Next generation probiotics: Engineering live biotherapeutics
Biotechnol Adv. 2024 Mar 1:108336. doi: 10.1016/j.biotechadv.2024.108336. Online ahead of print.ABSTRACTThe population dynamics of the human microbiome have been associated with inflammatory bowel disease, cancer, obesity, autoimmune diseases, and many other human disease states. An emerging paradigm in treatment is the administration of live engineered organisms, so- called next-generation probiotics. However, the efficacy of these microbial therapies can be limited by the organism's overall performance in the harsh and nutrient-limited environment of the gut. In this review, we summarize the current state of the art use ...
Source: Biotechnology Advances - March 3, 2024 Category: Biotechnology Authors: Sanjeeva Kumar Murali Thomas J Mansell Source Type: research
Next generation probiotics: Engineering live biotherapeutics
Biotechnol Adv. 2024 Mar 1:108336. doi: 10.1016/j.biotechadv.2024.108336. Online ahead of print.ABSTRACTThe population dynamics of the human microbiome have been associated with inflammatory bowel disease, cancer, obesity, autoimmune diseases, and many other human disease states. An emerging paradigm in treatment is the administration of live engineered organisms, so- called next-generation probiotics. However, the efficacy of these microbial therapies can be limited by the organism's overall performance in the harsh and nutrient-limited environment of the gut. In this review, we summarize the current state of the art use ...
Source: Biotechnology Advances - March 3, 2024 Category: Biotechnology Authors: Sanjeeva Kumar Murali Thomas J Mansell Source Type: research
Next generation probiotics: Engineering live biotherapeutics
Biotechnol Adv. 2024 Mar 1:108336. doi: 10.1016/j.biotechadv.2024.108336. Online ahead of print.ABSTRACTThe population dynamics of the human microbiome have been associated with inflammatory bowel disease, cancer, obesity, autoimmune diseases, and many other human disease states. An emerging paradigm in treatment is the administration of live engineered organisms, so- called next-generation probiotics. However, the efficacy of these microbial therapies can be limited by the organism's overall performance in the harsh and nutrient-limited environment of the gut. In this review, we summarize the current state of the art use ...
Source: Biotechnology Advances - March 3, 2024 Category: Biotechnology Authors: Sanjeeva Kumar Murali Thomas J Mansell Source Type: research
Next generation probiotics: Engineering live biotherapeutics
Biotechnol Adv. 2024 Mar 1:108336. doi: 10.1016/j.biotechadv.2024.108336. Online ahead of print.ABSTRACTThe population dynamics of the human microbiome have been associated with inflammatory bowel disease, cancer, obesity, autoimmune diseases, and many other human disease states. An emerging paradigm in treatment is the administration of live engineered organisms, so- called next-generation probiotics. However, the efficacy of these microbial therapies can be limited by the organism's overall performance in the harsh and nutrient-limited environment of the gut. In this review, we summarize the current state of the art use ...
Source: Biotechnology Advances - March 3, 2024 Category: Biotechnology Authors: Sanjeeva Kumar Murali Thomas J Mansell Source Type: research
Next generation probiotics: Engineering live biotherapeutics
Biotechnol Adv. 2024 Mar 1:108336. doi: 10.1016/j.biotechadv.2024.108336. Online ahead of print.ABSTRACTThe population dynamics of the human microbiome have been associated with inflammatory bowel disease, cancer, obesity, autoimmune diseases, and many other human disease states. An emerging paradigm in treatment is the administration of live engineered organisms, so- called next-generation probiotics. However, the efficacy of these microbial therapies can be limited by the organism's overall performance in the harsh and nutrient-limited environment of the gut. In this review, we summarize the current state of the art use ...
Source: Biotechnology Advances - March 3, 2024 Category: Biotechnology Authors: Sanjeeva Kumar Murali Thomas J Mansell Source Type: research
The Gompertz model and its applications in microbial growth and bioproduction kinetics: Past, present and future
Biotechnol Adv. 2024 Feb 27;72:108335. doi: 10.1016/j.biotechadv.2024.108335. Online ahead of print.ABSTRACTThe Gompertz model, initially proposed for human mortality rates, has found various applications in growth analysis across the biotechnological field. This paper presents a comprehensive review of the Gompertz model's applications in the biotechnological field, examining its past, present, and future. The past of the Gompertz model was examined by tracing its origins to 1825, and then it underwent various modifications throughout the 20th century to increase its applicability in biotechnological fields. The Zwieterin...
Source: Biotechnology Advances - February 28, 2024 Category: Biotechnology Authors: Jianlong Wang Xuan Guo Source Type: research
The Gompertz model and its applications in microbial growth and bioproduction kinetics: Past, present and future
Biotechnol Adv. 2024 Feb 27;72:108335. doi: 10.1016/j.biotechadv.2024.108335. Online ahead of print.ABSTRACTThe Gompertz model, initially proposed for human mortality rates, has found various applications in growth analysis across the biotechnological field. This paper presents a comprehensive review of the Gompertz model's applications in the biotechnological field, examining its past, present, and future. The past of the Gompertz model was examined by tracing its origins to 1825, and then it underwent various modifications throughout the 20th century to increase its applicability in biotechnological fields. The Zwieterin...
Source: Biotechnology Advances - February 28, 2024 Category: Biotechnology Authors: Jianlong Wang Xuan Guo Source Type: research
The Gompertz model and its applications in microbial growth and bioproduction kinetics: Past, present and future
Biotechnol Adv. 2024 Feb 26:108335. doi: 10.1016/j.biotechadv.2024.108335. Online ahead of print.ABSTRACTThe Gompertz model, initially proposed for human mortality rates, has found various applications in growth analysis across the biotechnological field. This paper presents a comprehensive review of the Gompertz model's applications in the biotechnological field, examining its past, present, and future. The past of the Gompertz model was examined by tracing its origins to 1825, and then it underwent various modifications throughout the 20th century to increase its applicability in biotechnological fields. The Zwietering-m...
Source: Biotechnology Advances - February 28, 2024 Category: Biotechnology Authors: Jianlong Wang Xuan Guo Source Type: research
The Gompertz model and its applications in microbial growth and bioproduction kinetics: Past, present and future
Biotechnol Adv. 2024 Feb 26:108335. doi: 10.1016/j.biotechadv.2024.108335. Online ahead of print.ABSTRACTThe Gompertz model, initially proposed for human mortality rates, has found various applications in growth analysis across the biotechnological field. This paper presents a comprehensive review of the Gompertz model's applications in the biotechnological field, examining its past, present, and future. The past of the Gompertz model was examined by tracing its origins to 1825, and then it underwent various modifications throughout the 20th century to increase its applicability in biotechnological fields. The Zwietering-m...
Source: Biotechnology Advances - February 28, 2024 Category: Biotechnology Authors: Jianlong Wang Xuan Guo Source Type: research
New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera
Biotechnol Adv. 2024 Feb 21:108325. doi: 10.1016/j.biotechadv.2024.108325. Online ahead of print.ABSTRACTHistorically, the genus Aloe has been an indispensable part of both traditional and modern medicine. Decades of intensive research have unveiled the major bioactive secondary metabolites of this plant. Recent pandemic outbreaks have revitalized curiosity in aloe metabolites, as they have proven pharmacokinetic profiles and repurposable chemical space. However, the structural complexity of these metabolites has hindered scientific advances in the chemical synthesis of these compounds. Multi-omics research interventions h...
Source: Biotechnology Advances - February 23, 2024 Category: Biotechnology Authors: Mrudulakumari Vasudevan Ushasree Qi Jia Seon Gil Do Eun Yeol Lee Source Type: research
New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera
Biotechnol Adv. 2024 Feb 21:108325. doi: 10.1016/j.biotechadv.2024.108325. Online ahead of print.ABSTRACTHistorically, the genus Aloe has been an indispensable part of both traditional and modern medicine. Decades of intensive research have unveiled the major bioactive secondary metabolites of this plant. Recent pandemic outbreaks have revitalized curiosity in aloe metabolites, as they have proven pharmacokinetic profiles and repurposable chemical space. However, the structural complexity of these metabolites has hindered scientific advances in the chemical synthesis of these compounds. Multi-omics research interventions h...
Source: Biotechnology Advances - February 23, 2024 Category: Biotechnology Authors: Mrudulakumari Vasudevan Ushasree Qi Jia Seon Gil Do Eun Yeol Lee Source Type: research
New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera
Biotechnol Adv. 2024 Feb 21:108325. doi: 10.1016/j.biotechadv.2024.108325. Online ahead of print.ABSTRACTHistorically, the genus Aloe has been an indispensable part of both traditional and modern medicine. Decades of intensive research have unveiled the major bioactive secondary metabolites of this plant. Recent pandemic outbreaks have revitalized curiosity in aloe metabolites, as they have proven pharmacokinetic profiles and repurposable chemical space. However, the structural complexity of these metabolites has hindered scientific advances in the chemical synthesis of these compounds. Multi-omics research interventions h...
Source: Biotechnology Advances - February 23, 2024 Category: Biotechnology Authors: Mrudulakumari Vasudevan Ushasree Qi Jia Seon Gil Do Eun Yeol Lee Source Type: research
New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera
Biotechnol Adv. 2024 Feb 21:108325. doi: 10.1016/j.biotechadv.2024.108325. Online ahead of print.ABSTRACTHistorically, the genus Aloe has been an indispensable part of both traditional and modern medicine. Decades of intensive research have unveiled the major bioactive secondary metabolites of this plant. Recent pandemic outbreaks have revitalized curiosity in aloe metabolites, as they have proven pharmacokinetic profiles and repurposable chemical space. However, the structural complexity of these metabolites has hindered scientific advances in the chemical synthesis of these compounds. Multi-omics research interventions h...
Source: Biotechnology Advances - February 23, 2024 Category: Biotechnology Authors: Mrudulakumari Vasudevan Ushasree Qi Jia Seon Gil Do Eun Yeol Lee Source Type: research
Progress in cyclodextrins as important molecules regulating catalytic processes of glycoside hydrolases
Biotechnol Adv. 2024 Feb 19;72:108326. doi: 10.1016/j.biotechadv.2024.108326. Online ahead of print.ABSTRACTCyclodextrins (CDs) are important starch derivatives and commonly comprise α-, β-, and γ-CDs. Their hydrophilic surface and hydrophobic inner cavity enable regulation of enzyme catalysis through direct or indirect interactions. Clarifying interactions between CDs and enzyme is of great value for enzyme screening, mechanism exploration, regulation of catalysis, and applications. We summarize the interactions between CDs and glycoside hydrolases (GHs) according to two aspects: 1) CD as products, substrates, inhibito...
Source: Biotechnology Advances - February 21, 2024 Category: Biotechnology Authors: Xiaoxiao Li Zhengyu Jin Yuxiang Bai Birte Svensson Source Type: research
Progress in cyclodextrins as important molecules regulating catalytic processes of glycoside hydrolases
Biotechnol Adv. 2024 Feb 19:108326. doi: 10.1016/j.biotechadv.2024.108326. Online ahead of print.ABSTRACTCyclodextrins (CDs) are important starch derivatives and commonly comprise α-, β-, and γ-CDs. Their hydrophilic surface and hydrophobic inner cavity enable regulation of enzyme catalysis through direct or indirect interactions. Clarifying interactions between CDs and enzyme is of great value for enzyme screening, mechanism exploration, regulation of catalysis, and applications. We summarize the interactions between CDs and glycoside hydrolases (GHs) according to two aspects: 1) CD as products, substrates, inhibitors ...
Source: Biotechnology Advances - February 21, 2024 Category: Biotechnology Authors: Xiaoxiao Li Zhengyu Jin Yuxiang Bai Birte Svensson Source Type: research
