High-throughput microbead assay system with a portable, cost-effective Wi-Fi imaging module, and disposable multi-layered microfluidic cartridges for virus and microparticle detection, and tracking
We present the development of a wireless, standalone device and disposable microfluidics chips that rapidly generate parallel readouts for selected, possible virus variants from a nasal or saliva sample, based on motorized and non-motorized microbeads detection, and imaging processing of the motion tracks of these beads in micrometers. Microbeads and SARS-CoV-2 COVID-19 Delta variant were tested as proof-of-concept for testing the microfluidic cartridges and wireless imaging module. The Microbead Assay (MA) system kit consists of a Wi-Fi readout module, a microfluidic chip, and a sample collection/processing sub-system. He...
Source: Biomedical Microdevices - June 7, 2023 Category: Biomedical Engineering Authors: Jorge Manrique Castro Frank Sommerhage Rishika Khanna Andre Childs David DeRoo Swaminathan Rajaraman Source Type: research
High-throughput microbead assay system with a portable, cost-effective Wi-Fi imaging module, and disposable multi-layered microfluidic cartridges for virus and microparticle detection, and tracking
We present the development of a wireless, standalone device and disposable microfluidics chips that rapidly generate parallel readouts for selected, possible virus variants from a nasal or saliva sample, based on motorized and non-motorized microbeads detection, and imaging processing of the motion tracks of these beads in micrometers. Microbeads and SARS-CoV-2 COVID-19 Delta variant were tested as proof-of-concept for testing the microfluidic cartridges and wireless imaging module. The Microbead Assay (MA) system kit consists of a Wi-Fi readout module, a microfluidic chip, and a sample collection/processing sub-system. He...
Source: Biomedical Microdevices - June 7, 2023 Category: Biomedical Engineering Authors: Jorge Manrique Castro Frank Sommerhage Rishika Khanna Andre Childs David DeRoo Swaminathan Rajaraman Source Type: research
High-throughput microbead assay system with a portable, cost-effective Wi-Fi imaging module, and disposable multi-layered microfluidic cartridges for virus and microparticle detection, and tracking
We present the development of a wireless, standalone device and disposable microfluidics chips that rapidly generate parallel readouts for selected, possible virus variants from a nasal or saliva sample, based on motorized and non-motorized microbeads detection, and imaging processing of the motion tracks of these beads in micrometers. Microbeads and SARS-CoV-2 COVID-19 Delta variant were tested as proof-of-concept for testing the microfluidic cartridges and wireless imaging module. The Microbead Assay (MA) system kit consists of a Wi-Fi readout module, a microfluidic chip, and a sample collection/processing sub-system. He...
Source: Biomedical Microdevices - June 7, 2023 Category: Biomedical Engineering Authors: Jorge Manrique Castro Frank Sommerhage Rishika Khanna Andre Childs David DeRoo Swaminathan Rajaraman Source Type: research
High-throughput microbead assay system with a portable, cost-effective Wi-Fi imaging module, and disposable multi-layered microfluidic cartridges for virus and microparticle detection, and tracking
We present the development of a wireless, standalone device and disposable microfluidics chips that rapidly generate parallel readouts for selected, possible virus variants from a nasal or saliva sample, based on motorized and non-motorized microbeads detection, and imaging processing of the motion tracks of these beads in micrometers. Microbeads and SARS-CoV-2 COVID-19 Delta variant were tested as proof-of-concept for testing the microfluidic cartridges and wireless imaging module. The Microbead Assay (MA) system kit consists of a Wi-Fi readout module, a microfluidic chip, and a sample collection/processing sub-system. He...
Source: Biomedical Microdevices - June 7, 2023 Category: Biomedical Engineering Authors: Jorge Manrique Castro Frank Sommerhage Rishika Khanna Andre Childs David DeRoo Swaminathan Rajaraman Source Type: research
Microneedles: materials, fabrication, and biomedical applications
Biomed Microdevices. 2023 Jun 6;25(3):20. doi: 10.1007/s10544-023-00658-y.ABSTRACTThe microneedles have attracted great interests for a wide range of transdermal biomedical applications, such as biosensing and drug delivery, due to the advantages of being painless, semi-invasive, and sustainable. The ongoing challenges are the materials and fabrication methods of the microneedles in order to obtain a specific shape, configuration and function of the microneedles to achieve a target biomedical application. Here, this review would introduce the types of materials of the microneedles firstly. The hardness, Young's modulus, ge...
Source: Biomedical Microdevices - June 6, 2023 Category: Biomedical Engineering Authors: Xiaojin Luo Li Yang Yue Cui Source Type: research
Portable and integrated microfluidic flow control system using off-the-shelf components towards organs-on-chip applications
Biomed Microdevices. 2023 Jun 2;25(2):19. doi: 10.1007/s10544-023-00657-z.ABSTRACTOrgan-on-a-chip (OoC) devices require the precise control of various media. This is mostly done using several fluid control components, which are much larger than the typical OoC device and connected through fluidic tubing, i.e., the fluidic system is not integrated, which inhibits the system's portability. Here, we explore the limits of fluidic system integration using off-the-shelf fluidic control components. A flow control configuration is proposed that uses a vacuum to generate a fluctuation-free flow and minimizes the number of component...
Source: Biomedical Microdevices - June 2, 2023 Category: Biomedical Engineering Authors: Haoyu Zhu G ürhan Özkayar Joost L ötters Marcel Tichem Murali Krishna Ghatkesar Source Type: research
Portable and integrated microfluidic flow control system using off-the-shelf components towards organs-on-chip applications
Biomed Microdevices. 2023 Jun 2;25(2):19. doi: 10.1007/s10544-023-00657-z.ABSTRACTOrgan-on-a-chip (OoC) devices require the precise control of various media. This is mostly done using several fluid control components, which are much larger than the typical OoC device and connected through fluidic tubing, i.e., the fluidic system is not integrated, which inhibits the system's portability. Here, we explore the limits of fluidic system integration using off-the-shelf fluidic control components. A flow control configuration is proposed that uses a vacuum to generate a fluctuation-free flow and minimizes the number of component...
Source: Biomedical Microdevices - June 2, 2023 Category: Biomedical Engineering Authors: Haoyu Zhu G ürhan Özkayar Joost L ötters Marcel Tichem Murali Krishna Ghatkesar Source Type: research
Portable and integrated microfluidic flow control system using off-the-shelf components towards organs-on-chip applications
Biomed Microdevices. 2023 Jun 2;25(2):19. doi: 10.1007/s10544-023-00657-z.ABSTRACTOrgan-on-a-chip (OoC) devices require the precise control of various media. This is mostly done using several fluid control components, which are much larger than the typical OoC device and connected through fluidic tubing, i.e., the fluidic system is not integrated, which inhibits the system's portability. Here, we explore the limits of fluidic system integration using off-the-shelf fluidic control components. A flow control configuration is proposed that uses a vacuum to generate a fluctuation-free flow and minimizes the number of component...
Source: Biomedical Microdevices - June 2, 2023 Category: Biomedical Engineering Authors: Haoyu Zhu G ürhan Özkayar Joost L ötters Marcel Tichem Murali Krishna Ghatkesar Source Type: research
Portable and integrated microfluidic flow control system using off-the-shelf components towards organs-on-chip applications
Biomed Microdevices. 2023 Jun 2;25(2):19. doi: 10.1007/s10544-023-00657-z.ABSTRACTOrgan-on-a-chip (OoC) devices require the precise control of various media. This is mostly done using several fluid control components, which are much larger than the typical OoC device and connected through fluidic tubing, i.e., the fluidic system is not integrated, which inhibits the system's portability. Here, we explore the limits of fluidic system integration using off-the-shelf fluidic control components. A flow control configuration is proposed that uses a vacuum to generate a fluctuation-free flow and minimizes the number of component...
Source: Biomedical Microdevices - June 2, 2023 Category: Biomedical Engineering Authors: Haoyu Zhu G ürhan Özkayar Joost L ötters Marcel Tichem Murali Krishna Ghatkesar Source Type: research
Point-of-care testing: a disposable label-free electrochemical CA125 and HE4 immunosensors for early detection of ovarian cancer
Biomed Microdevices. 2023 May 4;25(2):18. doi: 10.1007/s10544-023-00659-x.ABSTRACTCancer antigen 125 (CA125) and human epididymal secretory protein 4 (HE4) are critical biomarkers for ovarian cancer diagnosis and progression monitoring; therefore, sensitive determination of their levels in body fluids is crucial. In recent study, label-free CA125 and HE4 immunosensors were prepared using disposable screen-printed carbon electrodes modified with reduced graphene oxide, polythionine, and gold nanoparticles for the sensitive, fast, and practical determination of CA125 and HE4. Differential pulse voltammetry, square wave volta...
Source: Biomedical Microdevices - May 4, 2023 Category: Biomedical Engineering Authors: Melike Bilgi Kama ç Muhammed Altun Merve Y ılmaz Ayla Y ılmaz Aktan Soner Aktan Mustafa Kemal Sezgint ürk Source Type: research
Point-of-care testing: a disposable label-free electrochemical CA125 and HE4 immunosensors for early detection of ovarian cancer
Biomed Microdevices. 2023 May 4;25(2):18. doi: 10.1007/s10544-023-00659-x.ABSTRACTCancer antigen 125 (CA125) and human epididymal secretory protein 4 (HE4) are critical biomarkers for ovarian cancer diagnosis and progression monitoring; therefore, sensitive determination of their levels in body fluids is crucial. In recent study, label-free CA125 and HE4 immunosensors were prepared using disposable screen-printed carbon electrodes modified with reduced graphene oxide, polythionine, and gold nanoparticles for the sensitive, fast, and practical determination of CA125 and HE4. Differential pulse voltammetry, square wave volta...
Source: Biomedical Microdevices - May 4, 2023 Category: Biomedical Engineering Authors: Melike Bilgi Kama ç Muhammed Altun Merve Y ılmaz Ayla Y ılmaz Aktan Soner Aktan Mustafa Kemal Sezgint ürk Source Type: research
Point-of-care testing: a disposable label-free electrochemical CA125 and HE4 immunosensors for early detection of ovarian cancer
Biomed Microdevices. 2023 May 4;25(2):18. doi: 10.1007/s10544-023-00659-x.ABSTRACTCancer antigen 125 (CA125) and human epididymal secretory protein 4 (HE4) are critical biomarkers for ovarian cancer diagnosis and progression monitoring; therefore, sensitive determination of their levels in body fluids is crucial. In recent study, label-free CA125 and HE4 immunosensors were prepared using disposable screen-printed carbon electrodes modified with reduced graphene oxide, polythionine, and gold nanoparticles for the sensitive, fast, and practical determination of CA125 and HE4. Differential pulse voltammetry, square wave volta...
Source: Biomedical Microdevices - May 4, 2023 Category: Biomedical Engineering Authors: Melike Bilgi Kama ç Muhammed Altun Merve Y ılmaz Ayla Y ılmaz Aktan Soner Aktan Mustafa Kemal Sezgint ürk Source Type: research
Point-of-care testing: a disposable label-free electrochemical CA125 and HE4 immunosensors for early detection of ovarian cancer
Biomed Microdevices. 2023 May 4;25(2):18. doi: 10.1007/s10544-023-00659-x.ABSTRACTCancer antigen 125 (CA125) and human epididymal secretory protein 4 (HE4) are critical biomarkers for ovarian cancer diagnosis and progression monitoring; therefore, sensitive determination of their levels in body fluids is crucial. In recent study, label-free CA125 and HE4 immunosensors were prepared using disposable screen-printed carbon electrodes modified with reduced graphene oxide, polythionine, and gold nanoparticles for the sensitive, fast, and practical determination of CA125 and HE4. Differential pulse voltammetry, square wave volta...
Source: Biomedical Microdevices - May 4, 2023 Category: Biomedical Engineering Authors: Melike Bilgi Kama ç Muhammed Altun Merve Y ılmaz Ayla Y ılmaz Aktan Soner Aktan Mustafa Kemal Sezgint ürk Source Type: research
Point-of-care testing: a disposable label-free electrochemical CA125 and HE4 immunosensors for early detection of ovarian cancer
Biomed Microdevices. 2023 May 4;25(2):18. doi: 10.1007/s10544-023-00659-x.ABSTRACTCancer antigen 125 (CA125) and human epididymal secretory protein 4 (HE4) are critical biomarkers for ovarian cancer diagnosis and progression monitoring; therefore, sensitive determination of their levels in body fluids is crucial. In recent study, label-free CA125 and HE4 immunosensors were prepared using disposable screen-printed carbon electrodes modified with reduced graphene oxide, polythionine, and gold nanoparticles for the sensitive, fast, and practical determination of CA125 and HE4. Differential pulse voltammetry, square wave volta...
Source: Biomedical Microdevices - May 4, 2023 Category: Biomedical Engineering Authors: Melike Bilgi Kama ç Muhammed Altun Merve Y ılmaz Ayla Y ılmaz Aktan Soner Aktan Mustafa Kemal Sezgint ürk Source Type: research
Point-of-care testing: a disposable label-free electrochemical CA125 and HE4 immunosensors for early detection of ovarian cancer
Biomed Microdevices. 2023 May 4;25(2):18. doi: 10.1007/s10544-023-00659-x.ABSTRACTCancer antigen 125 (CA125) and human epididymal secretory protein 4 (HE4) are critical biomarkers for ovarian cancer diagnosis and progression monitoring; therefore, sensitive determination of their levels in body fluids is crucial. In recent study, label-free CA125 and HE4 immunosensors were prepared using disposable screen-printed carbon electrodes modified with reduced graphene oxide, polythionine, and gold nanoparticles for the sensitive, fast, and practical determination of CA125 and HE4. Differential pulse voltammetry, square wave volta...
Source: Biomedical Microdevices - May 4, 2023 Category: Biomedical Engineering Authors: Melike Bilgi Kama ç Muhammed Altun Merve Y ılmaz Ayla Y ılmaz Aktan Soner Aktan Mustafa Kemal Sezgint ürk Source Type: research
