Correction to “urban relatives ameliorate survival disparities for genitourinary cancer in rural patients”
(Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Tags: CORRECTION Source Type: research
Correction to “Dose‐dependent effects of calorie restriction on gene expression, metabolism, and tumor progression are partially mediated by insulin‐like growth factor‐1”
(Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Tags: CORRECTION Source Type: research
Analysis of related factors of CRA in lung cancer patients with different serum iron levels: A retrospective cohort study
ConclusionBoth models have good reliability and validity and have significant clinical value. They can help doctors better assess the risk of developing CRA in lung cancer patients. CRP is a risk factor for CRA in lung cancer patients with normal serum iron but not in patients with decreased serum iron. Therefore, whether CRP and the inflammatory state represented by CRP will further aggravate the decrease in serum iron levels, thus contributing to anemia, warrants further study. (Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Authors: Quan ‐yao Li,
Wen‐xiao Yang,
Hui Liu,
Jia‐lin Yao,
Qin Wang,
Dan Lin,
Jun Shi Tags: RESEARCH ARTICLE Source Type: research
Association between novel genetic variants of Notch signaling pathway genes and survival of hepatitis B virus ‐related hepatocellular carcinoma
ConclusionsThree potentially functional SNPs ofNEURL1B,CNTN1 andFCER2 may serve as potential prognostic biomarkers for HBV-related HCC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Authors: Liming Qin,
Moqin Qiu,
Qiuling Lin,
Binbin Jiang,
Shicheng Zhan,
Xueyan Wei,
Junjie Wei,
Yingchun Liu,
Qiuping Wen,
Peiqin Chen,
Yanji Jiang,
Zihan Zhou,
Xiumei Liang,
Ji Cao,
Yizhen Gong,
Yuying Wei,
Xiaoxia Wei,
Hongping Yu Tags: RESEARCH ARTICLE Source Type: research
Metformin suppresses NFE2L1 pathway activation to inhibit gap junction beta protein expression in NSCLC
ConclusionThis emphasizes the potential of targeting GJBs as a viable treatment approach for NSCLC patients receiving metformin. (Source: Cancer Medicine)
Source: Cancer Medicine - April 2, 2024 Category: Cancer & Oncology Authors: Shuo Yu,
Hui Ren,
Tingting Liu,
Xiaoyan Han,
Hui Guo,
Qian Ning,
Yang Li,
Hong Zhou,
Mingwei Chen,
Tinghua Hu Tags: RESEARCH ARTICLE Source Type: research
A real ‐world retrospective–prospective analysis of efficacy and safety of combined ixazomib, lenalidomide, and dexamethasone in relapsed/refractory multiple myeloma: The northern Italy experience
ConclusionIRd might be effective and safe in RRMM pts with an indolent disease, in early lines of treatment, and who proved Len-sensitive, independent of age, and cytogenetic risk. (Source: Cancer Medicine)
Source: Cancer Medicine - April 1, 2024 Category: Cancer & Oncology Authors: Anna Furlan,
Michele Cea,
Laura Pavan,
Monica Galli,
Cristina Clissa,
Silvia Mangiacavalli,
Anna Maria Cafro,
Stefania Girlanda,
Francesca Patriarca,
Claudia Minotto,
Giovanni Bertoldero,
Gregorio Baril à,
Anna Pascarella,
Albana Lico,
Ross Tags: RESEARCH ARTICLE Source Type: research
Tumor analysis of MMR genes in Lynch ‐like syndrome: Challenges associated with results interpretation
DiscussionMore biallelic somatic events were identified at VAF ≥ 5% than ≥10% (35.9% vs. 25.6%), although the rate of nonconcordant results regarding immunohistochemical pattern increased (30.8% vs. 20.5%). Interpretation difficulties question the current utility of the identification of MMR somatic hits in the diagnostic algorithm of suspected LS case s. (Source: Cancer Medicine)
Source: Cancer Medicine - April 1, 2024 Category: Cancer & Oncology Authors: Paula Rofes,
N úria Dueñas,
Jesús del Valle,
Matilde Navarro,
Judith Balmaña,
Teresa Ramón y Cajal,
Noemí Tuset,
Carmen Castillo,
Sara González,
Joan Brunet,
Gabriel Capellá,
Conxi Lázaro,
Marta Pineda Tags: RESEARCH ARTICLE Source Type: research
Characterization and impact of non ‐canonical WNT signaling on outcomes of urothelial carcinoma
ConclusionDistinct genomic and immune landscapes for the four investigated WNT5A pathway components were observed in patients with UC. External validation studies are needed. (Source: Cancer Medicine)
Source: Cancer Medicine - April 1, 2024 Category: Cancer & Oncology Authors: Margaret Meagher,
Harris Krause,
Andrew Elliott,
Alex Farrell,
Emmanuel S. Antonarakis,
Bruno Bastos,
Elisabeth I. Heath,
Christina Jamieson,
Tyler F. Stewart,
Aditya Bagrodia,
Chadi Nabhan,
Matt Oberley,
Rana R. McKay,
Amirali Salmasi Tags: RESEARCH ARTICLE Source Type: research
Prognostic significance of systemic immune ‐inflammation index in patients with nonfunction pancreatic neuroendocrine tumor undergoing surgical resection
ConclusionIn conclusion, our study revealed that a higher SII level was associated with tumor-related features (larger tumor size and advanced grade) and subsequent shorter DFS and OS in patients with nonfunctioning pNETs. These results indicated that the SII could serve as an efficient prognostic biomarker for nonfunctioning pNETs. (Source: Cancer Medicine)
Source: Cancer Medicine - March 31, 2024 Category: Cancer & Oncology Authors: Guanhua Chen,
Li Liu,
Chunlu Tan,
Qingquan Tan,
Yonghua Chen,
Xiangrong An,
Xubao Liu,
Xing Wang Tags: RESEARCH ARTICLE Source Type: research
Added value of whole ‐exome and RNA sequencing in advanced and refractory cancer patients with no molecular‐based treatment recommendation based on a 90‐gene panel
ConclusionsIn advanced and refractory cancer patients in whom no MBTR was recommended from TGP/aCGH, WES/RNA-Seq allowed to identify more alterations which may in turn, in a limited fraction of patients, lead to new MBTR. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Armelle Dufresne,
Val éry Attignon,
Anthony Ferrari,
Laurie Tonon,
Sandrine Boyault,
Séverine Tabone‐Eglinger,
Philippe Cassier,
Olivier Trédan,
Nadège Corradini,
Armelle Vinceneux,
Aurélie Swalduz,
Alain Viari,
Sylvie Chabaud,
David P Tags: RESEARCH ARTICLE Source Type: research
Association of household net worth with healthcare costs after radical cystectomy using real ‐world data
ConclusionsLower HHNW conferred greater risk of costly inpatient encounters while greater HHNW had greater odds of less costly office visits, illustrating how financial flexibility fosters differences in healthcare utilization and lower costs. HHNW may serve as a proxy for financial flexibility and risk of financial hardship than income alone. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Samuel L. Washington III,
Peter E. Lonergan,
Anobel Y. Odisho,
Maxwell V. Meng,
Sima P. Porten Tags: RESEARCH ARTICLE Source Type: research
The quantitative parameters based on marrow metabolism derived from synthetic MRI: A pilot study of prognostic value in participants with newly diagnosed multiple myeloma
ConclusionsSynthetic MRI is a promising tool for predicting early treatment response to MM and promoting R-ISS II stage risk stratification. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Sha Cui,
Yinnan Guo,
Weiran Niu,
Jianting Li,
Wenjin Bian,
Wenqi Wu,
Wenjia Zhang,
Qian Zheng,
Jun Wang,
Jinliang Niu Tags: RESEARCH ARTICLE Source Type: research
Toxicity profiles of immune checkpoint inhibitors for recurrent or metastatic head and neck squamous cell carcinoma: A systematic review and meta ‐analysis
ConclusionsOur study suggests that the incidences of grade three or more trAEs, treatment-related deaths, and trAEs leading to discontinuation of treatment are low in R/M HNSCC patients treated with ICIs. PD-L1 inhibitors monotherapy may be safer compared with PD-1 inhibitors monotherapy and ICIs combination therapy. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Shoutao Dang,
Xinyu Li,
Heshu Liu,
Shuyang Zhang,
Wei Li Tags: RESEARCH ARTICLE Source Type: research
Similar immune responses to alpha1 ‐oleate and Bacillus Calmette–Guérin treatment in patients with bladder cancer
ConclusionsThe cytokine response profile in alpha 1-oleate treated patients was similar to that reported in BCG treated patients, suggesting a significant overlap. A reduction in protein levels at the end of treatment coincided with inhibition of cancer-related gene expression in tissue biopsies, consistent with a positive treatment effect. Thus, in addition to killing tumor cells and inducing cell detachment, alpha 1-oleate is shown to activate a broad immune response with a protective potential. (Source: Cancer Medicine)
Source: Cancer Medicine - March 30, 2024 Category: Cancer & Oncology Authors: Shahram Ahmadi,
Ines Ambite,
Anton ín Brisuda,
Jaromír Háček,
Farhan Haq,
Samudra Sabari,
Kamala Vanarsa,
Chandra Mohan,
Marek Babjuk,
Catharina Svanborg Tags: RESEARCH ARTICLE Source Type: research
Development and internal validation of a nomogram based on peripheral blood inflammatory markers for predicting prognosis in nasopharyngeal carcinoma
ConclusionOur findings confirmed the prognostic significance of the PWR and PIV in NPC. High PIV levels (>363.47) and low PWR ( ≤36.42) values are associated with worse OS in NPC patients. (Source: Cancer Medicine)
Source: Cancer Medicine - March 29, 2024 Category: Cancer & Oncology Authors: Jing Lai,
Peixin Lin,
Jiafeng Zhuang,
Zhiwei Xie,
Hechao Zhou,
Donghong Yang,
Zihong Chen,
Danxian Jiang,
Jing Huang Tags: RESEARCH ARTICLE Source Type: research
