tHIS way to cognitive development
Cell Host Microbe. 2023 Dec 13;31(12):1947-1949. doi: 10.1016/j.chom.2023.11.018.ABSTRACTThe effect of the microbiota-gut-brain axis on cognitive development in infancy is increasingly being scrutinized. In this issue of Cell Host & Microbe, Cerdó, Ruiz, and colleagues skillfully combine clinical and preclinical analyses, including a fecal transplantation experiment, to reveal associations between microbiota composition, cognitive scores, and histidine metabolism.PMID:38096785 | DOI:10.1016/j.chom.2023.11.018 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - December 14, 2023 Category: Microbiology Authors: Sylvie Rabot Source Type: research
Fiber-deficient diets reprogram the microbiota
Cell Host Microbe. 2023 Dec 13;31(12):1950-1951. doi: 10.1016/j.chom.2023.11.014.ABSTRACTExclusive enteral nutrition, a diet lacking fiber, is used to treat pediatric Crohn's disease. In this issue of Cell Host & Microbe, Kuffa et al. find that a fiber-deficient diet thins the mucus layer and alters microbial cross-feeding, causing pro-inflammatory Mucispirillum to move away from the epithelium, which ameliorates colitis.PMID:38096786 | DOI:10.1016/j.chom.2023.11.014 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - December 14, 2023 Category: Microbiology Authors: Bradley G Fitzgerald Matthew T Sorbara Source Type: research
"AHR-ming" host defense against cryptosporidiosis
Cell Host Microbe. 2023 Dec 13;31(12):1952-1953. doi: 10.1016/j.chom.2023.11.019.ABSTRACTGlobally, cryptosporidiosis is a leading cause of childhood diarrheal disease and is a major risk factor for malnutrition and impairment of growth and cognitive development. In this issue of Cell Host & Microbe, Maradana et al. identify a target for dietary enhancement of innate immune defenses against cryptosporidiosis.PMID:38096787 | DOI:10.1016/j.chom.2023.11.019 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - December 14, 2023 Category: Microbiology Authors: Jojo Reyes George S Yap Source Type: research
Walking down the phosphorylation path to root immunity
Cell Host Microbe. 2023 Dec 13;31(12):1953-1955. doi: 10.1016/j.chom.2023.11.013.ABSTRACTPathogen perception in plant roots is under-explored compared to that in shoots. In this issue of Cell Host & Microbe, Wang et al. characterize the phosphorylation-mediated signaling pathway that positively and negatively regulates plant resistance to bacterial wilt disease upon perception of a metabolite from the soil-borne vascular pathogen Ralstonia solanacearum.PMID:38096788 | DOI:10.1016/j.chom.2023.11.013 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - December 14, 2023 Category: Microbiology Authors: Alberto P Macho Source Type: research
It takes a plant village to raise a microbiome
Cell Host Microbe. 2023 Dec 13;31(12):1956-1958. doi: 10.1016/j.chom.2023.11.009.ABSTRACTIn this issue of Cell Host and Microbe, Meyer et al. explore the effects of host history on the inheritance of the plant microbiome. They find that transmission from the same plant species resulted in microbiota specialization, while transmission from a different species resulted in host generalism.PMID:38096789 | DOI:10.1016/j.chom.2023.11.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - December 14, 2023 Category: Microbiology Authors: Melissa Y Chen Cara H Haney Source Type: research
Vivax malaria and Duffy antigen: Stop being so negative
Cell Host Microbe. 2023 Dec 13;31(12):1959-1960. doi: 10.1016/j.chom.2023.11.017.ABSTRACTDuffy blood group antigen (Duffy antigen/receptor for chemokines, atypical chemokine receptor-1, Duffy antigen), an essential Plasmodium vivax invasion receptor, is absent in most Africans. In this issue, two papers show erythroid precursors from Duffy-negative individuals transiently surface-express Duffy antigen and support vivax infection, potentially explaining low-density vivax infections across Africa.PMID:38096790 | DOI:10.1016/j.chom.2023.11.017 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - December 14, 2023 Category: Microbiology Authors: Patrick E Duffy Karthigayan Gunalan Louis H Miller Source Type: research
Infant gut DNA bacteriophage strain persistence during the first 3 years of life
Cell Host Microbe. 2023 Dec 5:S1931-3128(23)00466-3. doi: 10.1016/j.chom.2023.11.015. Online ahead of print.ABSTRACTBacteriophages are key components of gut microbiomes, yet the phage colonization process in the infant gut remains uncertain. Here, we establish a large phage sequence database and use strain-resolved analyses to investigate DNA phage succession in infants throughout the first 3 years of life. Analysis of 819 fecal metagenomes collected from 28 full-term and 24 preterm infants and their mothers revealed that early-life phageome richness increases over time and reaches adult-like complexity by age 3. Approxima...
Source: Cell Host and Microbe - December 14, 2023 Category: Microbiology Authors: Yue Clare Lou LinXing Chen Adair L Borges Jacob West-Roberts Brian A Firek Michael J Morowitz Jillian F Banfield Source Type: research
Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma
Cell Host Microbe. 2023 Dec 8:S1931-3128(23)00461-4. doi: 10.1016/j.chom.2023.11.011. Online ahead of print.ABSTRACTTimely liver function recovery (LFR) is crucial for postoperative hepatocellular carcinoma (HCC) patients. Here, we established the significance of LFR on patient long-term survival through retrospective and prospective cohorts and identified a key gut microbe, Bifidobacterium longum, depleted in patients with delayed recovery. Fecal microbiota transfer from HCC patients with delayed recovery to mice similarly impacted recovery time post hepatectomy. However, oral gavage of B. longum improved liver function a...
Source: Cell Host and Microbe - December 13, 2023 Category: Microbiology Authors: Jingjing Yu Peng Zhu Linlin Shi Na Gao Yani Li Chang Shu Ying Xu Ying Yu Junqing He Dingming Guo Xiaoman Zhang Xiangfeng Wang Sirui Shao Wei Dong Yuwei Wang Wei Zhang Wanguang Zhang Wei-Hua Chen Xiaoping Chen Zhi Liu Xiangliang Yang Bixiang Zhang Source Type: research
Bifidobacterium longum promotes postoperative liver function recovery in patients with hepatocellular carcinoma
Cell Host Microbe. 2023 Dec 8:S1931-3128(23)00461-4. doi: 10.1016/j.chom.2023.11.011. Online ahead of print.ABSTRACTTimely liver function recovery (LFR) is crucial for postoperative hepatocellular carcinoma (HCC) patients. Here, we established the significance of LFR on patient long-term survival through retrospective and prospective cohorts and identified a key gut microbe, Bifidobacterium longum, depleted in patients with delayed recovery. Fecal microbiota transfer from HCC patients with delayed recovery to mice similarly impacted recovery time post hepatectomy. However, oral gavage of B. longum improved liver function a...
Source: Cell Host and Microbe - December 13, 2023 Category: Microbiology Authors: Jingjing Yu Peng Zhu Linlin Shi Na Gao Yani Li Chang Shu Ying Xu Ying Yu Junqing He Dingming Guo Xiaoman Zhang Xiangfeng Wang Sirui Shao Wei Dong Yuwei Wang Wei Zhang Wanguang Zhang Wei-Hua Chen Xiaoping Chen Zhi Liu Xiangliang Yang Bixiang Zhang Source Type: research
Pre-existing SARS-2-specific T cells are predicted to cross-recognize BA.2.86
Cell Host Microbe. 2023 Dec 1:S1931-3128(23)00460-2. doi: 10.1016/j.chom.2023.11.010. Online ahead of print.ABSTRACTEffective monitoring of evolving SARS-CoV-2 variants requires understanding the potential effect of mutations on immune evasion. Here, we predicted the impact of BA.2.86-associated mutations on SARS-CoV-2-specific T cell responses. First, evaluating the effect on known experimentally defined T cell epitopes, we found that 72% and 89% of the total SARS-CoV-2 CD4 and CD8 responses were 100% conserved, with lower rates (56% and 72%) for just spike, a major structural protein. Among the mutated spike epitopes, ho...
Source: Cell Host and Microbe - December 9, 2023 Category: Microbiology Authors: Alessandro Sette John Sidney Alba Grifoni Source Type: research
Pre-existing SARS-2-specific T cells are predicted to cross-recognize BA.2.86
Cell Host Microbe. 2023 Dec 1:S1931-3128(23)00460-2. doi: 10.1016/j.chom.2023.11.010. Online ahead of print.ABSTRACTEffective monitoring of evolving SARS-CoV-2 variants requires understanding the potential effect of mutations on immune evasion. Here, we predicted the impact of BA.2.86-associated mutations on SARS-CoV-2-specific T cell responses. First, evaluating the effect on known experimentally defined T cell epitopes, we found that 72% and 89% of the total SARS-CoV-2 CD4 and CD8 responses were 100% conserved, with lower rates (56% and 72%) for just spike, a major structural protein. Among the mutated spike epitopes, ho...
Source: Cell Host and Microbe - December 9, 2023 Category: Microbiology Authors: Alessandro Sette John Sidney Alba Grifoni Source Type: research
Pre-existing SARS-2-specific T cells are predicted to cross-recognize BA.2.86
Cell Host Microbe. 2023 Dec 1:S1931-3128(23)00460-2. doi: 10.1016/j.chom.2023.11.010. Online ahead of print.ABSTRACTEffective monitoring of evolving SARS-CoV-2 variants requires understanding the potential effect of mutations on immune evasion. Here, we predicted the impact of BA.2.86-associated mutations on SARS-CoV-2-specific T cell responses. First, evaluating the effect on known experimentally defined T cell epitopes, we found that 72% and 89% of the total SARS-CoV-2 CD4 and CD8 responses were 100% conserved, with lower rates (56% and 72%) for just spike, a major structural protein. Among the mutated spike epitopes, ho...
Source: Cell Host and Microbe - December 9, 2023 Category: Microbiology Authors: Alessandro Sette John Sidney Alba Grifoni Source Type: research
Duffy antigen is expressed during erythropoiesis in Duffy-negative individuals
This study provides evidence that Fy is expressed in Fy-negative individuals and explains their susceptibility to P. vivax with major implications and challenges for P. vivax malaria eradication.PMID:38056457 | DOI:10.1016/j.chom.2023.10.019 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - December 6, 2023 Category: Microbiology Authors: Celia Dechavanne Sebastien Dechavanne J ürgen Bosch Sylvain Metral Karli R Redinger Quentin D Watson Arsene C Ratsimbasoa Brooke Roeper Sushma Krishnan Rich Fong Seth Bennett Lenore Carias Edwin Chen Nichole D Salinas Anil Ghosh Niraj H Tolia Philip G Wo Source Type: research
Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism
Cell Host Microbe. 2023 Dec 1:S1931-3128(23)00456-0. doi: 10.1016/j.chom.2023.11.006. Online ahead of print.ABSTRACTAcetaminophen overuse is a common cause of acute liver failure (ALF). During ALF, toxins are metabolized by enzymes such as CYP2E1 and transformed into reactive species, leading to oxidative damage and liver failure. Here, we found that oral magnesium (Mg) alleviated acetaminophen-induced ALF through metabolic changes in gut microbiota that inhibit CYP2E1. The gut microbiota from Mg-supplemented humans prevented acetaminophen-induced ALF in mice. Mg exposure modulated Bifidobacterium metabolism and enriched i...
Source: Cell Host and Microbe - December 6, 2023 Category: Microbiology Authors: Dongping Li Yu Chen Meijuan Wan Fengyi Mei Fangzhao Wang Peng Gu Xianglong Zhang Rongjuan Wei Yunong Zeng Hanzhao Zheng Bangguo Chen Qingquan Xiong Tao Xue Tianshan Guan Jiayin Guo Yuanxin Tian Li-Yan Zeng Zhanguo Liu Hang Yuan Ling Yang Hongbin Liu Lei D Source Type: research
Bacteroides methylmalonyl-CoA mutase produces propionate that promotes intestinal goblet cell differentiation and homeostasis
Cell Host Microbe. 2023 Dec 1:S1931-3128(23)00455-9. doi: 10.1016/j.chom.2023.11.005. Online ahead of print.ABSTRACTPropionate is a short-chain fatty acid that is generated upon microbiome-mediated fiber fermentation in the intestine. By modulating immune and metabolic pathways, propionate exerts many health benefits. Key bacterial species, such as Bacteroides thetaiotaomicron, generate propionate, but the biochemical pathways and specific functions remain undetermined. We identified a gene operon-encoding methylmalonyl-CoA mutase (MCM) that contributes to propionate biosynthesis in B. thetaiotaomicron. Colonization of ger...
Source: Cell Host and Microbe - December 6, 2023 Category: Microbiology Authors: Xingyu Wang Zhongle Cai Qiaoling Wang Chao Wu Yingkai Sun Zhifeng Wang Xiaoqiang Xu Wenzhi Xue Zhiwen Cao Minchun Zhang Yinmeng Zhu Huibin Lin Yi Zhang Mingyang Yuan Yuxiao Zhao Aibo Gao Yuqiang Yu Yufang Bi Guang Ning Weiqing Wang Jiqiu Wang Ruixin Liu Source Type: research
