Added value of whole ‐exome and RNA sequencing in advanced and refractory cancer patients with no molecular‐based treatment recommendation based on a 90‐gene panel
ConclusionsIn advanced and refractory cancer patients in whom no MBTR was recommended from TGP/aCGH, WES/RNA-Seq allowed to identify more alterations which may in turn, in a limited fraction of patients, lead to new MBTR. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Armelle Dufresne,
Val éry Attignon,
Anthony Ferrari,
Laurie Tonon,
Sandrine Boyault,
Séverine Tabone‐Eglinger,
Philippe Cassier,
Olivier Trédan,
Nadège Corradini,
Armelle Vinceneux,
Aurélie Swalduz,
Alain Viari,
Sylvie Chabaud,
David P Tags: RESEARCH ARTICLE Source Type: research
Association of household net worth with healthcare costs after radical cystectomy using real ‐world data
ConclusionsLower HHNW conferred greater risk of costly inpatient encounters while greater HHNW had greater odds of less costly office visits, illustrating how financial flexibility fosters differences in healthcare utilization and lower costs. HHNW may serve as a proxy for financial flexibility and risk of financial hardship than income alone. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Samuel L. Washington III,
Peter E. Lonergan,
Anobel Y. Odisho,
Maxwell V. Meng,
Sima P. Porten Tags: RESEARCH ARTICLE Source Type: research
The quantitative parameters based on marrow metabolism derived from synthetic MRI: A pilot study of prognostic value in participants with newly diagnosed multiple myeloma
ConclusionsSynthetic MRI is a promising tool for predicting early treatment response to MM and promoting R-ISS II stage risk stratification. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Sha Cui,
Yinnan Guo,
Weiran Niu,
Jianting Li,
Wenjin Bian,
Wenqi Wu,
Wenjia Zhang,
Qian Zheng,
Jun Wang,
Jinliang Niu Tags: RESEARCH ARTICLE Source Type: research
Toxicity profiles of immune checkpoint inhibitors for recurrent or metastatic head and neck squamous cell carcinoma: A systematic review and meta ‐analysis
ConclusionsOur study suggests that the incidences of grade three or more trAEs, treatment-related deaths, and trAEs leading to discontinuation of treatment are low in R/M HNSCC patients treated with ICIs. PD-L1 inhibitors monotherapy may be safer compared with PD-1 inhibitors monotherapy and ICIs combination therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Shoutao Dang,
Xinyu Li,
Heshu Liu,
Shuyang Zhang,
Wei Li Tags: RESEARCH ARTICLE Source Type: research
Similar immune responses to alpha1 ‐oleate and Bacillus Calmette–Guérin treatment in patients with bladder cancer
ConclusionsThe cytokine response profile in alpha 1-oleate treated patients was similar to that reported in BCG treated patients, suggesting a significant overlap. A reduction in protein levels at the end of treatment coincided with inhibition of cancer-related gene expression in tissue biopsies, consistent with a positive treatment effect. Thus, in addition to killing tumor cells and inducing cell detachment, alpha 1-oleate is shown to activate a broad immune response with a protective potential. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Shahram Ahmadi,
Ines Ambite,
Anton ín Brisuda,
Jaromír Háček,
Farhan Haq,
Samudra Sabari,
Kamala Vanarsa,
Chandra Mohan,
Marek Babjuk,
Catharina Svanborg Tags: RESEARCH ARTICLE Source Type: research
Development and internal validation of a nomogram based on peripheral blood inflammatory markers for predicting prognosis in nasopharyngeal carcinoma
ConclusionOur findings confirmed the prognostic significance of the PWR and PIV in NPC. High PIV levels (>363.47) and low PWR ( ≤36.42) values are associated with worse OS in NPC patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 29, 2024 Category: Cancer & Oncology Authors: Jing Lai,
Peixin Lin,
Jiafeng Zhuang,
Zhiwei Xie,
Hechao Zhou,
Donghong Yang,
Zihong Chen,
Danxian Jiang,
Jing Huang Tags: RESEARCH ARTICLE Source Type: research
Assessing EGFR ‐mutated NSCLC with bone metastasis: Clinical features and optimal treatment strategy
ConclusionsThe presence of BoM is a negative prognostic factor for NSCLC patients with an EGFR mutation, possibly due to the presence of extrathoracic metastases. However, adding AAT and denosumab, along with sequential osimertinib, to the treatment regimen for patients with BoM can improve survival outcomes. (Source: Cancer Medicine)
Source: Cancer Medicine - March 29, 2024 Category: Cancer & Oncology Authors: Wei ‐Chun Chen,
Wen‐Chien Cheng,
Chieh‐Lung Chen,
Wei‐Chih Liao,
Chia‐Hung Chen,
Hung‐Jen Chen,
Chih‐Yen Tu,
Chi‐Chen Lin,
Te‐Chun Hsia Tags: RESEARCH ARTICLE Source Type: research
Patterns of follow ‐up care in adult blood cancer survivors—Prospective evaluation of health‐related outcomes, resource use, and quality of life
ConclusionsPatients at high risk of relapse or late complications were preferentially treated by academic oncologists, while patients in stable condition requiring continuous monitoring were also seen by community oncologists, and patients with curable diseases in long-term remission by primary care physicians. For the latter, transfer of follow-up care from oncologists to well-informed primary care providers appears feasible. (Source: Cancer Medicine)
Source: Cancer Medicine - March 29, 2024 Category: Cancer & Oncology Authors: Hildegard Lax,
Julia Baum,
Nils Lehmann,
Anja Merkel ‐Jens,
Dietrich W. Beelen,
Karl‐Heinz Jöckel,
Ulrich Dührsen Tags: RESEARCH ARTICLE Source Type: research
Standardized uptake valuemax of the primary lesion combined with tumor markers for clinically predicting distant metastasis in de novo lung adenocarcinoma
ConclusionspSUVmax combined with serum levels of LDH, CEA, CYFRA21-1, CA125, and the grade of TMs may have good performance in predicting distant metastasis of de novo lung adenocarcinoma. (Source: Cancer Medicine)
Source: Cancer Medicine - March 29, 2024 Category: Cancer & Oncology Authors: Baoli Jin,
Xiaolian Wen,
Hanji Tian,
Hongxia Guo,
Mingyan Hao,
Jing Wu,
Xiaomin Li,
Yuejun Ren,
Xin Wang,
Xiaolu Ren Tags: RESEARCH ARTICLE Source Type: research
Retraction: Wang Y, Yue D. CUL4B promotes aggressive phenotypes of HNSCC via the activation of the Wnt/ β‐catenin signaling pathway
AbstractWang Y, Yue D. CUL4B promotes aggressive phenotypes of HNSCC via the activation of the Wnt/ β-catenin signaling pathway. Cancer Med. 2019; 8: 2278–2287.https://doi.org/10.1002/cam4.1960The above article, published online on 18 March 2019, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Stephen Tait, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding Figures 2, 3, and 4. The authors did not respond to requests for the original data. The retraction has been agreed because of concerns that the f...
Source: Cancer Medicine - March 28, 2024 Category: Cancer & Oncology Tags: RETRACTION Source Type: research
Relationship between educational level and survival of patients with cancer: A multicentre cohort study
ConclusionsEducational level was a significant prognostic factor for patients with cancer, independent of other known prognostic factors. This association was further improved by modifying the nutritional status. (Source: Cancer Medicine)
Source: Cancer Medicine - March 28, 2024 Category: Cancer & Oncology Authors: Xiao ‐Yue Liu,
Xi Zhang,
Guo‐Tian Ruan,
Xin Zheng,
Yue Chen,
Xiao‐Wei Zhang,
Tong Liu,
Yi‐Zhong Ge,
Han‐Ping Shi,
INSCOC Group Tags: RESEARCH ARTICLE Source Type: research
Inconsistency in steroid use as antiemetics in clinical trial protocols involving immune checkpoint inhibitors combined with chemotherapy
ConclusionThe research highlights the lack of uniformity in antiemetic steroid use in trials, reflecting diverse clinical practices and underscoring the need for further research to understand the implications on treatment outcomes. (Source: Cancer Medicine)
Source: Cancer Medicine - March 28, 2024 Category: Cancer & Oncology Authors: Soh Mee Park,
Yu Jung Kim,
Ju ‐Yeun Lee Tags: BRIEF COMMUNICATION Source Type: research
Trauma plays an important role in acral melanoma: A retrospective study of 303 patients
ConclusionThis study provides a clinical classification of Chinese AM based on diverse clinical onset characteristics and highlights the important role of trauma in AM. These findings may help to guide the diagnosis, treatment, and prognosis of AM patients. Further investigations are imperative to elucidate the underlying mechanisms governing the association between trauma and AM. (Source: Cancer Medicine)
Source: Cancer Medicine - March 28, 2024 Category: Cancer & Oncology Authors: Rong Huang,
Mengke Zhao,
Guiying Zhang,
Yueling Yang,
Jiayu Wang,
Kelin Zheng,
Lin Li,
Xinyu Su,
Lianjun Zhao,
Yirong Wu,
Zhengyun Zou Tags: RESEARCH ARTICLE Source Type: research
Mismatch repair protein deficiency and its implications on distant metastasis in colorectal cancer: A comprehensive analysis
ConclusionGeographical and ethnic factors might influence peculiarities in MMR protein loss. Our findings also highlight new gene expression networks and crucial regulatory molecules in CRC metastasis, enhancing our comprehension of the mechanisms driving distant metastasis. (Source: Cancer Medicine)
Source: Cancer Medicine - March 28, 2024 Category: Cancer & Oncology Authors: Chuanwen Fan,
Chao Fang,
Wei Wang,
Zhaoying Lv,
Xueli Zhang,
Feiwu Long,
Zongze Jiang,
Yuan Li,
Hong Zhang,
Zong ‐Guang Zhou,
Cun Wang,
Xiao‐Feng Sun Tags: RESEARCH ARTICLE Source Type: research
Targeting the receptor tyrosine kinase MerTK shows therapeutic value in gastric adenocarcinoma
ConclusionsOur findings demonstrate the potential value of MerTK as a prognostic biomarker for gastric adenocarcinoma. Targeting MerTK may become a new treatment option, especially for patients with advanced tumors, and may overcome resistance to established chemotherapies. (Source: Cancer Medicine)
Source: Cancer Medicine - March 28, 2024 Category: Cancer & Oncology Authors: Naita Maren Wirsik,
Mingyi Chen,
Liping He,
Uraz Yasar,
Justus Gaukel,
Alexander Quaas,
Henrik Nienh üser,
Ella Leugner,
Shuai Yuan,
Nikolai Schleussner,
Jin‐On Jung,
Jadie Sue Plücker,
Martin Schneider,
Thomas Schmidt Tags: RESEARCH ARTICLE Source Type: research
