Resource allocation in mammalian systems
Biotechnol Adv. 2024 Jan 11;71:108305. doi: 10.1016/j.biotechadv.2023.108305. Online ahead of print.ABSTRACTCells execute biological functions to support phenotypes such as growth, migration, and secretion. Complementarily, each function of a cell has resource costs that constrain phenotype. Resource allocation by a cell allows it to manage these costs and optimize their phenotypes. In fact, the management of resource constraints (e.g., nutrient availability, bioenergetic capacity, and macromolecular machinery production) shape activity and ultimately impact phenotype. In mammalian systems, quantification of resource alloc...
Source: Biotechnology Advances - January 12, 2024 Category: Biotechnology Authors: Hratch M Baghdassarian Nathan E Lewis Source Type: research
Rumen microbes, enzymes, metabolisms, and application in lignocellulosic waste conversion - A comprehensive review
Biotechnol Adv. 2024 Jan 9;71:108308. doi: 10.1016/j.biotechadv.2024.108308. Online ahead of print.ABSTRACTThe rumen of ruminants is a natural anaerobic fermentation system that efficiently degrades lignocellulosic biomass and mainly depends on synergistic interactions between multiple microbes and their secreted enzymes. Ruminal microbes have been employed as biomass waste converters and are receiving increasing attention because of their degradation performance. To explore the application of ruminal microbes and their secreted enzymes in biomass waste, a comprehensive understanding of these processes is required. Based o...
Source: Biotechnology Advances - January 11, 2024 Category: Biotechnology Authors: Jinsong Liang Ru Zhang Jianning Chang Le Chen Mohammad Nabi Haibo Zhang Guangming Zhang Panyue Zhang Source Type: research
Ionic liquids and deep eutectic solvents for the stabilization of biopharmaceuticals: A review
Biotechnol Adv. 2024 Jan 8;71:108316. doi: 10.1016/j.biotechadv.2024.108316. Online ahead of print.ABSTRACTBiopharmaceuticals have allowed the control of previously untreatable diseases. However, their low solubility and stability still hinder their application, transport, and storage. Hence, researchers have applied different compounds to preserve and enhance the delivery of biopharmaceuticals, such as ionic liquids (ILs) and deep eutectic solvents (DESs). Although the biopharmaceutical industry can employ various substances for enhancing formulations, their effect will change depending on the properties of the target bio...
Source: Biotechnology Advances - January 10, 2024 Category: Biotechnology Authors: Nathalia Vieira Porphirio Ver íssimo Cassamo Usemane Mussagy Heitor Buzetti Sim ões Bento Jorge Fernando Brand ão Pereira Val éria de Carvalho Santos-Ebinuma Source Type: research
A guide to the use of bioassays in exploration of natural resources
We present a comprehensive list of practical considerations for selecting appropriate bioassays and discuss in detail the bioassays typically used to explore antimicrobial, antibiofilm, cytotoxic, antiviral, antioxidant, and anti-ageing potential. The concept of quality control and bioassay validation are introduced, followed by safety considerations, which are critical to advancing bioactive compounds to a higher stage of development. We conclude by providing an application-oriented view focused on the development of pharmaceuticals, food supplements, and cosmetics, the industrial pipelines where currently known marine na...
Source: Biotechnology Advances - January 7, 2024 Category: Biotechnology Authors: Jerica Saboti č Engin Bayram David Ezra Susana P Gaud êncio Berat Z Haznedaro ğlu Nika Jane ž Leila Ktari Anna Luganini Manolis Mandalakis Ivo Safarik Dina Simes Evita Strode Anna Toru ńska-Sitarz Despoina Varamogianni-Mamatsi Giovanna Cristina Vares Source Type: research
A guide to the use of bioassays in exploration of natural resources
We present a comprehensive list of practical considerations for selecting appropriate bioassays and discuss in detail the bioassays typically used to explore antimicrobial, antibiofilm, cytotoxic, antiviral, antioxidant, and anti-ageing potential. The concept of quality control and bioassay validation are introduced, followed by safety considerations, which are critical to advancing bioactive compounds to a higher stage of development. We conclude by providing an application-oriented view focused on the development of pharmaceuticals, food supplements, and cosmetics, the industrial pipelines where currently known marine na...
Source: Biotechnology Advances - January 7, 2024 Category: Biotechnology Authors: Jerica Saboti č Engin Bayram David Ezra Susana P Gaud êncio Berat Z Haznedaro ğlu Nika Jane ž Leila Ktari Anna Luganini Manolis Mandalakis Ivo Safarik Dina Simes Evita Strode Anna Toru ńska-Sitarz Despoina Varamogianni-Mamatsi Giovanna Cristina Vares Source Type: research
A guide to the use of bioassays in exploration of natural resources
We present a comprehensive list of practical considerations for selecting appropriate bioassays and discuss in detail the bioassays typically used to explore antimicrobial, antibiofilm, cytotoxic, antiviral, antioxidant, and anti-ageing potential. The concept of quality control and bioassay validation are introduced, followed by safety considerations, which are critical to advancing bioactive compounds to a higher stage of development. We conclude by providing an application-oriented view focused on the development of pharmaceuticals, food supplements, and cosmetics, the industrial pipelines where currently known marine na...
Source: Biotechnology Advances - January 7, 2024 Category: Biotechnology Authors: Jerica Saboti č Engin Bayram David Ezra Susana P Gaud êncio Berat Z Haznedaro ğlu Nika Jane ž Leila Ktari Anna Luganini Manolis Mandalakis Ivo Safarik Dina Simes Evita Strode Anna Toru ńska-Sitarz Despoina Varamogianni-Mamatsi Giovanna Cristina Vares Source Type: research
Strategies for the biological production of ectoine by using different chassis strains
Biotechnol Adv. 2023 Dec 28;70:108306. doi: 10.1016/j.biotechadv.2023.108306. Online ahead of print.ABSTRACTAs an amino acid derivative and a typical compatible solute, ectoine can assist microorganisms in resisting high osmotic pressure. Own to its long-term moisturizing effects, ectoine shows extensive applications in cosmetics, medicine and other fields. With the rapid development of synthetic biology and fermentation engineering, many biological strategies have been developed to improve the ectoine production and simplify the production process. Currently, the microbial fermentation has been widely used for large scali...
Source: Biotechnology Advances - December 29, 2023 Category: Biotechnology Authors: Yifan Feng Min Qiu Lei Shao Yujia Jiang Wenming Zhang Wankui Jiang Fengxue Xin Min Jiang Source Type: research
Strategies for the biological production of ectoine by using different chassis strains
Biotechnol Adv. 2023 Dec 28;70:108306. doi: 10.1016/j.biotechadv.2023.108306. Online ahead of print.ABSTRACTAs an amino acid derivative and a typical compatible solute, ectoine can assist microorganisms in resisting high osmotic pressure. Own to its long-term moisturizing effects, ectoine shows extensive applications in cosmetics, medicine and other fields. With the rapid development of synthetic biology and fermentation engineering, many biological strategies have been developed to improve the ectoine production and simplify the production process. Currently, the microbial fermentation has been widely used for large scali...
Source: Biotechnology Advances - December 29, 2023 Category: Biotechnology Authors: Yifan Feng Min Qiu Lei Shao Yujia Jiang Wenming Zhang Wankui Jiang Fengxue Xin Min Jiang Source Type: research
Strategies for the biological production of ectoine by using different chassis strains
Biotechnol Adv. 2023 Dec 27:108306. doi: 10.1016/j.biotechadv.2023.108306. Online ahead of print.ABSTRACTAs an amino acid derivative and a typical compatible solute, ectoine can assist microorganisms in resisting high osmotic pressure. Own to its long-term moisturizing effects, ectoine shows extensive applications in cosmetics, medicine and other fields. With the rapid development of synthetic biology and fermentation engineering, many biological strategies have been developed to improve the ectoine production and simplify the production process. Currently, the microbial fermentation has been widely used for large scaling ...
Source: Biotechnology Advances - December 29, 2023 Category: Biotechnology Authors: Yifan Feng Min Qiu Lei Shao Yujia Jiang Wenming Zhang Wankui Jiang Fengxue Xin Min Jiang Source Type: research
Strategies for the biological production of ectoine by using different chassis strains
Biotechnol Adv. 2023 Dec 27:108306. doi: 10.1016/j.biotechadv.2023.108306. Online ahead of print.ABSTRACTAs an amino acid derivative and a typical compatible solute, ectoine can assist microorganisms in resisting high osmotic pressure. Own to its long-term moisturizing effects, ectoine shows extensive applications in cosmetics, medicine and other fields. With the rapid development of synthetic biology and fermentation engineering, many biological strategies have been developed to improve the ectoine production and simplify the production process. Currently, the microbial fermentation has been widely used for large scaling ...
Source: Biotechnology Advances - December 29, 2023 Category: Biotechnology Authors: Yifan Feng Min Qiu Lei Shao Yujia Jiang Wenming Zhang Wankui Jiang Fengxue Xin Min Jiang Source Type: research
Strategies for the biological production of ectoine by using different chassis strains
Biotechnol Adv. 2023 Dec 27:108306. doi: 10.1016/j.biotechadv.2023.108306. Online ahead of print.ABSTRACTAs an amino acid derivative and a typical compatible solute, ectoine can assist microorganisms in resisting high osmotic pressure. Own to its long-term moisturizing effects, ectoine shows extensive applications in cosmetics, medicine and other fields. With the rapid development of synthetic biology and fermentation engineering, many biological strategies have been developed to improve the ectoine production and simplify the production process. Currently, the microbial fermentation has been widely used for large scaling ...
Source: Biotechnology Advances - December 29, 2023 Category: Biotechnology Authors: Yifan Feng Min Qiu Lei Shao Yujia Jiang Wenming Zhang Wankui Jiang Fengxue Xin Min Jiang Source Type: research
Proteases immobilized on nanomaterials for biocatalytic, environmental and biomedical applications: Advantages and drawbacks
Biotechnol Adv. 2023 Dec 21;70:108304. doi: 10.1016/j.biotechadv.2023.108304. Online ahead of print.ABSTRACTProteases have gained significant scientific and industrial interest due to their unique biocatalytic characteristics and broad-spectrum applications in different industries. The development of robust nanobiocatalytic systems by attaching proteases onto various nanostructured materials as fascinating and novel nanocarriers has demonstrated exceptional biocatalytic performance, substantial stability, and ease of recyclability over multiple reaction cycles under different chemical and physical conditions. Proteases imm...
Source: Biotechnology Advances - December 22, 2023 Category: Biotechnology Authors: Muhammad Bilal Sarmad Ahmad Qamar Diego Carballares Ángel Berenguer-Murcia Roberto Fernandez-Lafuente Source Type: research
Proteases immobilized on nanomaterials for biocatalytic, environmental and biomedical applications: Advantages and drawbacks
Biotechnol Adv. 2023 Dec 21;70:108304. doi: 10.1016/j.biotechadv.2023.108304. Online ahead of print.ABSTRACTProteases have gained significant scientific and industrial interest due to their unique biocatalytic characteristics and broad-spectrum applications in different industries. The development of robust nanobiocatalytic systems by attaching proteases onto various nanostructured materials as fascinating and novel nanocarriers has demonstrated exceptional biocatalytic performance, substantial stability, and ease of recyclability over multiple reaction cycles under different chemical and physical conditions. Proteases imm...
Source: Biotechnology Advances - December 22, 2023 Category: Biotechnology Authors: Muhammad Bilal Sarmad Ahmad Qamar Diego Carballares Ángel Berenguer-Murcia Roberto Fernandez-Lafuente Source Type: research
Proteases immobilized on nanomaterials for biocatalytic, environmental and biomedical applications: Advantages and drawbacks
Biotechnol Adv. 2023 Dec 21;70:108304. doi: 10.1016/j.biotechadv.2023.108304. Online ahead of print.ABSTRACTProteases have gained significant scientific and industrial interest due to their unique biocatalytic characteristics and broad-spectrum applications in different industries. The development of robust nanobiocatalytic systems by attaching proteases onto various nanostructured materials as fascinating and novel nanocarriers has demonstrated exceptional biocatalytic performance, substantial stability, and ease of recyclability over multiple reaction cycles under different chemical and physical conditions. Proteases imm...
Source: Biotechnology Advances - December 22, 2023 Category: Biotechnology Authors: Muhammad Bilal Sarmad Ahmad Qamar Diego Carballares Ángel Berenguer-Murcia Roberto Fernandez-Lafuente Source Type: research
Proteases immobilized on nanomaterials for biocatalytic, environmental and biomedical applications: Advantages and drawbacks
Biotechnol Adv. 2023 Dec 21;70:108304. doi: 10.1016/j.biotechadv.2023.108304. Online ahead of print.ABSTRACTProteases have gained significant scientific and industrial interest due to their unique biocatalytic characteristics and broad-spectrum applications in different industries. The development of robust nanobiocatalytic systems by attaching proteases onto various nanostructured materials as fascinating and novel nanocarriers has demonstrated exceptional biocatalytic performance, substantial stability, and ease of recyclability over multiple reaction cycles under different chemical and physical conditions. Proteases imm...
Source: Biotechnology Advances - December 22, 2023 Category: Biotechnology Authors: Muhammad Bilal Sarmad Ahmad Qamar Diego Carballares Ángel Berenguer-Murcia Roberto Fernandez-Lafuente Source Type: research
