Feasible diet and circadian interventions reduce in  vivo progression of FLT3‐ITD‐positive acute myeloid leukemia

ConclusionsMouse models for FLT3-ITD AML show that diet composition and timing slows progression of FLT3-ITD AML growth in  vivo, potentially mediated by BMAL1. These interventions to enhance therapy efficacy show preliminary feasibility, as pediatric leukemia patients responded favorable to preparation of macronutrient matched meals.

Source: Cancer Medicine - February 9, 2024 Category: Cancer & Oncology Authors: Megan Rodriguez, Baharan Fekry, Brianna Murphy, Mary Figueroa, Tiewei Cheng, Margaret Raber, Lisa Wartenberg, Donna Bell, Lisa Triche, Karla Crawford, Huaxian Ma, Kendra Allton, Ruwaida Ahmed, Jaime Tran, Christine Ranieri, Marina Konopleva Tags: RESEARCH ARTICLE Source Type: research