Pursuing dynamics of minimal residual leukemic subclones in relapsed and refractory acute myeloid leukemia during conventional therapy
ConclusionsIn this study, we observed treatment persistent MR leukemic subclones and their phenotypic changes during the treatment process of R/R AML patients. This underscores the importance of preemptive inhibition of clonal promiscuity in R/R AML, proposing a practical method for monitoring AML MR subclones. (Source: Cancer Medicine)
Source: Cancer Medicine - April 9, 2024 Category: Cancer & Oncology Authors: Dongchan Kim,
Sheehyun Kim,
Hyojin Song,
Daehyeon Gwak,
Suji Min,
Ja Min Byun,
Youngil Koh,
Junshik Hong,
Sung ‐Soo Yoon,
Hongseok Yun,
Dong‐Yeop Shin Tags: BRIEF COMMUNICATION Source Type: research
The impact of the affordable care act and Medicaid expansion on colorectal cancer screening: Evidence from the 5th year of Medicaid expansion
ConclusionsMedicaid expansion was found to be associated with increased colorectal cancer screening rates among low-income individuals aged 50 –64. The observed variations in impact based on income levels and the time lag for newly eligible beneficiaries receiving colorectal cancer screening highlight the need for further research and precision public health strategies to maximize the benefits of Medicaid expansion on colorectal cancer s creening rates. (Source: Cancer Medicine)
Source: Cancer Medicine - April 9, 2024 Category: Cancer & Oncology Authors: Michael A. Preston,
Mahmoud Manouchehri Amoli,
Askar S. Chukmaitov,
Alex H. Krist,
Bassam Dahman Tags: RESEARCH ARTICLE Source Type: research
Switching from FOLFIRI plus cetuximab to FOLFIRI plus bevacizumab based on early tumor shrinkage in RAS wild ‐type metastatic colorectal cancer: A phase II trial (HYBRID)
ConclusionsOur novel treatment strategy delivered acceptable survival outcomes and reduced severe dermatologic toxicities. (Source: Cancer Medicine)
Source: Cancer Medicine - April 9, 2024 Category: Cancer & Oncology Authors: Hiroyuki Arai,
Takashi Tsuda,
Yu Sunakawa,
Mototsugu Shimokawa,
Kohei Akiyoshi,
Shinya Tokunaga,
Hirokazu Shoji,
Kenji Kunieda,
Masahito Kotaka,
Toshihiko Matsumoto,
Yusuke Nagata,
Takuro Mizukami,
Fumitaka Mizuki,
Kathleen D. Danenberg,
Nar Tags: RESEARCH ARTICLE Source Type: research
RSPO3 induced by Helicobacter pylori extracts promotes gastric cancer stem cell properties through the GNG7/ β‐catenin signaling pathway
ConclusionRSPO3 enhanced the stemness ofH. pylori extracts-infected GC cells through the GNG7/ β-catenin signaling pathway. (Source: Cancer Medicine)
Source: Cancer Medicine - April 6, 2024 Category: Cancer & Oncology Authors: Xiwu Rao,
Zhipeng Zhang,
Yunzhou Pu,
Gang Han,
Hangjun Gong,
Hao Hu,
Qing Ji,
Ningning Liu Tags: RESEARCH ARTICLE Source Type: research
Artificial intelligence in lung cancer screening: Detection, classification, prediction, and prognosis
ConclusionsAI offers a promising supportive approach to lung cancer screening, presenting considerable potential in enhancing nodule detection sensitivity, reducing false-positive rates, and classifying nodules. However, the universality and interpretability of AI results need further enhancement. Future research should focus on the large-scale validation of new deep learning-based algorithms and multi-center studies to improve the efficacy of AI in lung cancer screening. (Source: Cancer Medicine)
Source: Cancer Medicine - April 6, 2024 Category: Cancer & Oncology Authors: Wu Quanyang,
Huang Yao,
Wang Sicong,
Qi Linlin,
Zhang Zewei,
Hou Donghui,
Li Hongjia,
Zhao Shijun Tags: REVIEW Source Type: research
Risk of recurrence after neoadjuvant chemotherapy and transoral robotic surgery in patients with oropharynx cancer that avoid adjuvant radiation
ConclusionOur findings suggest that pathology-based risk-adapted omission of adjuvant treatment following NAC + S does not appear to elevate recurrence risk and that NAC may identify patients with favorable tumor biology, yielding a 2-year RFS probability exceeding 95% without adjuvant treatment. Further, the study identifies a patient subset experiencing disease recurrence despite triple modality ther apy. Despite limitations, including a retrospective design and modest sample size, the data advocate for controlled NAC + S studies. (Source: Cancer Medicine)
Source: Cancer Medicine - April 6, 2024 Category: Cancer & Oncology Authors: Alisha R. Pershad,
Punam G. Thakkar,
Joseph F. Goodman,
Arjun Joshi,
Seth M. Steinberg,
Clint T. Allen,
Charalampos S. Floudas Tags: BRIEF COMMUNICATION Source Type: research
Household income and health ‐related quality of life in children receiving treatment for acute myeloid leukemia: Potential impact of selection bias in health equity research
ConclusionsWhile primary analyses suggested lower household income was associated with superior HRQOL, differential participation may have biased these results. Future studies should partner with patients/families to identify strategies for equitable participation in clinical research. (Source: Cancer Medicine)
Source: Cancer Medicine - April 5, 2024 Category: Cancer & Oncology Authors: Haley Newman,
Yimei Li,
Yuan ‐Shung V. Huang,
Caitlin W. Elgarten,
Regina M. Myers,
Jenny Ruiz,
Daniel J. Zheng,
Alison Barz Leahy,
Catherine Aftandilian,
Staci D. Arnold,
Kira Bona,
M. Monica Gramatges,
Mallorie B. Heneghan,
Kelly W. Malon Tags: RESEARCH ARTICLE Source Type: research
Real ‐world data of poly (ADP‐ribose) polymerase inhibitor response in Japanese patients with ovarian cancer
ConclusionsInflammation-related blood data, such as neutrophil count, obtained at the initial pre-treatment visit might serve as potential predictors for prolonged olaparib treatment. While this study offers valuable insights into potential indicators for prolonged olaparib treatment, it underscores the need for more expansive research to strengthen our understanding of PARP inhibitors and optimize treatment strategies in ovarian cancer. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Ryosuke Uekusa,
Akira Yokoi,
Eri Watanabe,
Kosuke Yoshida,
Masato Yoshihara,
Satoshi Tamauchi,
Yusuke Shimizu,
Yoshiki Ikeda,
Nobuhisa Yoshikawa,
Kaoru Niimi,
Shiro Suzuki,
Hiroaki Kajiyama Tags: RESEARCH ARTICLE Source Type: research
Comparison between next ‐generation sequencing and multiplex polymerase chain reaction assays for nonsmall‐cell lung cancer molecular diagnosis
DiscussionThe AmoyDx PLC panel, a PCR-based multiplex diagnostic test, exhibits a high success rate. The frequency of the nine genes targeted for treatment detected by the AmoyDx PLC panel was comparable to the frequency of mutations detected by ODxTT-M. Clinicians should understand and use the AmoyDx PLC panel and ODxTT-M with respect to their respective performances and limitations. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Shuji Murakami,
Kanako Shinada,
Yuka Otsutsumi,
Fumiko Komine,
Yuan Yuan,
Junko Nakamura,
Seigo Katakura,
Tetsuro Kondo,
Terufumi Kato,
Tomoyuki Yokose,
Haruhiro Saito Tags: RESEARCH ARTICLE Source Type: research
A population study comparing tracheal and lung adenoid cystic carcinoma
ConclusionsLACC is more aggressive and has a worse prognosis than TACC. TACC patients have more opportunities for local treatment, which is important for the prognosis of both TACC and LACC. Nomograms were created for TACC and LACC to aid in personalized survival predictions and clinical decisions. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Yu Gu,
Songtao Lai,
Yang Wang,
Juan Yang,
Ping Zhou,
Tianxiang Chen Tags: RESEARCH ARTICLE Source Type: research
Changes in rural caregivers' health behaviors while supporting someone with cancer: A qualitative study
ConclusionsDesigning interventions to address rural caregivers' coping strategies, reduce carer burden and fatigue, improve access to cooking and exercise facilities and social support while away from home, reduce the need to travel for treatment, and increase the financial support available could yield widespread benefits for supporting the health and wellbeing of rural caregivers. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Elizabeth A. Johnston,
Katelyn E. Collins,
Jazmin N. Vicario,
Chris Sibthorpe,
Michael J. Ireland,
Belinda C. Goodwin Tags: RESEARCH ARTICLE Source Type: research
The inverted U ‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte
ConclusionEpinephrine played an anti-tumor or pro-tumor effect depending on the specific concentration. Circulating lymphocyte count was elevated and might acted as a compensation pathway to reduce the pro-tumor effect of epinephrine to PDAC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Bing ‐Xue Li,
Xiao‐Cen Zhu,
Xia‐Xing Deng Tags: RESEARCH ARTICLE Source Type: research
Trends in breast, colon, pancreatic, and uterine cancers in women during the COVID ‐19 pandemic in North Carolina
Conclusion and RelevanceIn women, the COVID-19 pandemic resulted in a significant reduction in the incidence of breast and uterine cancers, but not colon or pancreatic cancers. A change in the proportion of poor prognosis breast and uterine cancers suggests that some cancers that otherwise would have been diagnosed at an earlier stage will be detected in later years. Continued analysis of long-term trends is needed to understand the full impact of the pandemic on cancer incidence and outcomes. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Sarah J. Nyante,
Allison M. Deal,
Hillary M. Heiling,
Kyung Su Kim,
Cherie M. Kuzmiak,
Benjamin C. Calhoun,
Emily M. Ray Tags: RESEARCH ARTICLE Source Type: research
Treatment outcome and germline predictive factors of ropeginterferon alpha ‐2b in myeloproliferative neoplasm patients
ConclusionsOverall, this study provided valuable information on the ethnics- and genetics-based algorithm in the treatment of MPN. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Chih ‐Cheng Chen,
Ming‐Chung Kuo,
Ying‐Hsuan Wang,
Sung‐Nan Pei,
Ming‐Lih Huang,
Chiu‐Chen Chen,
Cih‐En Huang,
Yi‐Yang Chen,
Lee‐Yung Shih Tags: RESEARCH ARTICLE Source Type: research
Identification of molecular characteristics of hepatocellular carcinoma with microvascular invasion based on deep targeted sequencing
ConclusionsTERTp+/TP53+ was significantly enriched in MVI-positive patients, leading to poor prognosis for HCC patients by promoting proliferation of HCC cell and inhibiting infiltration of immune cell surrounding HCC. TERTp+/TP53+ can be utilized as a potential indicator for predicting MVI-positive patients and poor prognosis, laying a preliminary foundation for further exploration of co-mutation in HCC with MVI and clinical treatment. (Source: Cancer Medicine)
Source: Cancer Medicine - April 4, 2024 Category: Cancer & Oncology Authors: Linlin Zheng,
Yaru Wang,
Zhenrong Liu,
Zhihao Wang,
Changcheng Tao,
Anke Wu,
Haiyang Li,
Ting Xiao,
Zhuo Li,
Weiqi Rong Tags: RESEARCH ARTICLE Source Type: research
