Abiotic stress as a dynamic strategy for enhancing high value phytochemicals in microalgae: Critical insights, challenges and future prospects
This study delves into the pivotal impacts of manipulating abiotic stress on microalgae yields, with a particular focus on biomass and selected HVPCs that have received limited attention in the existing literature. Moreover, approaches to utilising abiotic stress to increase HVPCs production while minimising adverse effects on biomass productivity were discussed. The present study also encompasses a techno-economic assessment (TEA) aimed at pinpointing significant bottlenecks in the conversion of microalgae biomass into high-value products and evaluating the desirability of various conversion pathways. The TEA methodology ...
Source: Biotechnology Advances - November 9, 2023 Category: Biotechnology Authors: Uganeeswary Suparmaniam Man Kee Lam Jun Wei Lim Inn Shi Tan Bridgid Lai Fui Chin Siew Hoong Shuit Steven Lim Yean Ling Pang Peck Loo Kiew Source Type: research
Engineering status of protein for improving microbial cell factories
Biotechnol Adv. 2023 Nov 6:108282. doi: 10.1016/j.biotechadv.2023.108282. Online ahead of print.ABSTRACTWith the development of metabolic engineering and synthetic biology, microbial cell factories (MCFs) have provided an efficient and sustainable method to synthesize a series of chemicals from renewable feedstocks. However, the efficiency of MCFs is usually limited by the inappropriate status of protein. Thus, engineering status of protein is essential to achieve efficient bioproduction with high titer, yield and productivity. In this review, we summarize the engineering strategies for metabolic protein status, including ...
Source: Biotechnology Advances - November 8, 2023 Category: Biotechnology Authors: Pei Zhou Cong Gao Wei Song Wanqing Wei Jing Wu Liming Liu Xiulai Chen Source Type: research
Engineering status of protein for improving microbial cell factories
Biotechnol Adv. 2023 Nov 6:108282. doi: 10.1016/j.biotechadv.2023.108282. Online ahead of print.ABSTRACTWith the development of metabolic engineering and synthetic biology, microbial cell factories (MCFs) have provided an efficient and sustainable method to synthesize a series of chemicals from renewable feedstocks. However, the efficiency of MCFs is usually limited by the inappropriate status of protein. Thus, engineering status of protein is essential to achieve efficient bioproduction with high titer, yield and productivity. In this review, we summarize the engineering strategies for metabolic protein status, including ...
Source: Biotechnology Advances - November 8, 2023 Category: Biotechnology Authors: Pei Zhou Cong Gao Wei Song Wanqing Wei Jing Wu Liming Liu Xiulai Chen Source Type: research
Prospects and hazards of silica nanoparticles: Biological impacts and implicated mechanisms
Biotechnol Adv. 2023 Nov 3;69:108277. doi: 10.1016/j.biotechadv.2023.108277. Online ahead of print.ABSTRACTWith the thrive of nanotechnology, silica nanoparticles (SiNPs) have been extensively adopted in the agriculture, food, cosmetic, and even biomedical industries. Due to the mass production and use, SiNPs inevitably entered the environment, resulting in ecological toxicity and even posing a threat to human health. Although considerable investigations have been conducted to assess the toxicity of SiNPs, the correlation between SiNPs exposure and consequent health risks remains ambiguous. Since the biological impacts of ...
Source: Biotechnology Advances - November 3, 2023 Category: Biotechnology Authors: Ruiyang Ding Yang Li Yang Yu Zhiwei Sun Junchao Duan Source Type: research
Prospects and hazards of silica nanoparticles: Biological impacts and implicated mechanisms
Biotechnol Adv. 2023 Nov 3;69:108277. doi: 10.1016/j.biotechadv.2023.108277. Online ahead of print.ABSTRACTWith the thrive of nanotechnology, silica nanoparticles (SiNPs) have been extensively adopted in the agriculture, food, cosmetic, and even biomedical industries. Due to the mass production and use, SiNPs inevitably entered the environment, resulting in ecological toxicity and even posing a threat to human health. Although considerable investigations have been conducted to assess the toxicity of SiNPs, the correlation between SiNPs exposure and consequent health risks remains ambiguous. Since the biological impacts of ...
Source: Biotechnology Advances - November 3, 2023 Category: Biotechnology Authors: Ruiyang Ding Yang Li Yang Yu Zhiwei Sun Junchao Duan Source Type: research
Prospects and hazards of silica nanoparticles: Biological impacts and implicated mechanisms
Biotechnol Adv. 2023 Nov 3;69:108277. doi: 10.1016/j.biotechadv.2023.108277. Online ahead of print.ABSTRACTWith the thrive of nanotechnology, silica nanoparticles (SiNPs) have been extensively adopted in the agriculture, food, cosmetic, and even biomedical industries. Due to the mass production and use, SiNPs inevitably entered the environment, resulting in ecological toxicity and even posing a threat to human health. Although considerable investigations have been conducted to assess the toxicity of SiNPs, the correlation between SiNPs exposure and consequent health risks remains ambiguous. Since the biological impacts of ...
Source: Biotechnology Advances - November 3, 2023 Category: Biotechnology Authors: Ruiyang Ding Yang Li Yang Yu Zhiwei Sun Junchao Duan Source Type: research
Next-generation feedstocks methanol and ethylene glycol and their potential in industrial biotechnology
Biotechnol Adv. 2023 Oct 31;69:108276. doi: 10.1016/j.biotechadv.2023.108276. Online ahead of print.ABSTRACTMicrobial fermentation processes are expected to play an important role in reducing dependence on fossil-based raw materials for the production of everyday chemicals. In order to meet the growing demand for biotechnological products in the future, alternative carbon sources that do not compete with human nutrition must be exploited. The chemical conversion of the industrially emitted greenhouse gas CO2 into microbially utilizable platform chemicals such as methanol represents a sustainable strategy for the utilizatio...
Source: Biotechnology Advances - November 2, 2023 Category: Biotechnology Authors: Nils Wagner Linxuan Wen Cl áudio J R Frazão Thomas Walther Source Type: research
Next-generation feedstocks methanol and ethylene glycol and their potential in industrial biotechnology
Biotechnol Adv. 2023 Oct 31:108276. doi: 10.1016/j.biotechadv.2023.108276. Online ahead of print.ABSTRACTMicrobial fermentation processes are expected to play an important role in reducing dependence on fossil-based raw materials for the production of everyday chemicals. In order to meet the growing demand for biotechnological products in the future, alternative carbon sources that do not compete with human nutrition must be exploited. The chemical conversion of the industrially emitted greenhouse gas CO2 into microbially utilizable platform chemicals such as methanol represents a sustainable strategy for the utilization o...
Source: Biotechnology Advances - November 2, 2023 Category: Biotechnology Authors: Nils Wagner Linxuan Wen Cl áudio J R Frazão Thomas Walther Source Type: research
Next-generation feedstocks methanol and ethylene glycol and their potential in industrial biotechnology
Biotechnol Adv. 2023 Oct 31:108276. doi: 10.1016/j.biotechadv.2023.108276. Online ahead of print.ABSTRACTMicrobial fermentation processes are expected to play an important role in reducing dependence on fossil-based raw materials for the production of everyday chemicals. In order to meet the growing demand for biotechnological products in the future, alternative carbon sources that do not compete with human nutrition must be exploited. The chemical conversion of the industrially emitted greenhouse gas CO2 into microbially utilizable platform chemicals such as methanol represents a sustainable strategy for the utilization o...
Source: Biotechnology Advances - November 2, 2023 Category: Biotechnology Authors: Nils Wagner Linxuan Wen Cl áudio J R Frazão Thomas Walther Source Type: research
Unleashing the capacity of Rhodococcus for converting lignin into lipids
Biotechnol Adv. 2023 Oct 30:108274. doi: 10.1016/j.biotechadv.2023.108274. Online ahead of print.ABSTRACTBioconversion of bioresources/wastes (e.g., lignin, chemical pulping byproducts) represents a promising approach for developing a bioeconomy to help address growing energy and materials demands. Rhodococcus, a promising microbial strain, utilizes numerous carbon sources to produce lipids, which are precursors for synthesizing biodiesel and aviation fuels. However, compared to chemical conversion, bioconversion involves living cells, which is a more complex system that needs further understanding and upgrading. Various w...
Source: Biotechnology Advances - November 1, 2023 Category: Biotechnology Authors: Zhi-Min Zhao Zhi-Hua Liu Tongtong Zhang Rongqian Meng Zhiqun Gong Yibing Li Jing Hu Arthur J Ragauskas L Bing-Zhi Ying-Jin Yuan Source Type: research
Cell wall polysaccharides of streptococci: A genetic and structural perspective
Biotechnol Adv. 2023 Oct 30:108279. doi: 10.1016/j.biotechadv.2023.108279. Online ahead of print.ABSTRACTThe Streptococcus genus comprises both commensal and pathogenic species. Additionally, Streptococcus thermophilus is exploited in fermented foods and in probiotic preparations. The ecological and metabolic diversity of members of this genus is matched by the complex range of cell wall polysaccharides that they present on their cell surfaces. These glycopolymers facilitate their interactions and environmental adaptation. Here, current knowledge on the genetic and compositional diversity of streptococcal cell wall polysac...
Source: Biotechnology Advances - November 1, 2023 Category: Biotechnology Authors: Zoe Kampff Douwe van Sinderen Jennifer Mahony Source Type: research
Unleashing the capacity of Rhodococcus for converting lignin into lipids
Biotechnol Adv. 2023 Oct 30:108274. doi: 10.1016/j.biotechadv.2023.108274. Online ahead of print.ABSTRACTBioconversion of bioresources/wastes (e.g., lignin, chemical pulping byproducts) represents a promising approach for developing a bioeconomy to help address growing energy and materials demands. Rhodococcus, a promising microbial strain, utilizes numerous carbon sources to produce lipids, which are precursors for synthesizing biodiesel and aviation fuels. However, compared to chemical conversion, bioconversion involves living cells, which is a more complex system that needs further understanding and upgrading. Various w...
Source: Biotechnology Advances - November 1, 2023 Category: Biotechnology Authors: Zhi-Min Zhao Zhi-Hua Liu Tongtong Zhang Rongqian Meng Zhiqun Gong Yibing Li Jing Hu Arthur J Ragauskas L Bing-Zhi Ying-Jin Yuan Source Type: research
Cell wall polysaccharides of streptococci: A genetic and structural perspective
Biotechnol Adv. 2023 Oct 30:108279. doi: 10.1016/j.biotechadv.2023.108279. Online ahead of print.ABSTRACTThe Streptococcus genus comprises both commensal and pathogenic species. Additionally, Streptococcus thermophilus is exploited in fermented foods and in probiotic preparations. The ecological and metabolic diversity of members of this genus is matched by the complex range of cell wall polysaccharides that they present on their cell surfaces. These glycopolymers facilitate their interactions and environmental adaptation. Here, current knowledge on the genetic and compositional diversity of streptococcal cell wall polysac...
Source: Biotechnology Advances - November 1, 2023 Category: Biotechnology Authors: Zoe Kampff Douwe van Sinderen Jennifer Mahony Source Type: research
Bacillus sp. as a microbial cell factory: Advancements and future prospects
Biotechnol Adv. 2023 Oct 26:108278. doi: 10.1016/j.biotechadv.2023.108278. Online ahead of print.ABSTRACTBacillus sp. is one of the most distinctive gram-positive bacteria, able to grow efficiently using cheap carbon sources and secrete a variety of useful substances, which are widely used in food, pharmaceutical, agricultural and environmental industries. At the same time, Bacillus sp. is also recognized as a safe genus with a relatively clear genetic background, which is conducive to the industrial production of target metabolites. In this review, we discuss the reasons why Bacillus sp. has been so extensively studied an...
Source: Biotechnology Advances - October 28, 2023 Category: Biotechnology Authors: Jinyi Qian Yuzhou Wang Zijian Hu Tianqiong Shi Yuetong Wang Chao Ye He Huang Source Type: research
Bacillus sp. as a microbial cell factory: Advancements and future prospects
Biotechnol Adv. 2023 Oct 26:108278. doi: 10.1016/j.biotechadv.2023.108278. Online ahead of print.ABSTRACTBacillus sp. is one of the most distinctive gram-positive bacteria, able to grow efficiently using cheap carbon sources and secrete a variety of useful substances, which are widely used in food, pharmaceutical, agricultural and environmental industries. At the same time, Bacillus sp. is also recognized as a safe genus with a relatively clear genetic background, which is conducive to the industrial production of target metabolites. In this review, we discuss the reasons why Bacillus sp. has been so extensively studied an...
Source: Biotechnology Advances - October 28, 2023 Category: Biotechnology Authors: Jinyi Qian Yuzhou Wang Zijian Hu Tianqiong Shi Yuetong Wang Chao Ye He Huang Source Type: research
