Challenges in developing cell culture media using machine learning
Biotechnol Adv. 2023 Nov 18:108293. doi: 10.1016/j.biotechadv.2023.108293. Online ahead of print.ABSTRACTMicrobial and mammalian cells are widely used in the food, pharmaceutical, and medical industries. Developing or optimizing culture media is essential to improve cell culture performance as a critical technology in cell culture engineering. Methodologies for media optimization have been developed to a great extent, such as the approaches of one-factor-at-a-time (OFAT) and response surface methodology (RSM). The present review introduces the emerging machine learning (ML) technology in cell culture engineering by combini...
Source: Biotechnology Advances - November 20, 2023 Category: Biotechnology Authors: Takamasa Hashizume Bei-Wen Ying Source Type: research
Challenges in developing cell culture media using machine learning
Biotechnol Adv. 2023 Nov 18:108293. doi: 10.1016/j.biotechadv.2023.108293. Online ahead of print.ABSTRACTMicrobial and mammalian cells are widely used in the food, pharmaceutical, and medical industries. Developing or optimizing culture media is essential to improve cell culture performance as a critical technology in cell culture engineering. Methodologies for media optimization have been developed to a great extent, such as the approaches of one-factor-at-a-time (OFAT) and response surface methodology (RSM). The present review introduces the emerging machine learning (ML) technology in cell culture engineering by combini...
Source: Biotechnology Advances - November 20, 2023 Category: Biotechnology Authors: Takamasa Hashizume Bei-Wen Ying Source Type: research
Challenges in developing cell culture media using machine learning
Biotechnol Adv. 2023 Nov 18:108293. doi: 10.1016/j.biotechadv.2023.108293. Online ahead of print.ABSTRACTMicrobial and mammalian cells are widely used in the food, pharmaceutical, and medical industries. Developing or optimizing culture media is essential to improve cell culture performance as a critical technology in cell culture engineering. Methodologies for media optimization have been developed to a great extent, such as the approaches of one-factor-at-a-time (OFAT) and response surface methodology (RSM). The present review introduces the emerging machine learning (ML) technology in cell culture engineering by combini...
Source: Biotechnology Advances - November 20, 2023 Category: Biotechnology Authors: Takamasa Hashizume Bei-Wen Ying Source Type: research
Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens
Biotechnol Adv. 2023 Nov 14;70:108283. doi: 10.1016/j.biotechadv.2023.108283. Online ahead of print.ABSTRACTA key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies targeting viral attachment and fusion glycoproteins that embellish viral particles. This observation has catalyzed the development of numerous viral glycoprotein mimetics as vaccines. Glycans can dominate the surface of viral glycoproteins and as such, the viral glycome can influence the antigenicity and immunogenicity of a candidate vaccine. In one extreme, glycans can form an integral part of epitopes targeted by neutraliz...
Source: Biotechnology Advances - November 16, 2023 Category: Biotechnology Authors: Maddy L Newby Joel D Allen Max Crispin Source Type: research
Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens
Biotechnol Adv. 2023 Nov 14:108283. doi: 10.1016/j.biotechadv.2023.108283. Online ahead of print.ABSTRACTA key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies targeting viral attachment and fusion glycoproteins that embellish viral particles. This observation has catalyzed the development of numerous viral glycoprotein mimetics as vaccines. Glycans can dominate the surface of viral glycoproteins and as such, the viral glycome can influence the antigenicity and immunogenicity of a candidate vaccine. In one extreme, glycans can form an integral part of epitopes targeted by neutralizing...
Source: Biotechnology Advances - November 16, 2023 Category: Biotechnology Authors: M L Newby J D Allen M Crispin Source Type: research
Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens
Biotechnol Adv. 2023 Nov 14:108283. doi: 10.1016/j.biotechadv.2023.108283. Online ahead of print.ABSTRACTA key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies targeting viral attachment and fusion glycoproteins that embellish viral particles. This observation has catalyzed the development of numerous viral glycoprotein mimetics as vaccines. Glycans can dominate the surface of viral glycoproteins and as such, the viral glycome can influence the antigenicity and immunogenicity of a candidate vaccine. In one extreme, glycans can form an integral part of epitopes targeted by neutralizing...
Source: Biotechnology Advances - November 16, 2023 Category: Biotechnology Authors: M L Newby J D Allen M Crispin Source Type: research
Production and characterization of starch-lignin based materials: A review
Biotechnol Adv. 2023 Nov 11:108281. doi: 10.1016/j.biotechadv.2023.108281. Online ahead of print.ABSTRACTIn their pristine state, starch and lignin are abundant and inexpensive natural polymers frequently considered green alternatives to oil-based and synthetic polymers. Despite their availability and owing to their physicochemical properties; starch and lignin are not often utilized in their pristine forms for high-performance applications. Generally, chemical and physical modifications transform them into starch- and lignin-based materials with broadened properties and functionality. In the last decade, the combination o...
Source: Biotechnology Advances - November 13, 2023 Category: Biotechnology Authors: Jonathan A Diaz-Baca Pedram Fatehi Source Type: research
Production and characterization of starch-lignin based materials: A review
Biotechnol Adv. 2023 Nov 11:108281. doi: 10.1016/j.biotechadv.2023.108281. Online ahead of print.ABSTRACTIn their pristine state, starch and lignin are abundant and inexpensive natural polymers frequently considered green alternatives to oil-based and synthetic polymers. Despite their availability and owing to their physicochemical properties; starch and lignin are not often utilized in their pristine forms for high-performance applications. Generally, chemical and physical modifications transform them into starch- and lignin-based materials with broadened properties and functionality. In the last decade, the combination o...
Source: Biotechnology Advances - November 13, 2023 Category: Biotechnology Authors: Jonathan A Diaz-Baca Pedram Fatehi Source Type: research
Production and characterization of starch-lignin based materials: A review
Biotechnol Adv. 2023 Nov 11:108281. doi: 10.1016/j.biotechadv.2023.108281. Online ahead of print.ABSTRACTIn their pristine state, starch and lignin are abundant and inexpensive natural polymers frequently considered green alternatives to oil-based and synthetic polymers. Despite their availability and owing to their physicochemical properties; starch and lignin are not often utilized in their pristine forms for high-performance applications. Generally, chemical and physical modifications transform them into starch- and lignin-based materials with broadened properties and functionality. In the last decade, the combination o...
Source: Biotechnology Advances - November 13, 2023 Category: Biotechnology Authors: Jonathan A Diaz-Baca Pedram Fatehi Source Type: research
Production and characterization of starch-lignin based materials: A review
Biotechnol Adv. 2023 Nov 11:108281. doi: 10.1016/j.biotechadv.2023.108281. Online ahead of print.ABSTRACTIn their pristine state, starch and lignin are abundant and inexpensive natural polymers frequently considered green alternatives to oil-based and synthetic polymers. Despite their availability and owing to their physicochemical properties; starch and lignin are not often utilized in their pristine forms for high-performance applications. Generally, chemical and physical modifications transform them into starch- and lignin-based materials with broadened properties and functionality. In the last decade, the combination o...
Source: Biotechnology Advances - November 13, 2023 Category: Biotechnology Authors: Jonathan A Diaz-Baca Pedram Fatehi Source Type: research
Abiotic stress as a dynamic strategy for enhancing high value phytochemicals in microalgae: Critical insights, challenges and future prospects
This study delves into the pivotal impacts of manipulating abiotic stress on microalgae yields, with a particular focus on biomass and selected HVPCs that have received limited attention in the existing literature. Moreover, approaches to utilising abiotic stress to increase HVPCs production while minimising adverse effects on biomass productivity were discussed. The present study also encompasses a techno-economic assessment (TEA) aimed at pinpointing significant bottlenecks in the conversion of microalgae biomass into high-value products and evaluating the desirability of various conversion pathways. The TEA methodology ...
Source: Biotechnology Advances - November 9, 2023 Category: Biotechnology Authors: Uganeeswary Suparmaniam Man Kee Lam Jun Wei Lim Inn Shi Tan Bridgid Lai Fui Chin Siew Hoong Shuit Steven Lim Yean Ling Pang Peck Loo Kiew Source Type: research
Abiotic stress as a dynamic strategy for enhancing high value phytochemicals in microalgae: Critical insights, challenges and future prospects
This study delves into the pivotal impacts of manipulating abiotic stress on microalgae yields, with a particular focus on biomass and selected HVPCs that have received limited attention in the existing literature. Moreover, approaches to utilising abiotic stress to increase HVPCs production while minimising adverse effects on biomass productivity were discussed. The present study also encompasses a techno-economic assessment (TEA) aimed at pinpointing significant bottlenecks in the conversion of microalgae biomass into high-value products and evaluating the desirability of various conversion pathways. The TEA methodology ...
Source: Biotechnology Advances - November 9, 2023 Category: Biotechnology Authors: Uganeeswary Suparmaniam Man Kee Lam Jun Wei Lim Inn Shi Tan Bridgid Lai Fui Chin Siew Hoong Shuit Steven Lim Yean Ling Pang Peck Loo Kiew Source Type: research
Abiotic stress as a dynamic strategy for enhancing high value phytochemicals in microalgae: Critical insights, challenges and future prospects
This study delves into the pivotal impacts of manipulating abiotic stress on microalgae yields, with a particular focus on biomass and selected HVPCs that have received limited attention in the existing literature. Moreover, approaches to utilising abiotic stress to increase HVPCs production while minimising adverse effects on biomass productivity were discussed. The present study also encompasses a techno-economic assessment (TEA) aimed at pinpointing significant bottlenecks in the conversion of microalgae biomass into high-value products and evaluating the desirability of various conversion pathways. The TEA methodology ...
Source: Biotechnology Advances - November 9, 2023 Category: Biotechnology Authors: Uganeeswary Suparmaniam Man Kee Lam Jun Wei Lim Inn Shi Tan Bridgid Lai Fui Chin Siew Hoong Shuit Steven Lim Yean Ling Pang Peck Loo Kiew Source Type: research
Engineering status of protein for improving microbial cell factories
Biotechnol Adv. 2023 Nov 6:108282. doi: 10.1016/j.biotechadv.2023.108282. Online ahead of print.ABSTRACTWith the development of metabolic engineering and synthetic biology, microbial cell factories (MCFs) have provided an efficient and sustainable method to synthesize a series of chemicals from renewable feedstocks. However, the efficiency of MCFs is usually limited by the inappropriate status of protein. Thus, engineering status of protein is essential to achieve efficient bioproduction with high titer, yield and productivity. In this review, we summarize the engineering strategies for metabolic protein status, including ...
Source: Biotechnology Advances - November 8, 2023 Category: Biotechnology Authors: Pei Zhou Cong Gao Wei Song Wanqing Wei Jing Wu Liming Liu Xiulai Chen Source Type: research
Engineering status of protein for improving microbial cell factories
Biotechnol Adv. 2023 Nov 6:108282. doi: 10.1016/j.biotechadv.2023.108282. Online ahead of print.ABSTRACTWith the development of metabolic engineering and synthetic biology, microbial cell factories (MCFs) have provided an efficient and sustainable method to synthesize a series of chemicals from renewable feedstocks. However, the efficiency of MCFs is usually limited by the inappropriate status of protein. Thus, engineering status of protein is essential to achieve efficient bioproduction with high titer, yield and productivity. In this review, we summarize the engineering strategies for metabolic protein status, including ...
Source: Biotechnology Advances - November 8, 2023 Category: Biotechnology Authors: Pei Zhou Cong Gao Wei Song Wanqing Wei Jing Wu Liming Liu Xiulai Chen Source Type: research
