Issue Information
(Source: Cancer Medicine)
Source: Cancer Medicine - March 28, 2024 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research
The feasibility and acceptability of an app ‐based intervention with brief behavioural support (APPROACH) to promote brisk walking in people diagnosed with breast, prostate and colorectal cancer in the UK
ConclusionsThis pilot study demonstrates that a large trial of the brisk walking intervention with behavioural support is both feasible and acceptable to people LWBC. The results support progression onto a confirmatory phase III trial to determine the efficacy and cost-effectiveness of the intervention. (Source: Cancer Medicine)
Source: Cancer Medicine - March 27, 2024 Category: Cancer & Oncology Authors: Phillippa Lally,
Fiona Kennedy,
Susan Smith,
Rebecca J. Beeken,
Caroline Buck,
Chloe Thomas,
Nicholas Counsell,
Lynda Wyld,
Charlene Martin,
Sarah Williams,
Anna Roberts,
Diana M. Greenfield,
Jacqui Gath,
Henry W. W. Potts,
Nicholas Latimer, Tags: RESEARCH ARTICLE Source Type: research
Prognostic significance of glucose ‐lipid metabolic index in pancreatic cancer patients with diabetes mellitus
ConclusionsIR is associated with the outcome of PC patients with diabetes and higher level of IR indicates worse prognosis. GLMI has a good predictive value for PC with diabetes. (Source: Cancer Medicine)
Source: Cancer Medicine - March 25, 2024 Category: Cancer & Oncology Authors: Hailiang Wang,
Shiye Ruan,
Zelong Wu,
Qian Yan,
Yubin Chen,
Jinwei Cui,
Zhongyan Zhang,
Shanzhou Huang,
Baohua Hou,
Chuanzhao Zhang Tags: RESEARCH ARTICLE Source Type: research
Retrospective analysis of clinical characteristics and outcomes of patients with carcinoma of unknown primary from three tertiary centers in Australia
ConclusionsIn this real-world cohort, CUP presentations were heterogenous. Overall survival and rates of systemic treatment were poor. Poor performance status and unfavorable risk were associated with worse survival. For most patients, site-specific therapy did not improve survival outcome. Improved and timely access to diagnostic tests and therapeutics for this group of patients is urgently required. (Source: Cancer Medicine)
Source: Cancer Medicine - March 25, 2024 Category: Cancer & Oncology Authors: Emma L. Boys,
Bo Gao,
Peter Grimison,
Sarah Sutherland,
Karen L. MacKenzie,
Roger R. Reddel,
Jia Liu Tags: RESEARCH ARTICLE Source Type: research
Nomogram for predicting pathological response to neoadjuvant treatment in patients with locally advanced gastric cancer: Data from a phase III clinical trial
ConclusionA good pathological response after neoadjuvant treatment was associated with an improved prognosis in LAGC patients. The nomogram we established exhibits a high predictive capability for GR, offering potential value in devising personalized and precise treatment strategies for LAGC patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 25, 2024 Category: Cancer & Oncology Authors: Han Shao,
Nai Li,
Yi ‐hong Ling,
Ji‐jin Wang,
Yi Fang,
Ming Jing,
Zhi‐wei Zhou,
Yu‐jing Zhang Tags: RESEARCH ARTICLE Source Type: research
Complete DPYD genotyping combined with dihydropyrimidine dehydrogenase phenotyping to prevent fluoropyrimidine toxicity: A retrospective study
ConclusionDue to insufficient numbers, our study was not able to demonstrate any added value ofDPYD genotyping using complete genome sequencing to prevent 5-FU toxicity. The optimal strategy for DPD screening before fluoropyrimidine-based chemotherapy requires further clinical evaluation. (Source: Cancer Medicine)
Source: Cancer Medicine - March 25, 2024 Category: Cancer & Oncology Authors: C ôme De Metz,
Benjamin Hennart,
Estelle Aymes,
Pierre‐Yves Cren,
Niels Martignène,
Nicolas Penel,
Maël Barthoulot,
Aurélien Carnot Tags: RESEARCH ARTICLE Source Type: research
Patterns of B ‐cell lymphocyte expression changes in pre‐ and post‐malignant prostate tissue are associated with prostate cancer progression
ConclusionsLongitudinal and spatial expression patterns of both CD3+ and CD20+ suggest that increased expression in benign glands during prostate carcinogenesis is associated with an aggressive disease course. (Source: Cancer Medicine)
Source: Cancer Medicine - March 25, 2024 Category: Cancer & Oncology Authors: Sudha M. Sadasivan,
Ian M. Loveless,
Yalei Chen,
Nilesh S. Gupta,
Ryan Sanii,
Kevin R. Bobbitt,
Dhananjay A. Chitale,
Sean R. Williamson,
Andrew G. Rundle,
Benjamin A. Rybicki Tags: RESEARCH ARTICLE Source Type: research
Physical function patient ‐reported outcomes among adolescent and young adult cancer survivors: A systematic review
ConclusionsThe results overwhelmingly demonstrate that AYAs post a cancer diagnosis have worse health-related quality of life from a physical function perspective than their cancer-free peers, providing a compelling argument for the need to address this issue. All but one of the studies were cross-sectional, which highlights the need for further assessment of this group longitudinally throughout their cancer journey. (Source: Cancer Medicine)
Source: Cancer Medicine - March 23, 2024 Category: Cancer & Oncology Authors: Sarah Tanner,
Teyl Engstrom,
Cheryl Forbes,
Dhaval Patel,
Wen Ray Lee,
Rick Walker,
Natalie Bradford,
Jason D. Pole Tags: REVIEW Source Type: research
Comparisons of financial hardship in cancer care by family structure and among those with and without minor children using nationally representative data
ConclusionsOur findings suggest that having minor children, and being a single adult are risk factors for cancer-related financial hardship. Financial vulnerability associated with family structure should be taken into consideration in healthcare, and especially cancer care. (Source: Cancer Medicine)
Source: Cancer Medicine - March 23, 2024 Category: Cancer & Oncology Authors: Patricia I. Jewett,
Himal Purani,
Rachel I. Vogel,
Helen M. Parsons,
Maria Borrero,
Anne Blaes Tags: RESEARCH ARTICLE Source Type: research
Retrospective analysis of real ‐world prescribing data for managing cisplatin‐based chemotherapy‐induced nausea and vomiting in China
ConclusionsThe current study reveals suboptimal utilization of recommended antiemetic drugs for managing cisplatin-based HEC-induced nausea and vomiting in China. Improving the management of CINV is crucial, and these findings provide valuable insights into optimizing antiemetic drug practices. (Source: Cancer Medicine)
Source: Cancer Medicine - March 22, 2024 Category: Cancer & Oncology Authors: Xia Si,
Hongyan Zhang,
Qingming Ding,
Gang Liu,
Lin Huang,
Xin Sun Tags: RESEARCH ARTICLE Source Type: research
MAIT cells are associated with responsiveness to neoadjuvant immunotherapy in COPD ‐associated NSCLC
ConclusionsIn patients with NSCLC and COPD, response to immunotherapy is associated with accumulation of CD8+ MAIT cells showing immune exhaustion. These findings may contribute to innovative approaches for immunotherapy targeting CD8+ MAIT cells. (Source: Cancer Medicine)
Source: Cancer Medicine - March 21, 2024 Category: Cancer & Oncology Authors: Yanze Yin,
Ao Zeng,
Abudumijiti Abuduwayiti,
Zhilong Xu,
Keyi Chen,
Chao Wang,
Xinyun Fang,
Jiarui Wang,
Gening Jiang,
Jie Dai Tags: RESEARCH ARTICLE Source Type: research
Comparison of clinical outcomes of several risk stratification tools in newly diagnosed AML patients: A real ‐world evidence in our current therapeutic era
ConclusionsUsing Akaike ’s information criteria (AIC) to compare all five classifiers, ELN 2022 is the best classifier into younger and older patients and for prognosis. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Alexandre Iat,
Michael Loschi,
Sami Benachour,
Anne Calleja,
Edmond Chiche,
Isabelle Sudaka,
Dani èle Aquaronne,
Corinne Ferrero,
Laurène Fenwarth,
Alice Marceau,
Elise Fournier,
Berengere Dadone‐Montaudie,
Thomas Cluzeau Tags: RESEARCH ARTICLE Source Type: research
Transcriptional profile and immune infiltration in colorectal cancer reveal the significance of inducible T ‐cell costimulator as a crucial immune checkpoint molecule
ConclusionICOS might serve as a robust immune checkpoint for prognosis with several genes being potential targets of ICOS-directed immunotherapy in CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Jian Chu,
Yinghang Wu,
Zhanbo Qu,
Jing Zhuang,
Jiang Liu,
Shugao Han,
Wei Wu,
Shuwen Han Tags: RESEARCH ARTICLE Source Type: research
“Better at home”: Mixed methods report of intricacies in pediatric febrile neutropenia management
ConclusionEarly discharge of LR FN episodes positively impacts QoL, yet risk-stratified management for FN is intricately complex. Optimal FN management should prioritize the patient's overall health; shared decision-making is recommended and can improve care delivery. These results should be confirmed in a larger, more heterogeneous population. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Eleanor T. Smeallie,
Sung W. Choi,
Rajen Mody,
Timothy C. Guetterman,
Charles N. Nessle Tags: RESEARCH ARTICLE Source Type: research
Body composition change indices combined with Prognostic Nutritional Index predicts the clinical outcomes of patients with gastric cancer treated with immune checkpoint inhibitor
ConclusionThe comprehensive consideration of PNI-SFA and PNI-SMI proved to be a superior prognostic predictor for GC patients undergoing ICI treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - March 20, 2024 Category: Cancer & Oncology Authors: Guiming Deng,
Dayong Zhu,
Zhongze Du,
Yingwei Xue,
Hongjiang Song,
Yuanzhou Li Tags: RESEARCH ARTICLE Source Type: research
