Progress in cyclodextrins as important molecules regulating catalytic processes of glycoside hydrolases
Biotechnol Adv. 2024 Feb 19:108326. doi: 10.1016/j.biotechadv.2024.108326. Online ahead of print.ABSTRACTCyclodextrins (CDs) are important starch derivatives and commonly comprise α-, β-, and γ-CDs. Their hydrophilic surface and hydrophobic inner cavity enable regulation of enzyme catalysis through direct or indirect interactions. Clarifying interactions between CDs and enzyme is of great value for enzyme screening, mechanism exploration, regulation of catalysis, and applications. We summarize the interactions between CDs and glycoside hydrolases (GHs) according to two aspects: 1) CD as products, substrates, inhibitors ...
Source: Biotechnology Advances - February 21, 2024 Category: Biotechnology Authors: Xiaoxiao Li Zhengyu Jin Yuxiang Bai Birte Svensson Source Type: research
Emerging advances in glycoengineering of carbohydrates/glycans and their industrial applications
Biotechnol Adv. 2024 Feb 13:108324. doi: 10.1016/j.biotechadv.2024.108324. Online ahead of print.NO ABSTRACTPMID:38360155 | DOI:10.1016/j.biotechadv.2024.108324 (Source: Biotechnology Advances)
Source: Biotechnology Advances - February 15, 2024 Category: Biotechnology Authors: Brahma N Singh Meisam Tabatabaei Abhay Pandit Lothar Elling Vijai K Gupta Source Type: research
Emerging advances in glycoengineering of carbohydrates/glycans and their industrial applications
Biotechnol Adv. 2024 Feb 13:108324. doi: 10.1016/j.biotechadv.2024.108324. Online ahead of print.NO ABSTRACTPMID:38360155 | DOI:10.1016/j.biotechadv.2024.108324 (Source: Biotechnology Advances)
Source: Biotechnology Advances - February 15, 2024 Category: Biotechnology Authors: Brahma N Singh Meisam Tabatabaei Abhay Pandit Lothar Elling Vijai K Gupta Source Type: research
Emerging advances in glycoengineering of carbohydrates/glycans and their industrial applications
Biotechnol Adv. 2024 Feb 13:108324. doi: 10.1016/j.biotechadv.2024.108324. Online ahead of print.NO ABSTRACTPMID:38360155 | DOI:10.1016/j.biotechadv.2024.108324 (Source: Biotechnology Advances)
Source: Biotechnology Advances - February 15, 2024 Category: Biotechnology Authors: Brahma N Singh Meisam Tabatabaei Abhay Pandit Lothar Elling Vijai K Gupta Source Type: research
Emerging advances in glycoengineering of carbohydrates/glycans and their industrial applications
Biotechnol Adv. 2024 Feb 13:108324. doi: 10.1016/j.biotechadv.2024.108324. Online ahead of print.NO ABSTRACTPMID:38360155 | DOI:10.1016/j.biotechadv.2024.108324 (Source: Biotechnology Advances)
Source: Biotechnology Advances - February 15, 2024 Category: Biotechnology Authors: Brahma N Singh Meisam Tabatabaei Abhay Pandit Lothar Elling Vijai K Gupta Source Type: research
Emerging advances in glycoengineering of carbohydrates/glycans and their industrial applications
Biotechnol Adv. 2024 Feb 13:108324. doi: 10.1016/j.biotechadv.2024.108324. Online ahead of print.NO ABSTRACTPMID:38360155 | DOI:10.1016/j.biotechadv.2024.108324 (Source: Biotechnology Advances)
Source: Biotechnology Advances - February 15, 2024 Category: Biotechnology Authors: Brahma N Singh Meisam Tabatabaei Abhay Pandit Lothar Elling Vijai K Gupta Source Type: research
CRISPR-Cas systems of lactic acid bacteria and applications in food science
Biotechnol Adv. 2024 Feb 10;71:108323. doi: 10.1016/j.biotechadv.2024.108323. Online ahead of print.ABSTRACTCRISPR-Cas (Clustered regularly interspaced short palindromic repeats-CRISPR associated proteins) systems are widely distributed in lactic acid bacteria (LAB), contributing to their RNA-mediated adaptive defense immunity. The CRISPR-Cas-based genetic tools have exhibited powerful capability. It has been highly utilized in different organisms, accelerating the development of life science. The review summarized the components, adaptive immunity mechanisms, and classification of CRISPR-Cas systems; analyzed the distribu...
Source: Biotechnology Advances - February 12, 2024 Category: Biotechnology Authors: Yanhua Cui Xiaojun Qu Source Type: research
The thin line between monooxygenases and peroxygenases. P450s, UPOs, MMOs, and LPMOs: A brick to bridge fields of expertise
Biotechnol Adv. 2024 Feb 7:108321. doi: 10.1016/j.biotechadv.2024.108321. Online ahead of print.ABSTRACTMany scientific fields, although driven by similar purposes and dealing with similar technologies, often appear so isolated and far from each other that even the vocabularies to describe the very same phenomenon might differ. Concerning the vast field of biocatalysis, a special role is played by those redox enzymes that employ oxygen-based chemistry to unlock transformations otherwise possible only with metal-based catalysts. As such, greener chemical synthesis methods and environmentally-driven biotechnological approach...
Source: Biotechnology Advances - February 9, 2024 Category: Biotechnology Authors: Davide Decembrino David Cannella Source Type: research
Decoding cellular mechanism of recombinant adeno-associated virus (rAAV) and engineering host-cell factories toward intensified viral vector manufacturing
Biotechnol Adv. 2024 Feb 7;71:108322. doi: 10.1016/j.biotechadv.2024.108322. Online ahead of print.ABSTRACTRecombinant adeno-associated virus (rAAV) is one of the prominent gene delivery vehicles that has opened promising opportunities for novel gene therapeutic approaches. However, the current major viral vector production platform, triple transfection in mammalian cells, may not meet the increasing demand. Thus, it is highly required to understand production bottlenecks from the host cell perspective and engineer the cells to be more favorable and tolerant to viral vector production, thereby effectively enhancing rAAV ma...
Source: Biotechnology Advances - February 9, 2024 Category: Biotechnology Authors: Yongdan Wang Qiang Fu So Young Park Yong Suk Lee Seo-Young Park Dong-Yup Lee Seongkyu Yoon Source Type: research
Genome-scale metabolic network models for industrial microorganisms metabolic engineering: Current advances and future prospects
Biotechnol Adv. 2024 Jan 25:108319. doi: 10.1016/j.biotechadv.2024.108319. Online ahead of print.ABSTRACTThe construction of high-performance microbial cell factories (MCFs) is the centerpiece of biomanufacturing. However, the complex metabolic regulatory network of microorganisms poses great challenges for the efficient design and construction of MCFs. The genome-scale metabolic network models (GSMs) can systematically simulate the metabolic regulation process of microorganisms in silico, providing effective guidance for the rapid design and construction of MCFs. In this review, we summarized the development status of 16 ...
Source: Biotechnology Advances - January 27, 2024 Category: Biotechnology Authors: Zhijin Gong Jiayao Chen Xinyu Jiao Hao Gong Danzi Pan Lingli Liu Yang Zhang Kai Wang Meng Wang Hui Cao Tianwei Tan Source Type: research
PHA is not just a bioplastic!
Biotechnol Adv. 2024 Jan 23;71:108320. doi: 10.1016/j.biotechadv.2024.108320. Online ahead of print.ABSTRACTPolyhydroxyalkanoates (PHA) have evolved into versatile biopolymers, transcending their origins as mere bioplastics. This extensive review delves into the multifaceted landscape of PHA applications, shedding light on the diverse industries that have harnessed their potential. PHA has proven to be an invaluable eco-conscious option for packaging materials, finding use in films foams, paper coatings and even straws. In the textile industry, PHA offers a sustainable alternative, while its application as a carbon source ...
Source: Biotechnology Advances - January 25, 2024 Category: Biotechnology Authors: Helen Park Hongtao He Xu Yan Xu Liu Nigel S Scrutton Guo-Qiang Chen Source Type: research
Molecular imprinting technology for biomedical applications
Biotechnol Adv. 2024 Jan 22;71:108318. doi: 10.1016/j.biotechadv.2024.108318. Online ahead of print.ABSTRACTMolecularly imprinted polymers (MIPs), a type of biomimetic material, have attracted considerable interest owing to their cost-effectiveness, good physiochemical stability, favourable specificity and selectivity for target analytes, and widely used for various biological applications. It was demonstrated that MIPs with significant selectivity towards protein-based targets could be applied in medicine, diagnostics, proteomics, environmental analysis, sensors, various in vivo and/or in vitro applications, drug delivery...
Source: Biotechnology Advances - January 24, 2024 Category: Biotechnology Authors: Julija Sarvutiene Urte Prentice Simonas Ramanavicius Arunas Ramanavicius Source Type: research
Passive microfluidic devices for cell separation
Biotechnol Adv. 2024 Jan 12;71:108317. doi: 10.1016/j.biotechadv.2024.108317. Online ahead of print.ABSTRACTThe separation of specific cell populations is instrumental in gaining insights into cellular processes, elucidating disease mechanisms, and advancing applications in tissue engineering, regenerative medicine, diagnostics, and cell therapies. Microfluidic methods for cell separation have propelled the field forward, benefitting from miniaturization, advanced fabrication technologies, a profound understanding of fluid dynamics governing particle separation mechanisms, and a surge in interdisciplinary investigations fo...
Source: Biotechnology Advances - January 14, 2024 Category: Biotechnology Authors: Tianlong Zhang Dino Di Carlo Chwee Teck Lim Tianyuan Zhou Guizhong Tian Tao Tang Amy Q Shen Weihua Li Ming Li Yang Yang Keisuke Goda Ruopeng Yan Cheng Lei Yoichiroh Hosokawa Yaxiaer Yalikun Source Type: research
Resource allocation in mammalian systems
Biotechnol Adv. 2024 Jan 11;71:108305. doi: 10.1016/j.biotechadv.2023.108305. Online ahead of print.ABSTRACTCells execute biological functions to support phenotypes such as growth, migration, and secretion. Complementarily, each function of a cell has resource costs that constrain phenotype. Resource allocation by a cell allows it to manage these costs and optimize their phenotypes. In fact, the management of resource constraints (e.g., nutrient availability, bioenergetic capacity, and macromolecular machinery production) shape activity and ultimately impact phenotype. In mammalian systems, quantification of resource alloc...
Source: Biotechnology Advances - January 12, 2024 Category: Biotechnology Authors: Hratch M Baghdassarian Nathan E Lewis Source Type: research
Rumen microbes, enzymes, metabolisms, and application in lignocellulosic waste conversion - A comprehensive review
Biotechnol Adv. 2024 Jan 9;71:108308. doi: 10.1016/j.biotechadv.2024.108308. Online ahead of print.ABSTRACTThe rumen of ruminants is a natural anaerobic fermentation system that efficiently degrades lignocellulosic biomass and mainly depends on synergistic interactions between multiple microbes and their secreted enzymes. Ruminal microbes have been employed as biomass waste converters and are receiving increasing attention because of their degradation performance. To explore the application of ruminal microbes and their secreted enzymes in biomass waste, a comprehensive understanding of these processes is required. Based o...
Source: Biotechnology Advances - January 11, 2024 Category: Biotechnology Authors: Jinsong Liang Ru Zhang Jianning Chang Le Chen Mohammad Nabi Haibo Zhang Guangming Zhang Panyue Zhang Source Type: research
