qilin Yang Le Wang Jiaqu Cui Zhiliang Lin Jubao Lu Rong Yang Fang Yin Nan Qin Ning Li Qian Xu Huanlong Qin Source Type: research
Donor-recipient intermicrobial interactions impact transfer of subspecies and fecal microbiota transplantation outcome
Cell Host Microbe. 2024 Feb 12:S1931-3128(24)00017-9. doi: 10.1016/j.chom.2024.01.013. Online ahead of print.ABSTRACTStudies on fecal microbiota transplantation (FMT) have reported inconsistent connections between clinical outcomes and donor strain engraftment. Analyses of subspecies-level crosstalk and its influences on lineage transfer in metagenomic FMT datasets have proved challenging, as single-nucleotide polymorphisms (SNPs) are generally not linked and are often absent. Here, we utilized species genome bin (SGB), which employs co-abundance binning, to investigate subspecies-level microbiome dynamics in patients with...
Source: Cell Host and Microbe - February 17, 2024 Category: Microbiology Authors: Qiyi Chen Chunyan Wu Jinfeng Xu Chen Ye Xiang Chen Hongliang Tian Naixin Zong Shaoyi Zhang Long Li Yuan Gao Di Zhao Xiaoqiong Lv Qilin Yang Le Wang Jiaqu Cui Zhiliang Lin Jubao Lu Rong Yang Fang Yin Nan Qin Ning Li Qian Xu Huanlong Qin Source Type: research
Designing microbial communities to starve out invading pathogens
Cell Host Microbe. 2024 Feb 14;32(2):145-146. doi: 10.1016/j.chom.2024.01.008.ABSTRACTIdentifying key features required for specific community-level functions can be challenging, especially considering the complexity of the gut microbiome. In a recent study in Science, Spragge et al. present a high-throughput experimental framework to rationally design microbial communities that can resist invasion by specific bacterial pathogens.PMID:38359793 | DOI:10.1016/j.chom.2024.01.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Melissa Ellermann Source Type: research
Arming up against Omicron subvariants
Cell Host Microbe. 2024 Feb 14;32(2):147-148. doi: 10.1016/j.chom.2024.01.010.ABSTRACTThe rapid evolution of COVID-19 Omicron variants is driven by evasion of neutralizing antibodies. Breakthrough infections are common, even in highly vaccinated populations, making it vital to understand immune cross-protective repertoires to variants. Two studies in this issue show that the primed T cell repertoire comprises strong cross-recognition of current variants.PMID:38359794 | DOI:10.1016/j.chom.2024.01.010 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Daniel M Altmann Rosemary J Boyton Source Type: research
Milk to mucus: How B. fragilis colonizes the gut
Cell Host Microbe. 2024 Feb 14;32(2):149-150. doi: 10.1016/j.chom.2024.01.007.ABSTRACTHuman milk oligosaccharide (HMO) consumption by the infant microbiota is positively associated with immune health. In this issue of Cell Host & Microbe, Buzun et al. report a mechanism for HMO digestion by Bacteroides fragilis and demonstrate how the same pathway works on intestinal mucus to establish long-term gut residency.PMID:38359795 | DOI:10.1016/j.chom.2024.01.007 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Matthew R Olm Noel T Mueller Source Type: research
"Indole-gence" for the mind
Cell Host Microbe. 2024 Feb 14;32(2):151-153. doi: 10.1016/j.chom.2024.01.006.ABSTRACTSurging depression rates highlight the need for innovative strategies beyond the traditional focus on the brain. In this issue of Cell Host & Microbe, Cheng et al. uncover a role for the gut microbiota in depression through the intestinal receptor Grp35 and indole pathway, offering hope in fighting against depression.PMID:38359796 | DOI:10.1016/j.chom.2024.01.006 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Jordi Mayneris-Perxachs Anna Castells-Nobau Jos é Manuel Fernández-Real Source Type: research
A pathway linking atopic dermatitis to skin microbes
Cell Host Microbe. 2024 Feb 14;32(2):154-155. doi: 10.1016/j.chom.2024.01.009.ABSTRACTInteractions between microbiota and host skin have an important impact on cutaneous immunity and inflammation. In this issue of Cell Host & Microbe, Cha et al. report that skin commensal bacteria-mediated priming of group 2 innate lymphoid cells in early life predisposes the mice to atopic dermatitis-like inflammation in adulthood.PMID:38359797 | DOI:10.1016/j.chom.2024.01.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Jinfang Zhu Source Type: research
Susceptible bacteria "can" survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance
Cell Host Microbe. 2024 Feb 6:S1931-3128(24)00016-7. doi: 10.1016/j.chom.2024.01.012. Online ahead of print.ABSTRACTAntibiotic resistance and evasion are incompletely understood and complicated by the fact that murine interval dosing models do not fully recapitulate antibiotic pharmacokinetics in humans. To better understand how gastrointestinal bacteria respond to antibiotics, we colonized germ-free mice with a pan-susceptible genetically barcoded Escherichia coli clinical isolate and administered the antibiotic cefepime via programmable subcutaneous pumps, allowing closer emulation of human parenteral antibiotic dynamics...
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Marinelle Rodrigues Parastoo Sabaeifard Muhammed Sadik Yildiz Adam Lyon Laura Coughlin Sara Ahmed Nicole Poulides Ahmet C Toprak Cassie Behrendt Xiaoyu Wang Marguerite Monogue Jiwoong Kim Shuheng Gan Xiaowei Zhan Laura Filkins Noelle S Williams Lora V Hoo Source Type: research
Designing microbial communities to starve out invading pathogens
Cell Host Microbe. 2024 Feb 14;32(2):145-146. doi: 10.1016/j.chom.2024.01.008.ABSTRACTIdentifying key features required for specific community-level functions can be challenging, especially considering the complexity of the gut microbiome. In a recent study in Science, Spragge et al. present a high-throughput experimental framework to rationally design microbial communities that can resist invasion by specific bacterial pathogens.PMID:38359793 | DOI:10.1016/j.chom.2024.01.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Melissa Ellermann Source Type: research
Arming up against Omicron subvariants
Cell Host Microbe. 2024 Feb 14;32(2):147-148. doi: 10.1016/j.chom.2024.01.010.ABSTRACTThe rapid evolution of COVID-19 Omicron variants is driven by evasion of neutralizing antibodies. Breakthrough infections are common, even in highly vaccinated populations, making it vital to understand immune cross-protective repertoires to variants. Two studies in this issue show that the primed T cell repertoire comprises strong cross-recognition of current variants.PMID:38359794 | DOI:10.1016/j.chom.2024.01.010 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Daniel M Altmann Rosemary J Boyton Source Type: research
Milk to mucus: How B. fragilis colonizes the gut
Cell Host Microbe. 2024 Feb 14;32(2):149-150. doi: 10.1016/j.chom.2024.01.007.ABSTRACTHuman milk oligosaccharide (HMO) consumption by the infant microbiota is positively associated with immune health. In this issue of Cell Host & Microbe, Buzun et al. report a mechanism for HMO digestion by Bacteroides fragilis and demonstrate how the same pathway works on intestinal mucus to establish long-term gut residency.PMID:38359795 | DOI:10.1016/j.chom.2024.01.007 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Matthew R Olm Noel T Mueller Source Type: research
"Indole-gence" for the mind
Cell Host Microbe. 2024 Feb 14;32(2):151-153. doi: 10.1016/j.chom.2024.01.006.ABSTRACTSurging depression rates highlight the need for innovative strategies beyond the traditional focus on the brain. In this issue of Cell Host & Microbe, Cheng et al. uncover a role for the gut microbiota in depression through the intestinal receptor Grp35 and indole pathway, offering hope in fighting against depression.PMID:38359796 | DOI:10.1016/j.chom.2024.01.006 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Jordi Mayneris-Perxachs Anna Castells-Nobau Jos é Manuel Fernández-Real Source Type: research
