Performance gain and electro-mechanical design optimization of microneedles for wearable sensor systems
Biomed Microdevices. 2023 Dec 14;26(1):4. doi: 10.1007/s10544-023-00683-x.ABSTRACTMinimally invasive microneedle (MN) is an emerging technology platform for wearable and implantable diagnostics and therapeutics systems. These short MNs offer pain-free insertion and simple operation. Among the MN technologies proposed to enhance interstitial fluid (ISF) extraction, porous and swellable (P-S) hydrogels absorb analyte molecules across the entire lateral surface. Currently, the design, development, and optimization of the MNs rely on empirical, iterative approaches. Based on theory of fluid flow and analyte diffusion through g...
Source: Biomedical Microdevices - December 14, 2023 Category: Biomedical Engineering Authors: Marco Fratus Muhammad Ashraful Alam Source Type: research
Classification of fetal and adult red blood cells based on hydrodynamic deformation and deep video recognition
Biomed Microdevices. 2023 Dec 14;26(1):5. doi: 10.1007/s10544-023-00688-6.ABSTRACTFlow based deformation cytometry has shown potential for cell classification. We demonstrate the principle with an injection moulded microfluidic chip from which we capture videos of adult and fetal red blood cells, as they are being deformed in a microfluidic chip. Using a deep neural network - SlowFast - that takes the temporal behavior into account, we are able to discriminate between the cells with high accuracy. The accuracy was larger for adult blood cells than for fetal blood cells. However, no significant difference was observed betwe...
Source: Biomedical Microdevices - December 14, 2023 Category: Biomedical Engineering Authors: Peter Johannes Tejlgaard Kampen Gustav Ragnar St øttrup-Als Nicklas Bruun-Andersen Joachim Secher Freja H øier Anne Todsen Hansen Morten Hanefeld Dziegiel Anders Nymark Christensen Kirstine Berg-S ørensen Source Type: research
Performance gain and electro-mechanical design optimization of microneedles for wearable sensor systems
Biomed Microdevices. 2023 Dec 14;26(1):4. doi: 10.1007/s10544-023-00683-x.ABSTRACTMinimally invasive microneedle (MN) is an emerging technology platform for wearable and implantable diagnostics and therapeutics systems. These short MNs offer pain-free insertion and simple operation. Among the MN technologies proposed to enhance interstitial fluid (ISF) extraction, porous and swellable (P-S) hydrogels absorb analyte molecules across the entire lateral surface. Currently, the design, development, and optimization of the MNs rely on empirical, iterative approaches. Based on theory of fluid flow and analyte diffusion through g...
Source: Biomedical Microdevices - December 14, 2023 Category: Biomedical Engineering Authors: Marco Fratus Muhammad Ashraful Alam Source Type: research
Classification of fetal and adult red blood cells based on hydrodynamic deformation and deep video recognition
Biomed Microdevices. 2023 Dec 14;26(1):5. doi: 10.1007/s10544-023-00688-6.ABSTRACTFlow based deformation cytometry has shown potential for cell classification. We demonstrate the principle with an injection moulded microfluidic chip from which we capture videos of adult and fetal red blood cells, as they are being deformed in a microfluidic chip. Using a deep neural network - SlowFast - that takes the temporal behavior into account, we are able to discriminate between the cells with high accuracy. The accuracy was larger for adult blood cells than for fetal blood cells. However, no significant difference was observed betwe...
Source: Biomedical Microdevices - December 14, 2023 Category: Biomedical Engineering Authors: Peter Johannes Tejlgaard Kampen Gustav Ragnar St øttrup-Als Nicklas Bruun-Andersen Joachim Secher Freja H øier Anne Todsen Hansen Morten Hanefeld Dziegiel Anders Nymark Christensen Kirstine Berg-S ørensen Source Type: research
Label-free microfluidic chip for segregation and recovery of circulating leukemia cells: clinical applications in acute myeloid leukemia
We present a label-free microfluidic chip for the segregation of circulating leukemia cells (CLCs) from blood samples, with a focus on its clinical applications in Acute Myeloid Leukemia (AML). The microfluidic chip achieved an approximate capture efficiency of 92%. The study analyzed a comprehensive set of 66 blood specimens from AML patients in different disease stages, including newly diagnosed and relapsing cases, patients in complete remission, and those in partial remission. The results showed a significant difference in CLC counts between active disease stages and remission stages (p < 0.0001), with a proposed th...
Source: Biomedical Microdevices - December 12, 2023 Category: Biomedical Engineering Authors: Dongfang Ouyang Ningxin Ye Yue Jiang Yiyang Wang Lina Hu Shuen Chao Martin Yarmush Memet Tuner Yonghua Li Bin Tang Source Type: research
Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip
Biomed Microdevices. 2023 Dec 12;26(1):2. doi: 10.1007/s10544-023-00684-w.ABSTRACTMacrophages are innate immune cells that prevent infections and help in wound healing and vascular inflammation. While these cells are natural helper cells, they also contribute to chronic diseases, e.g., by infiltrating the endothelial layer in early atherosclerosis and by promoting vascular inflammation. There is a crosstalk between inflammatory pathways and key players in thrombosis, such as platelets and endothelial cells - a phenomenon known as 'thromboinflammation'. The role of the embedded macrophages in thromboinflammation in the cont...
Source: Biomedical Microdevices - December 12, 2023 Category: Biomedical Engineering Authors: H H T Middelkamp H J Weener T Gensheimer K Vermeul L E de Heus H J Albers A van den Berg A D van der Meer Source Type: research
Label-free microfluidic chip for segregation and recovery of circulating leukemia cells: clinical applications in acute myeloid leukemia
We present a label-free microfluidic chip for the segregation of circulating leukemia cells (CLCs) from blood samples, with a focus on its clinical applications in Acute Myeloid Leukemia (AML). The microfluidic chip achieved an approximate capture efficiency of 92%. The study analyzed a comprehensive set of 66 blood specimens from AML patients in different disease stages, including newly diagnosed and relapsing cases, patients in complete remission, and those in partial remission. The results showed a significant difference in CLC counts between active disease stages and remission stages (p < 0.0001), with a proposed th...
Source: Biomedical Microdevices - December 12, 2023 Category: Biomedical Engineering Authors: Dongfang Ouyang Ningxin Ye Yue Jiang Yiyang Wang Lina Hu Shuen Chao Martin Yarmush Memet Tuner Yonghua Li Bin Tang Source Type: research
Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip
Biomed Microdevices. 2023 Dec 12;26(1):2. doi: 10.1007/s10544-023-00684-w.ABSTRACTMacrophages are innate immune cells that prevent infections and help in wound healing and vascular inflammation. While these cells are natural helper cells, they also contribute to chronic diseases, e.g., by infiltrating the endothelial layer in early atherosclerosis and by promoting vascular inflammation. There is a crosstalk between inflammatory pathways and key players in thrombosis, such as platelets and endothelial cells - a phenomenon known as 'thromboinflammation'. The role of the embedded macrophages in thromboinflammation in the cont...
Source: Biomedical Microdevices - December 12, 2023 Category: Biomedical Engineering Authors: H H T Middelkamp H J Weener T Gensheimer K Vermeul L E de Heus H J Albers A van den Berg A D van der Meer Source Type: research
Label-free microfluidic chip for segregation and recovery of circulating leukemia cells: clinical applications in acute myeloid leukemia
We present a label-free microfluidic chip for the segregation of circulating leukemia cells (CLCs) from blood samples, with a focus on its clinical applications in Acute Myeloid Leukemia (AML). The microfluidic chip achieved an approximate capture efficiency of 92%. The study analyzed a comprehensive set of 66 blood specimens from AML patients in different disease stages, including newly diagnosed and relapsing cases, patients in complete remission, and those in partial remission. The results showed a significant difference in CLC counts between active disease stages and remission stages (p < 0.0001), with a proposed th...
Source: Biomedical Microdevices - December 12, 2023 Category: Biomedical Engineering Authors: Dongfang Ouyang Ningxin Ye Yue Jiang Yiyang Wang Lina Hu Shuen Chao Martin Yarmush Memet Tuner Yonghua Li Bin Tang Source Type: research
Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip
Biomed Microdevices. 2023 Dec 12;26(1):2. doi: 10.1007/s10544-023-00684-w.ABSTRACTMacrophages are innate immune cells that prevent infections and help in wound healing and vascular inflammation. While these cells are natural helper cells, they also contribute to chronic diseases, e.g., by infiltrating the endothelial layer in early atherosclerosis and by promoting vascular inflammation. There is a crosstalk between inflammatory pathways and key players in thrombosis, such as platelets and endothelial cells - a phenomenon known as 'thromboinflammation'. The role of the embedded macrophages in thromboinflammation in the cont...
Source: Biomedical Microdevices - December 12, 2023 Category: Biomedical Engineering Authors: H H T Middelkamp H J Weener T Gensheimer K Vermeul L E de Heus H J Albers A van den Berg A D van der Meer Source Type: research
An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow
Biomed Microdevices. 2023 Nov 27;26(1):1. doi: 10.1007/s10544-023-00685-9.ABSTRACTOne of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at sufficiently high doses while at the same time affecting healthy tissue and causing significant side effects and suffering in cancer patients. To overcome this deficiency, magnetic nanoparticles as transporter systems have emerged as a promising approach to achieve more specific tumour targeting. Drug-loaded magnetic nanoparticles can be directed to the target tissue by applying an external magnetic field. ...
Source: Biomedical Microdevices - November 26, 2023 Category: Biomedical Engineering Authors: Barbara Wirthl Christina Janko Stefan Lyer Bernhard A Schrefler Christoph Alexiou Wolfgang A Wall Source Type: research
An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow
Biomed Microdevices. 2023 Nov 27;26(1):1. doi: 10.1007/s10544-023-00685-9.ABSTRACTOne of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at sufficiently high doses while at the same time affecting healthy tissue and causing significant side effects and suffering in cancer patients. To overcome this deficiency, magnetic nanoparticles as transporter systems have emerged as a promising approach to achieve more specific tumour targeting. Drug-loaded magnetic nanoparticles can be directed to the target tissue by applying an external magnetic field. ...
Source: Biomedical Microdevices - November 26, 2023 Category: Biomedical Engineering Authors: Barbara Wirthl Christina Janko Stefan Lyer Bernhard A Schrefler Christoph Alexiou Wolfgang A Wall Source Type: research
An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow
Biomed Microdevices. 2023 Nov 27;26(1):1. doi: 10.1007/s10544-023-00685-9.ABSTRACTOne of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at sufficiently high doses while at the same time affecting healthy tissue and causing significant side effects and suffering in cancer patients. To overcome this deficiency, magnetic nanoparticles as transporter systems have emerged as a promising approach to achieve more specific tumour targeting. Drug-loaded magnetic nanoparticles can be directed to the target tissue by applying an external magnetic field. ...
Source: Biomedical Microdevices - November 26, 2023 Category: Biomedical Engineering Authors: Barbara Wirthl Christina Janko Stefan Lyer Bernhard A Schrefler Christoph Alexiou Wolfgang A Wall Source Type: research
An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow
Biomed Microdevices. 2023 Nov 27;26(1):1. doi: 10.1007/s10544-023-00685-9.ABSTRACTOne of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at sufficiently high doses while at the same time affecting healthy tissue and causing significant side effects and suffering in cancer patients. To overcome this deficiency, magnetic nanoparticles as transporter systems have emerged as a promising approach to achieve more specific tumour targeting. Drug-loaded magnetic nanoparticles can be directed to the target tissue by applying an external magnetic field. ...
Source: Biomedical Microdevices - November 26, 2023 Category: Biomedical Engineering Authors: Barbara Wirthl Christina Janko Stefan Lyer Bernhard A Schrefler Christoph Alexiou Wolfgang A Wall Source Type: research
An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow
Biomed Microdevices. 2023 Nov 27;26(1):1. doi: 10.1007/s10544-023-00685-9.ABSTRACTOne of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at sufficiently high doses while at the same time affecting healthy tissue and causing significant side effects and suffering in cancer patients. To overcome this deficiency, magnetic nanoparticles as transporter systems have emerged as a promising approach to achieve more specific tumour targeting. Drug-loaded magnetic nanoparticles can be directed to the target tissue by applying an external magnetic field. ...
Source: Biomedical Microdevices - November 26, 2023 Category: Biomedical Engineering Authors: Barbara Wirthl Christina Janko Stefan Lyer Bernhard A Schrefler Christoph Alexiou Wolfgang A Wall Source Type: research
