Design and fabrication of a microelectrode array for studying epileptiform discharges from rodents
In this study, a 13-channel silicon-based single-shank microelectrode array (MEA) was designed and fabricated to record local field potentials (LFPs) from the different depths of a rat's brain. A titanium/gold layer was patterned as electrodes on an oxidized silicon substrate, and silicon dioxide was deposited as a passivation layer. The fabricated array was implanted in the somatosensory cortex of the right hemisphere of an anesthetized rat. The developed MEA was interfaced with an OpenBCI Cyton Daisy Biosensing Board to acquire the local field potentials. The LFPs were acquired at three different neurophysiological condi...
Source: Biomedical Microdevices - August 16, 2023 Category: Biomedical Engineering Authors: Suman Chatterjee Rathin K Joshi Tushar Sakorikar Bhagaban Behera Nitu Bhaskar Shabari Girishan Kv Mahesh Jayachandra Hardik J Pandya Source Type: research
Design and fabrication of a microelectrode array for studying epileptiform discharges from rodents
In this study, a 13-channel silicon-based single-shank microelectrode array (MEA) was designed and fabricated to record local field potentials (LFPs) from the different depths of a rat's brain. A titanium/gold layer was patterned as electrodes on an oxidized silicon substrate, and silicon dioxide was deposited as a passivation layer. The fabricated array was implanted in the somatosensory cortex of the right hemisphere of an anesthetized rat. The developed MEA was interfaced with an OpenBCI Cyton Daisy Biosensing Board to acquire the local field potentials. The LFPs were acquired at three different neurophysiological condi...
Source: Biomedical Microdevices - August 16, 2023 Category: Biomedical Engineering Authors: Suman Chatterjee Rathin K Joshi Tushar Sakorikar Bhagaban Behera Nitu Bhaskar Shabari Girishan Kv Mahesh Jayachandra Hardik J Pandya Source Type: research
A multi-depth spiral milli fluidic device for whole mount zebrafish antibody staining
Biomed Microdevices. 2023 Aug 15;25(3):30. doi: 10.1007/s10544-023-00670-2.ABSTRACTWhole mount zebrafish antibody staining (ABS) is a common staining technique used to localize protein information in a zebrafish embryo or larva. Like most biological assays, the whole mount zebrafish ABS is still largely conducted manually through labor intensive and time-consuming steps which affect both consistency and throughput of the assay. In this work, we develop a milli fluidic device that can automatically trap and immobilize the fixed chorion-less zebrafish embryos for the whole mount ABS. With just a single loading step, the zebr...
Source: Biomedical Microdevices - August 15, 2023 Category: Biomedical Engineering Authors: Songtao Ye Wei-Chun Chin Chih-Wen Ni Source Type: research
Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
Biomed Microdevices. 2023 Aug 5;25(3):29. doi: 10.1007/s10544-023-00671-1.ABSTRACTThe association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluidics represents an ideal playground for ML tools, where multiple engineering parameters - flow rates and mixing configurations, type and concentrations of the reagents - contribute in a non-trivial fashion to determine the resultant morphological and pharmacological attributes of nanomedicines. Here we presen...
Source: Biomedical Microdevices - August 5, 2023 Category: Biomedical Engineering Authors: Valentina Di Francesco Daniela P Boso Thomas L Moore Bernhard A Schrefler Paolo Decuzzi Source Type: research
Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
Biomed Microdevices. 2023 Aug 5;25(3):29. doi: 10.1007/s10544-023-00671-1.ABSTRACTThe association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluidics represents an ideal playground for ML tools, where multiple engineering parameters - flow rates and mixing configurations, type and concentrations of the reagents - contribute in a non-trivial fashion to determine the resultant morphological and pharmacological attributes of nanomedicines. Here we presen...
Source: Biomedical Microdevices - August 5, 2023 Category: Biomedical Engineering Authors: Valentina Di Francesco Daniela P Boso Thomas L Moore Bernhard A Schrefler Paolo Decuzzi Source Type: research
Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
Biomed Microdevices. 2023 Aug 5;25(3):29. doi: 10.1007/s10544-023-00671-1.ABSTRACTThe association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluidics represents an ideal playground for ML tools, where multiple engineering parameters - flow rates and mixing configurations, type and concentrations of the reagents - contribute in a non-trivial fashion to determine the resultant morphological and pharmacological attributes of nanomedicines. Here we presen...
Source: Biomedical Microdevices - August 5, 2023 Category: Biomedical Engineering Authors: Valentina Di Francesco Daniela P Boso Thomas L Moore Bernhard A Schrefler Paolo Decuzzi Source Type: research
Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
Biomed Microdevices. 2023 Aug 5;25(3):29. doi: 10.1007/s10544-023-00671-1.ABSTRACTThe association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluidics represents an ideal playground for ML tools, where multiple engineering parameters - flow rates and mixing configurations, type and concentrations of the reagents - contribute in a non-trivial fashion to determine the resultant morphological and pharmacological attributes of nanomedicines. Here we presen...
Source: Biomedical Microdevices - August 5, 2023 Category: Biomedical Engineering Authors: Valentina Di Francesco Daniela P Boso Thomas L Moore Bernhard A Schrefler Paolo Decuzzi Source Type: research
Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
Biomed Microdevices. 2023 Aug 5;25(3):29. doi: 10.1007/s10544-023-00671-1.ABSTRACTThe association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluidics represents an ideal playground for ML tools, where multiple engineering parameters - flow rates and mixing configurations, type and concentrations of the reagents - contribute in a non-trivial fashion to determine the resultant morphological and pharmacological attributes of nanomedicines. Here we presen...
Source: Biomedical Microdevices - August 5, 2023 Category: Biomedical Engineering Authors: Valentina Di Francesco Daniela P Boso Thomas L Moore Bernhard A Schrefler Paolo Decuzzi Source Type: research
Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
Biomed Microdevices. 2023 Aug 5;25(3):29. doi: 10.1007/s10544-023-00671-1.ABSTRACTThe association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluidics represents an ideal playground for ML tools, where multiple engineering parameters - flow rates and mixing configurations, type and concentrations of the reagents - contribute in a non-trivial fashion to determine the resultant morphological and pharmacological attributes of nanomedicines. Here we presen...
Source: Biomedical Microdevices - August 5, 2023 Category: Biomedical Engineering Authors: Valentina Di Francesco Daniela P Boso Thomas L Moore Bernhard A Schrefler Paolo Decuzzi Source Type: research
Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
Biomed Microdevices. 2023 Aug 5;25(3):29. doi: 10.1007/s10544-023-00671-1.ABSTRACTThe association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluidics represents an ideal playground for ML tools, where multiple engineering parameters - flow rates and mixing configurations, type and concentrations of the reagents - contribute in a non-trivial fashion to determine the resultant morphological and pharmacological attributes of nanomedicines. Here we presen...
Source: Biomedical Microdevices - August 5, 2023 Category: Biomedical Engineering Authors: Valentina Di Francesco Daniela P Boso Thomas L Moore Bernhard A Schrefler Paolo Decuzzi Source Type: research
Machine learning instructed microfluidic synthesis of curcumin-loaded liposomes
Biomed Microdevices. 2023 Aug 5;25(3):29. doi: 10.1007/s10544-023-00671-1.ABSTRACTThe association of machine learning (ML) tools with the synthesis of nanoparticles has the potential to streamline the development of more efficient and effective nanomedicines. The continuous-flow synthesis of nanoparticles via microfluidics represents an ideal playground for ML tools, where multiple engineering parameters - flow rates and mixing configurations, type and concentrations of the reagents - contribute in a non-trivial fashion to determine the resultant morphological and pharmacological attributes of nanomedicines. Here we presen...
Source: Biomedical Microdevices - August 5, 2023 Category: Biomedical Engineering Authors: Valentina Di Francesco Daniela P Boso Thomas L Moore Bernhard A Schrefler Paolo Decuzzi Source Type: research
High-aspect-ratio three-dimensional polymer and metallic microstructure microfabrication using two-photon polymerization
Biomed Microdevices. 2023 Jul 29;25(3):28. doi: 10.1007/s10544-023-00665-z.ABSTRACTCreating micrometer-resolution high-aspect-ratio three-dimensional (3D) structures remain very challenging despite significant microfabrication methods developed for microelectromechanical systems (MEMS). This is especially the case when such structures are desired to be metallic to support electronic applications. Here, we present a microfabrication process that combines two-photon-polymerization (2PP) printing to create a polymeric high-aspect-ratio three-dimensional structure and electroless metal plating that selectively electroplates on...
Source: Biomedical Microdevices - July 29, 2023 Category: Biomedical Engineering Authors: Ethan Vargas Can Huang Zhiyu Yan Harold White Jun Zou Arum Han Source Type: research
High-aspect-ratio three-dimensional polymer and metallic microstructure microfabrication using two-photon polymerization
Biomed Microdevices. 2023 Jul 29;25(3):28. doi: 10.1007/s10544-023-00665-z.ABSTRACTCreating micrometer-resolution high-aspect-ratio three-dimensional (3D) structures remain very challenging despite significant microfabrication methods developed for microelectromechanical systems (MEMS). This is especially the case when such structures are desired to be metallic to support electronic applications. Here, we present a microfabrication process that combines two-photon-polymerization (2PP) printing to create a polymeric high-aspect-ratio three-dimensional structure and electroless metal plating that selectively electroplates on...
Source: Biomedical Microdevices - July 29, 2023 Category: Biomedical Engineering Authors: Ethan Vargas Can Huang Zhiyu Yan Harold White Jun Zou Arum Han Source Type: research
High-aspect-ratio three-dimensional polymer and metallic microstructure microfabrication using two-photon polymerization
Biomed Microdevices. 2023 Jul 29;25(3):28. doi: 10.1007/s10544-023-00665-z.ABSTRACTCreating micrometer-resolution high-aspect-ratio three-dimensional (3D) structures remain very challenging despite significant microfabrication methods developed for microelectromechanical systems (MEMS). This is especially the case when such structures are desired to be metallic to support electronic applications. Here, we present a microfabrication process that combines two-photon-polymerization (2PP) printing to create a polymeric high-aspect-ratio three-dimensional structure and electroless metal plating that selectively electroplates on...
Source: Biomedical Microdevices - July 29, 2023 Category: Biomedical Engineering Authors: Ethan Vargas Can Huang Zhiyu Yan Harold White Jun Zou Arum Han Source Type: research
High-aspect-ratio three-dimensional polymer and metallic microstructure microfabrication using two-photon polymerization
Biomed Microdevices. 2023 Jul 29;25(3):28. doi: 10.1007/s10544-023-00665-z.ABSTRACTCreating micrometer-resolution high-aspect-ratio three-dimensional (3D) structures remain very challenging despite significant microfabrication methods developed for microelectromechanical systems (MEMS). This is especially the case when such structures are desired to be metallic to support electronic applications. Here, we present a microfabrication process that combines two-photon-polymerization (2PP) printing to create a polymeric high-aspect-ratio three-dimensional structure and electroless metal plating that selectively electroplates on...
Source: Biomedical Microdevices - July 29, 2023 Category: Biomedical Engineering Authors: Ethan Vargas Can Huang Zhiyu Yan Harold White Jun Zou Arum Han Source Type: research
