Pathologic complete response in patients with esophageal cancer receiving neoadjuvant chemotherapy or chemoradiation: A systematic review and meta ‐analysis
ConclusionsUnder one-third of patients with esophageal cancer who receive neoadjuvant chemo(radiation) experience pCR. Patients diagnosed with squamous cell carcinomas had higher rates of pCR than those with adenocarcinomas. As pCR represents an increasingly utilized endpoint in neoadjuvant trials, these estimates of pooled pCR rates may serve as an important benchmark for future trial design. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Charles E. Gaber,
Jyotirmoy Sarker,
Abdullah I. Abdelaziz,
Ebere Okpara,
Todd A. Lee,
Samuel J. Klempner,
Ryan D. Nipp Tags: RESEARCH ARTICLE Source Type: research
Pivotal role of myeloid ‐derived suppressor cells in infection‐related tumor growth
ConclusionLong-lasting enhanced MDSCs associated with infection may contribute to infection-related tumor progression. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Nozomi Ito,
Hironori Tsujimoto,
Hiromi Miyazaki,
Risa Takahata,
Hideki Ueno Tags: RESEARCH ARTICLE Source Type: research
Mannitol versus furosemide in patients with thoracic malignancies who received cisplatin ‐based chemotherapy using short hydration: A randomized phase II trial
ConclusionsMannitol should remain the standard diuresis in CDDP-based chemotherapy assessed by conventional CTCAE grading, but furosemide can be room for consideration when assessed by actual serum Cr level and Cr clearance. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Eriko Murakami,
Hiroaki Akamatsu,
Shunsuke Teraoka,
Toshiaki Takakura,
Eri Takase,
Masanori Tanaka,
Takahiro Kaki,
Yuhei Harutani,
Katsuyuki Furuta,
Takeya Sugimoto,
Ryota Shibaki,
Daichi Fujimoto,
Atsushi Hayata,
Yuichi Ozawa,
Masanori Naka Tags: RESEARCH ARTICLE Source Type: research
An automatic parathyroid recognition and segmentation model based on deep learning of near ‐infrared autofluorescence imaging
ConclusionsThis AI model will help surgeons identify PGs, and develop their learning ability and self-confidence. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Fan Yu,
Tian Sang,
Jie Kang,
Xianzhao Deng,
Bomin Guo,
Hangzhou Yang,
Xiaoyi Chen,
Youben Fan,
Xuehai Ding,
Bo Wu Tags: RESEARCH ARTICLE Source Type: research
Treatments, prognostic factors, and genetic heterogeneity in advanced cholangiocarcinoma: A multicenter real ‐world study
ConclusionsAdvanced CCA displays aggressive clinical behavior, emphasizing the need for treatments beyond chemotherapy. Genetic diversity supports potential personalized therapies. Collaborative research and deeper CCA biology understanding are crucial to enhance patient outcomes in this challenging malignancy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Alessandro Ottaiano,
Mariachiara Santorsola,
Anna Diana,
Andrea Belli,
Maria Luisa Lentini Graziano,
Jessica Orefice,
Renato Patrone,
Annabella Di Mauro,
Giosuè Scognamiglio,
Fabiana Tatangelo,
Mario De Bellis,
Mauro Piccirillo,
Francesco Tags: RESEARCH ARTICLE Source Type: research
Quercetin ‐induced degradation of RhoC suppresses hepatocellular carcinoma invasion and metastasis
ConclusionsOur research has revealed the novel mechanisms quercetin regulates degradation of RhoC level by targeting SMURF2 and identified quercetin may be a potential compound for HCC therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Chunlong Huang,
Weihua Lai,
Shuai Mao,
Deli Song,
Jihong Zhang,
Xiao Xiao Tags: RESEARCH ARTICLE Source Type: research
Why is end ‐of‐life inpatient cost high among cancer patients? A prospective cohort study
ConclusionsFindings suggest that inpatient costs in last year of life may be reduced if maintenance care is availed in low-cost settings such as hospice/palliative care alongside steps to reduce non-beneficial surgeries and ICU admissions. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Ishwarya Balasubramanian,
Chetna Malhotra,
the COMPASS study group Tags: RESEARCH ARTICLE Source Type: research
Prescribing pre ‐ and post‐operative physical activity interventions for people undergoing breast cancer surgery: A qualitative systematic review
ConclusionPre- and post-operative physical activity interventions were well-accepted. Patients recognised factors which promoted or prevented engagement with interventions, as well as pre- and post-operative physical and psychological benefits that arose as a result. Evidence based co-design studies may further inform successful implementation of prescribed physical activity into standard care for surgical breast cancer patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Lauren Howe,
Andy Husband,
Anna Robinson ‐Barella Tags: REVIEW Source Type: research
Phenome ‐wide association study of ovarian cancer identifies common comorbidities and reveals shared genetics with complex diseases and biomarkers
ConclusionsOC is associated with digestive and respiratory comorbidities. Several variants affecting OC risk were associated with other diseases and biomarkers, with this study identifying a novel genetic locus shared between OC and skin conditions. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Anwar Mulugeta,
Amanda L. Lumsden,
Iqbal Madakkatel,
David Stacey,
S. Hong Lee,
Johanna M äenpää,
Martin K. Oehler,
Elina Hyppönen Tags: RESEARCH ARTICLE Source Type: research
Clinicopathological and genomic features of superficial esophageal squamous cell carcinomas in nondrinker, nonsmoker females
ConclusionOlder nondrinker, nonsmoker females with RE and fewer multiple LVLs may develop longitudinal 0-IIa ESCC with keratinization of the posterior wall of the mid-thoracic esophagus. ESCCs in nondrinker, nonsmoker females had fewerKMT2D alterations and moreCDKN2A alterations, which may be a biomarker for treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Motomitsu Fukuhara,
Yuji Urabe,
Hikaru Nakahara,
Akira Ishikawa,
Kazuki Ishibashi,
Hirona Konishi,
Junichi Mizuno,
Hidenori Tanaka,
Akiyoshi Tsuboi,
Ken Yamashita,
Yuichi Hiyama,
Hidehiko Takigawa,
Takahiro Kotachi,
Ryo Yuge,
C. Nelson Hayes Tags: RESEARCH ARTICLE Source Type: research
The generation of glioma organoids and the comparison of two culture methods
ConclusionThe success rates of the Matrigel and microtumor methods were 45.5% and 60.5%, respectively. The microtumor method had a higher success rate, shorter establishment time, more convenient passage and cryopreservation methods, better simulation of the cellular and histological characteristics of the parent tumor, and a high genetic guarantee. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Yang Zhang,
Yunxiang Shao,
Yanyan Li,
Xuetao Li,
Xuewen Zhang,
Qinzhi E,
Weichao Wang,
Zuoyu Jiang,
Wenjuan Gan,
Yulun Huang Tags: RESEARCH ARTICLE Source Type: research
Psoas muscle area is an independent survival prognosticator in patients undergoing surgery for long ‐bone metastases
ConclusionsDecreased PMA on CT is associated with worse survival in surgically treated patients with extremity metastases, even after controlling for three contemporary SPAs. Physicians should consider the additional prognostic value of PMA on survival in patients undergoing consideration for operative management due to extremity metastases. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Chia ‐Che Lee,
Ting‐En Tseng,
Ruey‐Feng Chang,
Hung‐Kuan Yen,
Yu‐An Chen,
Yu‐Yung Chen,
Chih‐Horng Wu,
Ming‐Hsiao Hu,
Mao‐Hsu Yen,
Michiel Bongers,
Olivier Q. Groot,
Cheng‐Yo Lai,
Wei‐Hsin Lin Tags: RESEARCH ARTICLE Source Type: research
Clinical utility of the Oncomine Dx Target Test multi ‐CDx system and the possibility of utilizing those original sequence data
ConclusionEven if sufficient tumor samples are obtained, rareEGFR mutations (which are excluded from the ODxTT's genetic mutation list) might not be detected using the current ODxTT system due to the program used for sequence analysis. However, such rareEGFR mutations can still be accurately detected on ODxTT's sequence data using next-generation sequencing. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Ayaka Saito,
Hideki Terai,
Tae ‐Jung Kim,
Katsura Emoto,
Ryutaro Kawano,
Kohei Nakamura,
Hideyuki Hayashi,
Hatsuyo Takaoka,
Akihiko Ogata,
Katsuhito Kinoshita,
Fumimaro Ito,
Lisa Shigematsu,
Masahiko Okada,
Takahiro Fukushima,
Akifumi Mits Tags: RESEARCH ARTICLE Source Type: research
Impact of measurable residual disease in combination with CD19 on postremission therapy choices for adult t(8;21) acute myeloid leukemia in first complete remission
ConclusionsMRD combined with CD19 might optimize PRT choices for adult t(8;21) AML patients in CR1. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Xi Jia,
Naying Liao,
Sijian Yu,
Huan Li,
Hui Liu,
Haiyan Zhang,
Jun Xu,
Yunqian Yao,
Han He,
Guopan Yu,
Qifa Liu,
Yu Zhang,
Pengcheng Shi Tags: RESEARCH ARTICLE Source Type: research
Laparoscopic liver resection versus radiofrequency ablation for caudate lobe solitary hepatocellular carcinoma: A propensity score matching study
ConclusionLLR should probably be recommended as the preferred method for solitary caudate lobe HCC. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Zhengzheng Wang,
Jingzhong Ouyang,
Binyang Jia,
Yanzhao Zhou,
Yi Yang,
Xiaoting Li,
Qingjun Li,
Jinxue Zhou Tags: RESEARCH ARTICLE Source Type: research
