A flexible implant for acute intrapancreatic electrophysiology
Biomed Microdevices. 2023 Aug 30;25(3):35. doi: 10.1007/s10544-023-00662-2.ABSTRACTMicroelectrode arrays (MEAs) have proven to be a powerful tool to study electrophysiological processes over the last decades with most technology developed for investigation of the heart or brain. Other targets in the field of bioelectronic medicine are the peripheral nervous system and its innervation of various organs. Beyond the heart and nervous systems, the beta cells of the pancreatic islets of Langerhans generate action potentials during the production of insulin. In vitro experiments have demonstrated that their activity is a biomark...
Source: Biomedical Microdevices - August 30, 2023 Category: Biomedical Engineering Authors: Domenic Pascual Lisa Brauns Ruth Domes Matthias Tisler Marco K ögel Angelika Stumpf Andreas Kirschniak Jens Rolinger Udo Kraushaar Peter D Jones Source Type: research
A flexible implant for acute intrapancreatic electrophysiology
Biomed Microdevices. 2023 Aug 30;25(3):35. doi: 10.1007/s10544-023-00662-2.ABSTRACTMicroelectrode arrays (MEAs) have proven to be a powerful tool to study electrophysiological processes over the last decades with most technology developed for investigation of the heart or brain. Other targets in the field of bioelectronic medicine are the peripheral nervous system and its innervation of various organs. Beyond the heart and nervous systems, the beta cells of the pancreatic islets of Langerhans generate action potentials during the production of insulin. In vitro experiments have demonstrated that their activity is a biomark...
Source: Biomedical Microdevices - August 30, 2023 Category: Biomedical Engineering Authors: Domenic Pascual Lisa Brauns Ruth Domes Matthias Tisler Marco K ögel Angelika Stumpf Andreas Kirschniak Jens Rolinger Udo Kraushaar Peter D Jones Source Type: research
A flexible implant for acute intrapancreatic electrophysiology
Biomed Microdevices. 2023 Aug 30;25(3):35. doi: 10.1007/s10544-023-00662-2.ABSTRACTMicroelectrode arrays (MEAs) have proven to be a powerful tool to study electrophysiological processes over the last decades with most technology developed for investigation of the heart or brain. Other targets in the field of bioelectronic medicine are the peripheral nervous system and its innervation of various organs. Beyond the heart and nervous systems, the beta cells of the pancreatic islets of Langerhans generate action potentials during the production of insulin. In vitro experiments have demonstrated that their activity is a biomark...
Source: Biomedical Microdevices - August 30, 2023 Category: Biomedical Engineering Authors: Domenic Pascual Lisa Brauns Ruth Domes Matthias Tisler Marco K ögel Angelika Stumpf Andreas Kirschniak Jens Rolinger Udo Kraushaar Peter D Jones Source Type: research
A flexible implant for acute intrapancreatic electrophysiology
Biomed Microdevices. 2023 Aug 30;25(3):35. doi: 10.1007/s10544-023-00662-2.ABSTRACTMicroelectrode arrays (MEAs) have proven to be a powerful tool to study electrophysiological processes over the last decades with most technology developed for investigation of the heart or brain. Other targets in the field of bioelectronic medicine are the peripheral nervous system and its innervation of various organs. Beyond the heart and nervous systems, the beta cells of the pancreatic islets of Langerhans generate action potentials during the production of insulin. In vitro experiments have demonstrated that their activity is a biomark...
Source: Biomedical Microdevices - August 30, 2023 Category: Biomedical Engineering Authors: Domenic Pascual Lisa Brauns Ruth Domes Matthias Tisler Marco K ögel Angelika Stumpf Andreas Kirschniak Jens Rolinger Udo Kraushaar Peter D Jones Source Type: research
A flexible implant for acute intrapancreatic electrophysiology
Biomed Microdevices. 2023 Aug 30;25(3):35. doi: 10.1007/s10544-023-00662-2.ABSTRACTMicroelectrode arrays (MEAs) have proven to be a powerful tool to study electrophysiological processes over the last decades with most technology developed for investigation of the heart or brain. Other targets in the field of bioelectronic medicine are the peripheral nervous system and its innervation of various organs. Beyond the heart and nervous systems, the beta cells of the pancreatic islets of Langerhans generate action potentials during the production of insulin. In vitro experiments have demonstrated that their activity is a biomark...
Source: Biomedical Microdevices - August 30, 2023 Category: Biomedical Engineering Authors: Domenic Pascual Lisa Brauns Ruth Domes Matthias Tisler Marco K ögel Angelika Stumpf Andreas Kirschniak Jens Rolinger Udo Kraushaar Peter D Jones Source Type: research
A flexible implant for acute intrapancreatic electrophysiology
Biomed Microdevices. 2023 Aug 30;25(3):35. doi: 10.1007/s10544-023-00662-2.ABSTRACTMicroelectrode arrays (MEAs) have proven to be a powerful tool to study electrophysiological processes over the last decades with most technology developed for investigation of the heart or brain. Other targets in the field of bioelectronic medicine are the peripheral nervous system and its innervation of various organs. Beyond the heart and nervous systems, the beta cells of the pancreatic islets of Langerhans generate action potentials during the production of insulin. In vitro experiments have demonstrated that their activity is a biomark...
Source: Biomedical Microdevices - August 30, 2023 Category: Biomedical Engineering Authors: Domenic Pascual Lisa Brauns Ruth Domes Matthias Tisler Marco K ögel Angelika Stumpf Andreas Kirschniak Jens Rolinger Udo Kraushaar Peter D Jones Source Type: research
A 3D printed microfluidic device for scalable multiplexed CRISPR-cas12a biosensing
We report a 3D-printed composable microfluidic plate (cPlate) device that utilizes miniaturized wells and microfluidic loading for a multiplexed CRISPR-Cas12a assay. The device easily combines loop-mediated isothermal amplification (LAMP) and CRISPR-Cas12a readout in a simple and high-throughput workflow with low reagent consumption. To ensure the maximum performance of the device, the concentration of Cas12a and detection probe was optimized, which yielded a four-fold sensitivity improvement. Our device demonstrates sensitive detection to the fg mL- 1 level for four waterborne pathogens including shigella, campylobacter, ...
Source: Biomedical Microdevices - August 29, 2023 Category: Biomedical Engineering Authors: Kathrine Curtin Jing Wang Bethany J Fike Brandi Binkley Peng Li Source Type: research
Absorbable cyst brushes
This study focuses on improving the safety of cell brushing in hard-to-reach locations by exploring brush construction from absorbable materials. We investigated the efficacy of loop brushes made of absorbable suture wires of Chirlac, Chirasorb, Monocryl, PDS II, Vicryl Rapid, Glycolon, and Catgut during their operation in conjunction with fine-needle aspiration in an artificial cyst model. PDS II brushes demonstrated the highest efficiency, while Monocryl and Catgut also provided a significant brushing effect. Efficient brushes portrayed higher flexural rigidity than their counterparts, and their efficiency was inversely ...
Source: Biomedical Microdevices - August 23, 2023 Category: Biomedical Engineering Authors: Filipe Marques Wouter van der Wijngaart Niclas Roxhed Source Type: research
Absorbable cyst brushes
This study focuses on improving the safety of cell brushing in hard-to-reach locations by exploring brush construction from absorbable materials. We investigated the efficacy of loop brushes made of absorbable suture wires of Chirlac, Chirasorb, Monocryl, PDS II, Vicryl Rapid, Glycolon, and Catgut during their operation in conjunction with fine-needle aspiration in an artificial cyst model. PDS II brushes demonstrated the highest efficiency, while Monocryl and Catgut also provided a significant brushing effect. Efficient brushes portrayed higher flexural rigidity than their counterparts, and their efficiency was inversely ...
Source: Biomedical Microdevices - August 23, 2023 Category: Biomedical Engineering Authors: Filipe Marques Wouter van der Wijngaart Niclas Roxhed Source Type: research
Absorbable cyst brushes
This study focuses on improving the safety of cell brushing in hard-to-reach locations by exploring brush construction from absorbable materials. We investigated the efficacy of loop brushes made of absorbable suture wires of Chirlac, Chirasorb, Monocryl, PDS II, Vicryl Rapid, Glycolon, and Catgut during their operation in conjunction with fine-needle aspiration in an artificial cyst model. PDS II brushes demonstrated the highest efficiency, while Monocryl and Catgut also provided a significant brushing effect. Efficient brushes portrayed higher flexural rigidity than their counterparts, and their efficiency was inversely ...
Source: Biomedical Microdevices - August 23, 2023 Category: Biomedical Engineering Authors: Filipe Marques Wouter van der Wijngaart Niclas Roxhed Source Type: research
Absorbable cyst brushes
This study focuses on improving the safety of cell brushing in hard-to-reach locations by exploring brush construction from absorbable materials. We investigated the efficacy of loop brushes made of absorbable suture wires of Chirlac, Chirasorb, Monocryl, PDS II, Vicryl Rapid, Glycolon, and Catgut during their operation in conjunction with fine-needle aspiration in an artificial cyst model. PDS II brushes demonstrated the highest efficiency, while Monocryl and Catgut also provided a significant brushing effect. Efficient brushes portrayed higher flexural rigidity than their counterparts, and their efficiency was inversely ...
Source: Biomedical Microdevices - August 23, 2023 Category: Biomedical Engineering Authors: Filipe Marques Wouter van der Wijngaart Niclas Roxhed Source Type: research
Absorbable cyst brushes
This study focuses on improving the safety of cell brushing in hard-to-reach locations by exploring brush construction from absorbable materials. We investigated the efficacy of loop brushes made of absorbable suture wires of Chirlac, Chirasorb, Monocryl, PDS II, Vicryl Rapid, Glycolon, and Catgut during their operation in conjunction with fine-needle aspiration in an artificial cyst model. PDS II brushes demonstrated the highest efficiency, while Monocryl and Catgut also provided a significant brushing effect. Efficient brushes portrayed higher flexural rigidity than their counterparts, and their efficiency was inversely ...
Source: Biomedical Microdevices - August 23, 2023 Category: Biomedical Engineering Authors: Filipe Marques Wouter van der Wijngaart Niclas Roxhed Source Type: research
Absorbable cyst brushes
This study focuses on improving the safety of cell brushing in hard-to-reach locations by exploring brush construction from absorbable materials. We investigated the efficacy of loop brushes made of absorbable suture wires of Chirlac, Chirasorb, Monocryl, PDS II, Vicryl Rapid, Glycolon, and Catgut during their operation in conjunction with fine-needle aspiration in an artificial cyst model. PDS II brushes demonstrated the highest efficiency, while Monocryl and Catgut also provided a significant brushing effect. Efficient brushes portrayed higher flexural rigidity than their counterparts, and their efficiency was inversely ...
Source: Biomedical Microdevices - August 23, 2023 Category: Biomedical Engineering Authors: Filipe Marques Wouter van der Wijngaart Niclas Roxhed Source Type: research
Fabrication of an electrospun polycaprolactone substrate for colorimetric bioassays
Biomed Microdevices. 2023 Aug 17;25(3):32. doi: 10.1007/s10544-023-00673-z.ABSTRACTColorimetric assays rely on detecting colour changes to measure the concentration of target molecules. Paper substrates are commonly used for the detection of biomarkers due to their availability, porous structure, and capillarity. However, the morphological and mechanical properties of paper, such as fibre diameter, pore size, and tensile strength, cannot be easily tuned to meet the specific requirements of colorimetric sensors, including liquid capacity and reagent immobilisation. As an alternative to paper materials, biodegradable polymer...
Source: Biomedical Microdevices - August 17, 2023 Category: Biomedical Engineering Authors: Chensong Xu Gwena ël Bonfante Jongho Park Vincent Salles Beomjoon Kim Source Type: research
Fabrication of an electrospun polycaprolactone substrate for colorimetric bioassays
Biomed Microdevices. 2023 Aug 17;25(3):32. doi: 10.1007/s10544-023-00673-z.ABSTRACTColorimetric assays rely on detecting colour changes to measure the concentration of target molecules. Paper substrates are commonly used for the detection of biomarkers due to their availability, porous structure, and capillarity. However, the morphological and mechanical properties of paper, such as fibre diameter, pore size, and tensile strength, cannot be easily tuned to meet the specific requirements of colorimetric sensors, including liquid capacity and reagent immobilisation. As an alternative to paper materials, biodegradable polymer...
Source: Biomedical Microdevices - August 17, 2023 Category: Biomedical Engineering Authors: Chensong Xu Gwena ël Bonfante Jongho Park Vincent Salles Beomjoon Kim Source Type: research
