Secondary bladder and colorectal cancer after treatments for prostate cancer: A population based study
ConclusionsCompared to PCa patients undergoing RP, the secondary bladder cancer was associated with EBRT, ADT, alone or in combination. The secondary colorectal cancer was also associated with receiving either EBRT, BT or ADT. (Source: Cancer Medicine)
Source: Cancer Medicine - February 14, 2024 Category: Cancer & Oncology Authors: Patricia Grisel Quintana B árcena,
Armen Garo Aprikian,
Alice Dragomir Tags: RESEARCH ARTICLE Source Type: research
Racial disparities in the relationship of regional socioeconomic status and colorectal cancer survival in the five regions of Georgia
ConclusionsBlack patients demonstrated lower CRC survival rates in Georgia compared to their White counterparts. White patients living in regions with persistent poverty, and Black patients living in regions with low education had an increased risk of CRC death. Our findings provide important evidence to all relevant stakeholders in allocating health resources aimed at CRC early detection and prevention and timely referral for CRC treatment by considering the patient's regional SES in Georgia. (Source: Cancer Medicine)
Source: Cancer Medicine - February 13, 2024 Category: Cancer & Oncology Authors: Meng ‐Han Tsai,
Marlo Vernon,
Shaoyong Su,
Steven S. Coughlin,
Yanbin Dong Tags: RESEARCH ARTICLE Source Type: research
The impact of body mass index on survival endpoints among patients with metastatic urothelial carcinoma undergoing treatment with immune checkpoint inhibitors: A real ‐world multicenter analysis
ConclusionBased on real-world data from the Asia-Pacific region, there appears to be a correlation between obesity and prolonged OS in patients receiving ICI treatment for mUC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 10, 2024 Category: Cancer & Oncology Authors: Shih ‐Yu Huang,
Po‐Jung Su,
Chang‐Ting Lin,
Ming‐Chun Kuo,
Yi‐Hua Chen,
Chia‐Che Wu,
Hao‐Lun Luo,
Chien‐Hsu Chen,
Chih‐Chi Chou,
Chun‐Chieh Huang,
Chung‐Wen Kuo,
Yu‐Li Su Tags: RESEARCH ARTICLE Source Type: research
Clinical and genetic characteristics predict outcomes of acute myeloid leukemia patients with FLT3 mutations receiving venetoclax ‐based therapy
ConclusionsFLT3 mutations may influence response to VEN-based therapy in R/R AML patients but not in ND AML patients. Furthermore, clinical and genetic characteristics could predict outcomes of FLT3mut patients receiving VEN-based therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Guangyang Weng,
Jingya Huang,
Na An,
Yu Zhang,
Guopan Yu,
Zhiqiang Sun,
Dongjun Lin,
Lan Deng,
Xinquan Liang,
Jie Xiao,
Hongyu Zhang,
Ziwen Guo,
Xin He,
Hua Jin,
Qifa Liu,
Xin Du Tags: RESEARCH ARTICLE Source Type: research
PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells
ConclusionsAltogether, our results reveal a new role for PIEZO1 mechanosensing in the survival and proliferation of leukemic blasts, which could pave the way for new therapeutic strategies to target AML cells. (Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Delphine Lebon,
Louison Collet,
Stefan Djordjevic,
Cathy Gomila,
Hakim Ouled ‐Haddou,
Jessica Platon,
Yohann Demont,
Jean‐Pierre Marolleau,
Alexis Caulier,
Loïc Garçon Tags: RESEARCH ARTICLE Source Type: research
Genetic variants in primary cilia ‐related genes associated with the prognosis of first‐line chemotherapy in colorectal cancer
ConclusionOur study indicates that rs4288573 inODF2L is a potential predictor of the chemotherapy prognosis of CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Lei Qiu,
Silu Chen,
Shuai Ben,
Jinxin Cui,
Shan Lu,
Rong Qu,
Jinghuan Lv,
Wei Shao,
Qiang Yu Tags: RESEARCH ARTICLE Source Type: research
Feasible diet and circadian interventions reduce in vivo progression of FLT3‐ITD‐positive acute myeloid leukemia
ConclusionsMouse models for FLT3-ITD AML show that diet composition and timing slows progression of FLT3-ITD AML growth in vivo, potentially mediated by BMAL1. These interventions to enhance therapy efficacy show preliminary feasibility, as pediatric leukemia patients responded favorable to preparation of macronutrient matched meals. (Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Megan Rodriguez,
Baharan Fekry,
Brianna Murphy,
Mary Figueroa,
Tiewei Cheng,
Margaret Raber,
Lisa Wartenberg,
Donna Bell,
Lisa Triche,
Karla Crawford,
Huaxian Ma,
Kendra Allton,
Ruwaida Ahmed,
Jaime Tran,
Christine Ranieri,
Marina Konopleva Tags: RESEARCH ARTICLE Source Type: research
Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis
ConclusionThese findings contribute valuable insights into the early stages of colorectal tumorigenesis and suggestDKK1 as a tumor suppressor. Additionally, serum DKK1 levels could serve as a biomarker to identify both cancer and adenoma, offering diagnostic possibilities for early-stage colon tumors.The present study has a few limitations. We considered using DKK1 as a candidate gene for gene transfer to organoids and NFs; however, it was difficult due to technical problems and the slow growth rate of NFs. Therefore, we used cancer cell lines instead. In addition, immunostaining and ELISA were based on the short-term coll...
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Yushi Inomata,
Masatake Kuroha,
Yusuke Shimoyama,
Takeo Naito,
Rintaro Moroi,
Hisashi Shiga,
Yoichi Kakuta,
Hideaki Karasawa,
Shinobu Onuma,
Yoshitaka Kinouchi,
Atsushi Masamune Tags: RESEARCH ARTICLE Source Type: research
Mitochondrial dynamics as a novel treatment strategy for triple ‐negative breast cancer
ConclusionOur findings indicated that the interplay between mitophagy, linked to a worse clinical prognosis, and OXPHOS metabolism promoted chemotherapy resistance in TNBC. Mitochondrial fission is prevalent in TNBC. These findings suggest that targeting the unique mitochondrial metabolism and dynamics in TNBC may offer a novel therapeutic strategy for patients with TNBC. (Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Yuechen Wang,
Narumi Harada ‐Shoji,
Narufumi Kitamura,
Yuto Yamazaki,
Akiko Ebata,
Masakazu Amari,
Mika Watanabe,
Minoru Miyashita,
Hiroshi Tada,
Takaaki Abe,
Takashi Suzuki,
Kohsuke Gonda,
Takanori Ishida Tags: RESEARCH ARTICLE Source Type: research
Retraction
(Source: Cancer Medicine)
Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Tags: RETRACTION Source Type: research
Neoadjuvant chemotherapy for breast cancer: Pathologic response rates but not tumor size, has an independent prognostic impact on survival
ConclusionAchievement of pCR, but not tumor size (pretreatment cT category), has an independent prognostic impact on survival. These results suggest potential NAC benefits in patients with small tumors (<2 cm), even in absence of clinically suspicious lymph nodes. Residual lymph node disease after NAC is the most powerful adverse prognostic factor. (Source: Cancer Medicine)
Source: Cancer Medicine - February 8, 2024 Category: Cancer & Oncology Authors: Gilles Houvenaeghel,
Alexandre de Nonneville,
Monique Cohen,
Laura Sabiani,
Max Buttarelli,
Emmanuelle Charaffe,
Aur élie Jalaguier,
Marie Bannier,
Agnès Tallet,
Frédéric Viret,
Anthony Gonçalves Tags: RESEARCH ARTICLE Source Type: research
Experiences of caregivers of children with cancer in Malawi: A qualitative study
ConclusionCaregivers of Malawian children with cancer experience physical and psychosocial challenges as they are caring for their children with cancer. Developing appropriate interventions would enable nurses to offer optimal support to these caregivers in dealing with these challenges and meeting their needs effectively. (Source: Cancer Medicine)
Source: Cancer Medicine - February 7, 2024 Category: Cancer & Oncology Authors: Lophina Phiri,
William Ho Cheung Li,
Patrick G. M. C. Phiri,
Ankie Tan Cheung,
Watipaso Wanda ‐Kalizang'oma,
Anizia Kamwendo,
Sellina Lemon Tags: RESEARCH ARTICLE Source Type: research
Comparative survival analysis of bladder preservation therapy versus radical cystectomy in muscle ‐invasive bladder cancer
ConclusionIn Asian populations, bladder preservation therapy yielded similar survival outcomes as radical cystectomy in MIBC patients. Based on the results, it is evident that a multidisciplinary approach and shared decision-making are recommended for bladder cancer treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - February 6, 2024 Category: Cancer & Oncology Authors: Nai ‐Wen Kang,
Yin‐Hsun Feng,
Kuei‐Li Lin,
Yi‐Chen Chen,
Chung‐Han Ho,
Ching‐Chieh Yang Tags: RESEARCH ARTICLE Source Type: research
Comparison of IL ‐2‐antibody to IL‐2‐Fc with or without stereotactic radiation therapy in CEA immunocompetent mice with CEA positive tumors
ConclusionsIL-2-Fc had comparable antitumor efficacy to CEA-targeted M5A-IL-2 ICK, while both fusion proteins induced immune memory when combined with SRT. Differences in the therapeutic mechanisms of both agents were observed. (Source: Cancer Medicine)
Source: Cancer Medicine - February 6, 2024 Category: Cancer & Oncology Authors: Lindsay Williams,
Lin Li,
Paul J. Yazaki,
Patty Wong,
Teresa Hong,
Erasmus K. Poku,
Susanta Hui,
Hemendra Ghimire,
John E. Shively,
Maciej Kujawski Tags: RESEARCH ARTICLE Source Type: research
Referred molecular testing as a barrier to optimal treatment decision making in metastatic non ‐small cell lung cancer: Experience at a tertiary academic institution in Canada
ConclusionOur results demonstrate the advantages of in-house biomarker testing for mNSCLC at a tertiary oncology center. Incorporation of in-house testing may reduce barriers to offering personalized medicine by improving the time to optimal systemic therapy decision. (Source: Cancer Medicine)
Source: Cancer Medicine - February 6, 2024 Category: Cancer & Oncology Authors: Grace K. Grafham,
Kenneth J. Craddock,
Weei ‐Yuarn Huang,
Alexander V. Louie,
Liying Zhang,
David M. Hwang,
Ambica Parmar Tags: RESEARCH ARTICLE Source Type: research
