Enhanced clinical outcomes with radiotherapy in diagnostically challenging intracranial plasmacytomas: Analysis of 190 cases
ConclusionsThis retrospective clinical analysis highlights the potential role of radiotherapy, rather than surgical resection, in improving the outcomes of intracranial plasmacytoma. Additionally, the Ki-67 index is identified as a valuable marker for predicting disease progression. This would provide some evidence for the paradigm of diagnosis and treatment modalities for intracranial plasmacytomas from the large cohort. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Yuan Feng,
Zongpu Zhang,
Fufang Qiu,
Zixiao Yang,
Ji Xiong,
Wei Zhu,
Fangzhu Wan,
Bobin Chen,
Jiguang Wang,
Yi Zhang,
Wei Hua Tags: RESEARCH ARTICLE Source Type: research
Do Hispanic Puerto Rican men have worse outcomes after radical prostatectomy? Results from SEARCH
ConclusionsIn an equal access setting, PRH RP patients generally had better pathological features, but despite this, they had significantly worse post-treatment outcomes than men from the Continental US, regardless of race. The reasons for the poorer prognosis among PRH men require further research. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Lourdes Guerrios ‐Rivera,
Jessica L. Janes,
Amanda M. De Hoedt,
Zachary Klaassen,
Martha K. Terris,
Matthew R. Cooperberg,
Christopher L. Amling,
Christopher J. Kane,
William J. Aronson,
Jay H. Fowke,
Stephen J. Freedland Tags: RESEARCH ARTICLE Source Type: research
Perceiving a need for dietary change in adults living with and beyond cancer: A cross ‐sectional study
ConclusionsMost of this sample of people LWBC did not perceive a need to improve their diet. More research is needed to understand the reasons for this and to target these reasons in dietary interventions. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Susan Smith,
Abi Fisher,
Phillippa J. Lally,
Helen A. Croker,
Anna Roberts,
Rana E. Conway,
Rebecca J. Beeken Tags: RESEARCH ARTICLE Source Type: research
Cell fusion between tumor cells and macrophages promotes the metastasis of OSCC patient through the activation of the chemokine signaling pathway
ConclusionAfter fusion with macrophages, the chemokine signaling pathway in OSCC tumor cells was activated, leading to metastasis. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Chengwan Xia,
Qian Zhang,
Yumei Pu,
Qingang Hu,
Yuxin Wang Tags: RESEARCH ARTICLE Source Type: research
POLQ identifies a better response subset to immunotherapy in muscle ‐invasive bladder cancer with high PD‐L1
ConclusionsThe study demonstrated that high POLQ expression was correlated with chromosome instability and antitumor immune microenvironment in MIBC, and the combination of POLQ and PD-L1 could be used as a superior companion biomarker for predicting the efficacy of immunotherapy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Ge Liu,
Kaifeng Jin,
Zhaopei Liu,
Xiaohe Su,
Ziyue Xu,
Bingyu Li,
Jingtong Xu,
Yuan Chang,
Yiwei Wang,
Yu Zhu,
Le Xu,
Jiejie Xu,
Zewei Wang,
Hailong Liu,
Weijuan Zhang Tags: RESEARCH ARTICLE Source Type: research
Deletion of concurrent chemotherapy on the basis of sequential chemoradiotherapy for non ‐metastatic stage T4 nasopharyngeal carcinoma in IMRT era
ConclusionThe survival outcomes of treating T4 NPC IMRT combined by induction chemotherapy deleting concurrent chemotherapy with or without adjuvant chemotherapy are encouraging. Moreover, mucosal reaction, nausea, and vomiting reaction were reduced during IMRT. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Yuming Zheng,
Fen Xue,
Dan Ou,
Xiaoshuang Niu,
Chaosu Hu,
Xiayun He Tags: RESEARCH ARTICLE Source Type: research
A single ‐centre, real‐world study of BTK inhibitors for the initial treatment of MYD88mut/CD79Bmut diffuse large B‐cell lymphoma
ConclusionThis study suggests that newly diagnosed DLBCL patients with MYD88mut and/or CD79Bmut may benefit from BTKis according to real-world clinical data. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Ting Deng,
Shiyuan Zhang,
Min Xiao,
Jia Gu,
Liang Huang,
Xiaoxi Zhou Tags: RESEARCH ARTICLE Source Type: research
Early recurrence, time ‐to‐recurrence, and recurrence patterns: Assessing their impact on survival outcomes in head and neck squamous cell carcinoma (R/M‐HNSCC) patients treated with first line platinum‐based chemotherapy
ConclusionTTRI significantly influenced the survival, while recurrence patterns did not. In our study, the retrospective design limited our ability to definitively establish whether early recurrent R/M-HNSCC patients would benefit more from platinum-doublet. Despite poor prognosis, early recurrent patients benefited from 1L systemic treatments. Given the variation in prognoses, TTRI should be considered a stratification factor in future clinical trials. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Pasvich Pitakpaiboonkul,
Chuleeporn Jiarpinitnun,
Poompis Pattaranutaporn,
Nuttapong Ngamphaiboon Tags: RESEARCH ARTICLE Source Type: research
Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis
ConclusionIn short, the prognosis of g-NEC/MiNEN was worse than that of g-NET, GAC and poorly differentiated GAC, but this group benefit from postoperative adjuvant therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Mengli Zi,
Yubo Ma,
Jinxia Chen,
Chuhong Pang,
Xiao Li,
Li Yuan,
Zhuo Liu,
Pengfei Yu Tags: RESEARCH ARTICLE Source Type: research
Comparison of genomic alterations in Epstein –Barr virus‐positive and Epstein–Barr virus‐negative diffuse large B‐cell lymphoma
ConclusionsOur results confirm that genomic alteration differs significantly between EBV-posDLBCL and EBV-negDLBCL, and reveal new genetic alterations in EBV-posDLBCL. The positive correlation of c-MET and PD-L1/c-Myc expression may be involved in the pathogenesis of EBV-posDLBCL, which is should be explored prospectively in trials involving MET-directed therapies. (Source: Cancer Medicine)
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Fang Liu,
Sufang Tian,
Qing Liu,
Yuanfei Deng,
Qingyan He,
Qianyun Shi,
Gang Chen,
Xiuli Xu,
Jiayin Yuan,
Shigeo Nakamura,
Kennosuke Karube,
Zhe Wang Tags: RESEARCH ARTICLE Source Type: research
Impact of inflammation and the immune system on hepatocellular carcinoma recurrence after hepatectomy
AbstractHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. Hepatectomy remains the first-line treatment for patients with resectable HCC. However, the reported recurrence rate of HCC at 5 years after surgery is between 50% and 70%. Tumor-related factors, including tumor size, number and differentiation, and underlying liver disease are well-known risk factors for recurrence after treatment. In addition to tumor-related factors, ever-increasing amounts of studies are finding that t he tumor microenvironment also plays an important role in the recurrence of HCC, including system...
Source: Cancer Medicine - March 8, 2024 Category: Cancer & Oncology Authors: Sha She,
Jinzhi Shi,
Jiling Zhu,
Fan Yang,
Jia Yu,
Kai Dai Tags: REVIEW Source Type: research
Expression of PTGS2 along with genes regulating VEGF signalling pathway and association with high ‐risk factors in locally advanced oral squamous cell carcinoma
ConclusionPTGS2 andVEGF signalling genes are upregulated in OSCC, which has a profound impact on clinical outcomes. (Source: Cancer Medicine)
Source: Cancer Medicine - March 2, 2024 Category: Cancer & Oncology Authors: Mehta Vedant Kamal,
Rama Rao Damerla,
Preetiparna Parida,
Mahadev Rao,
Vijetha Shenoy Belle,
Punit Singh Dikhit,
Akhil Palod,
Rinsha Gireesh,
Naveena AN Kumar Tags: RESEARCH ARTICLE Source Type: research
Defining and targeting macrophage heterogeneity in the mammary gland and breast cancer
ConclusionUnderstanding macrophage heterogeneity and the unique functions of each subset in both normal mammary gland development and breast cancer progression may lead to more promising targets for the treatment of breast cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - March 1, 2024 Category: Cancer & Oncology Authors: Alexis K. Elfstrum,
Aditi S. Bapat,
Kathryn L. Schwertfeger Tags: REVIEW Source Type: research
Reclassified the phenotypes of cancer types and construct a nomogram for predicting bone metastasis risk: A pan ‐cancer analysis
ConclusionThe classification system and prediction nomogram may guide the cancer management and individualized BM screening, thus allocating the medical resources to cancer patients. Moreover, it may also have important implications for studying the etiology of BM. (Source: Cancer Medicine)
Source: Cancer Medicine - March 1, 2024 Category: Cancer & Oncology Authors: Ming Li,
Wenqian Yu,
Chao Zhang,
Huiyang Li,
Xiuchuan Li,
Fengju Song,
Shiyi Li,
Guoheng Jiang,
Hongyu Li,
Min Mao,
Xin Wang Tags: RESEARCH ARTICLE Source Type: research
Biomarkers of systemic inflammation provide additional prognostic stratification in cancers of unknown primary
ConclusionsBiomarkers of systemic inflammation are reliable prognostic factors in patients with cCUP, regardless of clinicopathological subgroup. We recommend that CRP or SIPS are incorporated into routine clinical assessments of patients with cCUP as a tool to aid investigation and/or treatment decision-making across all groups. Established clinicopathological factors can then be used to inform management pathways and specific systemic anticancer therapy selection. (Source: Cancer Medicine)
Source: Cancer Medicine - February 26, 2024 Category: Cancer & Oncology Authors: Svenja Harvey,
Mark Stares,
Julie ‐Anne Scott,
Tharun Joseph Vattam Thottiyil,
Alicia‐Marie Conway,
Rachel Haigh,
Jackie Brown,
Gillian Knowles,
Sonali Dasgupta,
Kai‐Keen Shiu,
Claire Mitchell,
Colin Barrie,
Natalie Cook,
Sally Clive Tags: RESEARCH ARTICLE Source Type: research
