"Indole-gence" for the mind
Cell Host Microbe. 2024 Feb 14;32(2):151-153. doi: 10.1016/j.chom.2024.01.006.ABSTRACTSurging depression rates highlight the need for innovative strategies beyond the traditional focus on the brain. In this issue of Cell Host & Microbe, Cheng et al. uncover a role for the gut microbiota in depression through the intestinal receptor Grp35 and indole pathway, offering hope in fighting against depression.PMID:38359796 | DOI:10.1016/j.chom.2024.01.006 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Jordi Mayneris-Perxachs Anna Castells-Nobau Jos é Manuel Fernández-Real Source Type: research
A pathway linking atopic dermatitis to skin microbes
Cell Host Microbe. 2024 Feb 14;32(2):154-155. doi: 10.1016/j.chom.2024.01.009.ABSTRACTInteractions between microbiota and host skin have an important impact on cutaneous immunity and inflammation. In this issue of Cell Host & Microbe, Cha et al. report that skin commensal bacteria-mediated priming of group 2 innate lymphoid cells in early life predisposes the mice to atopic dermatitis-like inflammation in adulthood.PMID:38359797 | DOI:10.1016/j.chom.2024.01.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Jinfang Zhu Source Type: research
Susceptible bacteria "can" survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance
Cell Host Microbe. 2024 Feb 6:S1931-3128(24)00016-7. doi: 10.1016/j.chom.2024.01.012. Online ahead of print.ABSTRACTAntibiotic resistance and evasion are incompletely understood and complicated by the fact that murine interval dosing models do not fully recapitulate antibiotic pharmacokinetics in humans. To better understand how gastrointestinal bacteria respond to antibiotics, we colonized germ-free mice with a pan-susceptible genetically barcoded Escherichia coli clinical isolate and administered the antibiotic cefepime via programmable subcutaneous pumps, allowing closer emulation of human parenteral antibiotic dynamics...
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Marinelle Rodrigues Parastoo Sabaeifard Muhammed Sadik Yildiz Adam Lyon Laura Coughlin Sara Ahmed Nicole Poulides Ahmet C Toprak Cassie Behrendt Xiaoyu Wang Marguerite Monogue Jiwoong Kim Shuheng Gan Xiaowei Zhan Laura Filkins Noelle S Williams Lora V Hoo Source Type: research
Designing microbial communities to starve out invading pathogens
Cell Host Microbe. 2024 Feb 14;32(2):145-146. doi: 10.1016/j.chom.2024.01.008.ABSTRACTIdentifying key features required for specific community-level functions can be challenging, especially considering the complexity of the gut microbiome. In a recent study in Science, Spragge et al. present a high-throughput experimental framework to rationally design microbial communities that can resist invasion by specific bacterial pathogens.PMID:38359793 | DOI:10.1016/j.chom.2024.01.008 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Melissa Ellermann Source Type: research
Arming up against Omicron subvariants
Cell Host Microbe. 2024 Feb 14;32(2):147-148. doi: 10.1016/j.chom.2024.01.010.ABSTRACTThe rapid evolution of COVID-19 Omicron variants is driven by evasion of neutralizing antibodies. Breakthrough infections are common, even in highly vaccinated populations, making it vital to understand immune cross-protective repertoires to variants. Two studies in this issue show that the primed T cell repertoire comprises strong cross-recognition of current variants.PMID:38359794 | DOI:10.1016/j.chom.2024.01.010 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Daniel M Altmann Rosemary J Boyton Source Type: research
Milk to mucus: How B. fragilis colonizes the gut
Cell Host Microbe. 2024 Feb 14;32(2):149-150. doi: 10.1016/j.chom.2024.01.007.ABSTRACTHuman milk oligosaccharide (HMO) consumption by the infant microbiota is positively associated with immune health. In this issue of Cell Host & Microbe, Buzun et al. report a mechanism for HMO digestion by Bacteroides fragilis and demonstrate how the same pathway works on intestinal mucus to establish long-term gut residency.PMID:38359795 | DOI:10.1016/j.chom.2024.01.007 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Matthew R Olm Noel T Mueller Source Type: research
"Indole-gence" for the mind
Cell Host Microbe. 2024 Feb 14;32(2):151-153. doi: 10.1016/j.chom.2024.01.006.ABSTRACTSurging depression rates highlight the need for innovative strategies beyond the traditional focus on the brain. In this issue of Cell Host & Microbe, Cheng et al. uncover a role for the gut microbiota in depression through the intestinal receptor Grp35 and indole pathway, offering hope in fighting against depression.PMID:38359796 | DOI:10.1016/j.chom.2024.01.006 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Jordi Mayneris-Perxachs Anna Castells-Nobau Jos é Manuel Fernández-Real Source Type: research
A pathway linking atopic dermatitis to skin microbes
Cell Host Microbe. 2024 Feb 14;32(2):154-155. doi: 10.1016/j.chom.2024.01.009.ABSTRACTInteractions between microbiota and host skin have an important impact on cutaneous immunity and inflammation. In this issue of Cell Host & Microbe, Cha et al. report that skin commensal bacteria-mediated priming of group 2 innate lymphoid cells in early life predisposes the mice to atopic dermatitis-like inflammation in adulthood.PMID:38359797 | DOI:10.1016/j.chom.2024.01.009 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Jinfang Zhu Source Type: research
Susceptible bacteria "can" survive antibiotic treatment in the mammalian gastrointestinal tract without evolving resistance
Cell Host Microbe. 2024 Feb 6:S1931-3128(24)00016-7. doi: 10.1016/j.chom.2024.01.012. Online ahead of print.ABSTRACTAntibiotic resistance and evasion are incompletely understood and complicated by the fact that murine interval dosing models do not fully recapitulate antibiotic pharmacokinetics in humans. To better understand how gastrointestinal bacteria respond to antibiotics, we colonized germ-free mice with a pan-susceptible genetically barcoded Escherichia coli clinical isolate and administered the antibiotic cefepime via programmable subcutaneous pumps, allowing closer emulation of human parenteral antibiotic dynamics...
Source: Cell Host and Microbe - February 15, 2024 Category: Microbiology Authors: Marinelle Rodrigues Parastoo Sabaeifard Muhammed Sadik Yildiz Adam Lyon Laura Coughlin Sara Ahmed Nicole Poulides Ahmet C Toprak Cassie Behrendt Xiaoyu Wang Marguerite Monogue Jiwoong Kim Shuheng Gan Xiaowei Zhan Laura Filkins Noelle S Williams Lora V Hoo Source Type: research
The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers
In this study, we assess whether SYNB1353, an E. coli Nissle 1917 derivative, impacts circulating methionine and homocysteine levels in animals and healthy volunteers. In both mice and nonhuman primates (NHPs), SYNB1353 blunts the appearance of plasma methionine and plasma homocysteine in response to an oral methionine load. A phase 1 clinical study conducted in healthy volunteers subjected to an oral methionine challenge demonstrates that SYNB1353 is well tolerated and blunts plasma methionine by 26%. Overall, SYNB1353 represents a promising approach for methionine reduction with potential utility for the treatment of HCU...
Source: Cell Host and Microbe - February 3, 2024 Category: Microbiology Authors: Myl ène Perreault Jillian Means Erik Gerson Michael James Sean Cotton Christopher G Bergeron Mark Simon Dylan Alexander Carlin Nathan Schmidt Theodore C Moore Julie Blasbalg Neal Sondheimer Kenneth Ndugga-Kabuye William S Denney Vincent M Isabella David Source Type: research
DGK5 β-derived phosphatidic acid regulates ROS production in plant immunity by stabilizing NADPH oxidase
Cell Host Microbe. 2024 Feb 2:S1931-3128(24)00015-5. doi: 10.1016/j.chom.2024.01.011. Online ahead of print.ABSTRACTIn plant immunity, phosphatidic acid (PA) regulates reactive oxygen species (ROS) by binding to respiratory burst oxidase homolog D (RBOHD), an NADPH oxidase responsible for ROS production. Here, we analyze the influence of PA binding on RBOHD activity and the mechanism of RBOHD-bound PA generation. PA binding enhances RBOHD protein stability by inhibiting vacuolar degradation, thereby increasing chitin-induced ROS production. Mutations in diacylglycerol kinase 5 (DGK5), which phosphorylates diacylglycerol to...
Source: Cell Host and Microbe - February 3, 2024 Category: Microbiology Authors: Fan Qi Jianwei Li Yingfei Ai Keke Shangguan Ping Li Fucheng Lin Yan Liang Source Type: research
Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site
Cell Host Microbe. 2024 Feb 14;32(2):261-275.e4. doi: 10.1016/j.chom.2024.01.003. Epub 2024 Feb 1.ABSTRACTHemagglutinins (HAs) from human influenza viruses descend from avian progenitors that bind α2-3-linked sialosides and must adapt to glycans with α2-6-linked sialic acids on human airway cells to transmit within the human population. Since their introduction during the 1968 pandemic, H3N2 viruses have evolved over the past five decades to preferentially recognize human α2-6-sialoside receptors that are elongated through addition of poly-LacNAc. We show that more recent H3N2 viruses now make increasingly complex inter...
Source: Cell Host and Microbe - February 2, 2024 Category: Microbiology Authors: Andrew J Thompson Nicholas C Wu Angeles Canales Chika Kikuchi Xueyong Zhu Beatriz Fern ández de Toro Francisco J Ca ñada Charli Worth Shengyang Wang Ryan McBride Wenjie Peng Corwin M Nycholat Jes ús Jiménez-Barbero Ian A Wilson James C Paulson Source Type: research
Anaerobic respiration of host-derived methionine sulfoxide protects intracellular Salmonella from the phagocyte NADPH oxidase
Cell Host Microbe. 2024 Jan 24:S1931-3128(24)00008-8. doi: 10.1016/j.chom.2024.01.004. Online ahead of print.ABSTRACTIntracellular Salmonella experiencing oxidative stress downregulates aerobic respiration. To maintain cellular energetics during periods of oxidative stress, intracellular Salmonella must utilize terminal electron acceptors of lower energetic value than molecular oxygen. We show here that intracellular Salmonella undergoes anaerobic respiration during adaptation to the respiratory burst of the phagocyte NADPH oxidase in macrophages and in mice. Reactive oxygen species generated by phagocytes oxidize methioni...
Source: Cell Host and Microbe - February 2, 2024 Category: Microbiology Authors: Ju-Sim Kim Lin Liu Sashi Kant David J Orlicky Siva Uppalapati Alyssa Margolis Bennett J Davenport Thomas E Morrison Jennifer Matsuda Michael McClelland Jessica Jones-Carson Andres Vazquez-Torres Source Type: research
Intestinal microbiota programming of alveolar macrophages influences severity of respiratory viral infection
Cell Host Microbe. 2024 Jan 23:S1931-3128(24)00006-4. doi: 10.1016/j.chom.2024.01.002. Online ahead of print.ABSTRACTSusceptibility to respiratory virus infections (RVIs) varies widely across individuals. Because the gut microbiome impacts immune function, we investigated the influence of intestinal microbiota composition on RVI and determined that segmented filamentous bacteria (SFB), naturally acquired or exogenously administered, protected mice against influenza virus (IAV) infection. Such protection, which also applied to respiratory syncytial virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was ...
Source: Cell Host and Microbe - January 31, 2024 Category: Microbiology Authors: Vu L Ngo Carolin M Lieber Hae-Ji Kang Kaori Sakamoto Michal Kuczma Richard K Plemper Andrew T Gewirtz Source Type: research
Virological characteristics of the SARS-CoV-2 BA.2.86 variant
Cell Host Microbe. 2024 Feb 14;32(2):170-180.e12. doi: 10.1016/j.chom.2024.01.001. Epub 2024 Jan 26.ABSTRACTIn late 2023, several SARS-CoV-2 XBB descendants, notably EG.5.1, were predominant worldwide. However, a distinct SARS-CoV-2 lineage, the BA.2.86 variant, also emerged. BA.2.86 is phylogenetically distinct from other Omicron sublineages, accumulating over 30 amino acid mutations in its spike protein. Here, we examined the virological characteristics of the BA.2.86 variant. Our epidemic dynamics modeling suggested that the relative reproduction number of BA.2.86 is significantly higher than that of EG.5.1. Additionall...
Source: Cell Host and Microbe - January 27, 2024 Category: Microbiology Authors: Tomokazu Tamura Keita Mizuma Hesham Nasser Sayaka Deguchi Miguel Padilla-Blanco Yoshitaka Oda Keiya Uriu Jarel E M Tolentino Shuhei Tsujino Rigel Suzuki Isshu Kojima Naganori Nao Ryo Shimizu Lei Wang Masumi Tsuda Michael Jonathan Yusuke Kosugi Ziyi Guo Al Source Type: research
