Metabolic engineering and synthetic biology strategies for producing high-value natural pigments in Microalgae
Biotechnol Adv. 2023 Aug 14:108236. doi: 10.1016/j.biotechadv.2023.108236. Online ahead of print.ABSTRACTMicroalgae are microorganisms capable of producing bioactive compounds using photosynthesis. Microalgae contain a variety of high value-added natural pigments such as carotenoids, phycobilins, and chlorophylls. These pigments play an important role in many areas such as food, pharmaceuticals, and cosmetics. Natural pigments have a health value that is unmatched by synthetic pigments. However, the current commercial production of natural pigments from microalgae is not able to meet the growing market demand. The use of m...
Source: Biotechnology Advances - August 16, 2023 Category: Biotechnology Authors: Kai Cao Yunlin Cui Fengjie Sun Hao Zhang Jianhua Fan Baosheng Ge Yujiao Cao Xiaodong Wang Xiangyu Zhu Zuoxi Wei Qingshou Yao Jinju Ma Yu Wang Chunxiao Meng Zhengquan Gao Source Type: research
Harmful and beneficial properties of cyanotoxins: Two sides of the same coin
Biotechnol Adv. 2023 Aug 9;68:108235. doi: 10.1016/j.biotechadv.2023.108235. Online ahead of print.ABSTRACTCyanotoxins are by definition "harmful agents" produced by cyanobacteria. Their toxicity has been extensively studied and reviewed over the years. Cyanotoxins have been commonly classified, based on their poisonous effects on mammals, into three main classes, neurotoxins, hepatotoxins and dermatotoxins, and, considering their chemical features, mainly identified as peptides, alkaloids and lipopolysaccharides. Here we propose a broader subdivision of cyanotoxins into eight distinct classes, taking into account their mo...
Source: Biotechnology Advances - August 11, 2023 Category: Biotechnology Authors: Annarita Ricciardelli Antonino Pollio Maria Costantini Valerio Zupo Source Type: research
Harmful and beneficial properties of cyanotoxins: Two sides of the same coin
Biotechnol Adv. 2023 Aug 9:108235. doi: 10.1016/j.biotechadv.2023.108235. Online ahead of print.ABSTRACTCyanotoxins are by definition "harmful agents" produced by cyanobacteria. Their toxicity has been extensively studied and reviewed over the years. Cyanotoxins have been commonly classified, based on their poisonous effects on mammals, into three main classes, neurotoxins, hepatotoxins and dermatotoxins, and, considering their chemical features, mainly identified as peptides, alkaloids and lipopolysaccharides. Here we propose a broader subdivision of cyanotoxins into eight distinct classes, taking into account their molec...
Source: Biotechnology Advances - August 11, 2023 Category: Biotechnology Authors: Annarita Ricciardelli Antonino Pollio Maria Costantini Valerio Zupo Source Type: research
Harmful and beneficial properties of cyanotoxins: Two sides of the same coin
Biotechnol Adv. 2023 Aug 9:108235. doi: 10.1016/j.biotechadv.2023.108235. Online ahead of print.ABSTRACTCyanotoxins are by definition "harmful agents" produced by cyanobacteria. Their toxicity has been extensively studied and reviewed over the years. Cyanotoxins have been commonly classified, based on their poisonous effects on mammals, into three main classes, neurotoxins, hepatotoxins and dermatotoxins, and, considering their chemical features, mainly identified as peptides, alkaloids and lipopolysaccharides. Here we propose a broader subdivision of cyanotoxins into eight distinct classes, taking into account their molec...
Source: Biotechnology Advances - August 11, 2023 Category: Biotechnology Authors: Annarita Ricciardelli Antonino Pollio Maria Costantini Valerio Zupo Source Type: research
Harmful and beneficial properties of cyanotoxins: Two sides of the same coin
Biotechnol Adv. 2023 Aug 9:108235. doi: 10.1016/j.biotechadv.2023.108235. Online ahead of print.ABSTRACTCyanotoxins are by definition "harmful agents" produced by cyanobacteria. Their toxicity has been extensively studied and reviewed over the years. Cyanotoxins have been commonly classified, based on their poisonous effects on mammals, into three main classes, neurotoxins, hepatotoxins and dermatotoxins, and, considering their chemical features, mainly identified as peptides, alkaloids and lipopolysaccharides. Here we propose a broader subdivision of cyanotoxins into eight distinct classes, taking into account their molec...
Source: Biotechnology Advances - August 11, 2023 Category: Biotechnology Authors: Annarita Ricciardelli Antonino Pollio Maria Costantini Valerio Zupo Source Type: research
The technology, opportunities and challenges of synthetic biological intelligence
Biotechnol Adv. 2023 Aug 7:108233. doi: 10.1016/j.biotechadv.2023.108233. Online ahead of print.ABSTRACTIntegrating neural cultures developed through synthetic biology methods with digital computing has enabled the early development of Synthetic Biological Intelligence (SBI). Recently, key studies have emphasized the advantages of biological neural systems in some information processing tasks. However, neither the technology behind this early development, nor the potential ethical opportunities or challenges, have been explored in detail yet. Here, we review the key aspects that facilitate the development of SBI and explor...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Brett J Kagan Christopher Gyngell Tamra Lysaght Victor M Cole Tsutomu Sawai Julian Savulescu Source Type: research
The isolation of lignin with native-like structure
Biotechnol Adv. 2023 Aug 7:108230. doi: 10.1016/j.biotechadv.2023.108230. Online ahead of print.ABSTRACTSearching for renewable alternatives for fossil carbon resources to produce chemicals, fuels and materials is essential for the development of a sustainable society. Lignin, a major component of lignocellulosic biomass, is an abundant renewable source of aromatics and is currently underutilized as it is often burned as an undesired side stream in the production of paper and bioethanol. This lignin harbors great potential as source of high value aromatic chemicals and materials. Biorefinery schemes focused on lignin are c...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Zhiwen Wang Peter J Deuss Source Type: research
Glycovaccinology: The design and engineering of carbohydrate-based vaccine components
Biotechnol Adv. 2023 Aug 7:108234. doi: 10.1016/j.biotechadv.2023.108234. Online ahead of print.ABSTRACTVaccines remain one of the most important pillars in preventative medicine, providing protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of the many possible candidate antigens for subunit vaccine development, carbohydrates are particularly appealing because of their ubiquitous presence on the surface of all living cells, viruses, and parasites as well as their known interactions with both innate and adaptive immune cells. Indeed, several licensed vaccines leverage bacterial cell-su...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Sophia W Hulbert Primit Desai Michael C Jewett Matthew P DeLisa Asher J Williams Source Type: research
The technology, opportunities and challenges of synthetic biological intelligence
Biotechnol Adv. 2023 Aug 7:108233. doi: 10.1016/j.biotechadv.2023.108233. Online ahead of print.ABSTRACTIntegrating neural cultures developed through synthetic biology methods with digital computing has enabled the early development of Synthetic Biological Intelligence (SBI). Recently, key studies have emphasized the advantages of biological neural systems in some information processing tasks. However, neither the technology behind this early development, nor the potential ethical opportunities or challenges, have been explored in detail yet. Here, we review the key aspects that facilitate the development of SBI and explor...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Brett J Kagan Christopher Gyngell Tamra Lysaght Victor M Cole Tsutomu Sawai Julian Savulescu Source Type: research
The isolation of lignin with native-like structure
Biotechnol Adv. 2023 Aug 7:108230. doi: 10.1016/j.biotechadv.2023.108230. Online ahead of print.ABSTRACTSearching for renewable alternatives for fossil carbon resources to produce chemicals, fuels and materials is essential for the development of a sustainable society. Lignin, a major component of lignocellulosic biomass, is an abundant renewable source of aromatics and is currently underutilized as it is often burned as an undesired side stream in the production of paper and bioethanol. This lignin harbors great potential as source of high value aromatic chemicals and materials. Biorefinery schemes focused on lignin are c...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Zhiwen Wang Peter J Deuss Source Type: research
Glycovaccinology: The design and engineering of carbohydrate-based vaccine components
Biotechnol Adv. 2023 Aug 7:108234. doi: 10.1016/j.biotechadv.2023.108234. Online ahead of print.ABSTRACTVaccines remain one of the most important pillars in preventative medicine, providing protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of the many possible candidate antigens for subunit vaccine development, carbohydrates are particularly appealing because of their ubiquitous presence on the surface of all living cells, viruses, and parasites as well as their known interactions with both innate and adaptive immune cells. Indeed, several licensed vaccines leverage bacterial cell-su...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Sophia W Hulbert Primit Desai Michael C Jewett Matthew P DeLisa Asher J Williams Source Type: research
The technology, opportunities and challenges of synthetic biological intelligence
Biotechnol Adv. 2023 Aug 7:108233. doi: 10.1016/j.biotechadv.2023.108233. Online ahead of print.ABSTRACTIntegrating neural cultures developed through synthetic biology methods with digital computing has enabled the early development of Synthetic Biological Intelligence (SBI). Recently, key studies have emphasized the advantages of biological neural systems in some information processing tasks. However, neither the technology behind this early development, nor the potential ethical opportunities or challenges, have been explored in detail yet. Here, we review the key aspects that facilitate the development of SBI and explor...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Brett J Kagan Christopher Gyngell Tamra Lysaght Victor M Cole Tsutomu Sawai Julian Savulescu Source Type: research
The isolation of lignin with native-like structure
Biotechnol Adv. 2023 Aug 7:108230. doi: 10.1016/j.biotechadv.2023.108230. Online ahead of print.ABSTRACTSearching for renewable alternatives for fossil carbon resources to produce chemicals, fuels and materials is essential for the development of a sustainable society. Lignin, a major component of lignocellulosic biomass, is an abundant renewable source of aromatics and is currently underutilized as it is often burned as an undesired side stream in the production of paper and bioethanol. This lignin harbors great potential as source of high value aromatic chemicals and materials. Biorefinery schemes focused on lignin are c...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Zhiwen Wang Peter J Deuss Source Type: research
Glycovaccinology: The design and engineering of carbohydrate-based vaccine components
Biotechnol Adv. 2023 Aug 7:108234. doi: 10.1016/j.biotechadv.2023.108234. Online ahead of print.ABSTRACTVaccines remain one of the most important pillars in preventative medicine, providing protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of the many possible candidate antigens for subunit vaccine development, carbohydrates are particularly appealing because of their ubiquitous presence on the surface of all living cells, viruses, and parasites as well as their known interactions with both innate and adaptive immune cells. Indeed, several licensed vaccines leverage bacterial cell-su...
Source: Biotechnology Advances - August 9, 2023 Category: Biotechnology Authors: Sophia W Hulbert Primit Desai Michael C Jewett Matthew P DeLisa Asher J Williams Source Type: research
Peptaibiotics: Harnessing the potential of microbial secondary metabolites for mitigation of plant pathogens
Biotechnol Adv. 2023 Aug 1;68:108223. doi: 10.1016/j.biotechadv.2023.108223. Online ahead of print.ABSTRACTAgricultural systems are in need of low-cost, safe antibiotics to protect crops from pests and diseases. Peptaibiotics, a family of linear, membrane-active, amphipathic polypeptides, have been shown to exhibit antibacterial, antifungal, and antiviral activity, and to be inducers of plant resistance against a wide range of phytopathogens. Peptaibiotics belong to the new generation of alternatives to agrochemicals, aligned with the United Nations Sustainable Development Goals and the One Health approach toward ensuring ...
Source: Biotechnology Advances - August 3, 2023 Category: Biotechnology Authors: Leandro Pereira-Dias Paulo R Oliveira-Pinto Juliana O Fernandes Laura Regalado Rafael Mendes C átia Teixeira Nuno Mariz-Ponte Paula Gomes Concei ção Santos Source Type: research
