Multi-well plate lid for single-step pooling of 96 samples for high-throughput barcode-based sequencing
Biomed Microdevices. 2024 Feb 28;26(2):18. doi: 10.1007/s10544-024-00702-5.ABSTRACTHigh-throughput transcriptomics is of increasing fundamental biological and clinical interest. The generation of molecular data from large collections of samples, such as biobanks and drug libraries, is boosting the development of new biomarkers and treatments. Focusing on gene expression, the transcriptomic market exploits the benefits of next-generation sequencing (NGS), leveraging RNA sequencing (RNA-seq) as standard for measuring genome-wide gene expression in biological samples. The cumbersome sample preparation, including RNA extractio...
Source: Biomedical Microdevices - February 28, 2024 Category: Biomedical Engineering Authors: St éphanie Boder-Pasche Mustafa Demir Sarah Heub Manon Garzuel R éal Ischer Daniel Migliozzi Siegfried Graf Noa Schmid H Baris Atakan Daria Gudkova Daniel Alpern Riccardo Dainese Bart Deplancke Gilles Weder Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
A self-stiffening compliant intracortical microprobe
Biomed Microdevices. 2024 Feb 12;26(1):17. doi: 10.1007/s10544-024-00700-7.ABSTRACTUtilising a flexible intracortical microprobe to record/stimulate neurons minimises the incompatibility between the implanted microprobe and the brain, reducing tissue damage due to the brain micromotion. Applying bio-dissolvable coating materials temporarily makes a flexible microprobe stiff to tolerate the penetration force during insertion. However, the inability to adjust the dissolving time after the microprobe contact with the cerebrospinal fluid may lead to inaccuracy in the microprobe positioning. Furthermore, since the dissolving pr...
Source: Biomedical Microdevices - February 12, 2024 Category: Biomedical Engineering Authors: Naser Sharafkhani John M Long Scott D Adams Abbas Z Kouzani Source Type: research
SPIONs: Superparamagnetic iron oxide-based nanoparticles for the delivery of microRNAi-therapeutics in cancer
Biomed Microdevices. 2024 Feb 7;26(1):16. doi: 10.1007/s10544-024-00698-y.ABSTRACTNon-coding RNA (ncRNA)-based therapeutics that induce RNA interference (RNAi), such as microRNAs (miRNAs), have drawn considerable attention as a novel class of targeted cancer therapeutics because of their capacity to specifically target oncogenes/protooncogenes that regulate key signaling pathways involved in carcinogenesis, tumor growth and progression, metastasis, cell survival, proliferation, angiogenesis, and drug resistance. However, clinical translation of miRNA-based therapeutics, in particular, has been challenging due to the ineffe...
Source: Biomedical Microdevices - February 7, 2024 Category: Biomedical Engineering Authors: Goknur Kara Bulent Ozpolat Source Type: research
3D printed microfluidic valve on PCB for flow control applications using liquid metal
Biomed Microdevices. 2024 Jan 30;26(1):14. doi: 10.1007/s10544-024-00697-z.ABSTRACTDirect 3D printing of active microfluidic elements on PCB substrates enables high-speed fabrication of stand-alone microdevices for a variety of health and energy applications. Microvalves are key components of microfluidic devices and liquid metal (LM) microvalves exhibit promising flow control in microsystems integrated with PCBs. In this paper, we demonstrate LM microvalves directly 3D printed on PCB using advanced digital light processing (DLP). Electrodes on PCB are coated by carbon ink to prevent alloying between gallium-based LM plug ...
Source: Biomedical Microdevices - January 30, 2024 Category: Biomedical Engineering Authors: Ahmed Hamza Anagha Navale Qingchuan Song Sagar Bhagwat Frederik Kotz-Helmer Pegah Pezeshkpour Bastian E Rapp Source Type: research
Microneedle patch-based enzyme-linked immunosorbent assay to quantify protein biomarkers of tuberculosis
This study demonstrates the feasibility of an MNP-based ELISA for differential diagnosis of latent TB disease.PMID:38289481 | DOI:10.1007/s10544-024-00694-2 (Source: Biomedical Microdevices)
Source: Biomedical Microdevices - January 30, 2024 Category: Biomedical Engineering Authors: Youngeun Kim Mary Beth Lewis Jihyun Hwang Zheyu Wang Rohit Gupta Yuxiong Liu Tuhina Gupta James P Barber Srikanth Singamaneni Fred Quinn Mark R Prausnitz Source Type: research
Magnetic nanoparticles fabricated/integrated with microfluidics for biological applications: A review
Biomed Microdevices. 2024 Jan 25;26(1):13. doi: 10.1007/s10544-023-00693-9.ABSTRACTNanostructured materials have gained significant attention in recent years for their potential in biological applications, such as cell and biomolecular sorting, as well as early detection of metastatic cancer. Among these materials, magnetic nanoparticles (MNPs) stand out for their easy functionalization, high specific surface area, chemical stability, and superparamagnetic properties. However, conventional fabrication methods can lead to inconsistencies in MNPs' characteristics and performance, highlighting the need for a cost-effective, c...
Source: Biomedical Microdevices - January 25, 2024 Category: Biomedical Engineering Authors: Mahtab Ghasemi Toudeshkchouei Hassan Abdoos Source Type: research
