Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial
Cell Host Microbe. 2023 Dec 12:S1931-3128(23)00471-7. doi: 10.1016/j.chom.2023.11.021. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is characterized by the presence of restricted/repetitive behaviors and social communication deficits. Because effective treatments for ASD remain elusive, novel therapeutic strategies are necessary. Preclinical studies show that L. reuteri selectively reversed social deficits in several models for ASD. Here, in a double-blind, randomized, placebo-controlled trial, we tested the effect of L. reuteri (a product containing a combination of strains ATCC-PTA-6475 and DSM-17938) in ...
Source: Cell Host and Microbe - December 19, 2023 Category: Microbiology Authors: Luigi Mazzone Sean W Dooling Elisabetta Volpe Mirko Uljarevi ć Jillian L Waters Andrea Sabatini Lucrezia Arturi Roberta Abate Assia Riccioni Martina Siracusano Marcela Pereira Lars Engstrand Fernanda Cristofori Domenico Adduce Ruggiero Francavilla Mauro Source Type: research
Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial
Cell Host Microbe. 2023 Dec 12:S1931-3128(23)00471-7. doi: 10.1016/j.chom.2023.11.021. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is characterized by the presence of restricted/repetitive behaviors and social communication deficits. Because effective treatments for ASD remain elusive, novel therapeutic strategies are necessary. Preclinical studies show that L. reuteri selectively reversed social deficits in several models for ASD. Here, in a double-blind, randomized, placebo-controlled trial, we tested the effect of L. reuteri (a product containing a combination of strains ATCC-PTA-6475 and DSM-17938) in ...
Source: Cell Host and Microbe - December 19, 2023 Category: Microbiology Authors: Luigi Mazzone Sean W Dooling Elisabetta Volpe Mirko Uljarevi ć Jillian L Waters Andrea Sabatini Lucrezia Arturi Roberta Abate Assia Riccioni Martina Siracusano Marcela Pereira Lars Engstrand Fernanda Cristofori Domenico Adduce Ruggiero Francavilla Mauro Source Type: research
Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial
Cell Host Microbe. 2023 Dec 12:S1931-3128(23)00471-7. doi: 10.1016/j.chom.2023.11.021. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is characterized by the presence of restricted/repetitive behaviors and social communication deficits. Because effective treatments for ASD remain elusive, novel therapeutic strategies are necessary. Preclinical studies show that L. reuteri selectively reversed social deficits in several models for ASD. Here, in a double-blind, randomized, placebo-controlled trial, we tested the effect of L. reuteri (a product containing a combination of strains ATCC-PTA-6475 and DSM-17938) in ...
Source: Cell Host and Microbe - December 19, 2023 Category: Microbiology Authors: Luigi Mazzone Sean W Dooling Elisabetta Volpe Mirko Uljarevi ć Jillian L Waters Andrea Sabatini Lucrezia Arturi Roberta Abate Assia Riccioni Martina Siracusano Marcela Pereira Lars Engstrand Fernanda Cristofori Domenico Adduce Ruggiero Francavilla Mauro Source Type: research
Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial
Cell Host Microbe. 2023 Dec 12:S1931-3128(23)00471-7. doi: 10.1016/j.chom.2023.11.021. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is characterized by the presence of restricted/repetitive behaviors and social communication deficits. Because effective treatments for ASD remain elusive, novel therapeutic strategies are necessary. Preclinical studies show that L. reuteri selectively reversed social deficits in several models for ASD. Here, in a double-blind, randomized, placebo-controlled trial, we tested the effect of L. reuteri (a product containing a combination of strains ATCC-PTA-6475 and DSM-17938) in ...
Source: Cell Host and Microbe - December 19, 2023 Category: Microbiology Authors: Luigi Mazzone Sean W Dooling Elisabetta Volpe Mirko Uljarevi ć Jillian L Waters Andrea Sabatini Lucrezia Arturi Roberta Abate Assia Riccioni Martina Siracusano Marcela Pereira Lars Engstrand Fernanda Cristofori Domenico Adduce Ruggiero Francavilla Mauro Source Type: research
Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial
Cell Host Microbe. 2023 Dec 12:S1931-3128(23)00471-7. doi: 10.1016/j.chom.2023.11.021. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is characterized by the presence of restricted/repetitive behaviors and social communication deficits. Because effective treatments for ASD remain elusive, novel therapeutic strategies are necessary. Preclinical studies show that L. reuteri selectively reversed social deficits in several models for ASD. Here, in a double-blind, randomized, placebo-controlled trial, we tested the effect of L. reuteri (a product containing a combination of strains ATCC-PTA-6475 and DSM-17938) in ...
Source: Cell Host and Microbe - December 19, 2023 Category: Microbiology Authors: Luigi Mazzone Sean W Dooling Elisabetta Volpe Mirko Uljarevi ć Jillian L Waters Andrea Sabatini Lucrezia Arturi Roberta Abate Assia Riccioni Martina Siracusano Marcela Pereira Lars Engstrand Fernanda Cristofori Domenico Adduce Ruggiero Francavilla Mauro Source Type: research
Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial
Cell Host Microbe. 2023 Dec 12:S1931-3128(23)00471-7. doi: 10.1016/j.chom.2023.11.021. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is characterized by the presence of restricted/repetitive behaviors and social communication deficits. Because effective treatments for ASD remain elusive, novel therapeutic strategies are necessary. Preclinical studies show that L. reuteri selectively reversed social deficits in several models for ASD. Here, in a double-blind, randomized, placebo-controlled trial, we tested the effect of L. reuteri (a product containing a combination of strains ATCC-PTA-6475 and DSM-17938) in ...
Source: Cell Host and Microbe - December 19, 2023 Category: Microbiology Authors: Luigi Mazzone Sean W Dooling Elisabetta Volpe Mirko Uljarevi ć Jillian L Waters Andrea Sabatini Lucrezia Arturi Roberta Abate Assia Riccioni Martina Siracusano Marcela Pereira Lars Engstrand Fernanda Cristofori Domenico Adduce Ruggiero Francavilla Mauro Source Type: research
Precision microbial intervention improves social behavior but not autism severity: A pilot double-blind randomized placebo-controlled trial
Cell Host Microbe. 2023 Dec 12:S1931-3128(23)00471-7. doi: 10.1016/j.chom.2023.11.021. Online ahead of print.ABSTRACTAutism spectrum disorder (ASD) is characterized by the presence of restricted/repetitive behaviors and social communication deficits. Because effective treatments for ASD remain elusive, novel therapeutic strategies are necessary. Preclinical studies show that L. reuteri selectively reversed social deficits in several models for ASD. Here, in a double-blind, randomized, placebo-controlled trial, we tested the effect of L. reuteri (a product containing a combination of strains ATCC-PTA-6475 and DSM-17938) in ...
Source: Cell Host and Microbe - December 19, 2023 Category: Microbiology Authors: Luigi Mazzone Sean W Dooling Elisabetta Volpe Mirko Uljarevi ć Jillian L Waters Andrea Sabatini Lucrezia Arturi Roberta Abate Assia Riccioni Martina Siracusano Marcela Pereira Lars Engstrand Fernanda Cristofori Domenico Adduce Ruggiero Francavilla Mauro Source Type: research
Plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection
Cell Host Microbe. 2023 Dec 13:S1931-3128(23)00470-5. doi: 10.1016/j.chom.2023.11.020. Online ahead of print.ABSTRACTCross-kingdom small RNA trafficking between hosts and microbes modulates gene expression in the interacting partners during infection. However, whether other RNAs are also transferred is unclear. Here, we discover that host plant Arabidopsis thaliana delivers mRNAs via extracellular vesicles (EVs) into the fungal pathogen Botrytis cinerea. A fluorescent RNA aptamer reporter Broccoli system reveals host mRNAs in EVs and recipient fungal cells. Using translating ribosome affinity purification profiling and pol...
Source: Cell Host and Microbe - December 16, 2023 Category: Microbiology Authors: Shumei Wang Baoye He Huaitong Wu Qiang Cai Obed Ram írez-Sánchez Cei Abreu-Goodger Paul R J Birch Hailing Jin Source Type: research
Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection
Cell Host Microbe. 2023 Dec 9:S1931-3128(23)00465-1. doi: 10.1016/j.chom.2023.11.016. Online ahead of print.ABSTRACTMetabolites produced by the intestinal microbiome modulate mucosal immune defenses and optimize epithelial barrier function. Intestinal dysbiosis, including loss of intestinal microbiome diversity and expansion of antibiotic-resistant pathobionts, is accompanied by changes in fecal metabolite concentrations and increased incidence of systemic infection. Laboratory tests that quantify intestinal dysbiosis, however, have yet to be incorporated into clinical practice. We quantified fecal metabolites in 107 patie...
Source: Cell Host and Microbe - December 16, 2023 Category: Microbiology Authors: Christopher J Lehmann Nicholas P Dylla Matthew Odenwald Ravi Nayak Maryam Khalid Jaye Boissiere Jackelyn Cantoral Emerald Adler Matthew R Stutz Mark Dela Cruz Angelica Moran Huaiying Lin Ramanujam Ramaswamy Anitha Sundararajan Ashley M Sidebottom Jessica Source Type: research
Plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection
Cell Host Microbe. 2023 Dec 13:S1931-3128(23)00470-5. doi: 10.1016/j.chom.2023.11.020. Online ahead of print.ABSTRACTCross-kingdom small RNA trafficking between hosts and microbes modulates gene expression in the interacting partners during infection. However, whether other RNAs are also transferred is unclear. Here, we discover that host plant Arabidopsis thaliana delivers mRNAs via extracellular vesicles (EVs) into the fungal pathogen Botrytis cinerea. A fluorescent RNA aptamer reporter Broccoli system reveals host mRNAs in EVs and recipient fungal cells. Using translating ribosome affinity purification profiling and pol...
Source: Cell Host and Microbe - December 16, 2023 Category: Microbiology Authors: Shumei Wang Baoye He Huaitong Wu Qiang Cai Obed Ram írez-Sánchez Cei Abreu-Goodger Paul R J Birch Hailing Jin Source Type: research
Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection
Cell Host Microbe. 2023 Dec 9:S1931-3128(23)00465-1. doi: 10.1016/j.chom.2023.11.016. Online ahead of print.ABSTRACTMetabolites produced by the intestinal microbiome modulate mucosal immune defenses and optimize epithelial barrier function. Intestinal dysbiosis, including loss of intestinal microbiome diversity and expansion of antibiotic-resistant pathobionts, is accompanied by changes in fecal metabolite concentrations and increased incidence of systemic infection. Laboratory tests that quantify intestinal dysbiosis, however, have yet to be incorporated into clinical practice. We quantified fecal metabolites in 107 patie...
Source: Cell Host and Microbe - December 16, 2023 Category: Microbiology Authors: Christopher J Lehmann Nicholas P Dylla Matthew Odenwald Ravi Nayak Maryam Khalid Jaye Boissiere Jackelyn Cantoral Emerald Adler Matthew R Stutz Mark Dela Cruz Angelica Moran Huaiying Lin Ramanujam Ramaswamy Anitha Sundararajan Ashley M Sidebottom Jessica Source Type: research
Plant mRNAs move into a fungal pathogen via extracellular vesicles to reduce infection
Cell Host Microbe. 2023 Dec 13:S1931-3128(23)00470-5. doi: 10.1016/j.chom.2023.11.020. Online ahead of print.ABSTRACTCross-kingdom small RNA trafficking between hosts and microbes modulates gene expression in the interacting partners during infection. However, whether other RNAs are also transferred is unclear. Here, we discover that host plant Arabidopsis thaliana delivers mRNAs via extracellular vesicles (EVs) into the fungal pathogen Botrytis cinerea. A fluorescent RNA aptamer reporter Broccoli system reveals host mRNAs in EVs and recipient fungal cells. Using translating ribosome affinity purification profiling and pol...
Source: Cell Host and Microbe - December 16, 2023 Category: Microbiology Authors: Shumei Wang Baoye He Huaitong Wu Qiang Cai Obed Ram írez-Sánchez Cei Abreu-Goodger Paul R J Birch Hailing Jin Source Type: research
Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection
Cell Host Microbe. 2023 Dec 9:S1931-3128(23)00465-1. doi: 10.1016/j.chom.2023.11.016. Online ahead of print.ABSTRACTMetabolites produced by the intestinal microbiome modulate mucosal immune defenses and optimize epithelial barrier function. Intestinal dysbiosis, including loss of intestinal microbiome diversity and expansion of antibiotic-resistant pathobionts, is accompanied by changes in fecal metabolite concentrations and increased incidence of systemic infection. Laboratory tests that quantify intestinal dysbiosis, however, have yet to be incorporated into clinical practice. We quantified fecal metabolites in 107 patie...
Source: Cell Host and Microbe - December 16, 2023 Category: Microbiology Authors: Christopher J Lehmann Nicholas P Dylla Matthew Odenwald Ravi Nayak Maryam Khalid Jaye Boissiere Jackelyn Cantoral Emerald Adler Matthew R Stutz Mark Dela Cruz Angelica Moran Huaiying Lin Ramanujam Ramaswamy Anitha Sundararajan Ashley M Sidebottom Jessica Source Type: research
Bacterial antigens unleash tumor-targeting immunity
Cell Host Microbe. 2023 Dec 13;31(12):1945-1947. doi: 10.1016/j.chom.2023.11.001.ABSTRACTThe composition of the gut microbiome has been shown to influence disease outcome in patients with colorectal cancer (CRC). In a recent Nature Biotechnology article, Wang et al. demonstrate that killing CRC-associated bacteria with a liposomal antibiotic elicits CRC-targeting immune responses of therapeutic relevance as a consequence of epitope mimicry.PMID:38096784 | DOI:10.1016/j.chom.2023.11.001 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - December 14, 2023 Category: Microbiology Authors: Nina Boeck Zlatko Trajanoski Lorenzo Galluzzi Source Type: research
tHIS way to cognitive development
Cell Host Microbe. 2023 Dec 13;31(12):1947-1949. doi: 10.1016/j.chom.2023.11.018.ABSTRACTThe effect of the microbiota-gut-brain axis on cognitive development in infancy is increasingly being scrutinized. In this issue of Cell Host & Microbe, Cerdó, Ruiz, and colleagues skillfully combine clinical and preclinical analyses, including a fecal transplantation experiment, to reveal associations between microbiota composition, cognitive scores, and histidine metabolism.PMID:38096785 | DOI:10.1016/j.chom.2023.11.018 (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - December 14, 2023 Category: Microbiology Authors: Sylvie Rabot Source Type: research
